{"id":"https://openalex.org/W4400932431","doi":"https://doi.org/10.1093/bib/bbae337","title":"MiRAGE: mining relationships for advanced generative evaluation in drug repositioning","display_name":"MiRAGE: mining relationships for advanced generative evaluation in drug repositioning","publication_year":2024,"publication_date":"2024-05-23","ids":{"openalex":"https://openalex.org/W4400932431","doi":"https://doi.org/10.1093/bib/bbae337","pmid":"https://pubmed.ncbi.nlm.nih.gov/39038932"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae337","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae337","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae337/58609683/bbae337.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae337/58609683/bbae337.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105002308","display_name":"Aria Hassanali Aragh","orcid":null},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Aria Hassanali Aragh","raw_affiliation_strings":["Department of Computer and Data Sciences, Faculty of Mathematical Sciences, Shahid Beheshti University , Daneshjou Blvd, District 1, Tehran 1983969411 , Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer and Data Sciences, Faculty of Mathematical Sciences, Shahid Beheshti University , Daneshjou Blvd, District 1, Tehran 1983969411 , Iran","institution_ids":["https://openalex.org/I48379061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105002309","display_name":"Pegah Givehchian","orcid":null},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Pegah Givehchian","raw_affiliation_strings":["Department of Computer and Data Sciences, Faculty of Mathematical Sciences, Shahid Beheshti University , Daneshjou Blvd, District 1, Tehran 1983969411 , Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer and Data Sciences, Faculty of Mathematical Sciences, Shahid Beheshti University , Daneshjou Blvd, District 1, Tehran 1983969411 , Iran","institution_ids":["https://openalex.org/I48379061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105002310","display_name":"Razieh Moslemi Amirani","orcid":null},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Razieh Moslemi Amirani","raw_affiliation_strings":["Department of Computer and Data Sciences, Faculty of Mathematical Sciences, Shahid Beheshti University , Daneshjou Blvd, District 1, Tehran 1983969411 , Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer and Data Sciences, Faculty of Mathematical Sciences, Shahid Beheshti University , Daneshjou Blvd, District 1, Tehran 1983969411 , Iran","institution_ids":["https://openalex.org/I48379061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071242383","display_name":"Raziyeh Masumshah","orcid":"https://orcid.org/0000-0001-8166-3815"},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Raziyeh Masumshah","raw_affiliation_strings":["Department of Computer and Data Sciences, Faculty of Mathematical Sciences, Shahid Beheshti University , Daneshjou Blvd, District 1, Tehran 1983969411 , Iran"],"raw_orcid":"https://orcid.org/0000-0001-8166-3815","affiliations":[{"raw_affiliation_string":"Department of Computer and Data Sciences, Faculty of Mathematical Sciences, Shahid Beheshti University , Daneshjou Blvd, District 1, Tehran 1983969411 , Iran","institution_ids":["https://openalex.org/I48379061"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035605233","display_name":"Changiz Eslahchi","orcid":"https://orcid.org/0000-0002-8913-3904"},"institutions":[{"id":"https://openalex.org/I4210146419","display_name":"Institute for Research in Fundamental Sciences","ror":"https://ror.org/04xreqs31","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4210146419"]},{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Changiz Eslahchi","raw_affiliation_strings":["Department of Computer and Data Sciences, Faculty of Mathematical Sciences, Shahid Beheshti University , Daneshjou Blvd, District 1, Tehran 1983969411 , Iran","School of Biological Sciences, Institute for Research in Fundamental Sciences (IPM) , Farmanieh Ave, Tajrish, District 1, Tehran 193955746 , Iran"],"raw_orcid":"https://orcid.org/0000-0002-8913-3904","affiliations":[{"raw_affiliation_string":"Department of Computer and Data Sciences, Faculty of Mathematical Sciences, Shahid Beheshti University , Daneshjou Blvd, District 1, Tehran 1983969411 , Iran","institution_ids":["https://openalex.org/I48379061"]},{"raw_affiliation_string":"School of Biological Sciences, Institute for Research in Fundamental Sciences (IPM) , Farmanieh Ave, Tajrish, District 1, Tehran 193955746 , Iran","institution_ids":["https://openalex.org/I4210146419"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5105002308"],"corresponding_institution_ids":["https://openalex.org/I48379061"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":2.7711,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.91380984,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"25","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5029000043869019,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5029000043869019,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.1476999968290329,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.12680000066757202,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.763877272605896},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.756150484085083},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5847052335739136},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.5832647681236267},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5584925413131714},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5357178449630737},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.522296667098999},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.4983236789703369},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.42056357860565186},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.37130337953567505},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.198449045419693},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14977943897247314},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.09872943162918091}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.763877272605896},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.756150484085083},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5847052335739136},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.5832647681236267},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5584925413131714},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5357178449630737},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.522296667098999},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.4983236789703369},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.42056357860565186},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.37130337953567505},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.198449045419693},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14977943897247314},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.09872943162918091},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae337","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae337","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae337/58609683/bbae337.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39038932","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39038932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11262809","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11262809","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11262809/pdf/bbae337.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae337","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae337","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae337/58609683/bbae337.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4400932431.pdf"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W78516665","https://openalex.org/W1737223868","https://openalex.org/W1887652119","https://openalex.org/W1968217711","https://openalex.org/W1971387816","https://openalex.org/W1989629861","https://openalex.org/W1990112028","https://openalex.org/W1998898494","https://openalex.org/W2005302698","https://openalex.org/W2021936091","https://openalex.org/W2044491952","https://openalex.org/W2050078980","https://openalex.org/W2096240671","https://openalex.org/W2099646268","https://openalex.org/W2100929382","https://openalex.org/W2113072832","https://openalex.org/W2151357092","https://openalex.org/W2244209634","https://openalex.org/W2346950316","https://openalex.org/W2765950793","https://openalex.org/W2809156537","https://openalex.org/W2946099214","https://openalex.org/W2947133167","https://openalex.org/W3006508031","https://openalex.org/W3006521920","https://openalex.org/W3010110722","https://openalex.org/W3044334750","https://openalex.org/W3116650048","https://openalex.org/W3184519053","https://openalex.org/W3192134500","https://openalex.org/W4200110750","https://openalex.org/W4200140951","https://openalex.org/W4206547282","https://openalex.org/W4206923665","https://openalex.org/W4296777868","https://openalex.org/W4386148351","https://openalex.org/W4390331481","https://openalex.org/W4392450098","https://openalex.org/W6603214295","https://openalex.org/W6661268634","https://openalex.org/W6675007597","https://openalex.org/W6780812358","https://openalex.org/W6856019716","https://openalex.org/W6862315871"],"related_works":["https://openalex.org/W2378211422","https://openalex.org/W2399140686","https://openalex.org/W3010058077","https://openalex.org/W2920569584","https://openalex.org/W1980001478","https://openalex.org/W2951512731","https://openalex.org/W3166711969","https://openalex.org/W4400243266","https://openalex.org/W2046431380","https://openalex.org/W4392354878"],"abstract_inverted_index":{"MOTIVATION:":[0],"Drug":[1],"repositioning,":[2,197],"the":[3,33,58,66,72,84],"identification":[4],"of":[5,60,68],"new":[6,50,69],"therapeutic":[7,202],"uses":[8],"for":[9,14,48,88,110,195,201],"existing":[10],"drugs,":[11],"is":[12],"crucial":[13],"accelerating":[15],"drug":[16,111,196],"discovery":[17,67],"and":[18,38,130,169,189,204],"reducing":[19],"development":[20],"costs.":[21],"Some":[22],"methods":[23,158],"rely":[24],"on":[25,93,134,140,166],"heterogeneous":[26],"networks,":[27],"which":[28],"may":[29],"not":[30],"fully":[31],"capture":[32],"complex":[34],"relationships":[35],"between":[36],"drugs":[37,87,178],"diseases.":[39],"However,":[40,71],"integrating":[41,77],"diverse":[42],"biological":[43,79],"data":[44,80],"sources":[45,81],"offers":[46],"promise":[47],"discovering":[49],"drug-disease":[51,94],"associations":[52],"(DDAs).":[53],"Previous":[54],"evidence":[55],"indicates":[56],"that":[57],"combination":[59],"information":[61],"would":[62],"be":[63],"conducive":[64],"to":[65,82,100,174],"DDAs.":[70,162],"challenge":[73],"lies":[74],"in":[75,159],"effectively":[76],"different":[78],"identify":[83,175],"most":[85],"effective":[86],"a":[89,106,115,192],"certain":[90],"disease":[91,168],"based":[92,133],"coupled":[95],"mechanisms.":[96],"RESULTS:":[97],"In":[98],"response":[99],"this":[101],"challenge,":[102],"we":[103],"present":[104],"MiRAGE,":[105],"novel":[107,161],"computational":[108,193],"method":[109],"repositioning.":[112],"MiRAGE":[113,139,154],"leverages":[114],"three-step":[116],"framework,":[117],"comprising":[118],"negative":[119,123],"sampling":[120],"using":[121],"hard":[122],"mining,":[124],"classification":[125],"employing":[126],"random":[127],"forest":[128],"models,":[129],"feature":[131,135],"selection":[132],"importance.":[136],"We":[137],"evaluate":[138],"multiple":[141],"benchmark":[142],"datasets,":[143],"demonstrating":[144],"its":[145],"superiority":[146],"over":[147],"state-of-the-art":[148],"algorithms":[149],"across":[150],"various":[151],"metrics.":[152],"Notably,":[153],"consistently":[155],"outperforms":[156],"other":[157],"uncovering":[160],"Case":[163],"studies":[164],"focusing":[165],"Parkinson's":[167],"schizophrenia":[170],"showcase":[171],"MiRAGE's":[172,187],"ability":[173],"top":[176],"candidate":[177],"supported":[179],"by":[180],"previous":[181],"studies.":[182],"Overall,":[183],"our":[184],"study":[185],"underscores":[186],"efficacy":[188],"versatility":[190],"as":[191],"tool":[194],"offering":[198],"valuable":[199],"insights":[200],"discoveries":[203],"addressing":[205],"unmet":[206],"medical":[207],"needs.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2024-07-24T00:00:00"}
