{"id":"https://openalex.org/W4401794219","doi":"https://doi.org/10.1093/bib/bbae410","title":"TME-NET: an interpretable deep neural network for predicting pan-cancer immune checkpoint inhibitor responses","display_name":"TME-NET: an interpretable deep neural network for predicting pan-cancer immune checkpoint inhibitor responses","publication_year":2024,"publication_date":"2024-07-25","ids":{"openalex":"https://openalex.org/W4401794219","doi":"https://doi.org/10.1093/bib/bbae410","pmid":"https://pubmed.ncbi.nlm.nih.gov/39167797"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae410","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae410","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bib/bbae410","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073640578","display_name":"Xiaobao Ding","orcid":"https://orcid.org/0000-0002-5819-9150"},"institutions":[{"id":"https://openalex.org/I50760025","display_name":"Hangzhou Dianzi University","ror":"https://ror.org/0576gt767","country_code":"CN","type":"education","lineage":["https://openalex.org/I50760025"]},{"id":"https://openalex.org/I82760581","display_name":"Taizhou University","ror":"https://ror.org/04fzhyx73","country_code":"CN","type":"education","lineage":["https://openalex.org/I82760581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaobao Ding","raw_affiliation_strings":["Institute of Big Data and Artificial Intelligence in Medicine, School of Electronics and Information Engineering, Taizhou University , Taizhou 318000, Zhejiang , China","Institute of Biomedical Engineering and Instrumentation, Hangzhou Dianzi University , Hangzhou 310018, Zhejiang , China","School of Computer Science and Technology, Hangzhou Dianzi University , Hangzhou, 310018 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Big Data and Artificial Intelligence in Medicine, School of Electronics and Information Engineering, Taizhou University , Taizhou 318000, Zhejiang , China","institution_ids":["https://openalex.org/I82760581"]},{"raw_affiliation_string":"Institute of Biomedical Engineering and Instrumentation, Hangzhou Dianzi University , Hangzhou 310018, Zhejiang , China","institution_ids":["https://openalex.org/I50760025"]},{"raw_affiliation_string":"School of Computer Science and Technology, Hangzhou Dianzi University , Hangzhou, 310018 , China","institution_ids":["https://openalex.org/I50760025"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lin Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I50760025","display_name":"Hangzhou Dianzi University","ror":"https://ror.org/0576gt767","country_code":"CN","type":"education","lineage":["https://openalex.org/I50760025"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Zhang","raw_affiliation_strings":["Institute of Biomedical Engineering and Instrumentation, Hangzhou Dianzi University , Hangzhou 310018, Zhejiang , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering and Instrumentation, Hangzhou Dianzi University , Hangzhou 310018, Zhejiang , China","institution_ids":["https://openalex.org/I50760025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006907190","display_name":"Ming Fan","orcid":"https://orcid.org/0000-0002-5626-7076"},"institutions":[{"id":"https://openalex.org/I50760025","display_name":"Hangzhou Dianzi University","ror":"https://ror.org/0576gt767","country_code":"CN","type":"education","lineage":["https://openalex.org/I50760025"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Fan","raw_affiliation_strings":["Institute of Biomedical Engineering and Instrumentation, Hangzhou Dianzi University , Hangzhou 310018, Zhejiang , China"],"raw_orcid":"https://orcid.org/0000-0002-5626-7076","affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering and Instrumentation, Hangzhou Dianzi University , Hangzhou 310018, Zhejiang , China","institution_ids":["https://openalex.org/I50760025"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100440653","display_name":"Lihua Li","orcid":"https://orcid.org/0000-0003-0435-6453"},"institutions":[{"id":"https://openalex.org/I50760025","display_name":"Hangzhou Dianzi University","ror":"https://ror.org/0576gt767","country_code":"CN","type":"education","lineage":["https://openalex.org/I50760025"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lihua Li","raw_affiliation_strings":["Institute of Biomedical Engineering and Instrumentation, Hangzhou Dianzi University , Hangzhou 310018, Zhejiang , China","School of Computer Science and Technology, Hangzhou Dianzi University , Hangzhou, 310018 , China"],"raw_orcid":"https://orcid.org/0000-0003-0435-6453","affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering and Instrumentation, Hangzhou Dianzi University , Hangzhou 310018, Zhejiang , China","institution_ids":["https://openalex.org/I50760025"]},{"raw_affiliation_string":"School of Computer Science and Technology, Hangzhou Dianzi University , Hangzhou, 310018 , China","institution_ids":["https://openalex.org/I50760025"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":1.5956,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.85947397,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"25","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"Tumor microenvironment","score":0.7249450087547302},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.7134506702423096},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6455490589141846},{"id":"https://openalex.org/keywords/cd8","display_name":"CD8","score":0.4724723994731903},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.46892601251602173},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"Cancer immunotherapy","score":0.4552241563796997},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.44677236676216125},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.43043118715286255},{"id":"https://openalex.org/keywords/cytokine","display_name":"Cytokine","score":0.4188380539417267},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.36871710419654846},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3601085841655731},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3575340211391449},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.13203993439674377}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.7249450087547302},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7134506702423096},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6455490589141846},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4724723994731903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46892601251602173},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4552241563796997},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44677236676216125},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43043118715286255},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4188380539417267},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36871710419654846},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3601085841655731},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3575340211391449},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13203993439674377}],"mesh":[{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae410","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae410","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39167797","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39167797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11337220","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11337220","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11337220/pdf/bbae410.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae410","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae410","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.75,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1486555642","display_name":"\u80bf\u7624\u667a\u80fd\u89e3\u6790\u65b9\u6cd5\u4e0e\u7cbe\u51c6\u8bca\u7597\u7814\u7a76","funder_award_id":"LR23F010002","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G3557113049","display_name":null,"funder_award_id":"62271178","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7310643791","display_name":null,"funder_award_id":"U21A20521","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W1016059894","https://openalex.org/W1701068833","https://openalex.org/W1965765543","https://openalex.org/W2066671159","https://openalex.org/W2097455931","https://openalex.org/W2107429737","https://openalex.org/W2125818553","https://openalex.org/W2133536768","https://openalex.org/W2299181842","https://openalex.org/W2371138393","https://openalex.org/W2559804019","https://openalex.org/W2560367415","https://openalex.org/W2761575992","https://openalex.org/W2767533179","https://openalex.org/W2782183686","https://openalex.org/W2788142646","https://openalex.org/W2790179710","https://openalex.org/W2792468812","https://openalex.org/W2801270371","https://openalex.org/W2807014116","https://openalex.org/W2884397450","https://openalex.org/W2902292985","https://openalex.org/W2904997892","https://openalex.org/W2909679049","https://openalex.org/W2911752971","https://openalex.org/W2912137016","https://openalex.org/W2914335731","https://openalex.org/W2924122631","https://openalex.org/W2946663348","https://openalex.org/W2947554843","https://openalex.org/W2952391626","https://openalex.org/W2953813865","https://openalex.org/W2972212968","https://openalex.org/W2972751199","https://openalex.org/W2991341799","https://openalex.org/W2997831639","https://openalex.org/W3005490880","https://openalex.org/W3047026699","https://openalex.org/W3080758793","https://openalex.org/W3082479617","https://openalex.org/W3090386083","https://openalex.org/W3094540299","https://openalex.org/W3097803258","https://openalex.org/W3098118704","https://openalex.org/W3098592536","https://openalex.org/W3103119004","https://openalex.org/W3127051356","https://openalex.org/W3129646946","https://openalex.org/W3142565858","https://openalex.org/W3158086066","https://openalex.org/W3158147753","https://openalex.org/W3160367062","https://openalex.org/W3173369353","https://openalex.org/W3199585733","https://openalex.org/W3199772305","https://openalex.org/W3202748948","https://openalex.org/W3217192868","https://openalex.org/W4206010710","https://openalex.org/W4210676581","https://openalex.org/W4210697819","https://openalex.org/W4214818790","https://openalex.org/W4224909340","https://openalex.org/W4226335431","https://openalex.org/W4283592141","https://openalex.org/W4283662269","https://openalex.org/W4307432965","https://openalex.org/W4307969384","https://openalex.org/W4309506674","https://openalex.org/W4312179017","https://openalex.org/W4318923050","https://openalex.org/W4323036511","https://openalex.org/W4381149624","https://openalex.org/W4384523448","https://openalex.org/W4389037407","https://openalex.org/W4390582690","https://openalex.org/W4393278268","https://openalex.org/W6762947200","https://openalex.org/W6854423859"],"related_works":["https://openalex.org/W4200022043","https://openalex.org/W2112727616","https://openalex.org/W2884525857","https://openalex.org/W4322720888","https://openalex.org/W4296613612","https://openalex.org/W3111580887","https://openalex.org/W3193904228","https://openalex.org/W4292999066","https://openalex.org/W3185708072","https://openalex.org/W2902626376"],"abstract_inverted_index":{"Immunotherapy":[0],"with":[1,111,232],"immune":[2,56,155,215],"checkpoint":[3],"inhibitors":[4],"(ICIs)":[5],"is":[6],"increasingly":[7],"used":[8,32,86],"to":[9,17,33,73,76,87],"treat":[10],"various":[11],"tumor":[12,28],"types.":[13],"Determining":[14],"patient":[15,35],"responses":[16,75,216,243],"ICIs":[18],"presents":[19],"a":[20,46,66,101],"significant":[21],"clinical":[22],"challenge.":[23],"Although":[24],"components":[25],"of":[26,39,91,104,142,175,229],"the":[27,40,49,89,114,149,173,179,182,199,218,226,249],"microenvironment":[29],"(TME)":[30],"are":[31,42,211],"predict":[34,74],"outcomes,":[36],"comprehensive":[37],"assessments":[38],"TME":[41,50,92,196],"frequently":[43],"overlooked.":[44],"Using":[45,63],"top-down":[47],"approach,":[48],"was":[51,71,96],"divided":[52],"into":[53,248],"five":[54],"layers-outcome,":[55],"role,":[57],"cell,":[58],"cellular":[59,150],"component,":[60],"and":[61,81,98,117,134,139,161,189,206,244],"gene.":[62],"this":[64],"structure,":[65],"neural":[67],"network":[68],"called":[69],"TME-NET":[70,125,237],"developed":[72,97],"ICIs.":[77],"Model":[78],"parameter":[79,144],"weights":[80,145],"cell":[82],"ablation":[83,169],"studies":[84,170],"were":[85],"investigate":[88],"influence":[90],"components.":[93],"The":[94],"model":[95,143],"evaluated":[99],"using":[100],"pan-cancer":[102],"cohort":[103],"948":[105],"patients":[106],"across":[107],"four":[108],"cancer":[109],"types,":[110],"Area":[112],"Under":[113],"Curve":[115],"(AUC)":[116],"accuracy":[118],"as":[119,130],"performance":[120],"metrics.":[121],"Results":[122],"show":[123,164],"that":[124,147],"surpasses":[126],"established":[127],"models":[128],"such":[129],"support":[131],"vector":[132],"machine":[133],"k-nearest":[135],"neighbors":[136],"in":[137,186,191,240],"AUC":[138],"accuracy.":[140],"Visualization":[141],"showed":[146],"at":[148,256],"layer,":[151,181],"Th1":[152,187,204],"cells":[153,160,188,205],"enhance":[154],"responses,":[156],"whereas":[157],"myeloid-derived":[158],"suppressor":[159],"M2":[162,192,209],"macrophages":[163,193,210],"strong":[165],"immunosuppressive":[166],"effects.":[167],"Cell":[168],"further":[171],"confirmed":[172,225],"impact":[174],"these":[176,230],"cells.":[177],"At":[178],"gene":[180],"transcription":[183],"factors":[184],"STAT4":[185],"IRF4":[190],"significantly":[194],"affect":[195],"dynamics.":[197],"Additionally,":[198],"cytokine-encoding":[200],"genes":[201],"IFNG":[202],"from":[203,208,222],"ARG1":[207],"crucial":[212],"for":[213],"modulating":[214],"within":[217],"TME.":[219],"Survival":[220],"data":[221],"immunotherapy":[223,242,250],"cohorts":[224],"prognostic":[227],"ability":[228],"markers,":[231],"p-values":[233],"<0.01.":[234],"In":[235],"summary,":[236],"performs":[238],"well":[239],"predicting":[241],"offers":[245],"interpretable":[246],"insights":[247],"process.":[251],"It":[252],"can":[253],"be":[254],"customized":[255],"https://immbal.shinyapps.io/TME-NET.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3}],"updated_date":"2026-07-13T07:31:44.756512","created_date":"2025-10-10T00:00:00"}