{"id":"https://openalex.org/W4406619770","doi":"https://doi.org/10.1093/bib/bbaf012","title":"Unveiling cross-reactivity: implications for immune response modulation in cancer","display_name":"Unveiling cross-reactivity: implications for immune response modulation in cancer","publication_year":2024,"publication_date":"2024-11-22","ids":{"openalex":"https://openalex.org/W4406619770","doi":"https://doi.org/10.1093/bib/bbaf012","pmid":"https://pubmed.ncbi.nlm.nih.gov/39831892"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf012","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf012","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bib/bbaf012","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036531531","display_name":"Marco Ant\u00f4nio M. Pretti","orcid":"https://orcid.org/0000-0002-9511-294X"},"institutions":[{"id":"https://openalex.org/I2801345345","display_name":"Cancer Institute (WIA)","ror":"https://ror.org/01tc10z29","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2801345345"]},{"id":"https://openalex.org/I4210142683","display_name":"Instituto Nacional de C\u00e2ncer - INCA","ror":"https://ror.org/055n68305","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210142683"]}],"countries":["BR","IN"],"is_corresponding":false,"raw_author_name":"Marco Ant\u00f4nio M Pretti","raw_affiliation_strings":["Laboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA) , Rio de Janeiro ,","Program of Cell and Gene Therapy, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA) , Rio de Janeiro ,"],"raw_orcid":"https://orcid.org/0000-0002-9511-294X","affiliations":[{"raw_affiliation_string":"Laboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA) , Rio de Janeiro ,","institution_ids":[]},{"raw_affiliation_string":"Program of Cell and Gene Therapy, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA) , Rio de Janeiro ,","institution_ids":["https://openalex.org/I4210142683","https://openalex.org/I2801345345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079866895","display_name":"Gustavo Fioravanti Vieira","orcid":"https://orcid.org/0000-0002-2380-8059"},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]},{"id":"https://openalex.org/I4210102413","display_name":"Universidade La Salle","ror":"https://ror.org/01dzqrq04","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210102413"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gustavo Fioravanti Vieira","raw_affiliation_strings":["Postgraduate Program in Genetics and Molecular Biology, UFRGS , Porto Alegre ,","Postgraduate Program in Health and Human Development , La Salle University, Canoas,"],"raw_orcid":"https://orcid.org/0000-0002-2380-8059","affiliations":[{"raw_affiliation_string":"Postgraduate Program in Genetics and Molecular Biology, UFRGS , Porto Alegre ,","institution_ids":["https://openalex.org/I130442723"]},{"raw_affiliation_string":"Postgraduate Program in Health and Human Development , La Salle University, Canoas,","institution_ids":["https://openalex.org/I4210102413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042140942","display_name":"Mariana Boroni","orcid":"https://orcid.org/0000-0003-3495-9917"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariana Boroni","raw_affiliation_strings":["Laboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA) , Rio de Janeiro ,"],"raw_orcid":"https://orcid.org/0000-0003-3495-9917","affiliations":[{"raw_affiliation_string":"Laboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA) , Rio de Janeiro ,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036565811","display_name":"Mart\u00edn Bonamino","orcid":"https://orcid.org/0000-0002-4416-5822"},"institutions":[{"id":"https://openalex.org/I2801345345","display_name":"Cancer Institute (WIA)","ror":"https://ror.org/01tc10z29","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2801345345"]},{"id":"https://openalex.org/I4210142683","display_name":"Instituto Nacional de C\u00e2ncer - INCA","ror":"https://ror.org/055n68305","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210142683"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR","IN"],"is_corresponding":false,"raw_author_name":"Mart\u00edn H Bonamino","raw_affiliation_strings":["Program of Cell and Gene Therapy, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA) , Rio de Janeiro ,","Vice-Presidency of Research and Biological Collections (VPPCB), Oswaldo Cruz Foundation (FIOCRUZ) , Rio de Janeiro ,"],"raw_orcid":"https://orcid.org/0000-0002-4416-5822","affiliations":[{"raw_affiliation_string":"Program of Cell and Gene Therapy, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA) , Rio de Janeiro ,","institution_ids":["https://openalex.org/I4210142683","https://openalex.org/I2801345345"]},{"raw_affiliation_string":"Vice-Presidency of Research and Biological Collections (VPPCB), Oswaldo Cruz Foundation (FIOCRUZ) , Rio de Janeiro ,","institution_ids":["https://openalex.org/I52325"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.1994,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.58533432,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epitope","display_name":"Epitope","score":0.9733343124389648},{"id":"https://openalex.org/keywords/human-leukocyte-antigen","display_name":"Human leukocyte antigen","score":0.7192522883415222},{"id":"https://openalex.org/keywords/t-cell-receptor","display_name":"T-cell receptor","score":0.6282011270523071},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.5630943179130554},{"id":"https://openalex.org/keywords/cross-reactivity","display_name":"Cross-reactivity","score":0.5463753342628479},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.5360410809516907},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5351681709289551},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49327558279037476},{"id":"https://openalex.org/keywords/t-cell","display_name":"T cell","score":0.4818602502346039},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.4193876385688782},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3808066248893738},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.35415905714035034},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.12818574905395508}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.9733343124389648},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.7192522883415222},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.6282011270523071},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5630943179130554},{"id":"https://openalex.org/C2779142602","wikidata":"https://www.wikidata.org/wiki/Q1760689","display_name":"Cross-reactivity","level":4,"score":0.5463753342628479},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5360410809516907},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5351681709289551},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49327558279037476},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4818602502346039},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4193876385688782},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3808066248893738},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.35415905714035034},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12818574905395508},{"id":"https://openalex.org/C3020064264","wikidata":"https://www.wikidata.org/wiki/Q1760689","display_name":"Cross reactions","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf012","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf012","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39831892","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39831892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11744606","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11744606","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11744606/pdf/bbaf012.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf012","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf012","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4699999988079071,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"},{"id":"https://openalex.org/F4320323917","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W793398751","https://openalex.org/W1532828658","https://openalex.org/W1546831560","https://openalex.org/W1868344454","https://openalex.org/W1951588750","https://openalex.org/W1964115378","https://openalex.org/W1967195968","https://openalex.org/W1976112622","https://openalex.org/W1979731533","https://openalex.org/W1986216579","https://openalex.org/W2016228620","https://openalex.org/W2021315324","https://openalex.org/W2038023416","https://openalex.org/W2049204549","https://openalex.org/W2052035544","https://openalex.org/W2074167977","https://openalex.org/W2084965322","https://openalex.org/W2089000345","https://openalex.org/W2124728662","https://openalex.org/W2134724359","https://openalex.org/W2137879329","https://openalex.org/W2142269152","https://openalex.org/W2146652028","https://openalex.org/W2157384708","https://openalex.org/W2360792712","https://openalex.org/W2399366904","https://openalex.org/W2558508376","https://openalex.org/W2613978126","https://openalex.org/W2731784911","https://openalex.org/W2752126733","https://openalex.org/W2762030706","https://openalex.org/W2797967938","https://openalex.org/W2889980427","https://openalex.org/W2949635314","https://openalex.org/W2949975396","https://openalex.org/W2965921152","https://openalex.org/W2979330275","https://openalex.org/W2984055282","https://openalex.org/W2991067282","https://openalex.org/W3012770738","https://openalex.org/W3028523516","https://openalex.org/W3047159181","https://openalex.org/W3081312977","https://openalex.org/W3081393016","https://openalex.org/W3111377329","https://openalex.org/W3121259305","https://openalex.org/W3125756628","https://openalex.org/W3160101264","https://openalex.org/W3165566071","https://openalex.org/W3196984843","https://openalex.org/W4206678349","https://openalex.org/W4214826294","https://openalex.org/W4288434565","https://openalex.org/W4309516074","https://openalex.org/W4310945495","https://openalex.org/W4381252545","https://openalex.org/W4381432324","https://openalex.org/W4385223093","https://openalex.org/W4387246248","https://openalex.org/W4391542588","https://openalex.org/W4393098465"],"related_works":["https://openalex.org/W203802859","https://openalex.org/W2059333433","https://openalex.org/W2040128205","https://openalex.org/W2060075608","https://openalex.org/W2083920981","https://openalex.org/W1257198636","https://openalex.org/W2026444950","https://openalex.org/W2092033815","https://openalex.org/W2168929838","https://openalex.org/W2140205174"],"abstract_inverted_index":{"Antigen":[0,27],"recognition":[1],"by":[2,82],"CD8+":[3],"T-cell":[4,50,164,178,237],"receptors":[5],"(TCR)":[6],"is":[7],"crucial":[8],"for":[9,218],"immune":[10,42],"responses":[11],"to":[12,52,65,75,96,138,166,187,198,235],"pathogens":[13,54],"and":[14,55,87,109,112,154,177,208,211],"tumors.":[15,56],"TCRs":[16],"are":[17],"cross-reactive,":[18],"a":[19,77,171,232],"single":[20],"TCR":[21,67],"can":[22,34],"recognize":[23,147],"multiple":[24],"peptide-Human":[25],"Leukocyte":[26],"(HLA)":[28],"complexes.":[29],"The":[30,57],"study":[31,236],"of":[32,38,48,80,85,103,117,122,224],"cross-reactivity":[33],"support":[35],"the":[36,46,70,222],"development":[37],"therapies":[39],"focusing":[40],"on":[41],"modulation,":[43],"such":[44],"as":[45],"expansion":[47],"pre-existing":[49],"clones":[51],"fight":[53],"peptide-HLA":[58,81,225],"(pHLA)":[59],"surface":[60],"has":[61],"previously":[62],"been":[63],"used":[64],"identify":[66,97],"cross-reactivities.":[68],"In":[69],"present":[71],"work,":[72],"we":[73,169,191,202],"sought":[74],"perform":[76],"comprehensive":[78],"analysis":[79],"selecting":[83],"thousands":[84,223],"human":[86,131],"viral":[88,128,199,209],"epitopes.":[89],"We":[90,135],"profit":[91],"from":[92,99,126,144,159],"established":[93],"docking":[94],"models":[95],"features":[98,193],"different":[100],"spatial":[101,155],"perspectives":[102],"HLA-A*02:01,":[104],"explore":[105],"similarities":[106],"between":[107,174,206],"self":[108,188],"non-self":[110],"epitopes,":[111,168,189],"list":[113],"potential":[114,204],"cross-reactive":[115,141],"epitopes":[116,125,148,183,210],"therapeutic":[118,219],"interest.":[119],"A":[120],"total":[121],"2631":[123],"unique":[124],"representative":[127],"proteins":[129,132],"or":[130],"were":[133,136,184],"modeled.":[134],"able":[137],"demonstrate":[139],"that":[140,162],"CDR3":[142],"sequences":[143],"public":[145],"databases":[146],"with":[149],"similar":[150,186,197],"electrostatic":[151],"potential,":[152],"charge,":[153],"location.":[156],"Using":[157],"data":[158],"published":[160],"studies":[161],"measured":[163],"reactivity":[165],"mutated":[167],"observed":[170],"negative":[172],"correlation":[173],"epitope":[175],"dissimilarity":[176],"activation.":[179],"Most":[180],"analysed":[181],"cancer":[182],"more":[185,196],"yet":[190],"identified":[192],"distinguishing":[194],"those":[195],"antigens.":[200],"Finally,":[201],"enumerated":[203],"cross-reactivities":[205],"tumoral":[207],"highlighted":[212],"some":[213],"challenges":[214],"in":[215,228],"their":[216],"identification":[217],"use.":[220],"Moreover,":[221],"complexes":[226],"generated":[227],"our":[229],"work":[230],"constitute":[231],"valuable":[233],"resource":[234],"cross-reactivity.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-06-25T08:15:23.626066","created_date":"2025-10-10T00:00:00"}