{"id":"https://openalex.org/W4407196549","doi":"https://doi.org/10.1093/bib/bbaf027","title":"Post-transcriptional regulation supports the homeostatic expression of mature RNA","display_name":"Post-transcriptional regulation supports the homeostatic expression of mature RNA","publication_year":2024,"publication_date":"2024-11-22","ids":{"openalex":"https://openalex.org/W4407196549","doi":"https://doi.org/10.1093/bib/bbaf027","pmid":"https://pubmed.ncbi.nlm.nih.gov/39913622"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf027","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf027","pdf_url":"https://academic.oup.com/bib/article-pdf/26/1/bbaf027/61778089/bbaf027.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/26/1/bbaf027/61778089/bbaf027.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089383615","display_name":"Zheng Su","orcid":"https://orcid.org/0000-0002-1414-6970"},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Zheng Su","raw_affiliation_strings":["School of Biotechnology and Biomolecular Sciences, Faculty of Science, The University of New South Wales , Biological Sciences North Building (D26), Upper Kensington Campus, Sydney, New South Wales 2052 ,"],"raw_orcid":"https://orcid.org/0000-0002-1414-6970","affiliations":[{"raw_affiliation_string":"School of Biotechnology and Biomolecular Sciences, Faculty of Science, The University of New South Wales , Biological Sciences North Building (D26), Upper Kensington Campus, Sydney, New South Wales 2052 ,","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007972387","display_name":"Mingyan Fang","orcid":"https://orcid.org/0000-0001-7185-6445"},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]},{"id":"https://openalex.org/I4210127782","display_name":"Botswana Geoscience Institute","ror":"https://ror.org/038fqq280","country_code":"BW","type":"other","lineage":["https://openalex.org/I4210127782"]}],"countries":["AU","BW"],"is_corresponding":false,"raw_author_name":"Mingyan Fang","raw_affiliation_strings":["BGI Australia , L6, CBCRC, QIMR Medical Research Institute, 300 Herston Road, Herston, QLD 4006 ,","BGI Research , Building 1, Future Science and Technology Innovation Mansion, No. 59, Science and Technology 3rd Road, East Lake High-tech Development Zone, Wuhan City, Hubei Province, 430074 ,"],"raw_orcid":"https://orcid.org/0000-0001-7185-6445","affiliations":[{"raw_affiliation_string":"BGI Australia , L6, CBCRC, QIMR Medical Research Institute, 300 Herston Road, Herston, QLD 4006 ,","institution_ids":["https://openalex.org/I217937681"]},{"raw_affiliation_string":"BGI Research , Building 1, Future Science and Technology Innovation Mansion, No. 59, Science and Technology 3rd Road, East Lake High-tech Development Zone, Wuhan City, Hubei Province, 430074 ,","institution_ids":["https://openalex.org/I4210127782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064667591","display_name":"Andrei Smolnikov","orcid":"https://orcid.org/0000-0003-0983-5883"},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrei Smolnikov","raw_affiliation_strings":["School of Biotechnology and Biomolecular Sciences, Faculty of Science, The University of New South Wales , Biological Sciences North Building (D26), Upper Kensington Campus, Sydney, New South Wales 2052 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biotechnology and Biomolecular Sciences, Faculty of Science, The University of New South Wales , Biological Sciences North Building (D26), Upper Kensington Campus, Sydney, New South Wales 2052 ,","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090363651","display_name":"Fatemeh Vafaee","orcid":"https://orcid.org/0000-0002-7521-2417"},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Fatemeh Vafaee","raw_affiliation_strings":["School of Biotechnology and Biomolecular Sciences, Faculty of Science, The University of New South Wales , Biological Sciences North Building (D26), Upper Kensington Campus, Sydney, New South Wales 2052 ,"],"raw_orcid":"https://orcid.org/0000-0002-7521-2417","affiliations":[{"raw_affiliation_string":"School of Biotechnology and Biomolecular Sciences, Faculty of Science, The University of New South Wales , Biological Sciences North Building (D26), Upper Kensington Campus, Sydney, New South Wales 2052 ,","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049900685","display_name":"Marcel E. Dinger","orcid":"https://orcid.org/0000-0003-4423-934X"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Marcel E Dinger","raw_affiliation_strings":["School of Biotechnology and Biomolecular Sciences, Faculty of Science, The University of New South Wales , Biological Sciences North Building (D26), Upper Kensington Campus, Sydney, New South Wales 2052 ,","School of Life and Environmental Sciences, Faculty of Science, University of Sydney , F22 Life, Earth and Environmental Sciences (LEES) Building, Camperdown NSW 2050 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biotechnology and Biomolecular Sciences, Faculty of Science, The University of New South Wales , Biological Sciences North Building (D26), Upper Kensington Campus, Sydney, New South Wales 2052 ,","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"School of Life and Environmental Sciences, Faculty of Science, University of Sydney , F22 Life, Earth and Environmental Sciences (LEES) Building, Camperdown NSW 2050 ,","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011616116","display_name":"Emily C. Oates","orcid":"https://orcid.org/0000-0002-8836-1681"},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210125633","display_name":"Sydney Children's Hospital","ror":"https://ror.org/02tj04e91","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210125633","https://openalex.org/I4210149013"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Emily C Oates","raw_affiliation_strings":["Department of Neurology, Sydney Children\u2019s Hospital , High St, Randwick NSW 2031 ,","School of Biotechnology and Biomolecular Sciences, Faculty of Science, The University of New South Wales , Biological Sciences North Building (D26), Upper Kensington Campus, Sydney, New South Wales 2052 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Sydney Children\u2019s Hospital , High St, Randwick NSW 2031 ,","institution_ids":["https://openalex.org/I4210125633"]},{"raw_affiliation_string":"School of Biotechnology and Biomolecular Sciences, Faculty of Science, The University of New South Wales , Biological Sciences North Building (D26), Upper Kensington Campus, Sydney, New South Wales 2052 ,","institution_ids":["https://openalex.org/I31746571"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5011616116","https://openalex.org/A5049900685"],"corresponding_institution_ids":["https://openalex.org/I129604602","https://openalex.org/I31746571","https://openalex.org/I4210125633"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.6483,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.67860973,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.7939684391021729},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.7411752343177795},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6981222629547119},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.624735414981842},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.5389868021011353},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"Non-coding RNA","score":0.4649710953235626},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.4590413272380829},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"Post-transcriptional regulation","score":0.45218580961227417},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.43694180250167847},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.338127076625824}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7939684391021729},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.7411752343177795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6981222629547119},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.624735414981842},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5389868021011353},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.4649710953235626},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4590413272380829},{"id":"https://openalex.org/C178809742","wikidata":"https://www.wikidata.org/wiki/Q3455913","display_name":"Post-transcriptional regulation","level":4,"score":0.45218580961227417},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43694180250167847},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.338127076625824}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002679","descriptor_name":"Pan troglodytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002679","descriptor_name":"Pan troglodytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002679","descriptor_name":"Pan troglodytes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002679","descriptor_name":"Pan troglodytes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf027","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf027","pdf_url":"https://academic.oup.com/bib/article-pdf/26/1/bbaf027/61778089/bbaf027.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39913622","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39913622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11801271","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11801271","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11801271/pdf/bbaf027.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf027","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf027","pdf_url":"https://academic.oup.com/bib/article-pdf/26/1/bbaf027/61778089/bbaf027.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4300000071525574}],"awards":[],"funders":[{"id":"https://openalex.org/F4320319755","display_name":"Analytical Center for the Government of the Russian Federation","ror":null},{"id":"https://openalex.org/F4320320965","display_name":"University of New South Wales","ror":"https://ror.org/03r8z3t63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407196549.pdf","grobid_xml":"https://content.openalex.org/works/W4407196549.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W23563130","https://openalex.org/W144423133","https://openalex.org/W1569294608","https://openalex.org/W1968164444","https://openalex.org/W1974272975","https://openalex.org/W1979587260","https://openalex.org/W2044286001","https://openalex.org/W2049110540","https://openalex.org/W2070342831","https://openalex.org/W2089465951","https://openalex.org/W2090808827","https://openalex.org/W2096083625","https://openalex.org/W2102619694","https://openalex.org/W2114104545","https://openalex.org/W2116041602","https://openalex.org/W2120526590","https://openalex.org/W2131856634","https://openalex.org/W2137586531","https://openalex.org/W2138207763","https://openalex.org/W2144341217","https://openalex.org/W2151971476","https://openalex.org/W2160443244","https://openalex.org/W2162151166","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2276748084","https://openalex.org/W2288482887","https://openalex.org/W2336904388","https://openalex.org/W2430846749","https://openalex.org/W2469961971","https://openalex.org/W2470277042","https://openalex.org/W2525507785","https://openalex.org/W2553037660","https://openalex.org/W2582651071","https://openalex.org/W2602408874","https://openalex.org/W2605408626","https://openalex.org/W2606715885","https://openalex.org/W2735720719","https://openalex.org/W2766510537","https://openalex.org/W2769591387","https://openalex.org/W2793657534","https://openalex.org/W2806575796","https://openalex.org/W2950221693","https://openalex.org/W2985066250","https://openalex.org/W2990435446","https://openalex.org/W3000551897","https://openalex.org/W3042292144","https://openalex.org/W3042475334","https://openalex.org/W3049611888","https://openalex.org/W3111061871","https://openalex.org/W3133859624","https://openalex.org/W3145969289","https://openalex.org/W3161540023","https://openalex.org/W3171835979","https://openalex.org/W4205247356","https://openalex.org/W4220962903","https://openalex.org/W4254687493","https://openalex.org/W4294216483","https://openalex.org/W4308616307","https://openalex.org/W4323036511","https://openalex.org/W6773206724"],"related_works":["https://openalex.org/W2058984380","https://openalex.org/W1988125422","https://openalex.org/W2900182103","https://openalex.org/W3183769948","https://openalex.org/W3184762873","https://openalex.org/W4301752645","https://openalex.org/W2093806858","https://openalex.org/W4323965937","https://openalex.org/W2155884299","https://openalex.org/W1995876013"],"abstract_inverted_index":{"Gene":[0],"expression":[1,29,50,70,117,125,131,151,187],"regulation":[2,47],"is":[3,11,34],"a":[4,79,189],"sophisticated,":[5],"multi-stage":[6],"process,":[7],"and":[8,17,75,98,106,180],"its":[9],"robustness":[10],"critical":[12],"to":[13,114],"normal":[14,123],"cell":[15],"function":[16],"the":[18,31,38,53,67,144],"survival":[19],"of":[20,69,82,118,126,133,147,184],"an":[21],"organism.":[22],"Previous":[23],"studies":[24,162],"indicate":[25],"that":[26,111,157],"differential":[27],"gene":[28,150,186],"at":[30,37],"RNA":[32,54,74,77,90,120,135],"level":[33,40],"typically":[35],"attenuated":[36],"protein":[39],"through":[41],"translational":[42],"regulation.":[43],"However,":[44],"how":[45],"post-transcriptional":[46],"(PTR)":[48],"influences":[49],"change":[51,71,132],"during":[52],"maturation":[55],"process":[56],"remains":[57],"unclear.":[58],"In":[59],"this":[60,64],"study,":[61],"we":[62],"investigated":[63],"by":[65,121],"quantifying":[66],"magnitude":[68],"in":[72,136,160,175],"precursor":[73,127,134],"mature":[76,119],"across":[78],"vast":[80],"range":[81],"different":[83],"biological":[84],"conditions.":[85],"We":[86,109],"analyzed":[87],"bulk":[88],"tissue":[89],"sequencing":[91],"data":[92],"from":[93,101],"4689":[94],"samples,":[95],"including":[96],"healthy":[97],"diseased":[99],"tissues":[100],"human,":[102],"chimpanzee,":[103],"rhesus":[104],"macaque,":[105],"murine":[107],"sources.":[108],"demonstrated":[110],"PTR":[112,148],"tends":[113],"support":[115],"homeostatic":[116],"amplifying":[122],"tissue-specific":[124],"RNA,":[128],"while":[129],"reducing":[130],"disease":[137,168,178],"contexts.":[138],"Our":[139,153],"study":[140],"provides":[141],"insight":[142],"into":[143],"general":[145],"influence":[146],"on":[149],"homeostasis.":[152],"analysis":[154],"also":[155],"suggests":[156],"intronic":[158],"reads":[159],"RNA-seq":[161],"may":[163,173],"contain":[164],"under-utilized":[165],"information":[166],"about":[167],"associations.":[169],"Additionally,":[170],"our":[171],"findings":[172],"assist":[174],"identifying":[176],"new":[177],"biomarkers":[179],"more":[181],"effective":[182],"ways":[183],"altering":[185],"as":[188],"therapeutic":[190],"strategy.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3}],"updated_date":"2026-07-31T08:31:51.225901","created_date":"2025-10-10T00:00:00"}