{"id":"https://openalex.org/W4410459994","doi":"https://doi.org/10.1093/bib/bbaf216","title":"A novel prognostic framework for HBV-infected hepatocellular carcinoma: insights from ferroptosis and iron metabolism proteomics","display_name":"A novel prognostic framework for HBV-infected hepatocellular carcinoma: insights from ferroptosis and iron metabolism proteomics","publication_year":2025,"publication_date":"2025-05-01","ids":{"openalex":"https://openalex.org/W4410459994","doi":"https://doi.org/10.1093/bib/bbaf216","pmid":"https://pubmed.ncbi.nlm.nih.gov/40381315"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf216","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf216","pdf_url":"https://academic.oup.com/bib/article-pdf/26/3/bbaf216/63216997/bbaf216.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/26/3/bbaf216/63216997/bbaf216.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100781275","display_name":"Zhiwei Cheng","orcid":"https://orcid.org/0000-0002-4761-5243"},"institutions":[{"id":"https://openalex.org/I4210135742","display_name":"Shanghai First People's Hospital","ror":"https://ror.org/04a46mh28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135742"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiwei Cheng","raw_affiliation_strings":["Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","Department of Orthopedic Oncology, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , 100 Haining Road, Hongkou District, Shanghai 200080,","SJTU-Yale Joint Center of Biostatistics and Data Science, National Center for Translational Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Department of Orthopedic Oncology, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , 100 Haining Road, Hongkou District, Shanghai 200080,","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210135742"]},{"raw_affiliation_string":"SJTU-Yale Joint Center of Biostatistics and Data Science, National Center for Translational Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073613532","display_name":"Yongyong Ren","orcid":"https://orcid.org/0000-0001-9217-3483"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongyong Ren","raw_affiliation_strings":["Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","Institute of Bioinformatics, Shanghai Academy of Experimental Medicine , 528 Hongshan Road, Pudong New District, Shanghai 200126 ,"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Institute of Bioinformatics, Shanghai Academy of Experimental Medicine , 528 Hongshan Road, Pudong New District, Shanghai 200126 ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100762075","display_name":"Xinbo Wang","orcid":"https://orcid.org/0000-0001-8524-9662"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinbo Wang","raw_affiliation_strings":["Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","SJTU-Yale Joint Center of Biostatistics and Data Science, National Center for Translational Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"SJTU-Yale Joint Center of Biostatistics and Data Science, National Center for Translational Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042752885","display_name":"Yuening Zhang","orcid":"https://orcid.org/0000-0002-0306-2851"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuening Zhang","raw_affiliation_strings":["Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","SJTU-Yale Joint Center of Biostatistics and Data Science, National Center for Translational Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"SJTU-Yale Joint Center of Biostatistics and Data Science, National Center for Translational Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023480337","display_name":"Yingqi Hua","orcid":"https://orcid.org/0000-0002-7277-0958"},"institutions":[{"id":"https://openalex.org/I4210135742","display_name":"Shanghai First People's Hospital","ror":"https://ror.org/04a46mh28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135742"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingqi Hua","raw_affiliation_strings":["Department of Orthopedic Oncology, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , 100 Haining Road, Hongkou District, Shanghai 200080,"],"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Oncology, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , 100 Haining Road, Hongkou District, Shanghai 200080,","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210135742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074828414","display_name":"Hongyu Zhao","orcid":"https://orcid.org/0000-0003-1195-9607"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongyu Zhao","raw_affiliation_strings":["Department of Biostatistics, Yale University , 300 George Street, New Haven, CT 06511 ,"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Yale University , 300 George Street, New Haven, CT 06511 ,","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100716955","display_name":"Hui L\u00fc","orcid":"https://orcid.org/0000-0001-8347-0830"},"institutions":[{"id":"https://openalex.org/I4210159420","display_name":"Shanghai Children's Hospital","ror":"https://ror.org/05pea1m70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159420"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Lu","raw_affiliation_strings":["Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","Institute of Bioinformatics, Shanghai Academy of Experimental Medicine , 528 Hongshan Road, Pudong New District, Shanghai 200126 ,","SJTU-Yale Joint Center of Biostatistics and Data Science, National Center for Translational Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","Shanghai Engineering Research Center for Big Data in Pediatric Precision Medicine, Center for Biomedical Informatics, Shanghai Children\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University , 1400 Beijing West Road, Jing'an District, Shanghai 200040 ,"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Institute of Bioinformatics, Shanghai Academy of Experimental Medicine , 528 Hongshan Road, Pudong New District, Shanghai 200126 ,","institution_ids":[]},{"raw_affiliation_string":"SJTU-Yale Joint Center of Biostatistics and Data Science, National Center for Translational Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Shanghai Engineering Research Center for Big Data in Pediatric Precision Medicine, Center for Biomedical Informatics, Shanghai Children\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University , 1400 Beijing West Road, Jing'an District, Shanghai 200040 ,","institution_ids":["https://openalex.org/I4210159420","https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100781275"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210135742"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":3.1198,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.90788985,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"26","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.989799976348877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.8756717443466187},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.6681191921234131},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"Hepatitis B virus","score":0.4958887994289398},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.4186426103115082},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4132933020591736},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.39788106083869934},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3092392086982727},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2700498700141907},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.26529714465141296},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.21326017379760742},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.14919596910476685},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11337563395500183},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.09109845757484436}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8756717443466187},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6681191921234131},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.4958887994289398},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4186426103115082},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4132933020591736},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39788106083869934},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3092392086982727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2700498700141907},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.26529714465141296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21326017379760742},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.14919596910476685},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11337563395500183},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09109845757484436}],"mesh":[{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D049451","descriptor_name":"Nomograms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049451","descriptor_name":"Nomograms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049451","descriptor_name":"Nomograms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049451","descriptor_name":"Nomograms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049451","descriptor_name":"Nomograms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf216","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf216","pdf_url":"https://academic.oup.com/bib/article-pdf/26/3/bbaf216/63216997/bbaf216.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40381315","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40381315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12085197","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12085197","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf216","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf216","pdf_url":"https://academic.oup.com/bib/article-pdf/26/3/bbaf216/63216997/bbaf216.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6671595063","display_name":null,"funder_award_id":"23JS1400700","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"}],"funders":[{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320322999","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"},{"id":"https://openalex.org/F4320327639","display_name":"Centre Scientifique et Technique du B\u00e2timent","ror":"https://ror.org/02fsd1928"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410459994.pdf","grobid_xml":"https://content.openalex.org/works/W4410459994.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1975512811","https://openalex.org/W1997183854","https://openalex.org/W2002490399","https://openalex.org/W2006525603","https://openalex.org/W2016170717","https://openalex.org/W2038070749","https://openalex.org/W2130430382","https://openalex.org/W2131856634","https://openalex.org/W2146512944","https://openalex.org/W2153839710","https://openalex.org/W2158899340","https://openalex.org/W2170949754","https://openalex.org/W2508296626","https://openalex.org/W2625559053","https://openalex.org/W2626486519","https://openalex.org/W2771874080","https://openalex.org/W2791063392","https://openalex.org/W2803768106","https://openalex.org/W2891014905","https://openalex.org/W2918023653","https://openalex.org/W2922343610","https://openalex.org/W2942610007","https://openalex.org/W2977528366","https://openalex.org/W2985960345","https://openalex.org/W3001475835","https://openalex.org/W3003225928","https://openalex.org/W3012295934","https://openalex.org/W3019579920","https://openalex.org/W3045029533","https://openalex.org/W3092496866","https://openalex.org/W3097757673","https://openalex.org/W3122102409","https://openalex.org/W3128646645","https://openalex.org/W3134213186","https://openalex.org/W3167322268","https://openalex.org/W3169291549","https://openalex.org/W3182293965","https://openalex.org/W4200038751","https://openalex.org/W4200428208","https://openalex.org/W4213095840","https://openalex.org/W4214929667","https://openalex.org/W4296161022","https://openalex.org/W4319066792","https://openalex.org/W4375859102","https://openalex.org/W4378716917","https://openalex.org/W4385554155","https://openalex.org/W4385684105","https://openalex.org/W4389614270","https://openalex.org/W4391743535","https://openalex.org/W4393093944","https://openalex.org/W4393935425","https://openalex.org/W4394013522","https://openalex.org/W4399098282","https://openalex.org/W4400721005","https://openalex.org/W4402341090","https://openalex.org/W4410246008","https://openalex.org/W6870566055","https://openalex.org/W6947600722"],"related_works":["https://openalex.org/W2417822880","https://openalex.org/W628600844","https://openalex.org/W1570838273","https://openalex.org/W2410885201","https://openalex.org/W2385390897","https://openalex.org/W3172842848","https://openalex.org/W2418745692","https://openalex.org/W3015095084","https://openalex.org/W2369572641","https://openalex.org/W2088324202"],"abstract_inverted_index":{"Effective":[0],"classification":[1,9,240],"methods":[2],"and":[3,10,23,58,87,101,123,159,182,217,229,235,248],"prognostic":[4,34,45,63,99,227],"models":[5,35],"enable":[6],"more":[7],"accurate":[8],"treatment":[11],"of":[12,31,116,170,200,241],"hepatocellular":[13],"carcinoma":[14],"(HCC)":[15],"patients.":[16],"However,":[17],"the":[18,28,93,98,107,111,168,180,197,220,238],"weak":[19],"correlation":[20],"between":[21],"RNA":[22],"protein":[24,141],"data":[25],"has":[26],"limited":[27],"clinical":[29,246],"utility":[30],"previous":[32],"RNA-based":[33],"for":[36,47,166,188,237],"HCC.":[37],"In":[38,224],"this":[39,62],"work,":[40],"we":[41,105,162],"constructed":[42],"a":[43,164],"novel":[44,233],"framework":[46],"HCC":[48,67,132,171,202,242],"patients":[49,68,133,203],"using":[50],"seven":[51],"differentially":[52],"expressed":[53],"proteins":[54],"associated":[55],"with":[56,207],"ferroptosis":[57,208],"iron":[59,215],"metabolism.":[60],"Furthermore,":[61],"model":[64,100,228],"robustly":[65],"classifies":[66],"into":[69],"three":[70],"clinically":[71],"relevant":[72],"risk":[73,94,157],"groups.":[74,95],"Significant":[75],"differences":[76],"in":[77,131,178,209,214,219],"overall":[78],"survival,":[79],"age,":[80],"tumor":[81,129,160,221],"differentiation,":[82],"microvascular":[83],"invasion,":[84],"distant":[85],"metastasis,":[86],"alpha-fetoprotein":[88],"levels":[89],"were":[90],"observed":[91],"among":[92],"Based":[96],"on":[97,156],"known":[102],"biological":[103],"pathways,":[104],"explored":[106],"potential":[108],"mechanisms":[109],"underlying":[110],"inconsistent":[112],"differential":[113],"expression":[114],"patterns":[115],"FTH1":[117,140,146],"(Ferritin":[118],"heavy":[119],"chain":[120],"1)":[121],"mRNA":[122,147],"protein.":[124],"Our":[125],"findings":[126,194],"demonstrated":[127,174,195],"that":[128,196],"tissues":[130],"promote":[134],"liver":[135,210],"cancer":[136,211],"progression":[137],"by":[138],"downregulating":[139],"expression,":[142,148],"rather":[143],"than":[144],"upregulating":[145],"ultimately":[149],"leading":[150],"to":[151],"poor":[152],"prognosis.":[153],"Subsequently,":[154],"based":[155],"score":[158],"size,":[161],"developed":[163],"nomogram":[165,231],"predicting":[167],"prognosis":[169,199],"patients,":[172,243],"which":[173],"superior":[175],"predictive":[176,230],"performance":[177],"both":[179],"training":[181],"validation":[183],"cohorts":[184],"(C-index:":[185],"0.774;":[186],"AUC":[187],"1-5":[189],"years:":[190],"0.783-0.964).":[191],"Additionally,":[192],"our":[193,226],"adverse":[198],"high-risk":[201],"was":[204],"closely":[205],"correlated":[206],"tissues,":[212],"alterations":[213],"metabolism,":[216],"changes":[218],"immune":[222],"microenvironment.":[223],"conclusion,":[225],"offer":[232],"insights":[234],"tools":[236],"effective":[239],"potentially":[244],"enhancing":[245],"decision-making":[247],"outcomes.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-03-25T14:56:36.534964","created_date":"2025-10-10T00:00:00"}
