{"id":"https://openalex.org/W4410416107","doi":"https://doi.org/10.1093/bib/bbaf215","title":"<i>In-silico</i> discovery of type-2 diabetes-causing host key genes that are associated with the complexity of monkeypox and repurposing common drugs","display_name":"<i>In-silico</i> discovery of type-2 diabetes-causing host key genes that are associated with the complexity of monkeypox and repurposing common drugs","publication_year":2025,"publication_date":"2025-05-01","ids":{"openalex":"https://openalex.org/W4410416107","doi":"https://doi.org/10.1093/bib/bbaf215","pmid":"https://pubmed.ncbi.nlm.nih.gov/40370100"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf215","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf215","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bib/bbaf215","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106611237","display_name":"Alvira Ajadee","orcid":null},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":true,"raw_author_name":"Alvira Ajadee","raw_affiliation_strings":["Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi , Rajshahi 6205 ,"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi , Rajshahi 6205 ,","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114236880","display_name":"Sabkat Mahmud","orcid":null},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Sabkat Mahmud","raw_affiliation_strings":["Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi , Rajshahi 6205 ,"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi , Rajshahi 6205 ,","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033412526","display_name":"Md. Ahad Ali","orcid":"https://orcid.org/0000-0002-9200-7669"},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Md Ahad Ali","raw_affiliation_strings":["Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi , Rajshahi 6205 ,","Department of Chemistry, University of Rajshahi , Rajshahi 6205 ,"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi , Rajshahi 6205 ,","institution_ids":["https://openalex.org/I902853133"]},{"raw_affiliation_string":"Department of Chemistry, University of Rajshahi , Rajshahi 6205 ,","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058147712","display_name":"Mohammad Manir Hossain Mollah","orcid":"https://orcid.org/0009-0001-2165-9598"},"institutions":[{"id":"https://openalex.org/I31669788","display_name":"Independent University","ror":"https://ror.org/05qbbf772","country_code":"BD","type":"education","lineage":["https://openalex.org/I31669788"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Md Manir Hossain Mollah","raw_affiliation_strings":["Department of Physical Sciences, Independent University Bangladesh , Bashundhara Residential Area, Dhaka 1245 ,"],"affiliations":[{"raw_affiliation_string":"Department of Physical Sciences, Independent University Bangladesh , Bashundhara Residential Area, Dhaka 1245 ,","institution_ids":["https://openalex.org/I31669788"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111366605","display_name":"Reaz Ahmmed","orcid":null},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Reaz Ahmmed","raw_affiliation_strings":["Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi , Rajshahi 6205 ,","Department of Biochemistry and Molecular Biology, University of Rajshahi , Rajshahi 6205 ,"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi , Rajshahi 6205 ,","institution_ids":["https://openalex.org/I902853133"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Rajshahi , Rajshahi 6205 ,","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028741163","display_name":"Md. Nurul Haque Mollah","orcid":"https://orcid.org/0000-0002-3883-3396"},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Md Nurul Haque Mollah","raw_affiliation_strings":["Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi , Rajshahi 6205 ,"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi , Rajshahi 6205 ,","institution_ids":["https://openalex.org/I902853133"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5106611237"],"corresponding_institution_ids":["https://openalex.org/I902853133"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":3.6219,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.92799833,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"26","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adme","display_name":"ADME","score":0.7689701318740845},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.7267723083496094},{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.6788280010223389},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6254389882087708},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5135612487792969},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.5081226825714111},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.4573596715927124},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.44961613416671753},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.44702908396720886},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.4469534158706665},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4345206022262573},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.3981338143348694},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3303598165512085},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.29219457507133484},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.265034556388855},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.10231107473373413}],"concepts":[{"id":"https://openalex.org/C69366308","wikidata":"https://www.wikidata.org/wiki/Q2272286","display_name":"ADME","level":3,"score":0.7689701318740845},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7267723083496094},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.6788280010223389},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6254389882087708},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5135612487792969},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.5081226825714111},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4573596715927124},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.44961613416671753},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.44702908396720886},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.4469534158706665},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4345206022262573},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3981338143348694},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3303598165512085},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.29219457507133484},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.265034556388855},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10231107473373413}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045908","descriptor_name":"Mpox, Monkeypox","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045908","descriptor_name":"Mpox, Monkeypox","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf215","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf215","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40370100","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40370100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12078936","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12078936","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf215","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf215","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6499999761581421}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":143,"referenced_works":["https://openalex.org/W151851326","https://openalex.org/W1018047830","https://openalex.org/W1515706775","https://openalex.org/W1829520216","https://openalex.org/W1887653246","https://openalex.org/W1949100146","https://openalex.org/W1975085070","https://openalex.org/W1978491952","https://openalex.org/W1979281993","https://openalex.org/W1981737096","https://openalex.org/W2003873735","https://openalex.org/W2009867031","https://openalex.org/W2011505858","https://openalex.org/W2017199818","https://openalex.org/W2018459792","https://openalex.org/W2028046413","https://openalex.org/W2033620247","https://openalex.org/W2041250281","https://openalex.org/W2044327593","https://openalex.org/W2047950370","https://openalex.org/W2057811513","https://openalex.org/W2060809301","https://openalex.org/W2070050178","https://openalex.org/W2075815764","https://openalex.org/W2078010704","https://openalex.org/W2081098333","https://openalex.org/W2084976225","https://openalex.org/W2086137541","https://openalex.org/W2091517553","https://openalex.org/W2103912979","https://openalex.org/W2105668062","https://openalex.org/W2109154308","https://openalex.org/W2114900987","https://openalex.org/W2118258530","https://openalex.org/W2118744821","https://openalex.org/W2123335773","https://openalex.org/W2130330935","https://openalex.org/W2136920970","https://openalex.org/W2158470315","https://openalex.org/W2159675211","https://openalex.org/W2169353806","https://openalex.org/W2176831141","https://openalex.org/W2177317049","https://openalex.org/W2313326603","https://openalex.org/W2416509727","https://openalex.org/W2511670019","https://openalex.org/W2578175893","https://openalex.org/W2603758688","https://openalex.org/W2605563843","https://openalex.org/W2735527928","https://openalex.org/W2740811199","https://openalex.org/W2740986674","https://openalex.org/W2749147866","https://openalex.org/W2769915960","https://openalex.org/W2770178180","https://openalex.org/W2777166445","https://openalex.org/W2783611910","https://openalex.org/W2802914092","https://openalex.org/W2809200263","https://openalex.org/W2885821429","https://openalex.org/W2893359832","https://openalex.org/W2899070097","https://openalex.org/W2900569176","https://openalex.org/W2901882315","https://openalex.org/W2909905054","https://openalex.org/W2967498551","https://openalex.org/W2982027455","https://openalex.org/W3005833692","https://openalex.org/W3013556927","https://openalex.org/W3032889003","https://openalex.org/W3036575875","https://openalex.org/W3041797328","https://openalex.org/W3044728581","https://openalex.org/W3049658570","https://openalex.org/W3082119462","https://openalex.org/W3083508002","https://openalex.org/W3093377687","https://openalex.org/W3108286559","https://openalex.org/W3112440234","https://openalex.org/W3117949625","https://openalex.org/W3132900806","https://openalex.org/W3137393771","https://openalex.org/W3153235086","https://openalex.org/W3154258817","https://openalex.org/W3162389729","https://openalex.org/W3197590856","https://openalex.org/W3201967882","https://openalex.org/W3202985671","https://openalex.org/W3211795435","https://openalex.org/W3216238012","https://openalex.org/W4200567281","https://openalex.org/W4205254504","https://openalex.org/W4210567477","https://openalex.org/W4214547504","https://openalex.org/W4214704773","https://openalex.org/W4220831425","https://openalex.org/W4281647357","https://openalex.org/W4283708545","https://openalex.org/W4283809434","https://openalex.org/W4286600120","https://openalex.org/W4287958314","https://openalex.org/W4289313525","https://openalex.org/W4289731785","https://openalex.org/W4289837916","https://openalex.org/W4291452737","https://openalex.org/W4292547742","https://openalex.org/W4294637087","https://openalex.org/W4295896039","https://openalex.org/W4308444939","https://openalex.org/W4309314416","https://openalex.org/W4312413675","https://openalex.org/W4313217507","https://openalex.org/W4317935821","https://openalex.org/W4318464629","https://openalex.org/W4318776787","https://openalex.org/W4353048837","https://openalex.org/W4353072337","https://openalex.org/W4361274937","https://openalex.org/W4362468362","https://openalex.org/W4367183244","https://openalex.org/W4381799391","https://openalex.org/W4385406417","https://openalex.org/W4386388087","https://openalex.org/W4387375664","https://openalex.org/W4387764928","https://openalex.org/W4388615780","https://openalex.org/W4390246694","https://openalex.org/W4393055400","https://openalex.org/W4393278619","https://openalex.org/W4394927699","https://openalex.org/W4395010444","https://openalex.org/W4396240220","https://openalex.org/W4396517920","https://openalex.org/W4399046425","https://openalex.org/W4400770404","https://openalex.org/W4401710353","https://openalex.org/W4402314510","https://openalex.org/W4402978061","https://openalex.org/W4403528053","https://openalex.org/W4406801666","https://openalex.org/W4408084210","https://openalex.org/W4408804397","https://openalex.org/W6606161973"],"related_works":["https://openalex.org/W1964572291","https://openalex.org/W4387948744","https://openalex.org/W80237960","https://openalex.org/W1987520879","https://openalex.org/W2088837113","https://openalex.org/W4244023852","https://openalex.org/W4385680932","https://openalex.org/W2004741937","https://openalex.org/W3130148395","https://openalex.org/W2977457557"],"abstract_inverted_index":{"Monkeypox":[0],"(Mpox)":[1],"is":[2,36],"a":[3],"major":[4],"global":[5],"human":[6],"health":[7],"threat":[8],"after":[9],"COVID-19.":[10],"Its":[11],"treatment":[12],"becomes":[13],"complicated":[14],"with":[15,123,148,167,238],"type-2":[16],"diabetes":[17],"(T2D).":[18],"It":[19],"may":[20],"happen":[21],"due":[22],"to":[23,38,43,63],"the":[24,100,117,124,129,185,239,252],"influence":[25],"of":[26,74,126,158,208,266],"both":[27,40,94,191],"disease-causing":[28,41],"common":[29,54,85,135,187],"host":[30,86],"key":[31],"genes":[32,89],"(cHKGs).":[33],"Therefore,":[34,251],"it":[35],"necessary":[37],"explore":[39],"cHKGs":[42,119],"reveal":[44],"their":[45,53,213],"shared":[46],"pathogenetic":[47,136],"mechanisms":[48],"and":[49,76,82,96,112,140,155,160,163,170,180,193,203,205,231,245,264],"candidate":[50],"drugs":[51],"as":[52,116,184],"treatments":[55],"without":[56],"adverse":[57],"side":[58],"effect.":[59],"This":[60],"study":[61],"aimed":[62],"address":[64],"these":[65,209],"issues.":[66],"At":[67],"first,":[68],"3":[69],"transcriptomics":[70],"datasets":[71,79],"for":[72,190,262],"each":[73],"Mpox":[75,97,127,141,192,267],"6":[77],"T2D":[78,95,139,194],"were":[80,114,142,182],"analyzed":[81],"found":[83],"52":[84],"differentially":[87],"expressed":[88],"(cHDEGs)":[90],"that":[91,120],"can":[92],"separate":[93],"patients":[98,268],"from":[99,273],"control":[101],"samples.":[102],"Then":[103,134],"top-ranked":[104,174,240],"six":[105],"cHDEGs":[106],"(HSP90AA1,":[107],"B2M,":[108],"IGF1R,":[109],"ALD1HA1,":[110],"ASS1,":[111],"HADHA)":[113],"detected":[115],"T2D-causing":[118],"are":[121,270],"associated":[122],"complexity":[125],"through":[128],"protein-protein":[130],"interaction":[131],"network":[132,165],"analysis.":[133],"processes":[137],"between":[138],"disclosed":[143],"by":[144,195],"cHKG-set":[145],"enrichment":[146],"analysis":[147,166,207],"biological":[149],"processes,":[150],"molecular":[151,196,219,232],"functions,":[152],"cellular":[153],"components":[154],"Kyoto":[156],"Encyclopedia":[157],"Genes":[159],"Genomes":[161],"pathways,":[162],"regulatory":[164],"transcription":[168],"factors":[169],"microRNAs.":[171],"Finally,":[172],"cHKG-guided":[173],"three":[175,241],"drug":[176,210],"molecules":[177,211],"(tecovirimat,":[178],"vindoline,":[179],"brincidofovir)":[181],"recommended":[183],"repurposable":[186],"therapeutic":[188],"agents":[189],"docking.":[197],"The":[198,217],"absorption,":[199],"distribution,":[200],"metabolism,":[201],"excretion,":[202],"toxicity":[204],"drug-likeness":[206],"indicated":[212],"good":[214,248],"pharmacokinetics":[215],"properties.":[216,250],"100-ns":[218],"dynamics":[220],"simulation":[221],"results":[222,253],"(root":[223],"mean":[224,228],"square":[225,229],"deviation,":[226],"root":[227],"fluctuation,":[230],"mechanics":[233],"generalized":[234],"born":[235],"surface":[236],"area)":[237],"complexes":[242],"ASS1-tecovirimat,":[243],"ALDH1A1-vindoline,":[244],"B2M-brincidofovir":[246],"exhibited":[247],"pharmacodynamics":[249],"provided":[254],"in":[255],"this":[256],"article":[257],"might":[258],"be":[259],"important":[260],"resources":[261],"diagnosis":[263],"therapies":[265],"who":[269],"also":[271],"suffering":[272],"T2D.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-05-16T00:00:00"}
