{"id":"https://openalex.org/W4404568502","doi":"https://doi.org/10.1093/bib/bbae561","title":"Graph databases in systems biology: a systematic review","display_name":"Graph databases in systems biology: a systematic review","publication_year":2024,"publication_date":"2024-09-23","ids":{"openalex":"https://openalex.org/W4404568502","doi":"https://doi.org/10.1093/bib/bbae561","pmid":"https://pubmed.ncbi.nlm.nih.gov/39565895"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae561","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae561","pdf_url":"https://academic.oup.com/bib/article-pdf/25/6/bbae561/60766711/bbae561.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/6/bbae561/60766711/bbae561.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094240398","display_name":"Ilya Mazein","orcid":"https://orcid.org/0009-0000-1130-8332"},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ilya Mazein","raw_affiliation_strings":["Medical Informatics Laboratory, University Medicine Greifswald , Walther-Rathenau-Stra\u00dfe 48, Greifswald 17475 ,"],"raw_orcid":"https://orcid.org/0009-0000-1130-8332","affiliations":[{"raw_affiliation_string":"Medical Informatics Laboratory, University Medicine Greifswald , Walther-Rathenau-Stra\u00dfe 48, Greifswald 17475 ,","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080558337","display_name":"Adrien Rougny","orcid":"https://orcid.org/0000-0002-2118-035X"},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Adrien Rougny","raw_affiliation_strings":["Luxembourg Centre for Systems Biology, University of Luxembourg , 6 Avenue du Swing, Belvaux L-4367 ,"],"raw_orcid":"https://orcid.org/0000-0002-2118-035X","affiliations":[{"raw_affiliation_string":"Luxembourg Centre for Systems Biology, University of Luxembourg , 6 Avenue du Swing, Belvaux L-4367 ,","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044361124","display_name":"Alexander Mazein","orcid":"https://orcid.org/0000-0001-7137-4171"},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Alexander Mazein","raw_affiliation_strings":["Luxembourg Centre for Systems Biology, University of Luxembourg , 6 Avenue du Swing, Belvaux L-4367 ,"],"raw_orcid":"https://orcid.org/0000-0001-7137-4171","affiliations":[{"raw_affiliation_string":"Luxembourg Centre for Systems Biology, University of Luxembourg , 6 Avenue du Swing, Belvaux L-4367 ,","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029731037","display_name":"Ron Henkel","orcid":"https://orcid.org/0000-0001-6211-2719"},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ron Henkel","raw_affiliation_strings":["Medical Informatics Laboratory, University Medicine Greifswald , Walther-Rathenau-Stra\u00dfe 48, Greifswald 17475 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Informatics Laboratory, University Medicine Greifswald , Walther-Rathenau-Stra\u00dfe 48, Greifswald 17475 ,","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015671963","display_name":"Lea G\u00fctebier","orcid":"https://orcid.org/0000-0001-5504-5108"},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lea G\u00fctebier","raw_affiliation_strings":["Medical Informatics Laboratory, University Medicine Greifswald , Walther-Rathenau-Stra\u00dfe 48, Greifswald 17475 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Informatics Laboratory, University Medicine Greifswald , Walther-Rathenau-Stra\u00dfe 48, Greifswald 17475 ,","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084582986","display_name":"Lea Michaelis","orcid":"https://orcid.org/0000-0001-9691-2677"},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lea Michaelis","raw_affiliation_strings":["Medical Informatics Laboratory, University Medicine Greifswald , Walther-Rathenau-Stra\u00dfe 48, Greifswald 17475 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Informatics Laboratory, University Medicine Greifswald , Walther-Rathenau-Stra\u00dfe 48, Greifswald 17475 ,","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022319056","display_name":"Marek Ostaszewski","orcid":"https://orcid.org/0000-0003-1473-370X"},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Marek Ostaszewski","raw_affiliation_strings":["Luxembourg Centre for Systems Biology, University of Luxembourg , 6 Avenue du Swing, Belvaux L-4367 ,"],"raw_orcid":"https://orcid.org/0000-0003-1473-370X","affiliations":[{"raw_affiliation_string":"Luxembourg Centre for Systems Biology, University of Luxembourg , 6 Avenue du Swing, Belvaux L-4367 ,","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079833473","display_name":"Reinhard Schneider","orcid":"https://orcid.org/0000-0002-8278-1618"},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Reinhard Schneider","raw_affiliation_strings":["Luxembourg Centre for Systems Biology, University of Luxembourg , 6 Avenue du Swing, Belvaux L-4367 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Luxembourg Centre for Systems Biology, University of Luxembourg , 6 Avenue du Swing, Belvaux L-4367 ,","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088017410","display_name":"Venkata Satagopam","orcid":"https://orcid.org/0000-0002-6532-5880"},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Venkata Satagopam","raw_affiliation_strings":["Luxembourg Centre for Systems Biology, University of Luxembourg , 6 Avenue du Swing, Belvaux L-4367 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Luxembourg Centre for Systems Biology, University of Luxembourg , 6 Avenue du Swing, Belvaux L-4367 ,","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005772961","display_name":"Lars Juhl Jensen","orcid":"https://orcid.org/0000-0001-7885-715X"},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lars Juhl Jensen","raw_affiliation_strings":["Department of Veterinary and Animal Sciences , Faculty of Health and Medical Sciences, , Gr\u00f8nneg\u00e5rdsvej 15, 1870 Frederiksberg C ,","University of Copenhagen , Faculty of Health and Medical Sciences, , Gr\u00f8nneg\u00e5rdsvej 15, 1870 Frederiksberg C ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Animal Sciences , Faculty of Health and Medical Sciences, , Gr\u00f8nneg\u00e5rdsvej 15, 1870 Frederiksberg C ,","institution_ids":[]},{"raw_affiliation_string":"University of Copenhagen , Faculty of Health and Medical Sciences, , Gr\u00f8nneg\u00e5rdsvej 15, 1870 Frederiksberg C ,","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103188993","display_name":"Dagmar Waltemath","orcid":"https://orcid.org/0000-0002-5886-5563"},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dagmar Waltemath","raw_affiliation_strings":["Medical Informatics Laboratory, University Medicine Greifswald , Walther-Rathenau-Stra\u00dfe 48, Greifswald 17475 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Informatics Laboratory, University Medicine Greifswald , Walther-Rathenau-Stra\u00dfe 48, Greifswald 17475 ,","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033254039","display_name":"Judith A. H. Wodke","orcid":null},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Judith A H Wodke","raw_affiliation_strings":["Medical Informatics Laboratory, University Medicine Greifswald , Walther-Rathenau-Stra\u00dfe 48, Greifswald 17475 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Informatics Laboratory, University Medicine Greifswald , Walther-Rathenau-Stra\u00dfe 48, Greifswald 17475 ,","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071459650","display_name":"Irina Balaur","orcid":"https://orcid.org/0000-0002-3671-895X"},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Irina Balaur","raw_affiliation_strings":["Luxembourg Centre for Systems Biology, University of Luxembourg , 6 Avenue du Swing, Belvaux L-4367 ,"],"raw_orcid":"https://orcid.org/0000-0002-3671-895X","affiliations":[{"raw_affiliation_string":"Luxembourg Centre for Systems Biology, University of Luxembourg , 6 Avenue du Swing, Belvaux L-4367 ,","institution_ids":["https://openalex.org/I186903577"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":1.7928,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.82939633,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"25","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6145708560943604},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5612528324127197},{"id":"https://openalex.org/keywords/graph-database","display_name":"Graph database","score":0.5325791835784912},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.45166826248168945},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.35297852754592896},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.32308492064476013},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.307701051235199}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6145708560943604},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5612528324127197},{"id":"https://openalex.org/C176225458","wikidata":"https://www.wikidata.org/wiki/Q595971","display_name":"Graph database","level":3,"score":0.5325791835784912},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.45166826248168945},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.35297852754592896},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.32308492064476013},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.307701051235199}],"mesh":[{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbae561","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae561","pdf_url":"https://academic.oup.com/bib/article-pdf/25/6/bbae561/60766711/bbae561.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39565895","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39565895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11578065","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11578065","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11578065/pdf/bbae561.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/045fb246-d51f-4fe4-81fd-444151ecc592","is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/045fb246-d51f-4fe4-81fd-444151ecc592","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mazein , I , Rougny , A , Mazein , A , Henkel , R , G\u00fctebier , L , Michaelis , L , Ostaszewski , M , Schneider , R , Satagopam , V , Jensen , L J , Waltemath , D , Wodke , J A H & Balaur , I 2024 , ' Graph databases in systems biology : A systematic review ' , Briefings in Bioinformatics , vol. 25 , no. 6 , bbae561 . https://doi.org/10.1093/bib/bbae561","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae561","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae561","pdf_url":"https://academic.oup.com/bib/article-pdf/25/6/bbae561/60766711/bbae561.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46000000834465027,"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure"}],"awards":[{"id":"https://openalex.org/G115107253","display_name":"COMORBIDITY MECHANISMS UTILIZED IN HEALTHCARE","funder_award_id":"101136957","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404568502.pdf","grobid_xml":"https://content.openalex.org/works/W4404568502.grobid-xml"},"referenced_works_count":127,"referenced_works":["https://openalex.org/W1521166287","https://openalex.org/W1611787727","https://openalex.org/W1957485362","https://openalex.org/W1969709265","https://openalex.org/W1978486653","https://openalex.org/W1981352196","https://openalex.org/W1989277387","https://openalex.org/W2041228025","https://openalex.org/W2062826759","https://openalex.org/W2069157810","https://openalex.org/W2081213386","https://openalex.org/W2095867585","https://openalex.org/W2106980948","https://openalex.org/W2108798001","https://openalex.org/W2109904151","https://openalex.org/W2122863289","https://openalex.org/W2130962401","https://openalex.org/W2131941936","https://openalex.org/W2132218677","https://openalex.org/W2140445011","https://openalex.org/W2145435867","https://openalex.org/W2150908245","https://openalex.org/W2155723007","https://openalex.org/W2159092541","https://openalex.org/W2159482845","https://openalex.org/W2164298117","https://openalex.org/W2165428180","https://openalex.org/W2165439432","https://openalex.org/W2170146596","https://openalex.org/W2302501749","https://openalex.org/W2416349955","https://openalex.org/W2417366089","https://openalex.org/W2496792076","https://openalex.org/W2509717357","https://openalex.org/W2557399158","https://openalex.org/W2557833574","https://openalex.org/W2558643140","https://openalex.org/W2564769250","https://openalex.org/W2594844287","https://openalex.org/W2600074498","https://openalex.org/W2604749705","https://openalex.org/W2605630948","https://openalex.org/W2736196485","https://openalex.org/W2756944503","https://openalex.org/W2764023277","https://openalex.org/W2773351420","https://openalex.org/W2786122698","https://openalex.org/W2794274454","https://openalex.org/W2795216948","https://openalex.org/W2900044275","https://openalex.org/W2900090807","https://openalex.org/W2900569176","https://openalex.org/W2900810415","https://openalex.org/W2901332105","https://openalex.org/W2921853542","https://openalex.org/W2921868701","https://openalex.org/W2937346329","https://openalex.org/W2949311246","https://openalex.org/W2950329335","https://openalex.org/W2950595506","https://openalex.org/W2951841354","https://openalex.org/W2957193018","https://openalex.org/W2962889697","https://openalex.org/W2976494531","https://openalex.org/W2981350712","https://openalex.org/W2983166786","https://openalex.org/W2985948685","https://openalex.org/W2997551827","https://openalex.org/W3006436978","https://openalex.org/W3013783109","https://openalex.org/W3024722698","https://openalex.org/W3088646411","https://openalex.org/W3092371057","https://openalex.org/W3093053585","https://openalex.org/W3093150592","https://openalex.org/W3097759960","https://openalex.org/W3102245839","https://openalex.org/W3107626709","https://openalex.org/W3116663947","https://openalex.org/W3118615836","https://openalex.org/W3137319754","https://openalex.org/W3137694528","https://openalex.org/W3138600255","https://openalex.org/W3156378390","https://openalex.org/W3160761455","https://openalex.org/W3165513106","https://openalex.org/W3185914370","https://openalex.org/W3202281227","https://openalex.org/W3211402536","https://openalex.org/W3212342036","https://openalex.org/W3214131546","https://openalex.org/W3217284213","https://openalex.org/W4210706440","https://openalex.org/W4212919921","https://openalex.org/W4220660638","https://openalex.org/W4220819463","https://openalex.org/W4220976630","https://openalex.org/W4224278121","https://openalex.org/W4224570771","https://openalex.org/W4231254854","https://openalex.org/W4237358891","https://openalex.org/W4254464710","https://openalex.org/W4281704579","https://openalex.org/W4282012582","https://openalex.org/W4283643162","https://openalex.org/W4293567583","https://openalex.org/W4294216483","https://openalex.org/W4294953579","https://openalex.org/W4297494206","https://openalex.org/W4298005542","https://openalex.org/W4309506674","https://openalex.org/W4319813194","https://openalex.org/W4321611238","https://openalex.org/W4322719852","https://openalex.org/W4323036511","https://openalex.org/W4323808484","https://openalex.org/W4381190112","https://openalex.org/W4381599258","https://openalex.org/W4381856124","https://openalex.org/W4385331603","https://openalex.org/W6717391418","https://openalex.org/W6744980539","https://openalex.org/W6768806997","https://openalex.org/W6769692851","https://openalex.org/W6773926864","https://openalex.org/W6813094581","https://openalex.org/W6850524304"],"related_works":["https://openalex.org/W2003932708","https://openalex.org/W1967424056","https://openalex.org/W2284877871","https://openalex.org/W2138102289","https://openalex.org/W978295669","https://openalex.org/W868043274","https://openalex.org/W2513523087","https://openalex.org/W3115442681","https://openalex.org/W2007838763","https://openalex.org/W2972311463"],"abstract_inverted_index":{"Graph":[0],"databases":[1,51,139,159],"are":[2,23,69],"becoming":[3],"increasingly":[4],"popular":[5],"across":[6],"scientific":[7],"disciplines,":[8],"being":[9],"highly":[10],"suitable":[11],"for":[12,29,163],"storing":[13],"and":[14,36,55,75,80,83,86,92,104,121,126,155,169],"connecting":[15],"complex":[16],"heterogeneous":[17,174],"data.":[18,175],"In":[19,40],"systems":[20,116,167],"biology,":[21],"they":[22],"used":[24],"as":[25,100,140],"a":[26,141],"backend":[27],"solution":[28],"biological":[30,146],"data":[31,147],"repositories,":[32,148],"ontologies,":[33],"networks,":[34],"pathways,":[35],"knowledge":[37,123,164],"graph":[38,50,66,124,138,158],"databases.":[39],"this":[41],"review,":[42],"we":[43,149],"analyse":[44],"all":[45],"publications":[46],"using":[47],"or":[48],"mentioning":[49],"retrieved":[52],"from":[53],"PubMed":[54,56],"Central":[57],"full-text":[58],"search,":[59],"focusing":[60,77],"on":[61,78],"the":[62,94,115,127,135],"top":[63],"16":[64],"available":[65],"databases,":[67],"Publications":[68],"categorized":[70],"according":[71],"to":[72,119],"their":[73],"domain":[74],"application,":[76],"pathway":[79],"network":[81],"biology":[82,117,168],"relevant":[84],"ontologies":[85],"tools.":[87],"We":[88,110],"detail":[89],"different":[90],"approaches":[91],"highlight":[93],"advantages":[95],"of":[96,114,129,137,143,157],"outstanding":[97],"resources,":[98],"such":[99],"UniProtKB,":[101],"Disease":[102],"Ontology,":[103],"Reactome,":[105],"which":[106],"provide":[107],"graph-based":[108],"solutions.":[109],"discuss":[111],"ongoing":[112],"efforts":[113],"community":[118],"standardize":[120],"harmonize":[122],"creation":[125],"maintenance":[128,156],"integrated":[130],"resources.":[131],"Outlining":[132],"prospects,":[133],"including":[134],"use":[136],"way":[142],"communication":[144],"between":[145],"conclude":[150],"that":[151],"efficient":[152],"design,":[153],"querying,":[154],"will":[160],"be":[161],"key":[162],"generation":[165],"in":[166],"other":[170],"research":[171],"fields":[172],"with":[173]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
