{"id":"https://openalex.org/W4409143633","doi":"https://doi.org/10.1093/bib/bbaf134","title":"Data imbalance in drug response prediction: multi-objective optimization approach in deep learning setting","display_name":"Data imbalance in drug response prediction: multi-objective optimization approach in deep learning setting","publication_year":2025,"publication_date":"2025-03-01","ids":{"openalex":"https://openalex.org/W4409143633","doi":"https://doi.org/10.1093/bib/bbaf134","pmid":"https://pubmed.ncbi.nlm.nih.gov/40178282"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf134","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf134","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bib/bbaf134","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047293381","display_name":"Oleksandr Narykov","orcid":"https://orcid.org/0000-0002-3336-0534"},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Oleksandr Narykov","raw_affiliation_strings":["Computing, Environment and Life Sciences, Argonne National Laboratory , 9700 S Cass Ave, Lemont, IL 60439 ,"],"affiliations":[{"raw_affiliation_string":"Computing, Environment and Life Sciences, Argonne National Laboratory , 9700 S Cass Ave, Lemont, IL 60439 ,","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057761555","display_name":"Yitan Zhu","orcid":"https://orcid.org/0000-0001-5332-6125"},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yitan Zhu","raw_affiliation_strings":["Computing, Environment and Life Sciences, Argonne National Laboratory , 9700 S Cass Ave, Lemont, IL 60439 ,"],"affiliations":[{"raw_affiliation_string":"Computing, Environment and Life Sciences, Argonne National Laboratory , 9700 S Cass Ave, Lemont, IL 60439 ,","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046675967","display_name":"Thomas Brettin","orcid":"https://orcid.org/0000-0001-9301-9760"},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Brettin","raw_affiliation_strings":["Computing, Environment and Life Sciences, Argonne National Laboratory , 9700 S Cass Ave, Lemont, IL 60439 ,"],"affiliations":[{"raw_affiliation_string":"Computing, Environment and Life Sciences, Argonne National Laboratory , 9700 S Cass Ave, Lemont, IL 60439 ,","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044153234","display_name":"Yvonne A. Evrard","orcid":"https://orcid.org/0000-0002-3475-4850"},"institutions":[{"id":"https://openalex.org/I114662689","display_name":"Leidos (United States)","ror":"https://ror.org/012cvds63","country_code":"US","type":"company","lineage":["https://openalex.org/I114662689"]},{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yvonne A Evrard","raw_affiliation_strings":["Leidos Biomedical Research, Frederick National Laboratory for Cancer Research , 8560 Progress Drive, Frederick, MD 21702 ,"],"affiliations":[{"raw_affiliation_string":"Leidos Biomedical Research, Frederick National Laboratory for Cancer Research , 8560 Progress Drive, Frederick, MD 21702 ,","institution_ids":["https://openalex.org/I114662689","https://openalex.org/I4210130649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039059226","display_name":"Alexander Partin","orcid":"https://orcid.org/0000-0002-9279-9213"},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Partin","raw_affiliation_strings":["Computing, Environment and Life Sciences, Argonne National Laboratory , 9700 S Cass Ave, Lemont, IL 60439 ,"],"affiliations":[{"raw_affiliation_string":"Computing, Environment and Life Sciences, Argonne National Laboratory , 9700 S Cass Ave, Lemont, IL 60439 ,","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049471852","display_name":"Fangfang Xia","orcid":"https://orcid.org/0000-0001-6567-0564"},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fangfang Xia","raw_affiliation_strings":["Computing, Environment and Life Sciences, Argonne National Laboratory , 9700 S Cass Ave, Lemont, IL 60439 ,"],"affiliations":[{"raw_affiliation_string":"Computing, Environment and Life Sciences, Argonne National Laboratory , 9700 S Cass Ave, Lemont, IL 60439 ,","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040025864","display_name":"Maulik Shukla","orcid":"https://orcid.org/0009-0002-3396-5725"},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maulik Shukla","raw_affiliation_strings":["Computing, Environment and Life Sciences, Argonne National Laboratory , 9700 S Cass Ave, Lemont, IL 60439 ,"],"affiliations":[{"raw_affiliation_string":"Computing, Environment and Life Sciences, Argonne National Laboratory , 9700 S Cass Ave, Lemont, IL 60439 ,","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029563560","display_name":"Priyanka Vasanthakumari","orcid":"https://orcid.org/0000-0003-0822-5936"},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priyanka Vasanthakumari","raw_affiliation_strings":["Computing, Environment and Life Sciences, Argonne National Laboratory , 9700 S Cass Ave, Lemont, IL 60439 ,"],"affiliations":[{"raw_affiliation_string":"Computing, Environment and Life Sciences, Argonne National Laboratory , 9700 S Cass Ave, Lemont, IL 60439 ,","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041200743","display_name":"James H. Doroshow","orcid":"https://orcid.org/0000-0002-4463-1790"},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James H Doroshow","raw_affiliation_strings":["Developmental Therapeutics Branch, National Cancer Institute , 31 Center Dr, Bethesda, MD 20892 ,"],"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Branch, National Cancer Institute , 31 Center Dr, Bethesda, MD 20892 ,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053682943","display_name":"Rick Stevens","orcid":"https://orcid.org/0000-0002-4268-4020"},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rick L Stevens","raw_affiliation_strings":["Computing, Environment and Life Sciences, Argonne National Laboratory , 9700 S Cass Ave, Lemont, IL 60439 ,","Department of Computer Science, The University of Chicago , 5730 S Ellis Ave, Chicago, IL 60637 ,"],"affiliations":[{"raw_affiliation_string":"Computing, Environment and Life Sciences, Argonne National Laboratory , 9700 S Cass Ave, Lemont, IL 60439 ,","institution_ids":["https://openalex.org/I1282105669"]},{"raw_affiliation_string":"Department of Computer Science, The University of Chicago , 5730 S Ellis Ave, Chicago, IL 60637 ,","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5047293381"],"corresponding_institution_ids":["https://openalex.org/I1282105669"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":3.1375,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.90980996,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"26","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11948","display_name":"Machine Learning in Materials Science","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.963699996471405,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7292487025260925},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.659079909324646},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.6535640954971313},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.6386339068412781},{"id":"https://openalex.org/keywords/generalizability-theory","display_name":"Generalizability theory","score":0.6056311726570129},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.44370636343955994}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7292487025260925},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.659079909324646},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.6535640954971313},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.6386339068412781},{"id":"https://openalex.org/C27158222","wikidata":"https://www.wikidata.org/wiki/Q5532422","display_name":"Generalizability theory","level":2,"score":0.6056311726570129},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.44370636343955994},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf134","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf134","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40178282","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40178282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11966611","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11966611","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf134","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf134","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5600000023841858}],"awards":[{"id":"https://openalex.org/G2132873222","display_name":null,"funder_award_id":"75N91019D00024","funder_id":"https://openalex.org/F4320313762","funder_display_name":"Frederick National Laboratory for Cancer Research"}],"funders":[{"id":"https://openalex.org/F4320313762","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W70001371","https://openalex.org/W1522301498","https://openalex.org/W1968969471","https://openalex.org/W1975147762","https://openalex.org/W1975749451","https://openalex.org/W2001211064","https://openalex.org/W2004638738","https://openalex.org/W2008840001","https://openalex.org/W2042958169","https://openalex.org/W2043398720","https://openalex.org/W2125792789","https://openalex.org/W2126326837","https://openalex.org/W2129860849","https://openalex.org/W2133354214","https://openalex.org/W2148143831","https://openalex.org/W2152883907","https://openalex.org/W2153622690","https://openalex.org/W2164826904","https://openalex.org/W2514703208","https://openalex.org/W2562319768","https://openalex.org/W2768348081","https://openalex.org/W2803358834","https://openalex.org/W2806547269","https://openalex.org/W2810539707","https://openalex.org/W2899070097","https://openalex.org/W2901246787","https://openalex.org/W2911787226","https://openalex.org/W2911964244","https://openalex.org/W2955502047","https://openalex.org/W2995320383","https://openalex.org/W3007745092","https://openalex.org/W3086691441","https://openalex.org/W3094280424","https://openalex.org/W3116278528","https://openalex.org/W3130891725","https://openalex.org/W3137482466","https://openalex.org/W3165390445","https://openalex.org/W3165720345","https://openalex.org/W3215743644","https://openalex.org/W4214831389","https://openalex.org/W4295900303","https://openalex.org/W4306412305","https://openalex.org/W4320920782","https://openalex.org/W4378417908","https://openalex.org/W6631190155","https://openalex.org/W6745609711","https://openalex.org/W6756216553"],"related_works":["https://openalex.org/W2084164722","https://openalex.org/W2731899572","https://openalex.org/W2961085424","https://openalex.org/W3215138031","https://openalex.org/W4306674287","https://openalex.org/W3009238340","https://openalex.org/W4360585206","https://openalex.org/W4321369474","https://openalex.org/W4285208911","https://openalex.org/W4387369504"],"abstract_inverted_index":{"Drug":[0],"response":[1],"prediction":[2],"(DRP)":[3],"methods":[4,178],"tackle":[5],"the":[6,11,17,22,84,112,115,125,128,133,172,187,194],"complex":[7,72],"task":[8,30],"of":[9,13,21,75,81,114,174,186],"associating":[10],"effectiveness":[12],"small":[14,76],"molecules":[15],"with":[16,42],"specific":[18],"genetic":[19],"makeup":[20],"patient.":[23],"Anti-cancer":[24],"DRP":[25,116,129],"is":[26,87],"a":[27,60,136,166],"particularly":[28],"challenging":[29],"requiring":[31],"costly":[32],"experiments":[33],"as":[34,135],"underlying":[35],"pathogenic":[36],"mechanisms":[37],"are":[38,119],"broad":[39],"and":[40,78,110,162,179],"associated":[41],"multiple":[43,140],"genomic":[44],"pathways.":[45],"The":[46],"scientific":[47],"community":[48],"has":[49],"exerted":[50],"significant":[51],"efforts":[52],"to":[53,62,69,91,142,189],"generate":[54],"public":[55],"drug":[56,176],"screening":[57],"datasets,":[58],"giving":[59],"path":[61],"various":[63],"machine":[64],"learning":[65,104,145],"models":[66],"that":[67,122],"attempt":[68],"reason":[70],"over":[71],"data":[73,85],"space":[74],"compounds":[77],"biological":[79],"characteristics":[80],"tumors.":[82],"However,":[83],"depth":[86],"still":[88],"lacking":[89],"compared":[90],"application":[92,185],"domains":[93],"like":[94],"computer":[95],"vision":[96],"or":[97],"natural":[98],"language":[99],"processing":[100],"domains,":[101],"limiting":[102],"current":[103],"capabilities.":[105],"To":[106],"combat":[107],"this":[108,150],"issue":[109],"improves":[111],"generalizability":[113],"models,":[117],"we":[118],"exploring":[120],"strategies":[121],"explicitly":[123],"address":[124],"imbalance":[126],"in":[127,193],"datasets.":[130],"We":[131,148,170],"reframe":[132],"problem":[134],"multi-objective":[137],"optimization":[138],"across":[139],"drugs":[141],"maximize":[143],"deep":[144],"model":[146],"performance.":[147],"implement":[149],"approach":[151],"by":[152,157],"constructing":[153],"Multi-Objective":[154],"Optimization":[155],"Regularized":[156],"Loss":[158],"Entropy":[159],"loss":[160],"function":[161],"plugging":[163],"it":[164],"into":[165],"Deep":[167],"Learning":[168],"model.":[169],"demonstrate":[171],"utility":[173],"proposed":[175],"discovery":[177],"make":[180],"suggestions":[181],"for":[182],"further":[183],"potential":[184],"work":[188],"achieve":[190],"desirable":[191],"outcomes":[192],"healthcare":[195],"field.":[196]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
