{"id":"https://openalex.org/W4401157897","doi":"https://doi.org/10.1093/bib/bbae365","title":"GloEC: a hierarchical-aware global model for predicting enzyme function","display_name":"GloEC: a hierarchical-aware global model for predicting enzyme function","publication_year":2024,"publication_date":"2024-07-25","ids":{"openalex":"https://openalex.org/W4401157897","doi":"https://doi.org/10.1093/bib/bbae365","pmid":"https://pubmed.ncbi.nlm.nih.gov/39073830"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae365","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae365","pdf_url":"https://academic.oup.com/bib/article-pdf/25/5/bbae365/58677145/bbae365.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/5/bbae365/58677145/bbae365.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059183788","display_name":"Huang Yi-ran","orcid":"https://orcid.org/0000-0001-6289-8766"},"institutions":[{"id":"https://openalex.org/I150807315","display_name":"Guangxi University","ror":"https://ror.org/02c9qn167","country_code":"CN","type":"education","lineage":["https://openalex.org/I150807315"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiran Huang","raw_affiliation_strings":["Guangxi University Guangxi Key Laboratory of Multimedia Communications and Network Technology, , Nanning 530004, China","Guangxi University Key Laboratory of Parallel, Distributed and Intelligent Computing in Guangxi Universities and Colleges, , Nanning 530004, China","Guangxi University School of Computer, Electronics and Information, , Nanning 530004, China"],"affiliations":[{"raw_affiliation_string":"Guangxi University Guangxi Key Laboratory of Multimedia Communications and Network Technology, , Nanning 530004, China","institution_ids":["https://openalex.org/I150807315"]},{"raw_affiliation_string":"Guangxi University Key Laboratory of Parallel, Distributed and Intelligent Computing in Guangxi Universities and Colleges, , Nanning 530004, China","institution_ids":["https://openalex.org/I150807315"]},{"raw_affiliation_string":"Guangxi University School of Computer, Electronics and Information, , Nanning 530004, China","institution_ids":["https://openalex.org/I150807315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100384377","display_name":"Y. Lin","orcid":"https://orcid.org/0000-0002-3341-8396"},"institutions":[{"id":"https://openalex.org/I150807315","display_name":"Guangxi University","ror":"https://ror.org/02c9qn167","country_code":"CN","type":"education","lineage":["https://openalex.org/I150807315"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yufu Lin","raw_affiliation_strings":["Guangxi University School of Computer, Electronics and Information, , Nanning 530004, China"],"affiliations":[{"raw_affiliation_string":"Guangxi University School of Computer, Electronics and Information, , Nanning 530004, China","institution_ids":["https://openalex.org/I150807315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041285376","display_name":"Wei Lan","orcid":"https://orcid.org/0000-0001-5839-7504"},"institutions":[{"id":"https://openalex.org/I150807315","display_name":"Guangxi University","ror":"https://ror.org/02c9qn167","country_code":"CN","type":"education","lineage":["https://openalex.org/I150807315"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Lan","raw_affiliation_strings":["Guangxi University Guangxi Key Laboratory of Multimedia Communications and Network Technology, , Nanning 530004, China","Guangxi University Key Laboratory of Parallel, Distributed and Intelligent Computing in Guangxi Universities and Colleges, , Nanning 530004, China","Guangxi University School of Computer, Electronics and Information, , Nanning 530004, China"],"affiliations":[{"raw_affiliation_string":"Guangxi University Guangxi Key Laboratory of Multimedia Communications and Network Technology, , Nanning 530004, China","institution_ids":["https://openalex.org/I150807315"]},{"raw_affiliation_string":"Guangxi University Key Laboratory of Parallel, Distributed and Intelligent Computing in Guangxi Universities and Colleges, , Nanning 530004, China","institution_ids":["https://openalex.org/I150807315"]},{"raw_affiliation_string":"Guangxi University School of Computer, Electronics and Information, , Nanning 530004, China","institution_ids":["https://openalex.org/I150807315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109537668","display_name":"Cuiyu Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cuiyu Huang","raw_affiliation_strings":["Nankai University College of Chemistry, Tianjin Key Laboratory of Biosensing and Molecular Recognition, , Tianjin 300071, China"],"affiliations":[{"raw_affiliation_string":"Nankai University College of Chemistry, Tianjin Key Laboratory of Biosensing and Molecular Recognition, , Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101747550","display_name":"Cheng Zhong","orcid":"https://orcid.org/0000-0002-5560-2151"},"institutions":[{"id":"https://openalex.org/I150807315","display_name":"Guangxi University","ror":"https://ror.org/02c9qn167","country_code":"CN","type":"education","lineage":["https://openalex.org/I150807315"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cheng Zhong","raw_affiliation_strings":["Guangxi University Guangxi Key Laboratory of Multimedia Communications and Network Technology, , Nanning 530004, China","Guangxi University Key Laboratory of Parallel, Distributed and Intelligent Computing in Guangxi Universities and Colleges, , Nanning 530004, China","Guangxi University School of Computer, Electronics and Information, , Nanning 530004, China"],"affiliations":[{"raw_affiliation_string":"Guangxi University Guangxi Key Laboratory of Multimedia Communications and Network Technology, , Nanning 530004, China","institution_ids":["https://openalex.org/I150807315"]},{"raw_affiliation_string":"Guangxi University Key Laboratory of Parallel, Distributed and Intelligent Computing in Guangxi Universities and Colleges, , Nanning 530004, China","institution_ids":["https://openalex.org/I150807315"]},{"raw_affiliation_string":"Guangxi University School of Computer, Electronics and Information, , Nanning 530004, China","institution_ids":["https://openalex.org/I150807315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101747550","https://openalex.org/A5109537668"],"corresponding_institution_ids":["https://openalex.org/I150807315","https://openalex.org/I205237279"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":2.3783,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.8895574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"25","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7283443212509155},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5762332081794739},{"id":"https://openalex.org/keywords/hierarchy","display_name":"Hierarchy","score":0.5093954205513},{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.4994170665740967},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4937675893306732},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.4546298682689667},{"id":"https://openalex.org/keywords/encoder","display_name":"Encoder","score":0.4507678151130676},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.39259445667266846},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3461742401123047},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.33281588554382324},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.3061462640762329},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1290721893310547}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7283443212509155},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5762332081794739},{"id":"https://openalex.org/C31170391","wikidata":"https://www.wikidata.org/wiki/Q188619","display_name":"Hierarchy","level":2,"score":0.5093954205513},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.4994170665740967},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4937675893306732},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.4546298682689667},{"id":"https://openalex.org/C118505674","wikidata":"https://www.wikidata.org/wiki/Q42586063","display_name":"Encoder","level":2,"score":0.4507678151130676},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.39259445667266846},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3461742401123047},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.33281588554382324},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.3061462640762329},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1290721893310547},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C34447519","wikidata":"https://www.wikidata.org/wiki/Q179522","display_name":"Market economy","level":1,"score":0.0},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae365","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae365","pdf_url":"https://academic.oup.com/bib/article-pdf/25/5/bbae365/58677145/bbae365.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39073830","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39073830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11285194","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11285194","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11285194/pdf/bbae365.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae365","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae365","pdf_url":"https://academic.oup.com/bib/article-pdf/25/5/bbae365/58677145/bbae365.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure","score":0.5199999809265137}],"awards":[{"id":"https://openalex.org/G1251459292","display_name":null,"funder_award_id":"2020GXNSFAA159074","funder_id":"https://openalex.org/F4320313613","funder_display_name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region"},{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6058138561","display_name":null,"funder_award_id":", No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6754550571","display_name":null,"funder_award_id":"2020GXNSFAA159074","funder_id":"https://openalex.org/F4320322768","funder_display_name":"Natural Science Foundation of Guangxi Province"},{"id":"https://openalex.org/G7051453684","display_name":null,"funder_award_id":"2020GXNSFAA15907","funder_id":"https://openalex.org/F4320322768","funder_display_name":"Natural Science Foundation of Guangxi Province"},{"id":"https://openalex.org/G7386990451","display_name":null,"funder_award_id":"62362004","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7614210686","display_name":null,"funder_award_id":"2020GXNSFAA159074","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8262811428","display_name":null,"funder_award_id":"61862006","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320313613","display_name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322768","display_name":"Natural Science Foundation of Guangxi Province","ror":null},{"id":"https://openalex.org/F4320327522","display_name":"Guangxi University","ror":"https://ror.org/02c9qn167"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401157897.pdf","grobid_xml":"https://content.openalex.org/works/W4401157897.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1532305329","https://openalex.org/W2003144438","https://openalex.org/W2048322438","https://openalex.org/W2094196435","https://openalex.org/W2095705004","https://openalex.org/W2102461176","https://openalex.org/W2104812418","https://openalex.org/W2123347941","https://openalex.org/W2132083787","https://openalex.org/W2138290126","https://openalex.org/W2141652419","https://openalex.org/W2148853951","https://openalex.org/W2165446840","https://openalex.org/W2170747616","https://openalex.org/W2178043251","https://openalex.org/W2255466643","https://openalex.org/W2341861303","https://openalex.org/W2611792444","https://openalex.org/W2766352633","https://openalex.org/W2886476927","https://openalex.org/W2895484279","https://openalex.org/W2953321375","https://openalex.org/W2963775347","https://openalex.org/W2964015378","https://openalex.org/W2982425557","https://openalex.org/W2990045899","https://openalex.org/W2999481648","https://openalex.org/W3021030593","https://openalex.org/W3028039738","https://openalex.org/W3035690777","https://openalex.org/W3082755785","https://openalex.org/W3136918052","https://openalex.org/W3146944767","https://openalex.org/W3155413507","https://openalex.org/W3193965968","https://openalex.org/W3201686389","https://openalex.org/W3217216416","https://openalex.org/W4213149192","https://openalex.org/W4220831705","https://openalex.org/W4221074414","https://openalex.org/W4225487082","https://openalex.org/W4313555682","https://openalex.org/W4322494707","https://openalex.org/W4362471278","https://openalex.org/W4379985215","https://openalex.org/W4385245566","https://openalex.org/W4391100226","https://openalex.org/W4391338829","https://openalex.org/W6674330103","https://openalex.org/W6726873649","https://openalex.org/W6739901393","https://openalex.org/W6748768290","https://openalex.org/W6770844057","https://openalex.org/W6810149945","https://openalex.org/W6810204632"],"related_works":["https://openalex.org/W2378211422","https://openalex.org/W2745001401","https://openalex.org/W4321353415","https://openalex.org/W2130974462","https://openalex.org/W2028665553","https://openalex.org/W2086519370","https://openalex.org/W972276598","https://openalex.org/W2087343574","https://openalex.org/W4246352526","https://openalex.org/W2121910908"],"abstract_inverted_index":{"The":[0,190],"annotation":[1],"of":[2,43,63,73,132,199,204],"enzyme":[3,22,26,44,64,74,79,92,97,102,116,121,134,138,152,168],"function":[4,23,169,203],"is":[5,144,197,207],"a":[6,47,77,83],"fundamental":[7],"challenge":[8],"in":[9,38,46,156,167],"industrial":[10],"biotechnology":[11],"and":[12,81,128,159],"pathologies.":[13],"Numerous":[14],"computational":[15],"methods":[16,35],"have":[17],"been":[18,165],"proposed":[19],"to":[20,55,89,114,136,146,149,186],"predict":[21,115,137],"by":[24],"annotating":[25],"labels":[27],"with":[28],"Enzyme":[29],"Commission":[30],"number.":[31],"However,":[32],"the":[33,40,57,71,96,101,125,151,187,202],"existing":[34,188],"face":[36],"difficulties":[37],"modelling":[39],"hierarchical":[41],"structure":[42],"label":[45,75,93,122,153],"global":[48,110],"view.":[49],"Moreover,":[50],"they":[51],"haven't":[52],"gone":[53],"entirely":[54],"leverage":[56],"mutual":[58],"interactions":[59],"between":[60],"different":[61],"levels":[62],"label.":[65],"In":[66],"this":[67],"paper,":[68],"we":[69,105],"formulate":[70],"hierarchy":[72,103],"as":[76,184],"directed":[78],"graph":[80],"propose":[82],"hierarchy-GCN":[84,126,142],"(Graph":[85],"Convolutional":[86],"Network)":[87],"encoder":[88,127,143],"globally":[90],"model":[91,111],"dependency":[94],"on":[95,100,173],"graph.":[98],"Based":[99],"encoder,":[104],"develop":[106],"an":[107],"end-to-end":[108],"hierarchical-aware":[109,120],"named":[112],"GloEC":[113,118,179,196,206],"function.":[117],"learns":[119],"embeddings":[123],"via":[124],"conducts":[129],"deductive":[130],"fusion":[131],"label-aware":[133],"features":[135],"labels.":[139],"Meanwhile,":[140],"our":[141],"designed":[145],"bidirectionally":[147],"compute":[148],"investigate":[150],"correlation":[154],"information":[155],"both":[157],"bottom-up":[158],"top-down":[160],"manners,":[161],"which":[162],"has":[163],"not":[164],"explored":[166],"prediction.":[170],"Comparative":[171],"experiments":[172],"three":[174],"benchmark":[175],"datasets":[176],"show":[177],"that":[178,195],"achieves":[180],"better":[181],"predictive":[182],"performance":[183],"compared":[185],"methods.":[189],"case":[191],"studies":[192],"also":[193],"demonstrate":[194],"capable":[198],"effectively":[200],"predicting":[201],"isoenzyme.":[205],"available":[208],"at:":[209],"https://github.com/hyr0771/GloEC.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":1}],"updated_date":"2026-03-22T08:09:32.410652","created_date":"2025-10-10T00:00:00"}