{"id":"https://openalex.org/W4408414768","doi":"https://doi.org/10.1093/bib/bbaf099","title":"Scaling up drug combination surface prediction","display_name":"Scaling up drug combination surface prediction","publication_year":2025,"publication_date":"2025-02-25","ids":{"openalex":"https://openalex.org/W4408414768","doi":"https://doi.org/10.1093/bib/bbaf099","pmid":"https://pubmed.ncbi.nlm.nih.gov/40079263"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf099","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf099","pdf_url":"https://academic.oup.com/bib/article-pdf/26/2/bbaf099/62397908/bbaf099.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/26/2/bbaf099/62397908/bbaf099.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048948839","display_name":"Riikka Huusari","orcid":"https://orcid.org/0000-0001-7821-0313"},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Riikka Huusari","raw_affiliation_strings":["Department of Computer Science , Aalto University, Otakaari 1B, FI-00076 Espoo,"],"raw_orcid":"https://orcid.org/0000-0001-7821-0313","affiliations":[{"raw_affiliation_string":"Department of Computer Science , Aalto University, Otakaari 1B, FI-00076 Espoo,","institution_ids":["https://openalex.org/I9927081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014944014","display_name":"Tianduanyi Wang","orcid":"https://orcid.org/0000-0003-0642-7235"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tianduanyi Wang","raw_affiliation_strings":["Department of Computer Science , Aalto University, Otakaari 1B, FI-00076 Espoo,","Institute for Molecular Medicine Finland (FIMM) , HiLIFE, University of Helsinki, Tukholmankatu 8, FI-00270 Helsinki,"],"raw_orcid":"https://orcid.org/0000-0003-0642-7235","affiliations":[{"raw_affiliation_string":"Department of Computer Science , Aalto University, Otakaari 1B, FI-00076 Espoo,","institution_ids":["https://openalex.org/I9927081"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM) , HiLIFE, University of Helsinki, Tukholmankatu 8, FI-00270 Helsinki,","institution_ids":["https://openalex.org/I4210133586","https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056529215","display_name":"S\u00e1ndor Szedm\u00e1k","orcid":"https://orcid.org/0000-0003-1469-2215"},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sandor Szedmak","raw_affiliation_strings":["Department of Computer Science , Aalto University, Otakaari 1B, FI-00076 Espoo,"],"raw_orcid":"https://orcid.org/0000-0003-1469-2215","affiliations":[{"raw_affiliation_string":"Department of Computer Science , Aalto University, Otakaari 1B, FI-00076 Espoo,","institution_ids":["https://openalex.org/I9927081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115840101","display_name":"Diogo Dias","orcid":"https://orcid.org/0009-0006-7806-8277"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Diogo Dias","raw_affiliation_strings":["Hematology Research Unit , University of Helsinki and Helsinki University Hospital, Haartmaninkatu 8, FI-00290 Helsinki,","Institute for Molecular Medicine Finland (FIMM) , HiLIFE, University of Helsinki, Tukholmankatu 8, FI-00270 Helsinki,","Translational Immunology Research Program , University of Helsinki, Haartmaninkatu 8, FI-00290 Helsinki,"],"raw_orcid":"https://orcid.org/0009-0006-7806-8277","affiliations":[{"raw_affiliation_string":"Hematology Research Unit , University of Helsinki and Helsinki University Hospital, Haartmaninkatu 8, FI-00290 Helsinki,","institution_ids":["https://openalex.org/I2800394112","https://openalex.org/I133731052"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM) , HiLIFE, University of Helsinki, Tukholmankatu 8, FI-00270 Helsinki,","institution_ids":["https://openalex.org/I4210133586","https://openalex.org/I133731052"]},{"raw_affiliation_string":"Translational Immunology Research Program , University of Helsinki, Haartmaninkatu 8, FI-00290 Helsinki,","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016681267","display_name":"Tero Aittokallio","orcid":"https://orcid.org/0000-0002-0886-9769"},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4210145812","display_name":"Cancer Genetics (United States)","ror":"https://ror.org/05feyya22","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145812"]}],"countries":["FI","NO","US"],"is_corresponding":false,"raw_author_name":"Tero Aittokallio","raw_affiliation_strings":["Department of Cancer Genetics , Institute for Cancer Research, Oslo University Hospital, Ullernchausseen 70, N-0379 Oslo,","Institute for Molecular Medicine Finland (FIMM) , HiLIFE, University of Helsinki, Tukholmankatu 8, FI-00270 Helsinki,","Oslo Centre for Biostatistics and Epidemiology (OCBE) , Faculty of Medicine, University of Oslo, Sognsvannsveien 9, N-0372 Oslo,"],"raw_orcid":"https://orcid.org/0000-0002-0886-9769","affiliations":[{"raw_affiliation_string":"Department of Cancer Genetics , Institute for Cancer Research, Oslo University Hospital, Ullernchausseen 70, N-0379 Oslo,","institution_ids":["https://openalex.org/I1281400175","https://openalex.org/I4210145812"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM) , HiLIFE, University of Helsinki, Tukholmankatu 8, FI-00270 Helsinki,","institution_ids":["https://openalex.org/I4210133586","https://openalex.org/I133731052"]},{"raw_affiliation_string":"Oslo Centre for Biostatistics and Epidemiology (OCBE) , Faculty of Medicine, University of Oslo, Sognsvannsveien 9, N-0372 Oslo,","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091883185","display_name":"Juho Rousu","orcid":"https://orcid.org/0000-0002-0705-4314"},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Juho Rousu","raw_affiliation_strings":["Department of Computer Science , Aalto University, Otakaari 1B, FI-00076 Espoo,"],"raw_orcid":"https://orcid.org/0000-0002-0705-4314","affiliations":[{"raw_affiliation_string":"Department of Computer Science , Aalto University, Otakaari 1B, FI-00076 Espoo,","institution_ids":["https://openalex.org/I9927081"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":4.1771,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.93745405,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"26","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11948","display_name":"Machine Learning in Materials Science","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7239419221878052},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.6268354058265686},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5244691371917725},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.4344191253185272},{"id":"https://openalex.org/keywords/drug-response","display_name":"Drug response","score":0.4128722548484802},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.3320690393447876},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.143418550491333},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12422674894332886}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7239419221878052},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.6268354058265686},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5244691371917725},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.4344191253185272},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.4128722548484802},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3320690393447876},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.143418550491333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12422674894332886},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbaf099","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf099","pdf_url":"https://academic.oup.com/bib/article-pdf/26/2/bbaf099/62397908/bbaf099.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40079263","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40079263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:aaltodoc.aalto.fi:123456789/134905","is_oa":true,"landing_page_url":"http://www.scopus.com/inward/record.url?scp=105000098157&partnerID=8YFLogxK","pdf_url":null,"source":{"id":"https://openalex.org/S4306401663","display_name":"Aaltodoc (Aalto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I9927081","host_organization_name":"Aalto University","host_organization_lineage":["https://openalex.org/I9927081"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"publishedVersion"},{"id":"pmh:oai:europepmc.org:10720780","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11904408","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf099","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf099","pdf_url":"https://academic.oup.com/bib/article-pdf/26/2/bbaf099/62397908/bbaf099.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8399999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1326860812","display_name":null,"funder_award_id":"339421","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G1651447698","display_name":"AI technologies for interaction prediction in biomedicine","funder_award_id":"345802","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G2569998188","display_name":null,"funder_award_id":"273810","funder_id":"https://openalex.org/F4320310758","funder_display_name":"Kreftforeningen"},{"id":"https://openalex.org/G329941513","display_name":null,"funder_award_id":"340141","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G3732400637","display_name":null,"funder_award_id":"326238","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G4362438806","display_name":"AI technologies for interaction prediction in biomedicine","funder_award_id":"345803","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G4719929683","display_name":null,"funder_award_id":"345803","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G4888334468","display_name":null,"funder_award_id":"345802","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G4994675487","display_name":null,"funder_award_id":"334790","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G5066627347","display_name":null,"funder_award_id":"344698","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G606848473","display_name":null,"funder_award_id":"216104","funder_id":"https://openalex.org/F4320310758","funder_display_name":"Kreftforeningen"},{"id":"https://openalex.org/G6999706713","display_name":"Machine learning for digItal diagnostics of antimicrobial resistance","funder_award_id":"334790","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G757968218","display_name":"Machine Learning for Systems Pharmacology","funder_award_id":"339421","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G7701213674","display_name":"Tailoring the targeted treatment of chronic lymphocytic leukemia","funder_award_id":"344698","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G8194661698","display_name":"Machine Learning for Systems Pharmacology","funder_award_id":"340141","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"}],"funders":[{"id":"https://openalex.org/F4320310758","display_name":"Kreftforeningen","ror":"https://ror.org/01925vb10"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4408414768.pdf","grobid_xml":"https://content.openalex.org/works/W4408414768.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1696775091","https://openalex.org/W1915767302","https://openalex.org/W2060737851","https://openalex.org/W2088032561","https://openalex.org/W2103194807","https://openalex.org/W2126928912","https://openalex.org/W2255955546","https://openalex.org/W2264399954","https://openalex.org/W2299417213","https://openalex.org/W2329901740","https://openalex.org/W2335854816","https://openalex.org/W2414798983","https://openalex.org/W2440171437","https://openalex.org/W2545806747","https://openalex.org/W2580903965","https://openalex.org/W2608863179","https://openalex.org/W2614307272","https://openalex.org/W2741508285","https://openalex.org/W2775061087","https://openalex.org/W2892308164","https://openalex.org/W2901820815","https://openalex.org/W2917986762","https://openalex.org/W2964038500","https://openalex.org/W2972783946","https://openalex.org/W2992010506","https://openalex.org/W3082511454","https://openalex.org/W3098913413","https://openalex.org/W3107514561","https://openalex.org/W3164087725","https://openalex.org/W3177840694","https://openalex.org/W3194635166","https://openalex.org/W3196304395","https://openalex.org/W3209465832","https://openalex.org/W4205686435","https://openalex.org/W4212799760","https://openalex.org/W4212966936","https://openalex.org/W4226211056","https://openalex.org/W4281626350","https://openalex.org/W4283370352","https://openalex.org/W4285401056","https://openalex.org/W4287781687","https://openalex.org/W4366742618","https://openalex.org/W4377969220","https://openalex.org/W4382501842","https://openalex.org/W4390911994","https://openalex.org/W4396578907","https://openalex.org/W4407080901","https://openalex.org/W4407751074","https://openalex.org/W6675357706","https://openalex.org/W6683084963","https://openalex.org/W6703221619","https://openalex.org/W6729380625","https://openalex.org/W6732280925","https://openalex.org/W6734797129","https://openalex.org/W6776988300"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W4387369504","https://openalex.org/W3046775127","https://openalex.org/W4394896187","https://openalex.org/W3170094116","https://openalex.org/W4386462264","https://openalex.org/W3107602296","https://openalex.org/W4364306694","https://openalex.org/W4312192474"],"abstract_inverted_index":{"Drug":[0],"combinations":[1,33,55],"are":[2,34,42,50,66,96],"required":[3],"to":[4,164,176],"treat":[5],"advanced":[6],"cancers":[7],"and":[8,20,44,127,168],"other":[9],"complex":[10],"diseases.":[11],"Compared":[12],"with":[13,186,199,225],"monotherapy,":[14],"combination":[15,39,94,101,161],"treatments":[16],"can":[17],"enhance":[18],"efficacy":[19],"reduce":[21],"toxicity":[22],"by":[23],"lowering":[24],"the":[25,61,103,108,112,131,143,158,165,178,220,232],"doses":[26],"of":[27,35,60,111,130,142,196,234,239],"single":[28],"drugs-and":[29],"there":[30],"especially":[31],"synergistic":[32],"interest.":[36],"Since":[37],"drug":[38,80,100,160],"screening":[40],"experiments":[41],"costly":[43],"time-consuming,":[45],"reliable":[46],"machine":[47,63],"learning":[48,64],"models":[49,65],"needed":[51],"for":[52,56,79,98,157],"prioritizing":[53],"potential":[54],"further":[57,230],"studies.":[58],"Most":[59],"current":[62],"based":[67,119],"on":[68,102,120,241],"scalar-valued":[69],"approaches,":[70,237],"which":[71,90,117,145],"predict":[72],"individual":[73],"response":[74,132,162],"values":[75],"or":[76,212],"synergy":[77,226],"scores":[78],"combinations.":[81],"We":[82,106,191],"take":[83],"a":[84,121,139,171],"functional":[85,128],"output":[86,159],"prediction":[87,228,236],"approach,":[88],"in":[89,219],"full,":[91],"continuous":[92],"dose-response":[93,235],"surfaces":[95,163],"predicted":[97],"each":[99],"cell":[104,213],"lines.":[105],"investigate":[107],"predictive":[109],"power":[110],"recently":[113],"proposed":[114],"comboKR":[115,166,197],"method,":[116],"is":[118,183],"powerful":[122],"input-output":[123],"kernel":[124],"regression":[125],"technique":[126],"modeling":[129,149,155],"surface.":[133],"In":[134],"this":[135],"work,":[136],"we":[137,151],"develop":[138],"scaled-up":[140],"formulation":[141],"comboKR,":[144],"also":[146],"implements":[147],"improved":[148],"choices:":[150],"(1)":[152],"incorporate":[153],"new":[154],"choices":[156],"framework,":[167],"(2)":[169],"propose":[170],"projected":[172],"gradient":[173],"descent":[174],"method":[175],"solve":[177],"challenging":[179,205],"pre-image":[180],"problem":[181],"that":[182],"traditionally":[184],"solved":[185],"simple":[187,242],"candidate":[188],"set":[189],"approaches.":[190],"provide":[192],"thorough":[193],"experimental":[194,206],"analysis":[195],"2.0":[198],"three":[200],"real-word":[201],"datasets":[202],"within":[203],"various":[204],"settings,":[207],"including":[208],"cases":[209],"where":[210],"drugs":[211],"lines":[214],"have":[215],"not":[216],"been":[217],"encountered":[218],"training":[221],"data.":[222],"Our":[223],"comparison":[224],"score":[227],"methods":[229],"highlights":[231],"relevance":[233],"instead":[238],"relying":[240],"scoring":[243],"methods.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-06-22T08:00:12.763002","created_date":"2025-10-10T00:00:00"}
