{"id":"https://openalex.org/W4408333635","doi":"https://doi.org/10.1093/bib/bbaf095","title":"Dissecting genetic regulation of metabolic coordination","display_name":"Dissecting genetic regulation of metabolic coordination","publication_year":2025,"publication_date":"2025-03-01","ids":{"openalex":"https://openalex.org/W4408333635","doi":"https://doi.org/10.1093/bib/bbaf095","pmid":"https://pubmed.ncbi.nlm.nih.gov/40067114"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf095","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf095","pdf_url":"https://academic.oup.com/bib/article-pdf/26/2/bbaf095/62375012/bbaf095.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/26/2/bbaf095/62375012/bbaf095.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024819923","display_name":"Emily C. Hector","orcid":"https://orcid.org/0000-0003-1488-3150"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily C Hector","raw_affiliation_strings":["Department of Statistics, North Carolina State University , Raleigh, NC 27695 ,","Department of Statistics, North Carolina State University, Raleigh, NC 27695, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, North Carolina State University , Raleigh, NC 27695 ,","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Department of Statistics, North Carolina State University, Raleigh, NC 27695, United States","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068599759","display_name":"Daiwei Zhang","orcid":"https://orcid.org/0000-0002-5019-622X"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daiwei Zhang","raw_affiliation_strings":["Department of Biostatistics and Department of Genetics, University of North Carolina , Chapel Hill, NC 27599 ,","Department of Biostatistics, University of Michigan , Ann Arbor, MI 48109 ,","Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, United States","Department of Biostatistics and Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Department of Genetics, University of North Carolina , Chapel Hill, NC 27599 ,","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Biostatistics, University of Michigan , Ann Arbor, MI 48109 ,","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, United States","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Biostatistics and Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, United States","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087501793","display_name":"Leqi Tian","orcid":"https://orcid.org/0000-0001-6080-4076"},"institutions":[{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Leqi Tian","raw_affiliation_strings":["School of Data Science, the Chinese University of Hong Kong , Shenzhen, Guangdong 518172 ,","School of Data Science, the Chinese University of Hong Kong, Shenzhen, Guangdong 518172, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Data Science, the Chinese University of Hong Kong , Shenzhen, Guangdong 518172 ,","institution_ids":["https://openalex.org/I4210116924"]},{"raw_affiliation_string":"School of Data Science, the Chinese University of Hong Kong, Shenzhen, Guangdong 518172, P.R.China","institution_ids":["https://openalex.org/I4210116924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102353490","display_name":"Junning Feng","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junning Feng","raw_affiliation_strings":["School of Data Science, the Chinese University of Hong Kong , Shenzhen, Guangdong 518172 ,","School of Data Science, the Chinese University of Hong Kong, Shenzhen, Guangdong 518172, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Data Science, the Chinese University of Hong Kong , Shenzhen, Guangdong 518172 ,","institution_ids":["https://openalex.org/I4210116924"]},{"raw_affiliation_string":"School of Data Science, the Chinese University of Hong Kong, Shenzhen, Guangdong 518172, P.R.China","institution_ids":["https://openalex.org/I4210116924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100588516","display_name":"Xianyong Yin","orcid":null},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianyong Yin","raw_affiliation_strings":["Department of Biostatistics, University of Michigan , Ann Arbor, MI 48109 ,","Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Michigan , Ann Arbor, MI 48109 ,","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076135351","display_name":"Tianyi Xu","orcid":"https://orcid.org/0000-0003-4197-8163"},"institutions":[{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianyi Xu","raw_affiliation_strings":["School of Data Science, the Chinese University of Hong Kong , Shenzhen, Guangdong 518172 ,","School of Data Science, the Chinese University of Hong Kong, Shenzhen, Guangdong 518172, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Data Science, the Chinese University of Hong Kong , Shenzhen, Guangdong 518172 ,","institution_ids":["https://openalex.org/I4210116924"]},{"raw_affiliation_string":"School of Data Science, the Chinese University of Hong Kong, Shenzhen, Guangdong 518172, P.R.China","institution_ids":["https://openalex.org/I4210116924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110954866","display_name":"Markku Laakso","orcid":null},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Markku Laakso","raw_affiliation_strings":["School of Medicine, University of Eastern Finland , FI-70211 Kuopio ,","School of Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of Eastern Finland , FI-70211 Kuopio ,","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"School of Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101423378","display_name":"Yun Bai","orcid":"https://orcid.org/0000-0003-2773-2239"},"institutions":[{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Bai","raw_affiliation_strings":["School of Medicine, the Chinese University of Hong Kong , Shenzhen, Guangdong 518172 ,","School of Medicine, the Chinese University of Hong Kong, Shenzhen, Guangdong 518172, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, the Chinese University of Hong Kong , Shenzhen, Guangdong 518172 ,","institution_ids":["https://openalex.org/I4210116924"]},{"raw_affiliation_string":"School of Medicine, the Chinese University of Hong Kong, Shenzhen, Guangdong 518172, P.R.China","institution_ids":["https://openalex.org/I4210116924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073480648","display_name":"Jiashun Xiao","orcid":"https://orcid.org/0000-0002-0130-2102"},"institutions":[{"id":"https://openalex.org/I4210099586","display_name":"Shenzhen Research Institute of Big Data","ror":"https://ror.org/00z1gwf89","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210099586"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiashun Xiao","raw_affiliation_strings":["Shenzhen Research Institute of Big Data , Shenzhen, Guangdong 518172 ,","Shenzhen Research Institute of Big Data, Shenzhen, Guangdong 518172, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen Research Institute of Big Data , Shenzhen, Guangdong 518172 ,","institution_ids":["https://openalex.org/I4210099586"]},{"raw_affiliation_string":"Shenzhen Research Institute of Big Data, Shenzhen, Guangdong 518172, P.R.China","institution_ids":["https://openalex.org/I4210099586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021432602","display_name":"Jian Kang","orcid":"https://orcid.org/0000-0002-5643-2668"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Kang","raw_affiliation_strings":["Department of Biostatistics, University of Michigan , Ann Arbor, MI 48109 ,","Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Michigan , Ann Arbor, MI 48109 ,","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016835023","display_name":"Tianwei Yu","orcid":"https://orcid.org/0000-0003-2502-1628"},"institutions":[{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianwei Yu","raw_affiliation_strings":["School of Data Science, the Chinese University of Hong Kong , Shenzhen, Guangdong 518172 ,","School of Data Science, the Chinese University of Hong Kong, Shenzhen, Guangdong 518172, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Data Science, the Chinese University of Hong Kong , Shenzhen, Guangdong 518172 ,","institution_ids":["https://openalex.org/I4210116924"]},{"raw_affiliation_string":"School of Data Science, the Chinese University of Hong Kong, Shenzhen, Guangdong 518172, P.R.China","institution_ids":["https://openalex.org/I4210116924"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03571512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.809651792049408},{"id":"https://openalex.org/keywords/metabolome","display_name":"Metabolome","score":0.7931245565414429},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.7536087036132812},{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.6702791452407837},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.6623905301094055},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.6462271809577942},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6200937628746033},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5957546234130859},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.5573616027832031},{"id":"https://openalex.org/keywords/genotyping","display_name":"Genotyping","score":0.5527851581573486},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.549838662147522},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5269711017608643},{"id":"https://openalex.org/keywords/snp-genotyping","display_name":"SNP genotyping","score":0.4572010934352875},{"id":"https://openalex.org/keywords/metabolic-regulation","display_name":"Metabolic regulation","score":0.4352412819862366},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.43298542499542236},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.3081739842891693},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.29719120264053345},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.28790074586868286},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.21234527230262756},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.12396833300590515}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.809651792049408},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.7931245565414429},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.7536087036132812},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6702791452407837},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6623905301094055},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.6462271809577942},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6200937628746033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5957546234130859},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.5573616027832031},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.5527851581573486},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.549838662147522},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5269711017608643},{"id":"https://openalex.org/C163691529","wikidata":"https://www.wikidata.org/wiki/Q7391886","display_name":"SNP genotyping","level":5,"score":0.4572010934352875},{"id":"https://openalex.org/C2991986269","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolic regulation","level":3,"score":0.4352412819862366},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43298542499542236},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3081739842891693},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29719120264053345},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28790074586868286},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.21234527230262756},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12396833300590515}],"mesh":[{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf095","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf095","pdf_url":"https://academic.oup.com/bib/article-pdf/26/2/bbaf095/62375012/bbaf095.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40067114","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40067114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:10706909","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11894804","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf095","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf095","pdf_url":"https://academic.oup.com/bib/article-pdf/26/2/bbaf095/62375012/bbaf095.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2180360172","display_name":null,"funder_award_id":"R01MH105561","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3964006637","display_name":null,"funder_award_id":"R01GM124061","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4424110543","display_name":null,"funder_award_id":"R01GM087964","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4620911090","display_name":null,"funder_award_id":"IIS2123777","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5595980668","display_name":null,"funder_award_id":"R01DA048993","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4408333635.pdf"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W8928684","https://openalex.org/W1789883022","https://openalex.org/W1824047490","https://openalex.org/W1828872283","https://openalex.org/W1966775465","https://openalex.org/W1974171294","https://openalex.org/W1978299842","https://openalex.org/W1982425127","https://openalex.org/W1984283801","https://openalex.org/W1989568128","https://openalex.org/W1991491630","https://openalex.org/W1998653097","https://openalex.org/W2006393871","https://openalex.org/W2008047653","https://openalex.org/W2018838463","https://openalex.org/W2040239256","https://openalex.org/W2041999692","https://openalex.org/W2060457039","https://openalex.org/W2065678169","https://openalex.org/W2069616685","https://openalex.org/W2075401648","https://openalex.org/W2097265260","https://openalex.org/W2099598705","https://openalex.org/W2111219940","https://openalex.org/W2114954827","https://openalex.org/W2116011970","https://openalex.org/W2120049814","https://openalex.org/W2131110533","https://openalex.org/W2139845570","https://openalex.org/W2148861434","https://openalex.org/W2150105460","https://openalex.org/W2154514130","https://openalex.org/W2158229692","https://openalex.org/W2161474008","https://openalex.org/W2164339823","https://openalex.org/W2186824108","https://openalex.org/W2244638785","https://openalex.org/W2310662648","https://openalex.org/W2338241819","https://openalex.org/W2409656339","https://openalex.org/W2474747771","https://openalex.org/W2480680997","https://openalex.org/W2554705260","https://openalex.org/W2564771875","https://openalex.org/W2605404328","https://openalex.org/W2610272958","https://openalex.org/W2756221746","https://openalex.org/W2790635296","https://openalex.org/W2796799528","https://openalex.org/W2809854831","https://openalex.org/W2886358746","https://openalex.org/W2888213344","https://openalex.org/W2896828227","https://openalex.org/W2897073365","https://openalex.org/W2912181843","https://openalex.org/W2922405541","https://openalex.org/W2922706953","https://openalex.org/W2943293743","https://openalex.org/W2951837249","https://openalex.org/W2966363656","https://openalex.org/W2972412203","https://openalex.org/W2991033511","https://openalex.org/W2998625082","https://openalex.org/W3017310304","https://openalex.org/W3023998386","https://openalex.org/W3088992294","https://openalex.org/W3116438518","https://openalex.org/W3116746940","https://openalex.org/W3124247976","https://openalex.org/W3132255180","https://openalex.org/W3155010034","https://openalex.org/W3173875993","https://openalex.org/W3186175439","https://openalex.org/W3210686555","https://openalex.org/W4237054209","https://openalex.org/W4239334118","https://openalex.org/W4282937962","https://openalex.org/W4284666136","https://openalex.org/W4309090811","https://openalex.org/W4309662539","https://openalex.org/W4313890661","https://openalex.org/W6600336300","https://openalex.org/W6682954858"],"related_works":["https://openalex.org/W1961707331","https://openalex.org/W2341681417","https://openalex.org/W2063475537","https://openalex.org/W2012938657","https://openalex.org/W2096004952","https://openalex.org/W1578136679","https://openalex.org/W2087715585","https://openalex.org/W4223538309","https://openalex.org/W2940249735","https://openalex.org/W4385164381"],"abstract_inverted_index":{"Understanding":[0],"genetic":[1],"regulation":[2,150],"of":[3,13,133,151],"metabolism":[4],"is":[5],"critical":[6],"for":[7],"gaining":[8],"insights":[9],"into":[10],"the":[11,35,42,83,107,134,149,152],"causes":[12],"metabolic":[14,43,90,109,155],"diseases.":[15],"Traditional":[16],"metabolome-based":[17],"genome-wide":[18],"association":[19],"studies":[20],"(mGWAS)":[21],"focus":[22],"on":[23],"static":[24],"associations":[25],"between":[26,87,154],"single":[27],"nucleotide":[28],"polymorphisms":[29],"(SNPs)":[30],"and":[31,89,95,127,144],"metabolite":[32],"levels,":[33],"overlooking":[34],"changing":[36,84],"relationships":[37],"caused":[38],"by":[39,100],"genotypes":[40],"within":[41],"network.":[44],"Notably,":[45],"some":[46],"metabolites":[47,55,88],"exhibit":[48],"changes":[49],"in":[50,119,148],"correlation":[51,85],"patterns":[52,86],"with":[53,82],"other":[54],"under":[56],"certain":[57],"physiological":[58],"conditions":[59],"while":[60],"maintaining":[61],"their":[62],"overall":[63],"abundance":[64],"level.":[65],"In":[66,137],"this":[67],"manuscript,":[68],"we":[69],"develop":[70],"Metabolic":[71],"Differential-coordination":[72],"GWAS":[73],"(mdGWAS),":[74],"an":[75],"innovative":[76],"framework":[77],"that":[78,105],"detects":[79],"SNPs":[80,143],"associated":[81],"pathways.":[91,156],"This":[92],"approach":[93],"transcends":[94],"complements":[96],"conventional":[97],"mean-based":[98],"analyses":[99],"identifying":[101],"latent":[102],"regulatory":[103],"factors":[104],"govern":[106],"system-level":[108],"coordination.":[110],"Through":[111],"comprehensive":[112],"simulation":[113],"studies,":[114],"mdGWAS":[115,124],"demonstrated":[116],"robust":[117],"performance":[118],"detecting":[120],"SNP-metabolite-metabolite":[121],"associations.":[122],"Applying":[123],"to":[125],"genotyping":[126],"mass":[128],"spectrometry":[129],"(MS)-based":[130],"metabolomics":[131],"data":[132],"METabolic":[135],"Syndrome":[136],"Men":[138],"(METSIM)":[139],"Study":[140],"revealed":[141],"novel":[142],"genes":[145],"potentially":[146],"involved":[147],"coordination":[153]},"counts_by_year":[],"updated_date":"2026-06-21T07:57:09.225873","created_date":"2025-10-10T00:00:00"}