{"id":"https://openalex.org/W4406680003","doi":"https://doi.org/10.1093/bib/bbaf007","title":"Multimodal multiobjective optimization with structural network control principles to optimize personalized drug targets for drug discovery of individual patients","display_name":"Multimodal multiobjective optimization with structural network control principles to optimize personalized drug targets for drug discovery of individual patients","publication_year":2024,"publication_date":"2024-11-22","ids":{"openalex":"https://openalex.org/W4406680003","doi":"https://doi.org/10.1093/bib/bbaf007","pmid":"https://pubmed.ncbi.nlm.nih.gov/39835535"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf007","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf007","pdf_url":"https://academic.oup.com/bib/article-pdf/26/1/bbaf007/61525230/bbaf007.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/26/1/bbaf007/61525230/bbaf007.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100676081","display_name":"Jing Liang","orcid":"https://orcid.org/0000-0003-0811-0223"},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Liang","raw_affiliation_strings":["School of Electrical and Information Engineering, Zhengzhou University , No. 100, Science Avenue, Hightech District, Zhengzhou City 450001, Henan Province ,","State Key Laboratory of Intelligent Agricultural Power Equipment , No. 39, Xiyuan Road, Jianxi District, Luoyang City 471039, Henan Province ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Information Engineering, Zhengzhou University , No. 100, Science Avenue, Hightech District, Zhengzhou City 450001, Henan Province ,","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"State Key Laboratory of Intelligent Agricultural Power Equipment , No. 39, Xiyuan Road, Jianxi District, Luoyang City 471039, Henan Province ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101432362","display_name":"Zhuo Hu","orcid":"https://orcid.org/0000-0001-9368-4170"},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuo Hu","raw_affiliation_strings":["School of Electrical and Information Engineering, Zhengzhou University , No. 100, Science Avenue, Hightech District, Zhengzhou City 450001, Henan Province ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Information Engineering, Zhengzhou University , No. 100, Science Avenue, Hightech District, Zhengzhou City 450001, Henan Province ,","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076701363","display_name":"Ying Bi","orcid":"https://orcid.org/0000-0003-2758-6067"},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Bi","raw_affiliation_strings":["School of Electrical and Information Engineering, Zhengzhou University , No. 100, Science Avenue, Hightech District, Zhengzhou City 450001, Henan Province ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Information Engineering, Zhengzhou University , No. 100, Science Avenue, Hightech District, Zhengzhou City 450001, Henan Province ,","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083819240","display_name":"Han Cheng","orcid":"https://orcid.org/0000-0002-6684-317X"},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Cheng","raw_affiliation_strings":["School of Life Sciences, Zhengzhou University , No. 100, Science Avenue, High-tech District, Zhengzhou City 450001, Henan Province ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Zhengzhou University , No. 100, Science Avenue, High-tech District, Zhengzhou City 450001, Henan Province ,","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038446460","display_name":"Wei-Feng Guo","orcid":"https://orcid.org/0000-0003-0565-177X"},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei-Feng Guo","raw_affiliation_strings":["School of Electrical and Information Engineering, Zhengzhou University , No. 100, Science Avenue, Hightech District, Zhengzhou City 450001, Henan Province ,","State Key Laboratory of Intelligent Agricultural Power Equipment , No. 39, Xiyuan Road, Jianxi District, Luoyang City 471039, Henan Province ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Information Engineering, Zhengzhou University , No. 100, Science Avenue, Hightech District, Zhengzhou City 450001, Henan Province ,","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"State Key Laboratory of Intelligent Agricultural Power Equipment , No. 39, Xiyuan Road, Jianxi District, Luoyang City 471039, Henan Province ,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100676081"],"corresponding_institution_ids":["https://openalex.org/I38877650"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.9968,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.80416145,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6890126466751099},{"id":"https://openalex.org/keywords/weighting","display_name":"Weighting","score":0.483748197555542},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.47100773453712463},{"id":"https://openalex.org/keywords/multi-objective-optimization","display_name":"Multi-objective optimization","score":0.4380807876586914},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.42352136969566345},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3952709436416626},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.17224812507629395},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12972289323806763}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6890126466751099},{"id":"https://openalex.org/C183115368","wikidata":"https://www.wikidata.org/wiki/Q856577","display_name":"Weighting","level":2,"score":0.483748197555542},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.47100773453712463},{"id":"https://openalex.org/C68781425","wikidata":"https://www.wikidata.org/wiki/Q2052203","display_name":"Multi-objective optimization","level":2,"score":0.4380807876586914},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.42352136969566345},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3952709436416626},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.17224812507629395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12972289323806763},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf007","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf007","pdf_url":"https://academic.oup.com/bib/article-pdf/26/1/bbaf007/61525230/bbaf007.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39835535","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39835535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11747759","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11747759","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11747759/pdf/bbaf007.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf007","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf007","pdf_url":"https://academic.oup.com/bib/article-pdf/26/1/bbaf007/61525230/bbaf007.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6899999976158142,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G440889762","display_name":null,"funder_award_id":"242300421401","funder_id":"https://openalex.org/F4320323845","funder_display_name":"Natural Science Foundation of Henan Province"},{"id":"https://openalex.org/G7239235371","display_name":null,"funder_award_id":"62476253","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8391208399","display_name":null,"funder_award_id":"2021M692915","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G8599959440","display_name":null,"funder_award_id":"62002329","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320322766","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21"},{"id":"https://openalex.org/F4320323845","display_name":"Natural Science Foundation of Henan Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406680003.pdf","grobid_xml":"https://content.openalex.org/works/W4406680003.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1984675437","https://openalex.org/W2018239124","https://openalex.org/W2095334215","https://openalex.org/W2096166399","https://openalex.org/W2101420429","https://openalex.org/W2106334424","https://openalex.org/W2112912151","https://openalex.org/W2126105956","https://openalex.org/W2129973040","https://openalex.org/W2143381319","https://openalex.org/W2259538443","https://openalex.org/W2399184178","https://openalex.org/W2508622936","https://openalex.org/W2558610617","https://openalex.org/W2624136113","https://openalex.org/W2758008099","https://openalex.org/W2784142616","https://openalex.org/W2790739050","https://openalex.org/W2891614933","https://openalex.org/W2912180855","https://openalex.org/W2915168078","https://openalex.org/W2962947982","https://openalex.org/W2963115819","https://openalex.org/W2964234453","https://openalex.org/W2964315448","https://openalex.org/W2989260018","https://openalex.org/W2989906520","https://openalex.org/W3036925570","https://openalex.org/W3043065261","https://openalex.org/W3094311502","https://openalex.org/W3111679633","https://openalex.org/W3119720073","https://openalex.org/W3120732119","https://openalex.org/W3157466662","https://openalex.org/W3167591632","https://openalex.org/W3217374538","https://openalex.org/W4214886519","https://openalex.org/W4237954928","https://openalex.org/W4285219208","https://openalex.org/W4285987711","https://openalex.org/W4288064552","https://openalex.org/W4309452766","https://openalex.org/W4309629465","https://openalex.org/W4319967892","https://openalex.org/W4378804667","https://openalex.org/W4380303721","https://openalex.org/W4385731814","https://openalex.org/W4387107368","https://openalex.org/W4387637159","https://openalex.org/W4394997844","https://openalex.org/W4399733558","https://openalex.org/W4400875898","https://openalex.org/W4401109658"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W4387369504","https://openalex.org/W3046775127","https://openalex.org/W4394896187","https://openalex.org/W3170094116","https://openalex.org/W4386462264","https://openalex.org/W3107602296","https://openalex.org/W4364306694","https://openalex.org/W4312192474"],"abstract_inverted_index":{"Structural":[0],"network":[1,93],"control":[2,94],"principles":[3],"provided":[4],"novel":[5,79,123],"and":[6,47,118,121,135,139,153,179,186,210,214],"efficient":[7],"clues":[8],"for":[9,219],"the":[10,38,41,49,68,115,148,181,187,190,200,204,207],"optimization":[11,83,107],"of":[12,21,40,44,53,59,70,99,150,183,212],"personalized":[13],"drug":[14,35,60,64,72],"targets":[15,36,61,65,73],"(PDTs)":[16],"related":[17],"to":[18,89,146],"state":[19,50,202],"transitions":[20],"individual":[22],"patients.":[23],"However,":[24],"most":[25],"existing":[26],"methods":[27],"focus":[28],"on":[29,114,159],"one":[30],"subnetwork":[31],"or":[32],"module":[33],"as":[34,127],"through":[37],"identification":[39],"minimal":[42],"set":[43],"driver":[45],"nodes":[46],"ignore":[48],"transition":[51],"capabilities":[52],"other":[54],"modules":[55],"with":[56,92,111],"different":[57],"configurations":[58],"[i.e.":[62],"multimodal":[63,80,105],"(MDTs)]":[66],"embedding":[67],"knowledge":[69],"previous":[71],"(i.e.":[74],"multiobjective":[75,81,106],"optimization).":[76],"Therefore,":[77],"a":[78,103,122,133,140,173],"evolutionary":[82,124],"framework":[84],"(called":[85],"MMONCP)":[86],"is":[87,109,129],"proposed":[88],"optimize":[90],"PDTs":[91],"principles.":[95],"The":[96,156,165],"key":[97],"points":[98],"MMONCP":[100,171,197],"are":[101],"that":[102,170],"constrained":[104],"problem":[108],"formed":[110],"discrete":[112],"constraints":[113],"decision":[116,154],"space":[117],"multimodality":[119],"characteristics,":[120],"algorithm":[125,177],"denoted":[126],"CMMOEA-GLS-WSCD":[128],"designed":[130],"by":[131],"combining":[132],"global":[134],"local":[136],"search":[137],"strategy":[138,145],"weighting-based":[141],"special":[142],"crowding":[143],"distance":[144],"balance":[147],"diversity":[149],"both":[151],"objective":[152],"space.":[155],"experimental":[157],"results":[158],"three":[160],"cancer":[161,220],"genomics":[162],"data":[163],"from":[164,203],"Cancer":[166],"Genome":[167],"Atlas":[168],"indicate":[169],"achieves":[172],"higher":[174],"performance":[175],"including":[176],"convergence":[178],"diversity,":[180],"fraction":[182],"identified":[184],"MDTs,":[185],"area":[188],"under":[189],"curve":[191],"score":[192],"than":[193],"advanced":[194],"algorithms.":[195],"Additionally,":[196],"can":[198],"detect":[199],"early":[201,216],"difference":[205],"between":[206],"target":[208],"activity":[209],"toxicity":[211],"MDTs":[213],"provide":[215],"treatment":[217,221],"options":[218],"in":[222],"precision":[223],"medicine.":[224]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2026-05-22T09:01:20.584952","created_date":"2025-10-10T00:00:00"}