{"id":"https://openalex.org/W4411223899","doi":"https://doi.org/10.1093/bib/bbaf268","title":"scATD: a high-throughput and interpretable framework for single-cell cancer drug resistance prediction and biomarker identification","display_name":"scATD: a high-throughput and interpretable framework for single-cell cancer drug resistance prediction and biomarker identification","publication_year":2025,"publication_date":"2025-05-01","ids":{"openalex":"https://openalex.org/W4411223899","doi":"https://doi.org/10.1093/bib/bbaf268","pmid":"https://pubmed.ncbi.nlm.nih.gov/40501071"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf268","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf268","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bib/bbaf268","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062326911","display_name":"Murong Zhou","orcid":"https://orcid.org/0000-0001-9634-8164"},"institutions":[{"id":"https://openalex.org/I2802805919","display_name":"Science North","ror":"https://ror.org/028k36c88","country_code":"CA","type":"archive","lineage":["https://openalex.org/I2802805919"]},{"id":"https://openalex.org/I47689461","display_name":"Northeast Forestry University","ror":"https://ror.org/02yxnh564","country_code":"CN","type":"education","lineage":["https://openalex.org/I47689461"]}],"countries":["CA","CN"],"is_corresponding":true,"raw_author_name":"Murong Zhou","raw_affiliation_strings":["College of Computer and Control Engineering, Northeast Forestry University , Harbin 150040 ,","College of Life Science, Northeast Forestry University , Harbin 150040 ,"],"affiliations":[{"raw_affiliation_string":"College of Computer and Control Engineering, Northeast Forestry University , Harbin 150040 ,","institution_ids":["https://openalex.org/I47689461"]},{"raw_affiliation_string":"College of Life Science, Northeast Forestry University , Harbin 150040 ,","institution_ids":["https://openalex.org/I47689461","https://openalex.org/I2802805919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101920182","display_name":"Zeyu Luo","orcid":"https://orcid.org/0000-0001-6650-9975"},"institutions":[{"id":"https://openalex.org/I47689461","display_name":"Northeast Forestry University","ror":"https://ror.org/02yxnh564","country_code":"CN","type":"education","lineage":["https://openalex.org/I47689461"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zeyu Luo","raw_affiliation_strings":["College of Computer and Control Engineering, Northeast Forestry University , Harbin 150040 ,"],"affiliations":[{"raw_affiliation_string":"College of Computer and Control Engineering, Northeast Forestry University , Harbin 150040 ,","institution_ids":["https://openalex.org/I47689461"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yu-Hang Yin","orcid":null},"institutions":[{"id":"https://openalex.org/I2802805919","display_name":"Science North","ror":"https://ror.org/028k36c88","country_code":"CA","type":"archive","lineage":["https://openalex.org/I2802805919"]},{"id":"https://openalex.org/I47689461","display_name":"Northeast Forestry University","ror":"https://ror.org/02yxnh564","country_code":"CN","type":"education","lineage":["https://openalex.org/I47689461"]}],"countries":["CA","CN"],"is_corresponding":false,"raw_author_name":"Yu-Hang Yin","raw_affiliation_strings":["College of Computer and Control Engineering, Northeast Forestry University , Harbin 150040 ,","College of Life Science, Northeast Forestry University , Harbin 150040 ,"],"affiliations":[{"raw_affiliation_string":"College of Computer and Control Engineering, Northeast Forestry University , Harbin 150040 ,","institution_ids":["https://openalex.org/I47689461"]},{"raw_affiliation_string":"College of Life Science, Northeast Forestry University , Harbin 150040 ,","institution_ids":["https://openalex.org/I47689461","https://openalex.org/I2802805919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100649980","display_name":"Qiaoming Liu","orcid":"https://orcid.org/0000-0001-8454-9954"},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiaoming Liu","raw_affiliation_strings":["College of Artificial Intelligence, Henan University , Zhengzhou 450000 ,"],"affiliations":[{"raw_affiliation_string":"College of Artificial Intelligence, Henan University , Zhengzhou 450000 ,","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100649978","display_name":"Guohua Wang","orcid":"https://orcid.org/0000-0001-7381-2374"},"institutions":[{"id":"https://openalex.org/I47689461","display_name":"Northeast Forestry University","ror":"https://ror.org/02yxnh564","country_code":"CN","type":"education","lineage":["https://openalex.org/I47689461"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guohua Wang","raw_affiliation_strings":["College of Computer and Control Engineering, Northeast Forestry University , Harbin 150040 ,"],"affiliations":[{"raw_affiliation_string":"College of Computer and Control Engineering, Northeast Forestry University , Harbin 150040 ,","institution_ids":["https://openalex.org/I47689461"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100599476","display_name":"Yuming Zhao","orcid":"https://orcid.org/0000-0001-7219-0999"},"institutions":[{"id":"https://openalex.org/I47689461","display_name":"Northeast Forestry University","ror":"https://ror.org/02yxnh564","country_code":"CN","type":"education","lineage":["https://openalex.org/I47689461"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuming Zhao","raw_affiliation_strings":["College of Computer and Control Engineering, Northeast Forestry University , Harbin 150040 ,"],"affiliations":[{"raw_affiliation_string":"College of Computer and Control Engineering, Northeast Forestry University , Harbin 150040 ,","institution_ids":["https://openalex.org/I47689461"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5062326911"],"corresponding_institution_ids":["https://openalex.org/I2802805919","https://openalex.org/I47689461"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":4.1763,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.94294516,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"26","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6860841512680054},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.6160174608230591},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5195236802101135},{"id":"https://openalex.org/keywords/throughput","display_name":"Throughput","score":0.5118624567985535},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.487631231546402},{"id":"https://openalex.org/keywords/cancer-drugs","display_name":"Cancer drugs","score":0.4717997610569},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.46497535705566406},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.4173814058303833},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23885366320610046},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22169968485832214},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1307922899723053},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09510567784309387}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6860841512680054},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6160174608230591},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5195236802101135},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.5118624567985535},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.487631231546402},{"id":"https://openalex.org/C3020340455","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Cancer drugs","level":3,"score":0.4717997610569},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46497535705566406},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4173814058303833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23885366320610046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22169968485832214},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1307922899723053},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09510567784309387},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf268","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf268","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40501071","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40501071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12159290","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12159290","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf268","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf268","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1939021808","display_name":null,"funder_award_id":"62272094","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G870551797","display_name":null,"funder_award_id":"62225109","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G93292487","display_name":null,"funder_award_id":"62450112","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1987971958","https://openalex.org/W2020541351","https://openalex.org/W2043398720","https://openalex.org/W2108068107","https://openalex.org/W2148143831","https://openalex.org/W2255955546","https://openalex.org/W2373606074","https://openalex.org/W2461427403","https://openalex.org/W2586629973","https://openalex.org/W2795989238","https://openalex.org/W2892741787","https://openalex.org/W2931036699","https://openalex.org/W2962834855","https://openalex.org/W2966839838","https://openalex.org/W2999615587","https://openalex.org/W3041564249","https://openalex.org/W3041956526","https://openalex.org/W3109606946","https://openalex.org/W3116278528","https://openalex.org/W3209465832","https://openalex.org/W3216448540","https://openalex.org/W4220837089","https://openalex.org/W4223644783","https://openalex.org/W4224008639","https://openalex.org/W4225886114","https://openalex.org/W4229028861","https://openalex.org/W4283797918","https://openalex.org/W4291021272","https://openalex.org/W4297243391","https://openalex.org/W4298061300","https://openalex.org/W4307952312","https://openalex.org/W4308163361","https://openalex.org/W4311788484","https://openalex.org/W4319812794","https://openalex.org/W4327550249","https://openalex.org/W4360942779","https://openalex.org/W4367049415","https://openalex.org/W4367312557","https://openalex.org/W4378838672","https://openalex.org/W4385573177","https://openalex.org/W4389616313","https://openalex.org/W4390783938","https://openalex.org/W4391212816","https://openalex.org/W4391280974","https://openalex.org/W4392005379","https://openalex.org/W4392500220","https://openalex.org/W4392594225","https://openalex.org/W4399387478","https://openalex.org/W4399390205","https://openalex.org/W4400674289","https://openalex.org/W4400683630","https://openalex.org/W4401214450","https://openalex.org/W4401455022","https://openalex.org/W4401455176","https://openalex.org/W4402000573","https://openalex.org/W4402316248","https://openalex.org/W4408716377","https://openalex.org/W6748218292","https://openalex.org/W6780593937","https://openalex.org/W6850806529","https://openalex.org/W6860347561"],"related_works":["https://openalex.org/W2946241187","https://openalex.org/W4239208227","https://openalex.org/W3112602333","https://openalex.org/W3011352832","https://openalex.org/W3204245326","https://openalex.org/W2793983905","https://openalex.org/W4225936881","https://openalex.org/W2964191569","https://openalex.org/W3193400586","https://openalex.org/W3175832391"],"abstract_inverted_index":{"Transfer":[0,64],"learning":[1,71],"has":[2],"been":[3],"widely":[4],"applied":[5],"to":[6,27,48,112,130],"drug":[7,32,79,176],"sensitivity":[8,80],"prediction":[9,30,132],"based":[10],"on":[11,83],"single-cell":[12,43,62],"RNA":[13],"sequencing,":[14],"leveraging":[15,73],"knowledge":[16,125],"from":[17,127],"large":[18,74,85,128],"datasets":[19,144],"of":[20,31],"cancer":[21],"cell":[22],"lines":[23],"or":[24],"other":[25],"sources":[26],"improve":[28,134],"the":[29,50,170],"responses.":[33],"However,":[34],"previous":[35],"studies":[36],"require":[37],"model":[38,67,119],"fine-tuning":[39],"for":[40,53,77,115,159,183],"different":[41,84],"patient":[42],"datasets,":[44],"limiting":[45],"their":[46],"ability":[47],"meet":[49],"clinical":[51],"need":[52],"high-throughput":[54,78],"rapid":[55],"prediction.":[56,81],"In":[57],"this":[58],"research,":[59],"we":[60],"introduce":[61],"Adaptive":[63],"and":[65,89,91,101,104,136,150,175],"Distillation":[66],"(scATD),":[68],"a":[69],"transfer":[70,92,111],"framework":[72],"language":[75,86],"models":[76,87,129],"Based":[82],"(scFoundation":[88],"Geneformer)":[90],"strategies,":[93],"scATD":[94,163,180],"includes":[95],"three":[96],"distinct":[97],"sub-models:":[98],"scATD-sf,":[99],"scATD-gf,":[100],"scATD-sf-dist.":[102],"scATD-sf":[103],"scATD-gf":[105],"employs":[106],"an":[107],"important":[108],"bidirectional":[109],"style":[110],"enable":[113],"predictions":[114],"new":[116],"patients":[117],"without":[118],"parameter":[120],"training.":[121],"Additionally,":[122],"scATD-sf-dist":[123],"uses":[124],"distillation":[126],"enhance":[131],"performance,":[133],"efficiency,":[135],"reduce":[137],"resource":[138],"requirements.":[139],"Benchmarking":[140],"across":[141],"more":[142,166,181],"diverse":[143],"demonstrates":[145],"scATD's":[146],"superior":[147],"accuracy,":[148],"generalization":[149],"efficiency.":[151],"Besides,":[152],"by":[153],"rigorously":[154],"selecting":[155],"reference":[156],"background":[157],"samples":[158],"feature":[160],"attribution":[161],"algorithms,":[162],"also":[164],"provides":[165],"meaningful":[167],"insights":[168],"into":[169],"relationship":[171],"between":[172],"gene":[173],"expression":[174],"resistance":[177],"mechanisms.":[178],"Making":[179],"interpretability":[182],"addressing":[184],"critical":[185],"challenges":[186],"in":[187],"precision":[188],"oncology.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
