{"id":"https://openalex.org/W4407799860","doi":"https://doi.org/10.1093/bib/bbaf054","title":"iDOMO: identification of drug combinations via multi-set operations for treating diseases","display_name":"iDOMO: identification of drug combinations via multi-set operations for treating diseases","publication_year":2024,"publication_date":"2024-11-22","ids":{"openalex":"https://openalex.org/W4407799860","doi":"https://doi.org/10.1093/bib/bbaf054","pmid":"https://pubmed.ncbi.nlm.nih.gov/39973082"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf054","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf054","pdf_url":"https://academic.oup.com/bib/article-pdf/26/1/bbaf054/62005531/bbaf054.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/26/1/bbaf054/62005531/bbaf054.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058559125","display_name":"Xianxiao Zhou","orcid":"https://orcid.org/0000-0001-9350-4467"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianxiao Zhou","raw_affiliation_strings":["Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,","Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,","Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083621975","display_name":"Ling Wu","orcid":"https://orcid.org/0000-0002-5786-4315"},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling Wu","raw_affiliation_strings":["Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine , 4100 John R, Detroit, MI 48201 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine , 4100 John R, Detroit, MI 48201 ,","institution_ids":["https://openalex.org/I4210090317","https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100376896","display_name":"Minghui Wang","orcid":"https://orcid.org/0000-0001-9171-4962"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minghui Wang","raw_affiliation_strings":["Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,","Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,","Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078615235","display_name":"Guojun Wu","orcid":"https://orcid.org/0000-0002-7910-2813"},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guojun Wu","raw_affiliation_strings":["Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine , 4100 John R, Detroit, MI 48201 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine , 4100 John R, Detroit, MI 48201 ,","institution_ids":["https://openalex.org/I4210090317","https://openalex.org/I185443292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100392884","display_name":"Bin Zhang","orcid":"https://orcid.org/0000-0002-9549-5653"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin Zhang","raw_affiliation_strings":["Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,","Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,","Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,","Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,"],"raw_orcid":"https://orcid.org/0000-0002-9549-5653","affiliations":[{"raw_affiliation_string":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place , New York, NY 10029 ,","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.2593,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.61690731,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.7110937833786011},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6104228496551514},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4817390739917755},{"id":"https://openalex.org/keywords/concordance","display_name":"Concordance","score":0.44380781054496765},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3578328788280487},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3373122811317444},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.33135807514190674},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.27927452325820923},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18887284398078918},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1432446837425232}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7110937833786011},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6104228496551514},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4817390739917755},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.44380781054496765},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3578328788280487},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3373122811317444},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33135807514190674},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.27927452325820923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18887284398078918},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1432446837425232},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf054","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf054","pdf_url":"https://academic.oup.com/bib/article-pdf/26/1/bbaf054/62005531/bbaf054.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39973082","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39973082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12079396","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12079396","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf054","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf054","pdf_url":"https://academic.oup.com/bib/article-pdf/26/1/bbaf054/62005531/bbaf054.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.800000011920929}],"awards":[{"id":"https://openalex.org/G1403905118","display_name":null,"funder_award_id":"R01 AG062355","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1656146489","display_name":null,"funder_award_id":"R01 AG057907","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1857992759","display_name":null,"funder_award_id":"U01AG052411","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3094221994","display_name":null,"funder_award_id":"R01AG062355","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G387634293","display_name":null,"funder_award_id":"U01 AG052411","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4032549753","display_name":null,"funder_award_id":"R01AG057907","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4034756280","display_name":null,"funder_award_id":"U01AG046170","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G434761767","display_name":null,"funder_award_id":"U01 AG046170","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4437961438","display_name":null,"funder_award_id":"R01 AG074010","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4730064799","display_name":null,"funder_award_id":"U01AG058635","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4834979675","display_name":null,"funder_award_id":"U01 AG058635","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4858581876","display_name":null,"funder_award_id":"RF1 AG054014","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4881284252","display_name":null,"funder_award_id":"R01DK118243","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4957381807","display_name":null,"funder_award_id":"R56AG058655","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5340715155","display_name":null,"funder_award_id":"RF1AG057440","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5527392931","display_name":null,"funder_award_id":"R56 AG058655","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5529032662","display_name":null,"funder_award_id":"R01 AG068030","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6370361977","display_name":null,"funder_award_id":"RF1 AG074010","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6384979030","display_name":null,"funder_award_id":"R01DK118243","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7146508445","display_name":null,"funder_award_id":"R01 DK118243","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7428696593","display_name":null,"funder_award_id":"RF1AG054014","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8025383000","display_name":null,"funder_award_id":"RO1AG068030","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8517101770","display_name":null,"funder_award_id":"RF1AG074010","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8684559522","display_name":null,"funder_award_id":"RF1 AG057440","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407799860.pdf","grobid_xml":"https://content.openalex.org/works/W4407799860.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1490978052","https://openalex.org/W1596515083","https://openalex.org/W1966066354","https://openalex.org/W2027542963","https://openalex.org/W2035972738","https://openalex.org/W2036291018","https://openalex.org/W2043398720","https://openalex.org/W2044025814","https://openalex.org/W2077945404","https://openalex.org/W2096283457","https://openalex.org/W2103017472","https://openalex.org/W2110065044","https://openalex.org/W2110444464","https://openalex.org/W2118258530","https://openalex.org/W2121604817","https://openalex.org/W2125729063","https://openalex.org/W2141766149","https://openalex.org/W2142564546","https://openalex.org/W2143152083","https://openalex.org/W2146512944","https://openalex.org/W2160697532","https://openalex.org/W2170989872","https://openalex.org/W2173168040","https://openalex.org/W2311676973","https://openalex.org/W2511788166","https://openalex.org/W2600354335","https://openalex.org/W2608863179","https://openalex.org/W2612467560","https://openalex.org/W2621361707","https://openalex.org/W2774112395","https://openalex.org/W2775061087","https://openalex.org/W2783703583","https://openalex.org/W2799482038","https://openalex.org/W2800419012","https://openalex.org/W2905302554","https://openalex.org/W2915074980","https://openalex.org/W2922229918","https://openalex.org/W2924124844","https://openalex.org/W2943555376","https://openalex.org/W2971490764","https://openalex.org/W2982291409","https://openalex.org/W2992010506","https://openalex.org/W3047077846","https://openalex.org/W3055716132","https://openalex.org/W3081201079","https://openalex.org/W3086347240","https://openalex.org/W3087098279","https://openalex.org/W3156887422","https://openalex.org/W3165195325","https://openalex.org/W3172530361","https://openalex.org/W3189189889","https://openalex.org/W3196304395","https://openalex.org/W4212799760","https://openalex.org/W4281626350","https://openalex.org/W4297348289","https://openalex.org/W4402783130","https://openalex.org/W6675471023","https://openalex.org/W6747382165","https://openalex.org/W6769655052","https://openalex.org/W6794256691"],"related_works":["https://openalex.org/W2513589746","https://openalex.org/W2153919606","https://openalex.org/W2003194288","https://openalex.org/W2213189664","https://openalex.org/W2074002899","https://openalex.org/W2062254828","https://openalex.org/W4237480606","https://openalex.org/W2936968863","https://openalex.org/W1971792277","https://openalex.org/W3026240506"],"abstract_inverted_index":{"Combination":[0],"therapy":[1],"has":[2],"become":[3],"increasingly":[4],"important":[5],"for":[6,152,238,253,259],"treating":[7,106],"complex":[8,260],"diseases":[9],"which":[10],"often":[11],"involve":[12],"multiple":[13],"pathways":[14],"and":[15,25,35,81,102,121,126,140,179,204,247],"targets.":[16],"However,":[17],"experimental":[18],"screening":[19,242],"of":[20,29,64,79,90,93,135,185,202,243,256],"drug":[21,40,49,73,80,161,172,193,219,245],"combinations":[22,50,246],"is":[23,234],"costly":[24],"time-consuming.":[26],"The":[27],"availability":[28],"large-scale":[30,160],"transcriptomic":[31],"datasets":[32],"(e.g.":[33],"CMap":[34],"LINCS)":[36],"from":[37],"in":[38,112,158,211,226,240],"vitro":[39,212],"treatment":[41],"experiments":[42,213],"makes":[43],"it":[44],"possible":[45],"to":[46,71,187],"computationally":[47],"predict":[48,72],"with":[51,117,195,199],"synergistic":[52,88,197,224,244],"effects.":[53],"Towards":[54],"this":[55],"end,":[56],"we":[57],"developed":[58],"a":[59,91,107,113,222,250],"computational":[60],"approach,":[61],"termed":[62],"Identification":[63],"Drug":[65],"Combinations":[66],"via":[67],"Multi-Set":[68],"Operations":[69],"(iDOMO),":[70],"synergy":[74,150],"based":[75],"on":[76,105,143],"multi-set":[77],"operations":[78],"disease":[82],"gene":[83,123],"signatures.":[84],"iDOMO":[85,136,166,186,233],"quantifies":[86],"the":[87,99,118,133,145,176,180,200,207,216,239,254],"effect":[89,225],"pair":[92],"drugs":[94],"by":[95,137],"taking":[96],"into":[97],"account":[98],"combination's":[100],"beneficial":[101],"detrimental":[103],"effects":[104],"disease.":[108],"We":[109,130],"evaluated":[110,132],"iDOMO,":[111],"DREAM":[114],"Challenge":[115],"dataset":[116],"matched,":[119],"pre-":[120],"post-treatment":[122],"expression":[124],"data":[125],"cell":[127,229],"viability":[128],"information.":[129],"further":[131],"performance":[134],"concordance":[138],"index":[139],"Spearman":[141],"correlation":[142],"predicting":[144],"Highest":[146],"Single":[147],"Agency":[148],"(HSA)":[149],"scores":[151],"four":[153],"most":[154,208],"common":[155],"cancer":[156,190],"types":[157],"two":[159,169],"combination":[162,173,201,220],"databases,":[163],"showing":[164],"that":[165,215],"significantly":[167],"outperformed":[168],"existing":[170],"popular":[171],"approaches":[174],"including":[175],"Therapeutic":[177],"Score":[178],"SynergySeq":[181],"Orthogonality":[182],"Score.":[183],"Application":[184],"triple-negative":[188],"breast":[189],"(TNBC)":[191],"identified":[192],"pairs":[194],"potential":[196],"effects,":[198],"trifluridine":[203],"monobenzone":[205],"being":[206],"synergistic.":[209],"Our":[210],"confirmed":[214],"top":[217],"predicted":[218],"exerted":[221],"significant":[223],"inhibiting":[227],"TNBC":[228],"growth.":[230],"In":[231],"summary,":[232],"an":[235],"effective":[236],"method":[237],"silico":[241],"will":[248],"be":[249],"valuable":[251],"tool":[252],"development":[255],"novel":[257],"therapeutics":[258],"diseases.":[261]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-17T09:13:05.818461","created_date":"2025-10-10T00:00:00"}