{"id":"https://openalex.org/W4409567772","doi":"https://doi.org/10.1093/bib/bbaf167","title":"MINE: a new way to design genetics experiments for discovery","display_name":"MINE: a new way to design genetics experiments for discovery","publication_year":2025,"publication_date":"2025-03-01","ids":{"openalex":"https://openalex.org/W4409567772","doi":"https://doi.org/10.1093/bib/bbaf167","pmid":"https://pubmed.ncbi.nlm.nih.gov/40237762"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf167","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf167","pdf_url":"https://academic.oup.com/bib/article-pdf/26/2/bbaf167/62938903/bbaf167.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/26/2/bbaf167/62938903/bbaf167.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066515336","display_name":"Irene Torres","orcid":"https://orcid.org/0000-0002-0516-3090"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Isaac Torres","raw_affiliation_strings":["Institute of Bioinformatics, University of Georgia , Athens, GA 30602 \u00a0","Institute of Bioinformatics, University of Georgia, Athens, GA 30602 \u00a0USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics, University of Georgia , Athens, GA 30602 \u00a0","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Institute of Bioinformatics, University of Georgia, Athens, GA 30602 \u00a0USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038909663","display_name":"Shufan Zhang","orcid":"https://orcid.org/0000-0002-0983-2730"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shufan Zhang","raw_affiliation_strings":["Institute of Bioinformatics, University of Georgia , Athens, GA 30602 \u00a0","Institute of Bioinformatics, University of Georgia, Athens, GA 30602 \u00a0USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics, University of Georgia , Athens, GA 30602 \u00a0","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Institute of Bioinformatics, University of Georgia, Athens, GA 30602 \u00a0USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045108304","display_name":"Amanda Bouffier","orcid":null},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Bouffier","raw_affiliation_strings":["Institute of Bioinformatics, University of Georgia , Athens, GA 30602 \u00a0","Institute of Bioinformatics, University of Georgia, Athens, GA 30602 \u00a0USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics, University of Georgia , Athens, GA 30602 \u00a0","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Institute of Bioinformatics, University of Georgia, Athens, GA 30602 \u00a0USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063236475","display_name":"Michael Skaro","orcid":"https://orcid.org/0000-0002-4960-875X"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Skaro","raw_affiliation_strings":["Institute of Bioinformatics, University of Georgia , Athens, GA 30602 \u00a0","Institute of Bioinformatics, University of Georgia, Athens, GA 30602 \u00a0USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics, University of Georgia , Athens, GA 30602 \u00a0","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Institute of Bioinformatics, University of Georgia, Athens, GA 30602 \u00a0USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101545196","display_name":"Yue Wu","orcid":"https://orcid.org/0000-0002-0084-2510"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Wu","raw_affiliation_strings":["Department of Genetics, Stanford University , Stanford, CA 94309 \u00a0","Department of Genetics, Stanford University, Stanford, CA 94309 \u00a0USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University , Stanford, CA 94309 \u00a0","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Genetics, Stanford University, Stanford, CA 94309 \u00a0USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097929424","display_name":"Lauren Stupp","orcid":null},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Stupp","raw_affiliation_strings":["Genetics Department, University of Georgia , Athens, GA 30602 \u00a0","Genetics Department, University of Georgia, Athens, GA 30602 \u00a0USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Department, University of Georgia , Athens, GA 30602 \u00a0","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Genetics Department, University of Georgia, Athens, GA 30602 \u00a0USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087611693","display_name":"Jonathan Arnold","orcid":"https://orcid.org/0000-0001-5845-1048"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Arnold","raw_affiliation_strings":["Institute of Bioinformatics, University of Georgia , Athens, GA 30602 \u00a0","Institute of Bioinformatics, University of Georgia, Athens, GA 30602 \u00a0USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics, University of Georgia , Athens, GA 30602 \u00a0","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Institute of Bioinformatics, University of Georgia, Athens, GA 30602 \u00a0USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069833381","display_name":"Young-Soo Chung","orcid":"https://orcid.org/0000-0003-0806-0449"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]},{"id":"https://openalex.org/I4210095419","display_name":"Carnegie Department of Plant Biology","ror":"https://ror.org/00tdyb139","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210095419"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Anny Chung","raw_affiliation_strings":["Plant Biology and Plant Pathology, University of Georgia , Athens, GA 30602 \u00a0","Plant Biology and Plant Pathology, University of Georgia, Athens, GA 30602 \u00a0USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Biology and Plant Pathology, University of Georgia , Athens, GA 30602 \u00a0","institution_ids":["https://openalex.org/I4210095419","https://openalex.org/I165733156"]},{"raw_affiliation_string":"Plant Biology and Plant Pathology, University of Georgia, Athens, GA 30602 \u00a0USA","institution_ids":["https://openalex.org/I4210095419","https://openalex.org/I165733156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112512319","display_name":"H-Bernd Sch\u00fcttler","orcid":null},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H-Bernd Schuttler","raw_affiliation_strings":["Physics and Astronomy, University of Georgia , Athens, GA 30602 \u00a0","Physics and Astronomy, University of Georgia, Athens, GA 30602 \u00a0USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physics and Astronomy, University of Georgia , Athens, GA 30602 \u00a0","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Physics and Astronomy, University of Georgia, Athens, GA 30602 \u00a0USA","institution_ids":["https://openalex.org/I165733156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5066515336"],"corresponding_institution_ids":["https://openalex.org/I165733156"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":1.3723,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.79640956,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"26","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.5152999758720398,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.5152999758720398,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5079594254493713},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4766312837600708},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.34155893325805664},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3294100761413574}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5079594254493713},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4766312837600708},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34155893325805664},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3294100761413574}],"mesh":[{"descriptor_ui":"D009492","descriptor_name":"Neurospora crassa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009492","descriptor_name":"Neurospora crassa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009492","descriptor_name":"Neurospora crassa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D045868","descriptor_name":"Sorghum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045868","descriptor_name":"Sorghum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045868","descriptor_name":"Sorghum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf167","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf167","pdf_url":"https://academic.oup.com/bib/article-pdf/26/2/bbaf167/62938903/bbaf167.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40237762","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40237762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12001805","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12001805","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf167","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf167","pdf_url":"https://academic.oup.com/bib/article-pdf/26/2/bbaf167/62938903/bbaf167.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1606456483","display_name":null,"funder_award_id":"DE-SC0021386","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G1808829728","display_name":null,"funder_award_id":"2041546","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2690764287","display_name":null,"funder_award_id":"MCB-2041546","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409567772.pdf","grobid_xml":"https://content.openalex.org/works/W4409567772.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1033080672","https://openalex.org/W1437718448","https://openalex.org/W1801190464","https://openalex.org/W1965107569","https://openalex.org/W1975379811","https://openalex.org/W1978486653","https://openalex.org/W1979385177","https://openalex.org/W1985092783","https://openalex.org/W1989384719","https://openalex.org/W2000487298","https://openalex.org/W2005811101","https://openalex.org/W2017820767","https://openalex.org/W2019657347","https://openalex.org/W2026180573","https://openalex.org/W2027606054","https://openalex.org/W2031794121","https://openalex.org/W2042068133","https://openalex.org/W2047792415","https://openalex.org/W2056760934","https://openalex.org/W2084840427","https://openalex.org/W2092852266","https://openalex.org/W2117572717","https://openalex.org/W2122055675","https://openalex.org/W2130515385","https://openalex.org/W2141704722","https://openalex.org/W2141916112","https://openalex.org/W2146106266","https://openalex.org/W2149737737","https://openalex.org/W2168846334","https://openalex.org/W2334302577","https://openalex.org/W2337620333","https://openalex.org/W2466128109","https://openalex.org/W2529255293","https://openalex.org/W2616482252","https://openalex.org/W2793843965","https://openalex.org/W2794874156","https://openalex.org/W2871861292","https://openalex.org/W2889301719","https://openalex.org/W2894316894","https://openalex.org/W2905850320","https://openalex.org/W2914332755","https://openalex.org/W2920993229","https://openalex.org/W2959750635","https://openalex.org/W3009326661","https://openalex.org/W3177167018","https://openalex.org/W3194183032","https://openalex.org/W4226253757","https://openalex.org/W4298006192","https://openalex.org/W4304698823","https://openalex.org/W4396863718","https://openalex.org/W4406457856","https://openalex.org/W4407957544","https://openalex.org/W6882735263"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189"],"abstract_inverted_index":{"The":[0],"Maximally":[1],"Informative":[2],"Next":[3],"Experiment":[4],"or":[5,26],"MINE":[6,66,134,147],"is":[7,67,135,148],"a":[8,142,163,167,175],"new":[9,105],"experimental":[10,40,179],"design":[11,41,180],"approach":[12],"for":[13,46,104],"experiments,":[14,154],"such":[15],"as":[16,128,174],"those":[17],"in":[18,20,87,99,141,150,159,171,181],"omics,":[19],"which":[21,71],"the":[22,31,91,102],"number":[23,32],"of":[24,33,81,101],"effects":[25],"parameters":[27,49],"p":[28,45,54,63,110],"greatly":[29],"exceeds":[30],"samples":[34],"n":[35,43,56,108],"(p":[36],">":[37,44,55,64],"n).":[38],"Classical":[39],"presumes":[42],"inference":[47],"about":[48,74],"and":[50,111,117,137,162],"its":[51],"application":[52],"to":[53,59,89,114,121,177],"can":[57],"lead":[58],"over-fitting.":[60],"To":[61],"overcome":[62],"n,":[65],"an":[68,78,182],"ensemble":[69,80],"method,":[70],"makes":[72],"predictions":[73],"future":[75],"experiments":[76,120],"from":[77],"existing":[79],"models":[82],"consistent":[83],"with":[84,107],"available":[85],"data":[86,103],"order":[88],"select":[90],"most":[92],"informative":[93],"next":[94],"experiment.":[95],"Its":[96],"advantages":[97],"are":[98,130],"exploration":[100],"relationships":[106],"<":[109],"being":[112],"able":[113],"integrate":[115],"smaller":[116],"more":[118],"tractable":[119],"replace":[122],"adaptively":[123],"one":[124,155,165],"large":[125,143],"classic":[126,178],"experiment":[127],"discoveries":[129],"made.":[131],"Thus,":[132],"using":[133],"model-guided":[136],"adaptive":[138],"over":[139],"time":[140],"omics":[144],"study.":[145],"Here,":[146],"illustrated":[149],"two":[151],"distinct":[152],"multiyear":[153],"involving":[156,166],"genetic":[157],"networks":[158],"Neurospora":[160],"crassa":[161],"second":[164],"genome-wide":[168],"association":[169],"study":[170],"Sorghum":[172],"bicolor":[173],"comparison":[176],"agricultural":[183],"setting.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-05-05T08:41:31.759640","created_date":"2025-10-10T00:00:00"}