{"id":"https://openalex.org/W4404374152","doi":"https://doi.org/10.1093/bib/bbae585","title":"Molecular group and correlation guided structural learning for multi-phenotype prediction","display_name":"Molecular group and correlation guided structural learning for multi-phenotype prediction","publication_year":2024,"publication_date":"2024-09-23","ids":{"openalex":"https://openalex.org/W4404374152","doi":"https://doi.org/10.1093/bib/bbae585","pmid":"https://pubmed.ncbi.nlm.nih.gov/39541190"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae585","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae585","pdf_url":"https://academic.oup.com/bib/article-pdf/25/6/bbae585/60669538/bbae585.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/6/bbae585/60669538/bbae585.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100525288","display_name":"Zhou Xue-ping","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xueping Zhou","raw_affiliation_strings":["Department of Biostatistics, University of Pittsburgh , Pittsburgh, PA 15216 ,"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Pittsburgh , Pittsburgh, PA 15216 ,","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065190256","display_name":"Manqi Cai","orcid":"https://orcid.org/0000-0003-3296-1730"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manqi Cai","raw_affiliation_strings":["Department of Biostatistics, University of Pittsburgh , Pittsburgh, PA 15216 ,"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Pittsburgh , Pittsburgh, PA 15216 ,","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071704703","display_name":"Molin Yue","orcid":"https://orcid.org/0000-0002-3339-892X"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Molin Yue","raw_affiliation_strings":["Department of Biostatistics, University of Pittsburgh , Pittsburgh, PA 15216 ,"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Pittsburgh , Pittsburgh, PA 15216 ,","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024561283","display_name":"Juan C. Celed\u00f3n","orcid":"https://orcid.org/0000-0002-6139-5320"},"institutions":[{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan C Celed\u00f3n","raw_affiliation_strings":["Department of Pediatrics, University of Pittsburgh Medical Center Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA 15224 ,"],"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Pittsburgh Medical Center Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA 15224 ,","institution_ids":["https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042915991","display_name":"Jiebiao Wang","orcid":"https://orcid.org/0000-0003-3828-4400"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiebiao Wang","raw_affiliation_strings":["Department of Biostatistics, University of Pittsburgh , Pittsburgh, PA 15216 ,"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Pittsburgh , Pittsburgh, PA 15216 ,","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005323080","display_name":"Ying Ding","orcid":"https://orcid.org/0000-0001-5581-3058"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Ding","raw_affiliation_strings":["Department of Biostatistics, University of Pittsburgh , Pittsburgh, PA 15216 ,"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Pittsburgh , Pittsburgh, PA 15216 ,","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344323","display_name":"Wei Chen","orcid":"https://orcid.org/0000-0001-7196-8703"},"institutions":[{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Chen","raw_affiliation_strings":["Department of Pediatrics, University of Pittsburgh Medical Center Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA 15224 ,"],"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Pittsburgh Medical Center Children\u2019s Hospital of Pittsburgh , Pittsburgh, PA 15224 ,","institution_ids":["https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100393260","display_name":"Yanming Li","orcid":"https://orcid.org/0000-0001-9441-3698"},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanming Li","raw_affiliation_strings":["Department of Biostatistics & Data Science, University of Kansas Medical Center , Kansas, KS 66160 ,"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics & Data Science, University of Kansas Medical Center , Kansas, KS 66160 ,","institution_ids":["https://openalex.org/I4210128618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5100525288"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.229,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.58841668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"25","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.7023870944976807},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.6914236545562744},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.5765663981437683},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5198279023170471},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.5044182538986206},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49317044019699097},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4679105877876282},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4512287378311157},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.42835530638694763},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.4113214612007141},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3873981237411499},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.35888150334358215},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3514993190765381},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3409273624420166},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22720366716384888},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.19486621022224426},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1822606921195984}],"concepts":[{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.7023870944976807},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.6914236545562744},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.5765663981437683},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5198279023170471},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.5044182538986206},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49317044019699097},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4679105877876282},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4512287378311157},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.42835530638694763},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.4113214612007141},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3873981237411499},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35888150334358215},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3514993190765381},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3409273624420166},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22720366716384888},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19486621022224426},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1822606921195984},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae585","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae585","pdf_url":"https://academic.oup.com/bib/article-pdf/25/6/bbae585/60669538/bbae585.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39541190","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39541190","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11562839","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11562839","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11562839/pdf/bbae585.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae585","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae585","pdf_url":"https://academic.oup.com/bib/article-pdf/25/6/bbae585/60669538/bbae585.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/16","score":0.5199999809265137,"display_name":"Peace, Justice and strong institutions"}],"awards":[{"id":"https://openalex.org/G1370689234","display_name":null,"funder_award_id":"OAC-2117681","funder_id":"https://openalex.org/F4320310174","funder_display_name":"University of Pittsburgh"},{"id":"https://openalex.org/G2516251293","display_name":null,"funder_award_id":"HL150431","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3139966383","display_name":null,"funder_award_id":"HL117191","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3384453195","display_name":null,"funder_award_id":"OAC-2117681","funder_id":"https://openalex.org/F4320333934","funder_display_name":"Center for Research Computing, University of Pittsburgh"},{"id":"https://openalex.org/G4218792653","display_name":null,"funder_award_id":"R21HL150431","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4692388822","display_name":null,"funder_award_id":"R01HL117191","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5593089889","display_name":"MRI: Acquisition of Cutting-Edge GPU and MPI Nodes for the Interdisciplinary Pitt Center for Research Computing","funder_award_id":"2117681","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5626381280","display_name":null,"funder_award_id":"OAC-2117681","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5921281487","display_name":null,"funder_award_id":"number","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6345853531","display_name":null,"funder_award_id":"unknown","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6389623160","display_name":null,"funder_award_id":"2225775","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6755165505","display_name":null,"funder_award_id":"award","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7218924412","display_name":null,"funder_award_id":"OAC-2117681","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G848032724","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G865749150","display_name":null,"funder_award_id":"S10OD028483","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8918373189","display_name":null,"funder_award_id":"HL117191","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333934","display_name":"Center for Research Computing, University of Pittsburgh","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404374152.pdf","grobid_xml":"https://content.openalex.org/works/W4404374152.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1560240297","https://openalex.org/W1985987855","https://openalex.org/W1987371344","https://openalex.org/W2004185360","https://openalex.org/W2030322782","https://openalex.org/W2069328568","https://openalex.org/W2089709635","https://openalex.org/W2090384073","https://openalex.org/W2097360283","https://openalex.org/W2103017472","https://openalex.org/W2104950932","https://openalex.org/W2122825543","https://openalex.org/W2130523009","https://openalex.org/W2132555912","https://openalex.org/W2135046866","https://openalex.org/W2138019504","https://openalex.org/W2158549544","https://openalex.org/W2204185640","https://openalex.org/W2600132724","https://openalex.org/W2806551209","https://openalex.org/W2906476764","https://openalex.org/W2933324889","https://openalex.org/W2942157012","https://openalex.org/W2950843563","https://openalex.org/W2953365463","https://openalex.org/W2968984059","https://openalex.org/W3000010184","https://openalex.org/W3096486123","https://openalex.org/W3126812235","https://openalex.org/W3129869677","https://openalex.org/W3137890166","https://openalex.org/W3187464646","https://openalex.org/W4200395543","https://openalex.org/W4224215080","https://openalex.org/W4294541781"],"related_works":["https://openalex.org/W2406638334","https://openalex.org/W1991765889","https://openalex.org/W1990068454","https://openalex.org/W2472172556","https://openalex.org/W1570805059","https://openalex.org/W2357266745","https://openalex.org/W1578824628","https://openalex.org/W4390961098","https://openalex.org/W2324780611","https://openalex.org/W3122321533"],"abstract_inverted_index":{"We":[0,69],"propose":[1],"a":[2,53,104],"supervised":[3],"learning":[4],"bioinformatics":[5],"tool,":[6],"Biological":[7],"gRoup":[8],"guIded":[9],"muLtivariate":[10],"muLtiple":[11],"lIneAr":[12],"regression":[13,57],"with":[14,27],"peNalizaTion":[15],"(Brilliant),":[16],"designed":[17],"for":[18,97,129],"feature":[19,45],"selection":[20],"and":[21,49,89,133],"outcome":[22,50],"prediction":[23,51,117,132],"in":[24,44,103],"genomic":[25],"data":[26],"multi-phenotypic":[28],"responses.":[29],"Brilliant":[30,71],"specifically":[31],"incorporates":[32],"genome":[33],"and/or":[34],"phenotype":[35,41],"grouping":[36],"structures,":[37,43],"as":[38,40],"well":[39],"correlation":[42],"selection,":[46],"effect":[47],"estimation,":[48],"under":[52],"penalized":[54],"multi-response":[55],"linear":[56],"model.":[58],"Extensive":[59],"simulations":[60],"demonstrate":[61],"its":[62],"superior":[63],"performance":[64],"compared":[65],"to":[66,72],"competing":[67],"methods.":[68],"applied":[70],"two":[73],"omics":[74],"studies.":[75],"In":[76],"the":[77,98,127],"first":[78],"study,":[79],"we":[80,125],"identified":[81,134],"novel":[82,135],"association":[83],"signals":[84],"between":[85],"multivariate":[86],"gene":[87,120],"expressions":[88],"high-dimensional":[90,119],"DNA":[91],"methylation":[92],"profiles,":[93],"providing":[94],"biological":[95],"insights":[96],"baseline":[99],"CpG-to-gene":[100],"regulation":[101],"patterns":[102],"Puerto":[105],"Rican":[106],"children":[107],"asthma":[108],"cohort.":[109],"The":[110],"second":[111],"study":[112],"focused":[113],"on":[114],"cell-type":[115,130,136],"deconvolution":[116],"using":[118],"expression":[121],"profiles.":[122],"Using":[123],"Brilliant,":[124],"improved":[126],"accuracy":[128],"fraction":[131],"signature":[137],"genes.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
