{"id":"https://openalex.org/W4402466419","doi":"https://doi.org/10.1093/bib/bbae440","title":"Beyond the base pairs: comparative genome-wide DNA methylation profiling across sequencing technologies","display_name":"Beyond the base pairs: comparative genome-wide DNA methylation profiling across sequencing technologies","publication_year":2024,"publication_date":"2024-07-25","ids":{"openalex":"https://openalex.org/W4402466419","doi":"https://doi.org/10.1093/bib/bbae440","pmid":"https://pubmed.ncbi.nlm.nih.gov/39256199"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae440","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae440","pdf_url":"https://academic.oup.com/bib/article-pdf/25/5/bbae440/59074006/bbae440.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/5/bbae440/59074006/bbae440.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076990605","display_name":"Xin Liu","orcid":"https://orcid.org/0000-0002-6158-8341"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802624667","display_name":"Hefei Institutes of Physical Science","ror":"https://ror.org/046n57345","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802624667"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xin Liu","raw_affiliation_strings":["Anhui Province Key Laboratory of Medical Physics and Technology , Institute of Health and Medical Technology, Hefei Institutes of Physical Science, , Hefei, Anhui Province 230031, China","Chinese Academy of Sciences , Institute of Health and Medical Technology, Hefei Institutes of Physical Science, , Hefei, Anhui Province 230031, China","Hefei Cancer Hospital, Chinese Academy of Sciences , Hefei, Anhui Province 230031, China"],"affiliations":[{"raw_affiliation_string":"Anhui Province Key Laboratory of Medical Physics and Technology , Institute of Health and Medical Technology, Hefei Institutes of Physical Science, , Hefei, Anhui Province 230031, China","institution_ids":["https://openalex.org/I2802624667"]},{"raw_affiliation_string":"Chinese Academy of Sciences , Institute of Health and Medical Technology, Hefei Institutes of Physical Science, , Hefei, Anhui Province 230031, China","institution_ids":["https://openalex.org/I2802624667","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Hefei Cancer Hospital, Chinese Academy of Sciences , Hefei, Anhui Province 230031, China","institution_ids":["https://openalex.org/I2802624667","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102953035","display_name":"Yu Pang","orcid":"https://orcid.org/0000-0003-4938-516X"},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210107581","display_name":"Beijing Chest Hospital","ror":"https://ror.org/01espdw89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Pang","raw_affiliation_strings":["Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute , Beijing Chest Hospital, , Beijing 101149, China","Department of Bacteriology and Immunology , Beijing Chest Hospital, , Beijing 101149, China"],"affiliations":[{"raw_affiliation_string":"Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute , Beijing Chest Hospital, , Beijing 101149, China","institution_ids":["https://openalex.org/I4210107581","https://openalex.org/I183519381"]},{"raw_affiliation_string":"Department of Bacteriology and Immunology , Beijing Chest Hospital, , Beijing 101149, China","institution_ids":["https://openalex.org/I4210107581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084704808","display_name":"Junqi Shan","orcid":"https://orcid.org/0000-0002-4273-0808"},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junqi Shan","raw_affiliation_strings":["Department of Gastrointestinal Surgery , Shandong Cancer Hospital and Institute, , Jinan, Shandong 250117, China","Shandong First Medical University and Shandong Academy of Medical Sciences , Shandong Cancer Hospital and Institute, , Jinan, Shandong 250117, China"],"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery , Shandong Cancer Hospital and Institute, , Jinan, Shandong 250117, China","institution_ids":["https://openalex.org/I4210100830","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Shandong First Medical University and Shandong Academy of Medical Sciences , Shandong Cancer Hospital and Institute, , Jinan, Shandong 250117, China","institution_ids":["https://openalex.org/I4210163399","https://openalex.org/I4210100830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100413257","display_name":"Yunfei Wang","orcid":"https://orcid.org/0009-0000-4928-6853"},"institutions":[{"id":"https://openalex.org/I4210142178","display_name":"Hangzhou DAC Biotech (China)","ror":"https://ror.org/04hy71c73","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210142178"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunfei Wang","raw_affiliation_strings":["Hangzhou ShengTing Biotech Co. Ltd , Hangzhou, Zhejiang Province 310018, China"],"affiliations":[{"raw_affiliation_string":"Hangzhou ShengTing Biotech Co. Ltd , Hangzhou, Zhejiang Province 310018, China","institution_ids":["https://openalex.org/I4210142178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101458958","display_name":"Yanhua Zheng","orcid":"https://orcid.org/0000-0001-8393-9141"},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanhua Zheng","raw_affiliation_strings":["Department of Hematology, The First Hospital of China Medical University , Shenyang, Liaoning, Shenyang, Liaoning province 110001, China"],"affiliations":[{"raw_affiliation_string":"Department of Hematology, The First Hospital of China Medical University , Shenyang, Liaoning, Shenyang, Liaoning province 110001, China","institution_ids":["https://openalex.org/I91656880","https://openalex.org/I4210140515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088461030","display_name":"Yuhang Xue","orcid":"https://orcid.org/0000-0001-6491-239X"},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhang Xue","raw_affiliation_strings":["Department of Hematology, The First Hospital of China Medical University , Shenyang, Liaoning, Shenyang, Liaoning province 110001, China"],"affiliations":[{"raw_affiliation_string":"Department of Hematology, The First Hospital of China Medical University , Shenyang, Liaoning, Shenyang, Liaoning province 110001, China","institution_ids":["https://openalex.org/I91656880","https://openalex.org/I4210140515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075597574","display_name":"Xue\u2010Rong Zhou","orcid":"https://orcid.org/0000-0003-3717-2984"},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuerong Zhou","raw_affiliation_strings":["Department of Hematology, The First Hospital of China Medical University , Shenyang, Liaoning, Shenyang, Liaoning province 110001, China"],"affiliations":[{"raw_affiliation_string":"Department of Hematology, The First Hospital of China Medical University , Shenyang, Liaoning, Shenyang, Liaoning province 110001, China","institution_ids":["https://openalex.org/I91656880","https://openalex.org/I4210140515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100393016","display_name":"Wenjun Wang","orcid":"https://orcid.org/0000-0001-9065-6481"},"institutions":[{"id":"https://openalex.org/I4210142178","display_name":"Hangzhou DAC Biotech (China)","ror":"https://ror.org/04hy71c73","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210142178"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjun Wang","raw_affiliation_strings":["Hangzhou ShengTing Biotech Co. Ltd , Hangzhou, Zhejiang Province 310018, China"],"affiliations":[{"raw_affiliation_string":"Hangzhou ShengTing Biotech Co. Ltd , Hangzhou, Zhejiang Province 310018, China","institution_ids":["https://openalex.org/I4210142178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110022709","display_name":"Yanlai Sun","orcid":null},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanlai Sun","raw_affiliation_strings":["Department of Gastrointestinal Surgery , Shandong Cancer Hospital and Institute, , Jinan, Shandong 250117, China","Shandong First Medical University and Shandong Academy of Medical Sciences , Shandong Cancer Hospital and Institute, , Jinan, Shandong 250117, China"],"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery , Shandong Cancer Hospital and Institute, , Jinan, Shandong 250117, China","institution_ids":["https://openalex.org/I4210100830","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Shandong First Medical University and Shandong Academy of Medical Sciences , Shandong Cancer Hospital and Institute, , Jinan, Shandong 250117, China","institution_ids":["https://openalex.org/I4210163399","https://openalex.org/I4210100830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101484595","display_name":"Xiaojing Yan","orcid":"https://orcid.org/0000-0001-5819-538X"},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojing Yan","raw_affiliation_strings":["Department of Hematology, The First Hospital of China Medical University , Shenyang, Liaoning, Shenyang, Liaoning province 110001, China"],"affiliations":[{"raw_affiliation_string":"Department of Hematology, The First Hospital of China Medical University , Shenyang, Liaoning, Shenyang, Liaoning province 110001, China","institution_ids":["https://openalex.org/I91656880","https://openalex.org/I4210140515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040409553","display_name":"Jiantao Shi","orcid":"https://orcid.org/0000-0002-0039-8800"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiantao Shi","raw_affiliation_strings":["State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences , Shanghai 200031, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences , Shanghai 200031, China","institution_ids":["https://openalex.org/I4210121447","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100663568","display_name":"Xiaoxue Wang","orcid":"https://orcid.org/0000-0003-2612-6333"},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxue Wang","raw_affiliation_strings":["Department of Hematology, The First Hospital of China Medical University , Shenyang, Liaoning, Shenyang, Liaoning province 110001, China"],"affiliations":[{"raw_affiliation_string":"Department of Hematology, The First Hospital of China Medical University , Shenyang, Liaoning, Shenyang, Liaoning province 110001, China","institution_ids":["https://openalex.org/I91656880","https://openalex.org/I4210140515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059400646","display_name":"Hongcang Gu","orcid":"https://orcid.org/0000-0002-1439-7606"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802624667","display_name":"Hefei Institutes of Physical Science","ror":"https://ror.org/046n57345","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802624667"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongcang Gu","raw_affiliation_strings":["Anhui Province Key Laboratory of Medical Physics and Technology , Institute of Health and Medical Technology, Hefei Institutes of Physical Science, , Hefei, Anhui Province 230031, China","Chinese Academy of Sciences , Institute of Health and Medical Technology, Hefei Institutes of Physical Science, , Hefei, Anhui Province 230031, China","Hefei Cancer Hospital, Chinese Academy of Sciences , Hefei, Anhui Province 230031, China"],"affiliations":[{"raw_affiliation_string":"Anhui Province Key Laboratory of Medical Physics and Technology , Institute of Health and Medical Technology, Hefei Institutes of Physical Science, , Hefei, Anhui Province 230031, China","institution_ids":["https://openalex.org/I2802624667"]},{"raw_affiliation_string":"Chinese Academy of Sciences , Institute of Health and Medical Technology, Hefei Institutes of Physical Science, , Hefei, Anhui Province 230031, China","institution_ids":["https://openalex.org/I2802624667","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Hefei Cancer Hospital, Chinese Academy of Sciences , Hefei, Anhui Province 230031, China","institution_ids":["https://openalex.org/I2802624667","https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100766982","display_name":"Fan Zhang","orcid":"https://orcid.org/0000-0003-3453-0512"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802624667","display_name":"Hefei Institutes of Physical Science","ror":"https://ror.org/046n57345","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802624667"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Zhang","raw_affiliation_strings":["Anhui Province Key Laboratory of Medical Physics and Technology , Institute of Health and Medical Technology, Hefei Institutes of Physical Science, , Hefei, Anhui Province 230031, China","Chinese Academy of Sciences , Institute of Health and Medical Technology, Hefei Institutes of Physical Science, , Hefei, Anhui Province 230031, China","Hefei Cancer Hospital, Chinese Academy of Sciences , Hefei, Anhui Province 230031, China"],"affiliations":[{"raw_affiliation_string":"Anhui Province Key Laboratory of Medical Physics and Technology , Institute of Health and Medical Technology, Hefei Institutes of Physical Science, , Hefei, Anhui Province 230031, China","institution_ids":["https://openalex.org/I2802624667"]},{"raw_affiliation_string":"Chinese Academy of Sciences , Institute of Health and Medical Technology, Hefei Institutes of Physical Science, , Hefei, Anhui Province 230031, China","institution_ids":["https://openalex.org/I2802624667","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Hefei Cancer Hospital, Chinese Academy of Sciences , Hefei, Anhui Province 230031, China","institution_ids":["https://openalex.org/I2802624667","https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5076990605"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802624667"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":2.0478,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.87071925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"25","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9850999712944031,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9782000184059143,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisulfite-sequencing","display_name":"Bisulfite sequencing","score":0.7985057830810547},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6942210793495178},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6876420974731445},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5824089050292969},{"id":"https://openalex.org/keywords/illumina-methylation-assay","display_name":"Illumina Methylation Assay","score":0.5498174428939819},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.5469948053359985},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.532599151134491},{"id":"https://openalex.org/keywords/cpg-site","display_name":"CpG site","score":0.49245724081993103},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.46324577927589417},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.413469523191452},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.3329067826271057},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2842860221862793},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.08593499660491943}],"concepts":[{"id":"https://openalex.org/C189235521","wikidata":"https://www.wikidata.org/wiki/Q4087270","display_name":"Bisulfite sequencing","level":5,"score":0.7985057830810547},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6942210793495178},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6876420974731445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5824089050292969},{"id":"https://openalex.org/C136953436","wikidata":"https://www.wikidata.org/wiki/Q6000286","display_name":"Illumina Methylation Assay","level":5,"score":0.5498174428939819},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5469948053359985},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.532599151134491},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.49245724081993103},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.46324577927589417},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.413469523191452},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3329067826271057},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2842860221862793},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08593499660491943}],"mesh":[{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013447","descriptor_name":"Sulfites","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013447","descriptor_name":"Sulfites","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013447","descriptor_name":"Sulfites","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013447","descriptor_name":"Sulfites","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013447","descriptor_name":"Sulfites","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020029","descriptor_name":"Base Pairing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020029","descriptor_name":"Base Pairing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020029","descriptor_name":"Base Pairing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020029","descriptor_name":"Base Pairing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020029","descriptor_name":"Base Pairing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae440","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae440","pdf_url":"https://academic.oup.com/bib/article-pdf/25/5/bbae440/59074006/bbae440.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39256199","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39256199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11387064","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11387064","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11387064/pdf/bbae440.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae440","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae440","pdf_url":"https://academic.oup.com/bib/article-pdf/25/5/bbae440/59074006/bbae440.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure","score":0.4399999976158142}],"awards":[{"id":"https://openalex.org/G1121271761","display_name":null,"funder_award_id":"Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2712598156","display_name":null,"funder_award_id":"81900153","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3018457626","display_name":null,"funder_award_id":"2022YFC2302900","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G32612571","display_name":null,"funder_award_id":"2022-YGJC-62","funder_id":"https://openalex.org/F4320323086","funder_display_name":"Natural Science Foundation of Liaoning Province"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3371352073","display_name":null,"funder_award_id":"2022YFC2302900","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6258415954","display_name":null,"funder_award_id":"Chinese","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7608752429","display_name":null,"funder_award_id":"Talent","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7836423780","display_name":null,"funder_award_id":"Liaoning","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8764071032","display_name":null,"funder_award_id":"2022YFC","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320323086","display_name":"Natural Science Foundation of Liaoning Province","ror":null},{"id":"https://openalex.org/F4320335203","display_name":"Hefei Institutes of Physical Science, Chinese Academy of Sciences","ror":"https://ror.org/046n57345"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402466419.pdf","grobid_xml":"https://content.openalex.org/works/W4402466419.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W1973950074","https://openalex.org/W1980943135","https://openalex.org/W1987557775","https://openalex.org/W1990363857","https://openalex.org/W2004078197","https://openalex.org/W2010587730","https://openalex.org/W2012016911","https://openalex.org/W2015845481","https://openalex.org/W2017502278","https://openalex.org/W2029683459","https://openalex.org/W2036897871","https://openalex.org/W2051974123","https://openalex.org/W2053309035","https://openalex.org/W2056040742","https://openalex.org/W2058087601","https://openalex.org/W2059099579","https://openalex.org/W2064302386","https://openalex.org/W2064397275","https://openalex.org/W2070429620","https://openalex.org/W2074746593","https://openalex.org/W2091414779","https://openalex.org/W2106889224","https://openalex.org/W2108234281","https://openalex.org/W2111281047","https://openalex.org/W2114970231","https://openalex.org/W2119154507","https://openalex.org/W2119180969","https://openalex.org/W2123032740","https://openalex.org/W2130222411","https://openalex.org/W2131374955","https://openalex.org/W2133046153","https://openalex.org/W2135157239","https://openalex.org/W2149171139","https://openalex.org/W2150194502","https://openalex.org/W2152656267","https://openalex.org/W2158789637","https://openalex.org/W2161224111","https://openalex.org/W2163327652","https://openalex.org/W2168133698","https://openalex.org/W2170551349","https://openalex.org/W2341539131","https://openalex.org/W2396849069","https://openalex.org/W2432815617","https://openalex.org/W2468965472","https://openalex.org/W2529838505","https://openalex.org/W2555332535","https://openalex.org/W2604685034","https://openalex.org/W2608406409","https://openalex.org/W2754041971","https://openalex.org/W2775271009","https://openalex.org/W2808533107","https://openalex.org/W2886228936","https://openalex.org/W2936052783","https://openalex.org/W2949796709","https://openalex.org/W2950199861","https://openalex.org/W2953218432","https://openalex.org/W2968658941","https://openalex.org/W2979032248","https://openalex.org/W2979265372","https://openalex.org/W3006828128","https://openalex.org/W3024314143","https://openalex.org/W3044989759","https://openalex.org/W3090774330","https://openalex.org/W3100668870","https://openalex.org/W3124427154","https://openalex.org/W3135267925","https://openalex.org/W3137923010","https://openalex.org/W3154810354","https://openalex.org/W3158391114","https://openalex.org/W3171783357","https://openalex.org/W3197828878","https://openalex.org/W3198016106","https://openalex.org/W3199647353","https://openalex.org/W4206719811","https://openalex.org/W4220711101","https://openalex.org/W4281852402","https://openalex.org/W4283661028","https://openalex.org/W4298001473","https://openalex.org/W4377291469","https://openalex.org/W4380369675","https://openalex.org/W4385836909","https://openalex.org/W4386741438","https://openalex.org/W4390663438","https://openalex.org/W4390859415","https://openalex.org/W6677996473","https://openalex.org/W6719533065"],"related_works":["https://openalex.org/W2150651400","https://openalex.org/W1975609775","https://openalex.org/W2008284862","https://openalex.org/W2163125553","https://openalex.org/W2911544435","https://openalex.org/W2033244804","https://openalex.org/W2344200017","https://openalex.org/W2127500890","https://openalex.org/W3030889166","https://openalex.org/W1983904019"],"abstract_inverted_index":{"Deoxyribonucleic":[0],"acid":[1],"(DNA)":[2],"methylation":[3,34,102],"plays":[4],"a":[5,191],"key":[6],"role":[7],"in":[8,110,149],"gene":[9],"regulation":[10],"and":[11,16,26,44,54,73,85,105,108,145,157,169,174],"is":[12],"critical":[13],"for":[14,76,172,180,193],"development":[15],"human":[17],"disease.":[18],"Techniques":[19],"such":[20],"as":[21],"whole-genome":[22],"bisulfite":[23,29,194],"sequencing":[24,30,91,143],"(WGBS)":[25],"reduced":[27],"representation":[28],"(RRBS)":[31],"allow":[32],"DNA":[33],"analysis":[35],"at":[36],"the":[37,119,154,183],"genome":[38],"scale,":[39],"with":[40,176],"Illumina":[41],"NovaSeq":[42,155,177],"6000":[43],"MGI":[45],"Tech":[46],"DNBSEQ-T7":[47],"being":[48],"popular":[49],"due":[50],"to":[51,159],"their":[52,61],"efficiency":[53],"affordability.":[55],"However,":[56],"detailed":[57],"comparative":[58],"studies":[59],"of":[60,82,90,134,185],"performance":[62,109],"are":[63],"not":[64],"available.":[65],"In":[66],"this":[67],"study,":[68],"we":[69],"constructed":[70],"60":[71],"WGBS":[72],"RRBS":[74,173],"libraries":[75],"two":[77],"platforms":[78,165],"using":[79],"different":[80],"types":[81],"clinical":[83],"samples":[84],"generated":[86],"approximately":[87],"2.8":[88],"terabases":[89],"data.":[92],"We":[93],"systematically":[94],"compared":[95],"quality":[96,129],"control":[97],"metrics,":[98],"genomic":[99],"coverage,":[100],"CpG":[101],"levels,":[103],"intra-":[104,168],"interplatform":[106,170],"correlations,":[107],"detecting":[111],"differentially":[112],"methylated":[113,161],"positions.":[114],"Our":[115],"results":[116],"revealed":[117],"that":[118],"DNBSEQ":[120,138],"platform":[121,139,156,192],"exhibited":[122],"better":[123,179],"raw":[124],"read":[125],"quality,":[126],"although":[127],"base":[128,135],"recalibration":[130],"indicated":[131],"potential":[132],"overestimation":[133],"quality.":[136],"The":[137],"also":[140],"showed":[141],"lower":[142],"depth":[144],"less":[146],"coverage":[147],"uniformity":[148],"GC-rich":[150],"regions":[151],"than":[152],"did":[153],"tended":[158],"enrich":[160],"regions.":[162],"Overall,":[163],"both":[164],"demonstrated":[166],"robust":[167],"reproducibility":[171],"WGBS,":[175,181],"performing":[178],"highlighting":[182],"importance":[184],"considering":[186],"these":[187],"factors":[188],"when":[189],"selecting":[190],"sequencing.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6}],"updated_date":"2026-04-14T08:04:32.555800","created_date":"2025-10-10T00:00:00"}
