{"id":"https://openalex.org/W4408296244","doi":"https://doi.org/10.1093/bib/bbaf100","title":"Consensus statement on the credibility assessment of machine learning predictors","display_name":"Consensus statement on the credibility assessment of machine learning predictors","publication_year":2025,"publication_date":"2025-02-25","ids":{"openalex":"https://openalex.org/W4408296244","doi":"https://doi.org/10.1093/bib/bbaf100","pmid":"https://pubmed.ncbi.nlm.nih.gov/40062621"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf100","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf100","pdf_url":"https://academic.oup.com/bib/article-pdf/26/2/bbaf100/62365889/bbaf100.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/26/2/bbaf100/62365889/bbaf100.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031154949","display_name":"Alessandra Aldieri","orcid":"https://orcid.org/0000-0002-2397-3353"},"institutions":[{"id":"https://openalex.org/I177477856","display_name":"Politecnico di Torino","ror":"https://ror.org/00bgk9508","country_code":"IT","type":"education","lineage":["https://openalex.org/I177477856"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Aldieri","raw_affiliation_strings":["Department of Mechanical and Aerospace Engineering, Politecnico di Torino , Corso Duca degli Abruzzi, 24 - 10129 Torino ,","Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi, 24 - 10129 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, Politecnico di Torino , Corso Duca degli Abruzzi, 24 - 10129 Torino ,","institution_ids":["https://openalex.org/I177477856"]},{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi, 24 - 10129 Torino, Italy","institution_ids":["https://openalex.org/I177477856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116094312","display_name":"Thiranja Prasad Babarenda Gamage","orcid":null},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Thiranja Prasad Babarenda Gamage","raw_affiliation_strings":["Auckland Bioengineering Institute, University of Auckland , Private Bag 92019, Auckland 1142 - \u00a0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auckland Bioengineering Institute, University of Auckland , Private Bag 92019, Auckland 1142 - \u00a0","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003371321","display_name":"Antonino A. La Mattina","orcid":"https://orcid.org/0000-0002-9927-2393"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN","IT"],"is_corresponding":false,"raw_author_name":"Antonino Amedeo La Mattina","raw_affiliation_strings":["Medical Technology Laboratory, IRCCS Istituto Ortopedico Rizzoli , Via di Barbiano, 1/10 - 40136 Bologna ,","Medical Technology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1/10 - 40136 Bologna, Italy","Yi Li National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, 512 Huashan Rd, Jing'An, 200031, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Technology Laboratory, IRCCS Istituto Ortopedico Rizzoli , Via di Barbiano, 1/10 - 40136 Bologna ,","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Medical Technology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1/10 - 40136 Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Yi Li National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, 512 Huashan Rd, Jing'An, 200031, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yi Li","orcid":null},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Yi Li","raw_affiliation_strings":["National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University , 512 Huashan Rd, Jing'An, 200031, Shanghai ,","Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University , 512 Huashan Rd, Jing'An, 200031, Shanghai ,","institution_ids":["https://openalex.org/I4210159575"]},{"raw_affiliation_string":"Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039680827","display_name":"Axel Loewe","orcid":"https://orcid.org/0000-0002-2487-4744"},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["DE","IT"],"is_corresponding":false,"raw_author_name":"Axel Loewe","raw_affiliation_strings":["Karlsruhe Institute of Technology (KIT) , Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen ,","Department of Drug and Health Sciences, University of Catania, V.le A. Doria, 6, 95125 Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karlsruhe Institute of Technology (KIT) , Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen ,","institution_ids":["https://openalex.org/I102335020"]},{"raw_affiliation_string":"Department of Drug and Health Sciences, University of Catania, V.le A. Doria, 6, 95125 Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044340074","display_name":"Francesco Pappalardo","orcid":"https://orcid.org/0000-0003-1668-3320"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Pappalardo","raw_affiliation_strings":["Department of Drug and Health Sciences, University of Catania , V.le A. Doria, 6, 95125 Catania ,","Department of Industrial Engineering, Alma Mater Studiorum\u2014University of Bologna , Via Zamboni, 33 - 40126 Bologna ,"],"raw_orcid":"https://orcid.org/0000-0003-1668-3320","affiliations":[{"raw_affiliation_string":"Department of Drug and Health Sciences, University of Catania , V.le A. Doria, 6, 95125 Catania ,","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department of Industrial Engineering, Alma Mater Studiorum\u2014University of Bologna , Via Zamboni, 33 - 40126 Bologna ,","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086585880","display_name":"Marco Viceconti","orcid":"https://orcid.org/0000-0002-2293-1530"},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Viceconti","raw_affiliation_strings":["Department of Industrial Engineering, Alma Mater Studiorum\u2014University of Bologna , Via Zamboni, 33 - 40126 Bologna ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial Engineering, Alma Mater Studiorum\u2014University of Bologna , Via Zamboni, 33 - 40126 Bologna ,","institution_ids":["https://openalex.org/I9360294"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":1.6008,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.84138414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"26","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12026","display_name":"Explainable Artificial Intelligence (XAI)","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11689","display_name":"Adversarial Robustness in Machine Learning","score":0.9819999933242798,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/credibility","display_name":"Credibility","score":0.8429893255233765},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6755028963088989},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6238272190093994},{"id":"https://openalex.org/keywords/statement","display_name":"Statement (logic)","score":0.46838051080703735},{"id":"https://openalex.org/keywords/position-paper","display_name":"Position paper","score":0.45649874210357666},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4472962021827698},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.44196417927742004},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4339922368526459},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.38269463181495667},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.3257341682910919},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16264650225639343},{"id":"https://openalex.org/keywords/computer-security","display_name":"Computer security","score":0.0817861557006836}],"concepts":[{"id":"https://openalex.org/C2780224610","wikidata":"https://www.wikidata.org/wiki/Q1530061","display_name":"Credibility","level":2,"score":0.8429893255233765},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6755028963088989},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6238272190093994},{"id":"https://openalex.org/C2777026412","wikidata":"https://www.wikidata.org/wiki/Q2684591","display_name":"Statement (logic)","level":2,"score":0.46838051080703735},{"id":"https://openalex.org/C78780964","wikidata":"https://www.wikidata.org/wiki/Q7233193","display_name":"Position paper","level":2,"score":0.45649874210357666},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4472962021827698},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.44196417927742004},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4339922368526459},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.38269463181495667},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.3257341682910919},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16264650225639343},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0817861557006836},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D032921","descriptor_name":"Consensus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D032921","descriptor_name":"Consensus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D032921","descriptor_name":"Consensus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D032921","descriptor_name":"Consensus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D032921","descriptor_name":"Consensus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D032921","descriptor_name":"Consensus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D032921","descriptor_name":"Consensus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbaf100","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf100","pdf_url":"https://academic.oup.com/bib/article-pdf/26/2/bbaf100/62365889/bbaf100.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40062621","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40062621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:cris.unibo.it:11585/1014414","is_oa":true,"landing_page_url":"https://hdl.handle.net/11585/1014414","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:10702904","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11891646","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf100","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf100","pdf_url":"https://academic.oup.com/bib/article-pdf/26/2/bbaf100/62365889/bbaf100.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4408296244.pdf"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W2036816374","https://openalex.org/W2069816479","https://openalex.org/W2083780116","https://openalex.org/W2095848001","https://openalex.org/W2104787607","https://openalex.org/W2111547563","https://openalex.org/W2142201329","https://openalex.org/W2177870565","https://openalex.org/W2927351257","https://openalex.org/W3100511085","https://openalex.org/W3116286104","https://openalex.org/W3163993681","https://openalex.org/W4206028796","https://openalex.org/W4287589597","https://openalex.org/W4385253081","https://openalex.org/W4392027102","https://openalex.org/W4395689557","https://openalex.org/W4404185697"],"related_works":["https://openalex.org/W2388687352","https://openalex.org/W1990162851","https://openalex.org/W2370187191","https://openalex.org/W2369854048","https://openalex.org/W2374291020","https://openalex.org/W2355907197","https://openalex.org/W3171042291","https://openalex.org/W2390961115","https://openalex.org/W2388138913","https://openalex.org/W4396769302"],"abstract_inverted_index":{"The":[0],"rapid":[1],"integration":[2],"of":[3,16,18,30,58,73,79,128],"machine":[4],"learning":[5],"(ML)":[6],"predictors":[7,32,92,130],"into":[8],"in":[9,122,131],"silico":[10],"medicine":[11],"has":[12],"revolutionized":[13],"the":[14,28,53,66,71,77,123],"estimation":[15],"quantities":[17],"interest":[19],"that":[20],"are":[21],"otherwise":[22],"challenging":[23],"to":[24,87,108,116],"measure":[25],"directly.":[26],"However,":[27],"credibility":[29,72],"these":[31],"is":[33],"critical,":[34],"especially":[35],"when":[36],"they":[37],"inform":[38],"high-stakes":[39],"healthcare":[40],"decisions.":[41],"This":[42],"position":[43],"paper":[44],"presents":[45],"a":[46],"consensus":[47],"statement":[48],"developed":[49],"by":[50],"experts":[51],"within":[52],"In":[54],"Silico":[55],"World":[56],"Community":[57],"Practice.":[59],"We":[60],"outline":[61],"12":[62],"key":[63],"statements":[64],"forming":[65],"theoretical":[67],"foundation":[68],"for":[69],"evaluating":[70],"ML":[74,91,129],"predictors,":[75],"emphasizing":[76],"necessity":[78],"causal":[80,103],"knowledge,":[81],"rigorous":[82,124],"error":[83],"quantification,":[84],"and":[85,105,111,120,126,133],"robustness":[86],"biases.":[88],"By":[89],"comparing":[90],"with":[93,101],"biophysical":[94],"models,":[95],"we":[96],"highlight":[97],"unique":[98],"challenges":[99],"associated":[100],"implicit":[102],"knowledge":[104],"propose":[106],"strategies":[107],"ensure":[109],"reliability":[110],"applicability.":[112],"Our":[113],"recommendations":[114],"aim":[115],"guide":[117],"researchers,":[118],"developers,":[119],"regulators":[121],"assessment":[125],"deployment":[127],"clinical":[132],"biomedical":[134],"contexts.":[135]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}