{"id":"https://openalex.org/W4411112547","doi":"https://doi.org/10.1093/bib/bbaf250","title":"A multivariable <i>cis</i>-Mendelian randomization method robust to weak instrument bias and horizontal pleiotropy bias","display_name":"A multivariable <i>cis</i>-Mendelian randomization method robust to weak instrument bias and horizontal pleiotropy bias","publication_year":2025,"publication_date":"2025-05-01","ids":{"openalex":"https://openalex.org/W4411112547","doi":"https://doi.org/10.1093/bib/bbaf250","pmid":"https://pubmed.ncbi.nlm.nih.gov/40471990"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf250","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf250","pdf_url":"https://academic.oup.com/bib/article-pdf/26/3/bbaf250/63441663/bbaf250.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/26/3/bbaf250/63441663/bbaf250.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051611729","display_name":"Yihe Yang","orcid":"https://orcid.org/0000-0001-6563-3579"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yihe Yang","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine , 10900 Euclid Ave, Cleveland, OH 44106 ,"],"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine , 10900 Euclid Ave, Cleveland, OH 44106 ,","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047904732","display_name":"Noah Lorincz\u2010Comi","orcid":"https://orcid.org/0000-0002-0517-2499"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noah Lorincz-Comi","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine , 10900 Euclid Ave, Cleveland, OH 44106 ,"],"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine , 10900 Euclid Ave, Cleveland, OH 44106 ,","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101544067","display_name":"Mengxuan Li","orcid":"https://orcid.org/0000-0001-8209-655X"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mengxuan Li","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine , 10900 Euclid Ave, Cleveland, OH 44106 ,"],"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine , 10900 Euclid Ave, Cleveland, OH 44106 ,","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007766399","display_name":"Xiaofeng Zhu","orcid":"https://orcid.org/0000-0003-0037-411X"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofeng Zhu","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine , 10900 Euclid Ave, Cleveland, OH 44106 ,"],"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine , 10900 Euclid Ave, Cleveland, OH 44106 ,","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5051611729"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":5.1837,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.95112836,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"26","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.9485828280448914},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"Pleiotropy","score":0.7073997259140015},{"id":"https://openalex.org/keywords/genetic-architecture","display_name":"Genetic architecture","score":0.6056193113327026},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"Linkage disequilibrium","score":0.5543901324272156},{"id":"https://openalex.org/keywords/causal-inference","display_name":"Causal inference","score":0.4779110848903656},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.4584616422653198},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4242188632488251},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4145326614379883},{"id":"https://openalex.org/keywords/allele","display_name":"Allele","score":0.39150092005729675},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.33127227425575256},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32613667845726013},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.30159664154052734},{"id":"https://openalex.org/keywords/econometrics","display_name":"Econometrics","score":0.28806033730506897},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2544836401939392},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"Genetic variants","score":0.22514334321022034},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.18595167994499207},{"id":"https://openalex.org/keywords/haplotype","display_name":"Haplotype","score":0.13035190105438232},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.11534512042999268},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.10430416464805603}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9485828280448914},{"id":"https://openalex.org/C26207810","wikidata":"https://www.wikidata.org/wiki/Q1134884","display_name":"Pleiotropy","level":4,"score":0.7073997259140015},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.6056193113327026},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.5543901324272156},{"id":"https://openalex.org/C158600405","wikidata":"https://www.wikidata.org/wiki/Q5054566","display_name":"Causal inference","level":2,"score":0.4779110848903656},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.4584616422653198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4242188632488251},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4145326614379883},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.39150092005729675},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33127227425575256},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32613667845726013},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.30159664154052734},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.28806033730506897},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2544836401939392},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.22514334321022034},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18595167994499207},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.13035190105438232},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.11534512042999268},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.10430416464805603}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D058685","descriptor_name":"Genetic Pleiotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058685","descriptor_name":"Genetic Pleiotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058685","descriptor_name":"Genetic Pleiotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058685","descriptor_name":"Genetic Pleiotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058685","descriptor_name":"Genetic Pleiotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf250","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf250","pdf_url":"https://academic.oup.com/bib/article-pdf/26/3/bbaf250/63441663/bbaf250.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40471990","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40471990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12140020","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12140020","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf250","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf250","pdf_url":"https://academic.oup.com/bib/article-pdf/26/3/bbaf250/63441663/bbaf250.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.44999998807907104,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G3113783901","display_name":null,"funder_award_id":"HG011052-03S1","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G3944590867","display_name":null,"funder_award_id":"HG011052","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411112547.pdf","grobid_xml":"https://content.openalex.org/works/W4411112547.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1512134098","https://openalex.org/W1965125844","https://openalex.org/W1969515697","https://openalex.org/W2023784754","https://openalex.org/W2054007740","https://openalex.org/W2074682976","https://openalex.org/W2075193321","https://openalex.org/W2106036991","https://openalex.org/W2108150034","https://openalex.org/W2135046866","https://openalex.org/W2147848557","https://openalex.org/W2152603994","https://openalex.org/W2161633633","https://openalex.org/W2198755677","https://openalex.org/W2209106767","https://openalex.org/W2322235902","https://openalex.org/W2324862792","https://openalex.org/W2724719188","https://openalex.org/W2741572302","https://openalex.org/W2761312904","https://openalex.org/W2803072880","https://openalex.org/W2805983714","https://openalex.org/W2953072478","https://openalex.org/W2963368478","https://openalex.org/W3020059669","https://openalex.org/W3027865872","https://openalex.org/W3042068575","https://openalex.org/W3042936392","https://openalex.org/W3061843793","https://openalex.org/W3089981509","https://openalex.org/W3098306969","https://openalex.org/W3101729234","https://openalex.org/W3108357298","https://openalex.org/W3133859624","https://openalex.org/W3174084468","https://openalex.org/W3174540256","https://openalex.org/W3197290161","https://openalex.org/W3202745359","https://openalex.org/W3205644245","https://openalex.org/W3215894083","https://openalex.org/W4211059518","https://openalex.org/W4221072634","https://openalex.org/W4286218496","https://openalex.org/W4289261763","https://openalex.org/W4294762973","https://openalex.org/W4307106797","https://openalex.org/W4307953159","https://openalex.org/W4310461604","https://openalex.org/W4321611595","https://openalex.org/W4324032790","https://openalex.org/W4328055067","https://openalex.org/W4387344289","https://openalex.org/W4389174513","https://openalex.org/W4391172075","https://openalex.org/W4391505433","https://openalex.org/W4392001964","https://openalex.org/W4394014733","https://openalex.org/W4395004719","https://openalex.org/W4396514135","https://openalex.org/W4400767200","https://openalex.org/W4401332639","https://openalex.org/W4401339790","https://openalex.org/W4403731918","https://openalex.org/W4404451722","https://openalex.org/W4405366830","https://openalex.org/W4405996030","https://openalex.org/W4406314097","https://openalex.org/W4409568690"],"related_works":["https://openalex.org/W2153103238","https://openalex.org/W3202647813","https://openalex.org/W2898194682","https://openalex.org/W3106324371","https://openalex.org/W4293531535","https://openalex.org/W2784614321","https://openalex.org/W2096434975","https://openalex.org/W4396219410","https://openalex.org/W4306658544","https://openalex.org/W2129465958"],"abstract_inverted_index":{"Multivariable":[0],"cis-Mendelian":[1,41],"randomization":[2,42],"(cis-MVMR)":[3],"has":[4],"become":[5],"an":[6],"effective":[7],"approach":[8],"for":[9,107,173,212],"identifying":[10],"therapeutic":[11],"targets":[12],"that":[13,113,187,197],"influence":[14],"disease":[15,214],"susceptibility.":[16],"However,":[17],"biases":[18],"from":[19],"invalid":[20],"instruments,":[21],"such":[22],"as":[23,169],"weak":[24,50,118],"instruments":[25,119],"and":[26,96,105,120,132,159,167,176,207,215,220],"horizontal":[27,108,121],"pleiotropy,":[28,122],"remain":[29],"unsolved.":[30],"In":[31,142],"this":[32],"paper,":[33],"we":[34,192],"propose":[35],"a":[36,55,63,69,75,98,161,182],"new":[37],"method":[38],"called":[39],"the":[40,93,115,156,198,203],"bias":[43,52],"correction":[44],"estimating":[45],"equation":[46],"(cis-MRBEE),":[47],"which":[48],"mitigates":[49],"instrument":[51],"by":[53],"leveraging":[54],"local":[56],"sparse":[57],"genetic":[58,90],"architecture:":[59],"most":[60],"variants":[61,82],"within":[62],"genomic":[64],"region":[65],"are":[66],"associated":[67],"with":[68,74],"trait":[70],"through":[71],"linkage":[72],"disequilibrium":[73],"few":[76],"causal":[77,81,103,171,211],"variants.":[78],"Cis-MRBEE":[79],"identifies":[80],"or":[83],"proxies":[84],"of":[85,117,150,200],"exposures":[86,104],"via":[87],"fine-mapping,":[88],"re-estimates":[89],"associations":[91],"using":[92],"identified":[94,160],"variants,":[95],"applies":[97],"double-penalized":[99],"minimization":[100],"to":[101,128,137,147,155,195],"estimate":[102],"account":[106],"pleiotropic":[109],"effects.":[110],"Simulations":[111],"showed":[112],"in":[114,202,222],"presence":[116],"directly":[123],"adapting":[124],"standard":[125],"MVMR":[126],"methods":[127,135],"cis-MVMR":[129,134],"was":[130],"infeasible,":[131],"existing":[133],"failed":[136],"control":[138],"type":[139],"I":[140],"errors.":[141],"contrast,":[143],"cis-MRBEE":[144,154,194],"exhibited":[145],"robustness":[146],"these":[148],"sources":[149],"bias.":[151],"We":[152],"applied":[153],"ANGPTL3":[157],"locus":[158],"credible":[162],"set":[163],"comprising":[164],"APOA1,":[165],"APOC1,":[166],"PCSK9":[168],"likely":[170],"proteins":[172],"LDL-C,":[174],"HDL-C,":[175],"TG.":[177],"The":[178],"subsequent":[179],"analysis":[180],"revealed":[181],"complex":[183],"protein":[184],"regulation":[185],"network":[186],"influenced":[188],"lipid":[189],"traits.":[190],"Furthermore,":[191],"used":[193],"discover":[196],"expressions":[199],"CR1":[201],"basal":[204],"ganglia,":[205],"hippocampus,":[206],"oligodendrocytes":[208],"were":[209],"potentially":[210],"Alzheimer's":[213],"its":[216],"biomarkers,":[217],"A$\\beta":[218],"$42":[219],"pTau,":[221],"cerebrospinal":[223],"fluid.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-06-07T00:00:00"}
