{"id":"https://openalex.org/W4403055586","doi":"https://doi.org/10.1093/bib/bbae491","title":"Development and validation of an explainable machine learning model for predicting multidimensional frailty in hospitalized patients with cirrhosis","display_name":"Development and validation of an explainable machine learning model for predicting multidimensional frailty in hospitalized patients with cirrhosis","publication_year":2024,"publication_date":"2024-09-23","ids":{"openalex":"https://openalex.org/W4403055586","doi":"https://doi.org/10.1093/bib/bbae491","pmid":"https://pubmed.ncbi.nlm.nih.gov/39358034"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae491","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae491","pdf_url":"https://academic.oup.com/bib/article-pdf/25/6/bbae491/59536318/bbae491.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/6/bbae491/59536318/bbae491.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102905625","display_name":"Fang Yang","orcid":"https://orcid.org/0000-0002-9682-659X"},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Yang","raw_affiliation_strings":["Department of Digestive System, Baodi Clinical College of Tianjin Medical University , No.8 Guangchuan Road, Baodi District, Tianjin 301800,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Digestive System, Baodi Clinical College of Tianjin Medical University , No.8 Guangchuan Road, Baodi District, Tianjin 301800,","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100682054","display_name":"Chaoqun Li","orcid":"https://orcid.org/0000-0002-5888-4182"},"institutions":[{"id":"https://openalex.org/I4210142182","display_name":"Tianjin Hospital","ror":"https://ror.org/04j9yn198","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142182"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaoqun Li","raw_affiliation_strings":["Department of Geriatrics, Tianjin Hexi Hospital , No.43 Qiongzhou Road, Hexi District, Tianjin 300202,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Tianjin Hexi Hospital , No.43 Qiongzhou Road, Hexi District, Tianjin 300202,","institution_ids":["https://openalex.org/I4210142182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074244556","display_name":"Wanting Yang","orcid":"https://orcid.org/0000-0002-6918-3701"},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanting Yang","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital , Anshan Road 154, Heping District, Tianjin 300052,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital , Anshan Road 154, Heping District, Tianjin 300052,","institution_ids":["https://openalex.org/I2802534033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100529450","display_name":"Yumei He","orcid":"https://orcid.org/0000-0002-2135-150X"},"institutions":[{"id":"https://openalex.org/I4210093384","display_name":"Third People's Hospital of Chengdu","ror":"https://ror.org/00ebdgr24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093384"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yumei He","raw_affiliation_strings":["Department of Gastroenterology, The Third People's Hospital of Chengdu , Chengdu 610031, Sichuan Province,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The Third People's Hospital of Chengdu , Chengdu 610031, Sichuan Province,","institution_ids":["https://openalex.org/I4210093384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066602475","display_name":"Liping Wu","orcid":"https://orcid.org/0000-0002-1615-3832"},"institutions":[{"id":"https://openalex.org/I4210093384","display_name":"Third People's Hospital of Chengdu","ror":"https://ror.org/00ebdgr24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093384"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liping Wu","raw_affiliation_strings":["Department of Gastroenterology, The Third People's Hospital of Chengdu , Chengdu 610031, Sichuan Province,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The Third People's Hospital of Chengdu , Chengdu 610031, Sichuan Province,","institution_ids":["https://openalex.org/I4210093384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053176595","display_name":"Kui Jiang","orcid":"https://orcid.org/0000-0001-7097-7771"},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kui Jiang","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital , Anshan Road 154, Heping District, Tianjin 300052,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital , Anshan Road 154, Heping District, Tianjin 300052,","institution_ids":["https://openalex.org/I2802534033"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056235310","display_name":"Chao Sun","orcid":"https://orcid.org/0000-0002-0380-7999"},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Sun","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital , Anshan Road 154, Heping District, Tianjin 300052,"],"raw_orcid":"https://orcid.org/0000-0002-0380-7999","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital , Anshan Road 154, Heping District, Tianjin 300052,","institution_ids":["https://openalex.org/I2802534033"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":2.812,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.90796267,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"25","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11509","display_name":"Hip and Femur Fractures","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/generalizability-theory","display_name":"Generalizability theory","score":0.7367644309997559},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.6046047806739807},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5814144611358643},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5526769161224365},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5391756296157837},{"id":"https://openalex.org/keywords/cirrhosis","display_name":"Cirrhosis","score":0.5048242211341858},{"id":"https://openalex.org/keywords/ascites","display_name":"Ascites","score":0.4699093699455261},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43711382150650024},{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.4121955335140228},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.322133332490921},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2293928861618042},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1947246789932251}],"concepts":[{"id":"https://openalex.org/C27158222","wikidata":"https://www.wikidata.org/wiki/Q5532422","display_name":"Generalizability theory","level":2,"score":0.7367644309997559},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6046047806739807},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5814144611358643},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5526769161224365},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5391756296157837},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.5048242211341858},{"id":"https://openalex.org/C2780496750","wikidata":"https://www.wikidata.org/wiki/Q193889","display_name":"Ascites","level":2,"score":0.4699093699455261},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43711382150650024},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.4121955335140228},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.322133332490921},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2293928861618042},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1947246789932251}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae491","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae491","pdf_url":"https://academic.oup.com/bib/article-pdf/25/6/bbae491/59536318/bbae491.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39358034","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39358034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11446601","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11446601","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11446601/pdf/bbae491.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae491","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae491","pdf_url":"https://academic.oup.com/bib/article-pdf/25/6/bbae491/59536318/bbae491.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403055586.pdf","grobid_xml":"https://content.openalex.org/works/W4403055586.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W2153975492","https://openalex.org/W2162670203","https://openalex.org/W2254383138","https://openalex.org/W2478947510","https://openalex.org/W2725246371","https://openalex.org/W2768199180","https://openalex.org/W2790396162","https://openalex.org/W2797367331","https://openalex.org/W2804083274","https://openalex.org/W2892741787","https://openalex.org/W2909229977","https://openalex.org/W2923071500","https://openalex.org/W2938791143","https://openalex.org/W2998807005","https://openalex.org/W3010339641","https://openalex.org/W3014413945","https://openalex.org/W3086038201","https://openalex.org/W3086732843","https://openalex.org/W3087059313","https://openalex.org/W3098674050","https://openalex.org/W3100666310","https://openalex.org/W3108236962","https://openalex.org/W3134943158","https://openalex.org/W3157515107","https://openalex.org/W3164554479","https://openalex.org/W3181395511","https://openalex.org/W3198710875","https://openalex.org/W3212191674","https://openalex.org/W4200469052","https://openalex.org/W4205924067","https://openalex.org/W4280498794","https://openalex.org/W4283837314","https://openalex.org/W4297231646","https://openalex.org/W4361215440","https://openalex.org/W4379769013","https://openalex.org/W4383998182","https://openalex.org/W4386128375","https://openalex.org/W4387336518","https://openalex.org/W4390599059"],"related_works":["https://openalex.org/W2352171123","https://openalex.org/W4213200513","https://openalex.org/W2981829875","https://openalex.org/W2009823908","https://openalex.org/W2377446345","https://openalex.org/W2340382683","https://openalex.org/W2613952836","https://openalex.org/W2358399733","https://openalex.org/W2368857971","https://openalex.org/W2414281636"],"abstract_inverted_index":{"We":[0,217],"sought":[1],"to":[2,40,76,92,239,242],"develop":[3],"and":[4,18,55,105,124,130,135,142,154,187,205,234,247],"validate":[5],"a":[6,44,77,209],"machine":[7],"learning":[8],"(ML)":[9],"model":[10,25,159,221],"for":[11,195],"predicting":[12],"multidimensional":[13],"frailty":[14],"based":[15],"on":[16],"clinical":[17],"laboratory":[19],"data.":[20],"Moreover,":[21,175],"an":[22,219],"explainable":[23],"ML":[24,98,109,150,173,220],"utilizing":[26],"SHapley":[27],"Additive":[28],"exPlanations":[29],"(SHAP)":[30],"was":[31,60,73,90],"constructed.":[32],"This":[33],"study":[34],"enrolled":[35],"622":[36],"patients":[37,65,121],"hospitalized":[38],"due":[39],"decompensating":[41],"episodes":[42],"at":[43],"tertiary":[45,68],"hospital.":[46],"The":[47,70,82,100,117,232],"cohort":[48],"data":[49],"were":[50,111,133,140,152],"randomly":[51],"divided":[52],"into":[53],"training":[54,129],"test":[56,131],"sets.":[57],"External":[58],"validation":[59,147],"carried":[61],"out":[62],"using":[63,113],"131":[64],"from":[66],"other":[67,172],"hospitals.":[69],"frail":[71,125,227],"phenotype":[72,228],"defined":[74],"according":[75],"self-reported":[78],"questionnaire":[79],"(Frailty":[80],"Index).":[81],"area":[83],"under":[84],"the":[85,94,103,108,114,145,155,165,168,176,191,198,201,214],"receiver":[86],"operating":[87],"characteristics":[88],"curve":[89],"adopted":[91],"compare":[93],"performance":[95],"of":[96,102,107,119,213,226],"five":[97],"models.":[99,174],"importance":[101],"features":[104],"interpretation":[106],"models":[110],"determined":[112],"SHAP":[115,177,202],"method.":[116],"proportions":[118],"cirrhotic":[120],"with":[122],"nonfrail":[123],"phenotypes":[126],"in":[127,144,229],"combined":[128],"sets":[132],"87.8%":[134],"12.2%,":[136],"respectively,":[137],"while":[138],"they":[139],"88.5%":[141],"11.5%":[143],"external":[146,166],"dataset.":[148],"Five":[149],"algorithms":[151],"used,":[153],"random":[156],"forest":[157],"(RF)":[158,222],"exhibited":[160,208],"substantially":[161],"predictive":[162],"performance.":[163],"Regarding":[164],"validation,":[167],"RF":[169,215],"algorithm":[170],"outperformed":[171],"method":[178],"demonstrated":[179],"that":[180],"neutrophil-to-lymphocyte":[181],"ratio,":[182,185],"age,":[183],"lymphocyte-to-monocyte":[184],"ascites,":[186],"albumin":[188],"served":[189],"as":[190],"most":[192],"important":[193],"predictors":[194],"frailty.":[196],"At":[197],"patient":[199],"level,":[200],"force":[203],"plot":[204,207],"decision":[206],"clinically":[210],"meaningful":[211],"explanation":[212],"algorithm.":[216],"constructed":[218],"providing":[223],"accurate":[224],"prediction":[225],"decompensated":[230],"cirrhosis.":[231],"explainability":[233],"generalizability":[235],"may":[236],"foster":[237],"clinicians":[238],"understand":[240],"contributors":[241],"this":[243],"physiologically":[244],"vulnerable":[245],"situation":[246],"tailor":[248],"interventions.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6}],"updated_date":"2026-07-04T07:58:01.006859","created_date":"2025-10-10T00:00:00"}