{"id":"https://openalex.org/W4406289617","doi":"https://doi.org/10.1093/bib/bbae654","title":"ET-PROTACs: modeling ternary complex interactions using cross-modal learning and ternary attention for accurate PROTAC-induced degradation prediction","display_name":"ET-PROTACs: modeling ternary complex interactions using cross-modal learning and ternary attention for accurate PROTAC-induced degradation prediction","publication_year":2024,"publication_date":"2024-11-22","ids":{"openalex":"https://openalex.org/W4406289617","doi":"https://doi.org/10.1093/bib/bbae654","pmid":"https://pubmed.ncbi.nlm.nih.gov/39783892"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae654","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae654","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bib/bbae654","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101775555","display_name":"Lijun Cai","orcid":"https://orcid.org/0000-0002-8538-5602"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijun Cai","raw_affiliation_strings":["College of Computer Science and Electronic Engineering, Hunan University , Changsha, Hunan 410082 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Electronic Engineering, Hunan University , Changsha, Hunan 410082 ,","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Guanyu Yue","orcid":null},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanyu Yue","raw_affiliation_strings":["College of Computer Science and Electronic Engineering, Hunan University , Changsha, Hunan 410082 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Electronic Engineering, Hunan University , Changsha, Hunan 410082 ,","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100405151","display_name":"Yifan Chen","orcid":"https://orcid.org/0000-0003-1353-7192"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifan Chen","raw_affiliation_strings":["College of Computer Science and Electronic Engineering, Hunan University , Changsha, Hunan 410082 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Electronic Engineering, Hunan University , Changsha, Hunan 410082 ,","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111499609","display_name":"Li Wang","orcid":"https://orcid.org/0000-0002-3356-0704"},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Li Wang","raw_affiliation_strings":["Degree Programs in Systems and Information Engineering , Graduate School of Science and Technology Doctoral Program in Computer Science, , Tsukuba ,","University of Tsukuba , Graduate School of Science and Technology Doctoral Program in Computer Science, , Tsukuba ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Degree Programs in Systems and Information Engineering , Graduate School of Science and Technology Doctoral Program in Computer Science, , Tsukuba ,","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"University of Tsukuba , Graduate School of Science and Technology Doctoral Program in Computer Science, , Tsukuba ,","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101655871","display_name":"Xiaojun Yao","orcid":"https://orcid.org/0000-0002-6972-2971"},"institutions":[{"id":"https://openalex.org/I49835588","display_name":"Macao Polytechnic University","ror":"https://ror.org/02sf5td35","country_code":"MO","type":"education","lineage":["https://openalex.org/I49835588"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Xiaojun Yao","raw_affiliation_strings":["Faculty of Applied Sciences , Centre for Artificial Intelligence Driven Drug Discovery, , Macao 999078 ,","Macao Polytechnic University , Centre for Artificial Intelligence Driven Drug Discovery, , Macao 999078 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Applied Sciences , Centre for Artificial Intelligence Driven Drug Discovery, , Macao 999078 ,","institution_ids":[]},{"raw_affiliation_string":"Macao Polytechnic University , Centre for Artificial Intelligence Driven Drug Discovery, , Macao 999078 ,","institution_ids":["https://openalex.org/I49835588"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073446170","display_name":"Q. Zou","orcid":"https://orcid.org/0000-0003-0038-5038"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quan Zou","raw_affiliation_strings":["Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China , Chengdu 610054 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China , Chengdu 610054 ,","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiangzheng Fu","orcid":null},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangzheng Fu","raw_affiliation_strings":["College of Computer Science and Electronic Engineering, Hunan University , Changsha, Hunan 410082 ,","Research Institute of Hunan University in Chongqing, Chongqing 401120 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Electronic Engineering, Hunan University , Changsha, Hunan 410082 ,","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"Research Institute of Hunan University in Chongqing, Chongqing 401120 ,","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083809384","display_name":"Dongsheng Cao","orcid":"https://orcid.org/0000-0003-3604-3785"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongsheng Cao","raw_affiliation_strings":["Xiangya School of Pharmaceutical Sciences, Central South University , Changsha, Hunan 410003 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiangya School of Pharmaceutical Sciences, Central South University , Changsha, Hunan 410003 ,","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":2.3098,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.89351578,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6482573747634888},{"id":"https://openalex.org/keywords/ternary-operation","display_name":"Ternary operation","score":0.5891781449317932},{"id":"https://openalex.org/keywords/modal","display_name":"Modal","score":0.5786907076835632},{"id":"https://openalex.org/keywords/ternary-complex","display_name":"Ternary complex","score":0.44427162408828735},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.43291914463043213},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4156843423843384},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3722529113292694},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.13505440950393677}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6482573747634888},{"id":"https://openalex.org/C64452783","wikidata":"https://www.wikidata.org/wiki/Q1524945","display_name":"Ternary operation","level":2,"score":0.5891781449317932},{"id":"https://openalex.org/C71139939","wikidata":"https://www.wikidata.org/wiki/Q910194","display_name":"Modal","level":2,"score":0.5786907076835632},{"id":"https://openalex.org/C86756495","wikidata":"https://www.wikidata.org/wiki/Q7702931","display_name":"Ternary complex","level":3,"score":0.44427162408828735},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.43291914463043213},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4156843423843384},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3722529113292694},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13505440950393677},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000094243","descriptor_name":"Proteolysis Targeting Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094243","descriptor_name":"Proteolysis Targeting Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094243","descriptor_name":"Proteolysis Targeting Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae654","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae654","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39783892","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39783892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11713031","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11713031","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11713031/pdf/bbae654.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae654","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae654","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1208914126","display_name":null,"funder_award_id":"62402533","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G268992786","display_name":null,"funder_award_id":"U22A2037","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2796437284","display_name":null,"funder_award_id":"CSTB2022NSCQ","funder_id":"https://openalex.org/F4320323172","funder_display_name":"Natural Science Foundation of Chongqing"},{"id":"https://openalex.org/G2886615","display_name":null,"funder_award_id":"2022JJ40090","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G4469130931","display_name":null,"funder_award_id":"62472165","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5477186794","display_name":null,"funder_award_id":"62122025","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G552737822","display_name":null,"funder_award_id":"62372158","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6325630020","display_name":null,"funder_award_id":"CSTB2022NSCQ-MSX1032","funder_id":"https://openalex.org/F4320323172","funder_display_name":"Natural Science Foundation of Chongqing"},{"id":"https://openalex.org/G6446245973","display_name":null,"funder_award_id":"62250028","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null},{"id":"https://openalex.org/F4320323172","display_name":"Natural Science Foundation of Chongqing","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327639","display_name":"Centre Scientifique et Technique du B\u00e2timent","ror":"https://ror.org/02fsd1928"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W2008056655","https://openalex.org/W2042380110","https://openalex.org/W2085140422","https://openalex.org/W2105344995","https://openalex.org/W2148512505","https://openalex.org/W2151683271","https://openalex.org/W2154654162","https://openalex.org/W2329592726","https://openalex.org/W2583907533","https://openalex.org/W2597078857","https://openalex.org/W2767856718","https://openalex.org/W2806672448","https://openalex.org/W2809216727","https://openalex.org/W2860192827","https://openalex.org/W2903964626","https://openalex.org/W2909034820","https://openalex.org/W2909353434","https://openalex.org/W2954861308","https://openalex.org/W3000982932","https://openalex.org/W3010110722","https://openalex.org/W3027099090","https://openalex.org/W3028589594","https://openalex.org/W3090754737","https://openalex.org/W3096561213","https://openalex.org/W3104705366","https://openalex.org/W3118936575","https://openalex.org/W3131891239","https://openalex.org/W3138412820","https://openalex.org/W3146944767","https://openalex.org/W3161252167","https://openalex.org/W3167897185","https://openalex.org/W3206585172","https://openalex.org/W4220824576","https://openalex.org/W4281871249","https://openalex.org/W4287325738","https://openalex.org/W4294873403","https://openalex.org/W4296128995","https://openalex.org/W4307178567","https://openalex.org/W4309650743","https://openalex.org/W4323653718","https://openalex.org/W4360770766","https://openalex.org/W4380792423","https://openalex.org/W4383711298","https://openalex.org/W4392061709","https://openalex.org/W4394726128"],"related_works":["https://openalex.org/W2928193004","https://openalex.org/W2070443794","https://openalex.org/W2914488349","https://openalex.org/W1994030850","https://openalex.org/W260863705","https://openalex.org/W3181709876","https://openalex.org/W2072179000","https://openalex.org/W2365603750","https://openalex.org/W3192101209","https://openalex.org/W2039354323"],"abstract_inverted_index":{"MOTIVATION:":[0],"Accurately":[1],"predicting":[2],"the":[3,53,62,78,116,126,140,156,178,184,197],"degradation":[4,67,118],"capabilities":[5,119],"of":[6,26,56,65,77,120,128,146,162,181,187,233],"proteolysis-targeting":[7],"chimeras":[8],"(PROTACs)":[9],"for":[10,19,177,224],"given":[11],"target":[12],"proteins":[13],"and":[14,58,89,109,143,168,190,211,222],"E3":[15],"ligases":[16],"is":[17,165],"important":[18],"PROTAC":[20,86,147,189],"design.":[21],"The":[22,231],"distinctive":[23],"ternary":[24,80,95,110,172],"structure":[25,55,75,142,180],"PROTACs":[27,57],"presents":[28],"a":[29,103,171],"challenge":[30],"to":[31,114,138,154],"traditional":[32],"drug-target":[33],"interaction":[34,92],"prediction":[35,64],"methods,":[36],"necessitating":[37],"more":[38],"innovative":[39],"approaches.":[40],"While":[41],"current":[42],"state-of-the-art":[43],"(SOTA)":[44],"methods":[45,130,153],"using":[46,132],"graph":[47,135,141],"neural":[48,136],"networks":[49,137],"(GNNs)":[50],"can":[51],"discern":[52],"molecular":[54],"proteins,":[59],"thus":[60,218],"enabling":[61,183],"efficient":[63],"PROTACs'":[66],"capabilities,":[68],"they":[69],"rely":[70],"heavily":[71],"on":[72,106,125],"limited":[73],"crystal":[74],"data":[76,88],"POI-PROTAC-E3":[79,216],"complex.":[81],"This":[82,160],"reliance":[83],"underutilizes":[84],"rich":[85],"experimental":[87],"neglects":[90],"intricate":[91],"relationships":[93],"within":[94],"complexes.":[96],"RESULTS:":[97],"In":[98],"this":[99],"study,":[100],"we":[101],"propose":[102],"model":[104,123,199,235],"based":[105],"cross-modal":[107,129,163],"strategy":[108],"attention":[111,173,206],"technology,":[112],"ET-PROTACs,":[113],"predict":[115],"targeted":[117],"PROTACs.":[121],"Our":[122],"capitalizes":[124],"strengths":[127],"by":[131],"equivariant":[133],"GNN":[134],"process":[139],"spatial":[144],"coordinates":[145],"molecules":[148],"concurrently":[149],"while":[150],"utilizing":[151],"sequence-based":[152],"learn":[155],"protein":[157,191],"sequence":[158],"information.":[159],"integration":[161],"information":[164],"cohesively":[166],"harnessed":[167],"channeled":[169],"into":[170],"mechanism,":[174],"specially":[175],"tailored":[176],"unique":[179],"PROTACs,":[182],"congruent":[185],"modeling":[186],"both":[188],"modalities.":[192],"Experimental":[193],"results":[194],"demonstrate":[195],"that":[196],"ET-PROTACs":[198],"outperforms":[200],"existing":[201],"SOTA":[202],"methods.":[203],"Moreover,":[204],"visualizing":[205],"scores":[207],"illuminates":[208],"crucial":[209],"residues":[210],"atoms":[212],"pivotal":[213],"in":[214],"specific":[215],"interactions,":[217],"offering":[219],"invaluable":[220],"insights":[221],"guidance":[223],"future":[225],"pharmaceutical":[226],"research.":[227],"AVAILABILITY":[228],"AND":[229],"IMPLEMENTATION:":[230],"codes":[232],"our":[234],"are":[236],"available":[237],"at":[238],"https://github.com/GuanyuYue/ET-PROTACs.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9}],"updated_date":"2026-07-21T08:15:58.654021","created_date":"2025-10-10T00:00:00"}