{"id":"https://openalex.org/W4402575005","doi":"https://doi.org/10.1093/bib/bbae448","title":"Multimodal functional deep learning for multiomics data","display_name":"Multimodal functional deep learning for multiomics data","publication_year":2024,"publication_date":"2024-07-25","ids":{"openalex":"https://openalex.org/W4402575005","doi":"https://doi.org/10.1093/bib/bbae448","pmid":"https://pubmed.ncbi.nlm.nih.gov/39285512"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae448","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae448","pdf_url":"https://academic.oup.com/bib/article-pdf/25/5/bbae448/59142732/bbae448.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/5/bbae448/59142732/bbae448.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104667327","display_name":"Yuan Zhou","orcid":"https://orcid.org/0009-0005-8734-4686"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuan Zhou","raw_affiliation_strings":["Department of Biostatistics, University of Florida , 2004 Mowry Rd, Gainesville, FL 32611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Florida , 2004 Mowry Rd, Gainesville, FL 32611, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053800333","display_name":"Pei Geng","orcid":"https://orcid.org/0000-0001-8760-7785"},"institutions":[{"id":"https://openalex.org/I161057412","display_name":"University of New Hampshire","ror":"https://ror.org/01rmh9n78","country_code":"US","type":"education","lineage":["https://openalex.org/I161057412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pei Geng","raw_affiliation_strings":["Department of Mathematics and Statistics, University of New Hampshire , 33 Academic Way, Durham, NH 03824, USA"],"raw_orcid":"https://orcid.org/0000-0001-8760-7785","affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, University of New Hampshire , 33 Academic Way, Durham, NH 03824, USA","institution_ids":["https://openalex.org/I161057412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104668593","display_name":"Shan Zhang","orcid":"https://orcid.org/0009-0000-6734-7373"},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shan Zhang","raw_affiliation_strings":["Department of Statistics and Probability, Michigan State University , 619 Red Cedar Road, East Lansing, MI 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics and Probability, Michigan State University , 619 Red Cedar Road, East Lansing, MI 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086844078","display_name":"Feifei Xiao","orcid":"https://orcid.org/0000-0002-1597-4719"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feifei Xiao","raw_affiliation_strings":["Department of Biostatistics, University of Florida , 2004 Mowry Rd, Gainesville, FL 32611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Florida , 2004 Mowry Rd, Gainesville, FL 32611, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078945127","display_name":"Guoshuai Cai","orcid":"https://orcid.org/0000-0002-5331-1297"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guoshuai Cai","raw_affiliation_strings":["Department of Surgery, University of Florida , Gainesville, 1600 SW Archer Rd, FL 32611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Florida , Gainesville, 1600 SW Archer Rd, FL 32611, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100379195","display_name":"Li Chen","orcid":"https://orcid.org/0000-0001-9372-5606"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Chen","raw_affiliation_strings":["Department of Biostatistics, University of Florida , 2004 Mowry Rd, Gainesville, FL 32611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Florida , 2004 Mowry Rd, Gainesville, FL 32611, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"For the Alzheimer\u2019s Disease Neuroimaging Initiative","orcid":null},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"For the Alzheimer\u2019s Disease Neuroimaging Initiative","raw_affiliation_strings":["Department of Biostatistics, University of Florida , 2004 Mowry Rd, Gainesville, FL 32611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Florida , 2004 Mowry Rd, Gainesville, FL 32611, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":null,"display_name":"Qing Lu","orcid":"https://orcid.org/0000-0002-7943-966X"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Lu","raw_affiliation_strings":["Department of Biostatistics, University of Florida , 2004 Mowry Rd, Gainesville, FL 32611, USA"],"raw_orcid":"https://orcid.org/0000-0002-7943-966X","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Florida , 2004 Mowry Rd, Gainesville, FL 32611, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5104667327"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":2.8328,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.91284915,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"25","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9840999841690063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6435397863388062},{"id":"https://openalex.org/keywords/omics","display_name":"Omics","score":0.6283760070800781},{"id":"https://openalex.org/keywords/curse-of-dimensionality","display_name":"Curse of dimensionality","score":0.5573717355728149},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.49109578132629395},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4739161431789398},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.44775551557540894},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.43250831961631775},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4159530997276306},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3922802209854126},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3842097520828247},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3192461431026459},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1904880404472351}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6435397863388062},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.6283760070800781},{"id":"https://openalex.org/C111030470","wikidata":"https://www.wikidata.org/wiki/Q1430460","display_name":"Curse of dimensionality","level":2,"score":0.5573717355728149},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.49109578132629395},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4739161431789398},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.44775551557540894},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.43250831961631775},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4159530997276306},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3922802209854126},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3842097520828247},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3192461431026459},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1904880404472351},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae448","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae448","pdf_url":"https://academic.oup.com/bib/article-pdf/25/5/bbae448/59142732/bbae448.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39285512","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39285512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11405129","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11405129","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11405129/pdf/bbae448.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae448","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae448","pdf_url":"https://academic.oup.com/bib/article-pdf/25/5/bbae448/59142732/bbae448.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8733380644","display_name":null,"funder_award_id":"R01DA043501","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402575005.pdf","grobid_xml":"https://content.openalex.org/works/W4402575005.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W6908809","https://openalex.org/W29779864","https://openalex.org/W592963477","https://openalex.org/W1882839933","https://openalex.org/W1928755576","https://openalex.org/W1967827763","https://openalex.org/W1985728412","https://openalex.org/W1987219048","https://openalex.org/W1992549770","https://openalex.org/W2007044705","https://openalex.org/W2028260332","https://openalex.org/W2097553067","https://openalex.org/W2101355788","https://openalex.org/W2129256542","https://openalex.org/W2159082702","https://openalex.org/W2171777347","https://openalex.org/W2287154159","https://openalex.org/W2307267906","https://openalex.org/W2808845633","https://openalex.org/W2912411326","https://openalex.org/W2921144944","https://openalex.org/W2950985821","https://openalex.org/W2965116998","https://openalex.org/W2973131617","https://openalex.org/W2995867266","https://openalex.org/W3112212292","https://openalex.org/W4210845242","https://openalex.org/W4252676770","https://openalex.org/W4391759643","https://openalex.org/W4392979544","https://openalex.org/W6601200593"],"related_works":["https://openalex.org/W4296209631","https://openalex.org/W3097449145","https://openalex.org/W2561617217","https://openalex.org/W177137871","https://openalex.org/W4375867731","https://openalex.org/W4294811468","https://openalex.org/W4292302930","https://openalex.org/W2355801475","https://openalex.org/W4386960635","https://openalex.org/W3149361930"],"abstract_inverted_index":{"With":[0],"rapidly":[1],"evolving":[2],"high-throughput":[3],"technologies":[4],"and":[5,42,74,108,119,151,165,172],"consistently":[6],"decreasing":[7],"costs,":[8],"collecting":[9],"multimodal":[10,85,137],"omics":[11,40,50,122,146],"data":[12,41,123,127],"in":[13,27,52,160],"large-scale":[14],"studies":[15,150],"has":[16],"become":[17],"feasible.":[18],"Although":[19],"studying":[20],"multiomics":[21,77,96,106],"provides":[22],"a":[23,63,84],"new":[24],"comprehensive":[25],"approach":[26],"understanding":[28],"the":[29,36,43,46,92,102,112,125,133,136,156,169,175],"complex":[30,103],"biological":[31],"mechanisms":[32],"of":[33,39,45,66,94,115,135,145,158,162],"human":[34],"diseases,":[35],"high":[37,170],"dimensionality":[38,171],"complexity":[44],"interactions":[47,141],"among":[48],"various":[49],"levels":[51],"contributing":[53],"to":[54,70,75,139,168],"disease":[55,109],"phenotypes":[56,110],"present":[57],"tremendous":[58],"analytical":[59,68],"challenges.":[60],"There":[61],"is":[62],"great":[64],"need":[65],"novel":[67],"methods":[69],"address":[71],"these":[72],"challenges":[73],"facilitate":[76],"analyses.":[78],"In":[79],"this":[80],"paper,":[81],"we":[82,154],"propose":[83],"functional":[86,126],"deep":[87,116],"learning":[88],"(MFDL)":[89],"method":[90,100],"for":[91],"analysis":[93,128],"high-dimensional":[95,121],"data.":[97,147,176],"The":[98],"MFDL":[99,131,159],"models":[101],"relationships":[104],"between":[105,142],"variants":[107],"through":[111],"hierarchical":[113],"structure":[114,134],"neural":[117],"networks":[118],"handles":[120],"using":[124],"technique.":[129],"Furthermore,":[130],"leverages":[132],"model":[138],"capture":[140],"different":[143],"types":[144],"Through":[148],"simulation":[149],"real-data":[152],"applications,":[153],"demonstrate":[155],"advantages":[157],"terms":[161],"prediction":[163],"accuracy":[164],"its":[166],"robustness":[167],"noise":[173],"within":[174]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10}],"updated_date":"2026-05-07T13:39:58.223016","created_date":"2025-10-10T00:00:00"}