{"id":"https://openalex.org/W4402857655","doi":"https://doi.org/10.1093/bib/bbae481","title":"CMFHMDA: a prediction framework for human disease-microbe associations based on cross-domain matrix factorization","display_name":"CMFHMDA: a prediction framework for human disease-microbe associations based on cross-domain matrix factorization","publication_year":2024,"publication_date":"2024-09-23","ids":{"openalex":"https://openalex.org/W4402857655","doi":"https://doi.org/10.1093/bib/bbae481","pmid":"https://pubmed.ncbi.nlm.nih.gov/39327064"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae481","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae481","pdf_url":"https://academic.oup.com/bib/article-pdf/25/6/bbae481/59344065/bbae481.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/6/bbae481/59344065/bbae481.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103539455","display_name":"Jing Chen","orcid":"https://orcid.org/0009-0001-6510-1211"},"institutions":[{"id":"https://openalex.org/I308837","display_name":"Suzhou University of Science and Technology","ror":"https://ror.org/04en8wb91","country_code":"CN","type":"education","lineage":["https://openalex.org/I308837"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Chen","raw_affiliation_strings":["School of Electronic and Information Engineering, Suzhou University of Science and Technology , 215009 Suzhou ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electronic and Information Engineering, Suzhou University of Science and Technology , 215009 Suzhou ,","institution_ids":["https://openalex.org/I308837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108904849","display_name":"Ran Tao","orcid":null},"institutions":[{"id":"https://openalex.org/I308837","display_name":"Suzhou University of Science and Technology","ror":"https://ror.org/04en8wb91","country_code":"CN","type":"education","lineage":["https://openalex.org/I308837"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ran Tao","raw_affiliation_strings":["School of Electronic and Information Engineering, Suzhou University of Science and Technology , 215009 Suzhou ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electronic and Information Engineering, Suzhou University of Science and Technology , 215009 Suzhou ,","institution_ids":["https://openalex.org/I308837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102026192","display_name":"Yi Qiu","orcid":"https://orcid.org/0000-0001-7291-5187"},"institutions":[{"id":"https://openalex.org/I308837","display_name":"Suzhou University of Science and Technology","ror":"https://ror.org/04en8wb91","country_code":"CN","type":"education","lineage":["https://openalex.org/I308837"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Qiu","raw_affiliation_strings":["School of Electronic and Information Engineering, Suzhou University of Science and Technology , 215009 Suzhou ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electronic and Information Engineering, Suzhou University of Science and Technology , 215009 Suzhou ,","institution_ids":["https://openalex.org/I308837"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102385786","display_name":"Qun Yuan","orcid":null},"institutions":[{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qun Yuan","raw_affiliation_strings":["Nanjing University , Affiliated Hospital of Medical School, , 215153 Suzhou ,","Suzhou Research Center of Medical School, Suzhou Hospital , Affiliated Hospital of Medical School, , 215153 Suzhou ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanjing University , Affiliated Hospital of Medical School, , 215153 Suzhou ,","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"Suzhou Research Center of Medical School, Suzhou Hospital , Affiliated Hospital of Medical School, , 215153 Suzhou ,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102385786"],"corresponding_institution_ids":["https://openalex.org/I881766915"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":1.2925,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.79528047,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"25","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9675999879837036,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cross-validation","display_name":"Cross-validation","score":0.6576889157295227},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6285995841026306},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.5916736721992493},{"id":"https://openalex.org/keywords/non-negative-matrix-factorization","display_name":"Non-negative matrix factorization","score":0.5744304656982422},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.5559037923812866},{"id":"https://openalex.org/keywords/gaussian","display_name":"Gaussian","score":0.4763096570968628},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.46924781799316406},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.4562091529369354},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.43536460399627686},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4284459054470062},{"id":"https://openalex.org/keywords/matrix-decomposition","display_name":"Matrix decomposition","score":0.34714043140411377},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.23400333523750305},{"id":"https://openalex.org/keywords/eigenvalues-and-eigenvectors","display_name":"Eigenvalues and eigenvectors","score":0.06918743252754211}],"concepts":[{"id":"https://openalex.org/C27181475","wikidata":"https://www.wikidata.org/wiki/Q541014","display_name":"Cross-validation","level":2,"score":0.6576889157295227},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6285995841026306},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.5916736721992493},{"id":"https://openalex.org/C152671427","wikidata":"https://www.wikidata.org/wiki/Q10843505","display_name":"Non-negative matrix factorization","level":4,"score":0.5744304656982422},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.5559037923812866},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.4763096570968628},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.46924781799316406},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.4562091529369354},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.43536460399627686},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4284459054470062},{"id":"https://openalex.org/C42355184","wikidata":"https://www.wikidata.org/wiki/Q1361088","display_name":"Matrix decomposition","level":3,"score":0.34714043140411377},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23400333523750305},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.06918743252754211},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae481","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae481","pdf_url":"https://academic.oup.com/bib/article-pdf/25/6/bbae481/59344065/bbae481.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39327064","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39327064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11427075","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11427075","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11427075/pdf/bbae481.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae481","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae481","pdf_url":"https://academic.oup.com/bib/article-pdf/25/6/bbae481/59344065/bbae481.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4399999976158142,"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals"}],"awards":[{"id":"https://openalex.org/G1857610291","display_name":null,"funder_award_id":"62073231","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2891303054","display_name":null,"funder_award_id":"62176175","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5280656057","display_name":null,"funder_award_id":"62372318","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402857655.pdf","grobid_xml":"https://content.openalex.org/works/W4402857655.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W1763867024","https://openalex.org/W1988082133","https://openalex.org/W2033829415","https://openalex.org/W2041073071","https://openalex.org/W2047885502","https://openalex.org/W2068234766","https://openalex.org/W2073332363","https://openalex.org/W2074072621","https://openalex.org/W2080988476","https://openalex.org/W2097875133","https://openalex.org/W2115699469","https://openalex.org/W2125826054","https://openalex.org/W2131186249","https://openalex.org/W2132929849","https://openalex.org/W2141820585","https://openalex.org/W2141980700","https://openalex.org/W2161548174","https://openalex.org/W2324847332","https://openalex.org/W2343107734","https://openalex.org/W2497274407","https://openalex.org/W2567465856","https://openalex.org/W2576112076","https://openalex.org/W2590194234","https://openalex.org/W2739664659","https://openalex.org/W2752131265","https://openalex.org/W2756148272","https://openalex.org/W2757038198","https://openalex.org/W2765928324","https://openalex.org/W2793951981","https://openalex.org/W2806774580","https://openalex.org/W2809156537","https://openalex.org/W2892502396","https://openalex.org/W2899378876","https://openalex.org/W2901312953","https://openalex.org/W2912204568","https://openalex.org/W2922817064","https://openalex.org/W2936110251","https://openalex.org/W2944330168","https://openalex.org/W2957404091","https://openalex.org/W2995175648","https://openalex.org/W3022121690","https://openalex.org/W3033622586","https://openalex.org/W3034046925","https://openalex.org/W3043440374","https://openalex.org/W3048259272","https://openalex.org/W3097604612","https://openalex.org/W3119299567","https://openalex.org/W3133921169","https://openalex.org/W3153696845","https://openalex.org/W3177710193","https://openalex.org/W3203997343","https://openalex.org/W4200424115","https://openalex.org/W4200431538","https://openalex.org/W4205736070","https://openalex.org/W4210631936","https://openalex.org/W4211248483","https://openalex.org/W4220708064","https://openalex.org/W4284891747","https://openalex.org/W4294376371","https://openalex.org/W4307925134","https://openalex.org/W4309452766","https://openalex.org/W4309842604","https://openalex.org/W4318756885","https://openalex.org/W4377091541","https://openalex.org/W4379967792","https://openalex.org/W4380266573","https://openalex.org/W4384664737","https://openalex.org/W4385144108","https://openalex.org/W4385345563","https://openalex.org/W4387106535","https://openalex.org/W4387670944","https://openalex.org/W4389056356","https://openalex.org/W4389918314","https://openalex.org/W4389937842","https://openalex.org/W4390269270","https://openalex.org/W4390563851","https://openalex.org/W4392094009","https://openalex.org/W4392111029","https://openalex.org/W4392571650","https://openalex.org/W4394014430","https://openalex.org/W4394749617","https://openalex.org/W6680974625","https://openalex.org/W6855493752","https://openalex.org/W6860330062"],"related_works":["https://openalex.org/W4390394189","https://openalex.org/W2037504162","https://openalex.org/W2539013788","https://openalex.org/W2792706544","https://openalex.org/W1568451138","https://openalex.org/W2156699640","https://openalex.org/W2045265907","https://openalex.org/W2972997031","https://openalex.org/W2146544734","https://openalex.org/W2075222291"],"abstract_inverted_index":{"Predicting":[0,55],"associations":[1,25,198],"between":[2],"microbes":[3,110,141],"and":[4,14,29,72,111,136,142,181,191],"diseases":[5,71,112,143],"opens":[6],"up":[7],"new":[8,42],"avenues":[9],"for":[10,36,212],"developing":[11],"diagnostic,":[12],"preventive,":[13],"therapeutic":[15],"strategies.":[16],"Given":[17],"that":[18,165],"laboratory-based":[19],"biological":[20],"tests":[21],"to":[22,40,91,113,128,157],"verify":[23],"these":[24],"are":[26],"often":[27],"time-consuming":[28],"expensive,":[30],"there":[31],"is":[32,100],"a":[33,50],"critical":[34],"need":[35],"innovative":[37],"computational":[38],"frameworks":[39],"predict":[41,114],"microbe-disease":[43,94],"associations.":[44,116],"In":[45],"this":[46,121],"work,":[47],"we":[48,65,151],"introduce":[49],"novel":[51],"prediction":[52],"algorithm":[53,90,127],"called":[54],"Human":[56],"Disease-Microbe":[57],"Associations":[58],"using":[59,124],"Cross-Domain":[60],"Matrix":[61],"Factorization":[62],"(CMFHMDA).":[63],"Initially,":[64],"calculate":[66],"the":[67,73,83,93,105,125,133,145,159,166,172],"composite":[68],"similarity":[69,77],"of":[70,78,108,120,178],"Gaussian":[74],"interaction":[75],"profile":[76],"microbes.":[79,216],"We":[80],"then":[81],"apply":[82],"Weighted":[84],"K":[85],"Nearest":[86],"Known":[87],"Neighbors":[88],"(WKNKN)":[89],"refine":[92],"association":[95,134],"matrix.":[96],"Our":[97],"CMFHMDA":[98,146,167,207],"model":[99,168],"subsequently":[101],"developed":[102],"by":[103,202],"integrating":[104],"network":[106],"data":[107],"both":[109],"potential":[115,214],"The":[117,162],"key":[118],"innovations":[119],"method":[122],"include":[123],"WKNKN":[126],"preprocess":[129],"missing":[130],"values":[131],"in":[132,184],"matrix":[135],"incorporating":[137],"cross-domain":[138],"information":[139],"from":[140],"into":[144],"model.":[147],"To":[148],"validate":[149],"CMFHMDA,":[150],"employed":[152],"three":[153],"different":[154],"cross-validation":[155],"techniques":[156],"evaluate":[158],"model's":[160],"accuracy.":[161],"results":[163],"indicate":[164],"achieved":[169],"Area":[170],"Under":[171],"Receiver":[173],"Operating":[174],"Characteristic":[175],"Curve":[176],"scores":[177],"0.9172,":[179],"0.8551,":[180],"0.9351$\\pm":[182],"$0.0052":[183],"global":[185],"Leave-One-Out":[186],"Cross-Validation":[187],"(LOOCV),":[188],"local":[189],"LOOCV,":[190],"five-fold":[192],"CV,":[193],"respectively.":[194],"Furthermore,":[195],"many":[196],"predicted":[197],"have":[199],"been":[200],"confirmed":[201],"published":[203],"experimental":[204],"studies,":[205],"establishing":[206],"as":[208],"an":[209],"effective":[210],"tool":[211],"predicting":[213],"disease-associated":[215]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}