{"id":"https://openalex.org/W4405419044","doi":"https://doi.org/10.1093/bib/bbae648","title":"THOR: a TMB heterogeneity-adaptive optimization model predicts immunotherapy response using clonal genomic features in group-structured data","display_name":"THOR: a TMB heterogeneity-adaptive optimization model predicts immunotherapy response using clonal genomic features in group-structured data","publication_year":2024,"publication_date":"2024-11-22","ids":{"openalex":"https://openalex.org/W4405419044","doi":"https://doi.org/10.1093/bib/bbae648","pmid":"https://pubmed.ncbi.nlm.nih.gov/39679440"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae648","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae648","pdf_url":"https://academic.oup.com/bib/article-pdf/26/1/bbae648/61196002/bbae648.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/26/1/bbae648/61196002/bbae648.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113308684","display_name":"Yixuan Wang","orcid":"https://orcid.org/0000-0002-2041-1769"},"institutions":[{"id":"https://openalex.org/I4210157642","display_name":"Institute of Automation","ror":"https://ror.org/056qj1t15","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157642","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I9842412","display_name":"Nanjing University of Aeronautics and Astronautics","ror":"https://ror.org/01scyh794","country_code":"CN","type":"education","lineage":["https://openalex.org/I9842412"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Yixuan Wang","raw_affiliation_strings":["Department of Biomedical Engineering , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,","Nanjing University of Aeronautics and Astronautics , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,"],"raw_orcid":"https://orcid.org/0000-0002-2041-1769","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,","institution_ids":["https://openalex.org/I4210157642"]},{"raw_affiliation_string":"Nanjing University of Aeronautics and Astronautics , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,","institution_ids":["https://openalex.org/I9842412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103274879","display_name":"Yanfang Guan","orcid":"https://orcid.org/0000-0002-6722-2615"},"institutions":[{"id":"https://openalex.org/I4210101555","display_name":"Hubei University of Science and Technology","ror":"https://ror.org/018wg9441","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210101555"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanfang Guan","raw_affiliation_strings":["Geneplus-Beijing Institute , 8 Life Park Road, Changping, Beijing 102206,","School of Computer Science and Technology , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","Xi\u2019an Jiaotong University , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geneplus-Beijing Institute , 8 Life Park Road, Changping, Beijing 102206,","institution_ids":[]},{"raw_affiliation_string":"School of Computer Science and Technology , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","institution_ids":["https://openalex.org/I4210101555"]},{"raw_affiliation_string":"Xi\u2019an Jiaotong University , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047344339","display_name":"Xin Lai","orcid":"https://orcid.org/0000-0003-3850-5680"},"institutions":[{"id":"https://openalex.org/I4210101555","display_name":"Hubei University of Science and Technology","ror":"https://ror.org/018wg9441","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210101555"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Lai","raw_affiliation_strings":["School of Computer Science and Technology , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","Xi\u2019an Jiaotong University , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","institution_ids":["https://openalex.org/I4210101555"]},{"raw_affiliation_string":"Xi\u2019an Jiaotong University , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067706647","display_name":"Yuqian Liu","orcid":"https://orcid.org/0000-0001-6210-1147"},"institutions":[{"id":"https://openalex.org/I4210101555","display_name":"Hubei University of Science and Technology","ror":"https://ror.org/018wg9441","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210101555"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqian Liu","raw_affiliation_strings":["School of Computer Science and Technology , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","Xi\u2019an Jiaotong University , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","institution_ids":["https://openalex.org/I4210101555"]},{"raw_affiliation_string":"Xi\u2019an Jiaotong University , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081685345","display_name":"Zhili Chang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210101555","display_name":"Hubei University of Science and Technology","ror":"https://ror.org/018wg9441","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210101555"]},{"id":"https://openalex.org/I86659429","display_name":"Genesee Community College","ror":"https://ror.org/053j19t39","country_code":"US","type":"education","lineage":["https://openalex.org/I86659429"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zhili Chang","raw_affiliation_strings":["Geneseeq Research Institute, Nanjing Geneseeq Technology Inc. , 128 Huakang Road, Pukou, Nanjing 210032,","School of Computer Science and Technology , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","Xi\u2019an Jiaotong University , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geneseeq Research Institute, Nanjing Geneseeq Technology Inc. , 128 Huakang Road, Pukou, Nanjing 210032,","institution_ids":["https://openalex.org/I86659429"]},{"raw_affiliation_string":"School of Computer Science and Technology , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","institution_ids":["https://openalex.org/I4210101555"]},{"raw_affiliation_string":"Xi\u2019an Jiaotong University , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100410939","display_name":"Xiaonan Wang","orcid":"https://orcid.org/0000-0001-9775-2417"},"institutions":[{"id":"https://openalex.org/I4210101555","display_name":"Hubei University of Science and Technology","ror":"https://ror.org/018wg9441","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210101555"]},{"id":"https://openalex.org/I86659429","display_name":"Genesee Community College","ror":"https://ror.org/053j19t39","country_code":"US","type":"education","lineage":["https://openalex.org/I86659429"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xiaonan Wang","raw_affiliation_strings":["Geneseeq Research Institute, Nanjing Geneseeq Technology Inc. , 128 Huakang Road, Pukou, Nanjing 210032,","School of Computer Science and Technology , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","Xi\u2019an Jiaotong University , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geneseeq Research Institute, Nanjing Geneseeq Technology Inc. , 128 Huakang Road, Pukou, Nanjing 210032,","institution_ids":["https://openalex.org/I86659429"]},{"raw_affiliation_string":"School of Computer Science and Technology , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","institution_ids":["https://openalex.org/I4210101555"]},{"raw_affiliation_string":"Xi\u2019an Jiaotong University , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100418253","display_name":"Quan Wang","orcid":"https://orcid.org/0000-0002-2821-5017"},"institutions":[{"id":"https://openalex.org/I4210157642","display_name":"Institute of Automation","ror":"https://ror.org/056qj1t15","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157642","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I9842412","display_name":"Nanjing University of Aeronautics and Astronautics","ror":"https://ror.org/01scyh794","country_code":"CN","type":"education","lineage":["https://openalex.org/I9842412"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Quan Wang","raw_affiliation_strings":["Department of Biomedical Engineering , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,","Nanjing University of Aeronautics and Astronautics , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,","institution_ids":["https://openalex.org/I4210157642"]},{"raw_affiliation_string":"Nanjing University of Aeronautics and Astronautics , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,","institution_ids":["https://openalex.org/I9842412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100442566","display_name":"Jingjing Liu","orcid":"https://orcid.org/0000-0002-3266-7331"},"institutions":[{"id":"https://openalex.org/I4210157642","display_name":"Institute of Automation","ror":"https://ror.org/056qj1t15","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157642","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I9842412","display_name":"Nanjing University of Aeronautics and Astronautics","ror":"https://ror.org/01scyh794","country_code":"CN","type":"education","lineage":["https://openalex.org/I9842412"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Jingjing Liu","raw_affiliation_strings":["Department of Biomedical Engineering , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,","Nanjing University of Aeronautics and Astronautics , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,","institution_ids":["https://openalex.org/I4210157642"]},{"raw_affiliation_string":"Nanjing University of Aeronautics and Astronautics , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,","institution_ids":["https://openalex.org/I9842412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025609330","display_name":"Jian Zhao","orcid":"https://orcid.org/0000-0001-7857-4766"},"institutions":[{"id":"https://openalex.org/I4210157642","display_name":"Institute of Automation","ror":"https://ror.org/056qj1t15","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157642","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I9842412","display_name":"Nanjing University of Aeronautics and Astronautics","ror":"https://ror.org/01scyh794","country_code":"CN","type":"education","lineage":["https://openalex.org/I9842412"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Jian Zhao","raw_affiliation_strings":["Department of Biomedical Engineering , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,","Nanjing University of Aeronautics and Astronautics , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,","institution_ids":["https://openalex.org/I4210157642"]},{"raw_affiliation_string":"Nanjing University of Aeronautics and Astronautics , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,","institution_ids":["https://openalex.org/I9842412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100647085","display_name":"Shuanying Yang","orcid":"https://orcid.org/0000-0002-9676-9302"},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuanying Yang","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi\u2019an Jiaotong University , 3 Shangqin Road, Xincheng, Xi\u2019an 710004,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi\u2019an Jiaotong University , 3 Shangqin Road, Xincheng, Xi\u2019an 710004,","institution_ids":["https://openalex.org/I4210131893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027360778","display_name":"Jiayin Wang","orcid":"https://orcid.org/0000-0002-3862-6557"},"institutions":[{"id":"https://openalex.org/I4210101555","display_name":"Hubei University of Science and Technology","ror":"https://ror.org/018wg9441","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210101555"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayin Wang","raw_affiliation_strings":["School of Computer Science and Technology , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","Xi\u2019an Jiaotong University , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","institution_ids":["https://openalex.org/I4210101555"]},{"raw_affiliation_string":"Xi\u2019an Jiaotong University , Faculty of Electronics and Information Engineering, , 28 Xianning West Road, Beilin, Xi\u2019an 710049,","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5115588839","display_name":"Xiaofeng Song","orcid":null},"institutions":[{"id":"https://openalex.org/I4210157642","display_name":"Institute of Automation","ror":"https://ror.org/056qj1t15","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157642","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I9842412","display_name":"Nanjing University of Aeronautics and Astronautics","ror":"https://ror.org/01scyh794","country_code":"CN","type":"education","lineage":["https://openalex.org/I9842412"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Xiaofeng Song","raw_affiliation_strings":["Department of Biomedical Engineering , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,","Nanjing University of Aeronautics and Astronautics , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,","institution_ids":["https://openalex.org/I4210157642"]},{"raw_affiliation_string":"Nanjing University of Aeronautics and Astronautics , College of Automation Engineering, , 29 Jiangjun Avenue, Jiangning, Nanjing 211106,","institution_ids":["https://openalex.org/I9842412"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":1.4642,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.85580245,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.5722575783729553},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.5041395425796509},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48850905895233154},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.45436790585517883},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41921672224998474},{"id":"https://openalex.org/keywords/proportional-hazards-model","display_name":"Proportional hazards model","score":0.41565030813217163},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"Cancer immunotherapy","score":0.41494864225387573},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3675733208656311},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3528323769569397},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3224228620529175},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.30652058124542236},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.24812495708465576},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.2409672737121582},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.20716100931167603},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10797154903411865}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5722575783729553},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5041395425796509},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48850905895233154},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.45436790585517883},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41921672224998474},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.41565030813217163},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.41494864225387573},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3675733208656311},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3528323769569397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3224228620529175},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.30652058124542236},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.24812495708465576},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2409672737121582},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20716100931167603},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10797154903411865}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae648","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae648","pdf_url":"https://academic.oup.com/bib/article-pdf/26/1/bbae648/61196002/bbae648.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39679440","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39679440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11647273","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11647273","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11647273/pdf/bbae648.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae648","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae648","pdf_url":"https://academic.oup.com/bib/article-pdf/26/1/bbae648/61196002/bbae648.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/16","display_name":"Peace, Justice and strong institutions","score":0.6800000071525574}],"awards":[{"id":"https://openalex.org/G5918323401","display_name":null,"funder_award_id":"62302215","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405419044.pdf","grobid_xml":"https://content.openalex.org/works/W4405419044.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1905165690","https://openalex.org/W2015182193","https://openalex.org/W2019607817","https://openalex.org/W2049553585","https://openalex.org/W2077609937","https://openalex.org/W2107429737","https://openalex.org/W2138019504","https://openalex.org/W2140514146","https://openalex.org/W2165009258","https://openalex.org/W2299181842","https://openalex.org/W2593030814","https://openalex.org/W2747774814","https://openalex.org/W2761575992","https://openalex.org/W2782183686","https://openalex.org/W2783897381","https://openalex.org/W2792006020","https://openalex.org/W2797855256","https://openalex.org/W2890100090","https://openalex.org/W2890468594","https://openalex.org/W2891479958","https://openalex.org/W2896930952","https://openalex.org/W2909679049","https://openalex.org/W2942698526","https://openalex.org/W2943298863","https://openalex.org/W2945998739","https://openalex.org/W2948374725","https://openalex.org/W2950756851","https://openalex.org/W2963477960","https://openalex.org/W2972939290","https://openalex.org/W2991341799","https://openalex.org/W2999306320","https://openalex.org/W3047253098","https://openalex.org/W3047400464","https://openalex.org/W3088005314","https://openalex.org/W3097803258","https://openalex.org/W3101970349","https://openalex.org/W3118913605","https://openalex.org/W3127371144","https://openalex.org/W3136653115","https://openalex.org/W3176474008","https://openalex.org/W3203575974","https://openalex.org/W3213116647","https://openalex.org/W4210957314","https://openalex.org/W4211059381","https://openalex.org/W4283644334","https://openalex.org/W4289731323","https://openalex.org/W4294653669","https://openalex.org/W4296169829","https://openalex.org/W4324099018","https://openalex.org/W4362543562","https://openalex.org/W4378348452","https://openalex.org/W4386506190","https://openalex.org/W4387131703","https://openalex.org/W4399300438","https://openalex.org/W4401908548"],"related_works":["https://openalex.org/W3111580887","https://openalex.org/W3049036915","https://openalex.org/W4313343001","https://openalex.org/W4223914026","https://openalex.org/W3158104901","https://openalex.org/W4396582463","https://openalex.org/W2999675030","https://openalex.org/W2400599632","https://openalex.org/W2806333505","https://openalex.org/W3154696046"],"abstract_inverted_index":{"With":[0],"the":[1,15,51,58,76,83,93,101,110,137,140,153,197,224],"increasing":[2],"number":[3],"of":[4,17,62,80,86,95,113,156,166,199,205,223,228],"indications":[5],"for":[6,43,191],"immune":[7,52],"checkpoint":[8],"inhibitors":[9],"in":[10,47,105,188,201],"early":[11],"and":[12,54,130,139,162,181,226,238,246],"advanced":[13,115],"cancers,":[14],"prospect":[16],"a":[18,31,70,144,163,202],"tumor-agnostic":[19],"biomarker":[20,34],"to":[21,132,176],"prioritize":[22],"patients":[23,208,214],"is":[24,30],"compelling.":[25],"Tumor":[26],"mutation":[27],"burden":[28],"(TMB)":[29],"widely":[32],"endorsed":[33],"that":[35,232],"quantifies":[36],"nonsynonymous":[37],"mutations":[38],"within":[39],"tumor":[40,160],"DNA,":[41],"essential":[42],"neoantigen":[44],"production,":[45],"which,":[46],"turn,":[48],"correlates":[49],"with":[50],"response":[53],"guides":[55],"decision-making.":[56],"However,":[57],"general":[59],"clinical":[60,167],"application":[61],"TMB-relying":[63],"on":[64],"simple":[65],"mutational":[66],"counts":[67],"targeted":[68],"at":[69],"single":[71],"endpoint-does":[72],"not":[73],"adequately":[74],"capture":[75],"complex":[77,243],"clonal":[78],"structure":[79],"tumors":[81],"nor":[82],"multifaceted":[84],"nature":[85],"prognostic":[87,239],"indicators.":[88],"This":[89,149],"recognition":[90],"has":[91],"spurred":[92],"exploration":[94],"sophisticated":[96],"high-dimensional":[97],"regression":[98,147],"techniques.":[99],"Unfortunately,":[100],"limited":[102],"cohort":[103,204],"sizes":[104],"immunotherapy":[106],"trials":[107],"have":[108],"hindered":[109],"full":[111],"potential":[112],"these":[114],"methods.":[116],"Our":[117,183],"approach":[118],"considers":[119],"patient":[120,236],"subgroups":[121,175,217],"as":[122],"related":[123],"yet":[124],"distinct":[125],"entities,":[126],"enabling":[127],"precise":[128],"tailoring":[129],"refinement":[131],"address":[133],"subgroup-specific":[134,247],"dynamics.":[135,248],"Given":[136],"deficiencies":[138],"constraints,":[141],"we":[142,195],"introduce":[143],"TMB":[145,157],"heterogeneity-optimized":[146],"(THOR).":[148],"innovative":[150],"model":[151],"enhances":[152,235],"predictive":[154],"capabilities":[155],"by":[158,171,212,241],"integrating":[159],"clonality":[161],"diverse":[164],"spectrum":[165],"endpoints,":[168],"further":[169],"augmented":[170],"fusion":[172],"techniques":[173],"across":[174,215],"facilitate":[177],"robust":[178],"data":[179],"sharing":[180],"interpretation.":[182],"simulations":[184],"validate":[185],"THOR's":[186],"superiority":[187],"parameter":[189],"estimation":[190],"statistical":[192],"inference.":[193],"Clinically,":[194],"assess":[196],"utility":[198],"THOR":[200,233],"structured":[203],"238":[206],"cancer":[207],"undergoing":[209],"immunotherapy,":[210],"supplemented":[211],"2212":[213],"19":[216],"from":[218],"public":[219],"datasets.":[220],"The":[221],"forecast":[222],"responses":[225],"comparison":[227],"survival":[229],"hazards":[230],"demonstrate":[231],"significantly":[234],"stratification":[237],"predictions":[240],"incorporating":[242],"immunogenetic":[244],"biology":[245]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
