{"id":"https://openalex.org/W4399760089","doi":"https://doi.org/10.1093/bib/bbae290","title":"FastBiCmrMLM: a fast and powerful compressed variance component mixed logistic model for big genomic case-control genome-wide association study","display_name":"FastBiCmrMLM: a fast and powerful compressed variance component mixed logistic model for big genomic case-control genome-wide association study","publication_year":2024,"publication_date":"2024-05-23","ids":{"openalex":"https://openalex.org/W4399760089","doi":"https://doi.org/10.1093/bib/bbae290","pmid":"https://pubmed.ncbi.nlm.nih.gov/38888457"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae290","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/bib/bbae290","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae290/58267785/bbae290.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae290/58267785/bbae290.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104326154","display_name":"Jing-Tian Wang","orcid":"https://orcid.org/0009-0005-4682-3445"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing-Tian Wang","raw_affiliation_strings":["Statistical Genomics at College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China","College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistical Genomics at College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002422800","display_name":"Xiaoyu Chang","orcid":"https://orcid.org/0000-0001-8361-3977"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Yu Chang","raw_affiliation_strings":["College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China","Statistical Genomics at College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Statistical Genomics at College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101537123","display_name":"Qiong Zhao","orcid":"https://orcid.org/0000-0002-6897-7972"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiong Zhao","raw_affiliation_strings":["College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China","Statistical Genomics at College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Statistical Genomics at College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114378107","display_name":"Yuan\u2010Ming Zhang","orcid":"https://orcid.org/0000-0003-2317-2190"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuan-Ming Zhang","raw_affiliation_strings":["Corresponding author. College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China"],"raw_orcid":"https://orcid.org/0000-0003-2317-2190","affiliations":[{"raw_affiliation_string":"Corresponding author. College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5114378107"],"corresponding_institution_ids":["https://openalex.org/I204823248"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":1.302,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.81281694,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"25","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"Linkage disequilibrium","score":0.6190921664237976},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.5685777068138123},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5675438642501831},{"id":"https://openalex.org/keywords/heritability","display_name":"Heritability","score":0.5371487736701965},{"id":"https://openalex.org/keywords/variance","display_name":"Variance (accounting)","score":0.49443602561950684},{"id":"https://openalex.org/keywords/sample-size-determination","display_name":"Sample size determination","score":0.47485899925231934},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.45788586139678955},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.43600282073020935},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3338255286216736},{"id":"https://openalex.org/keywords/haplotype","display_name":"Haplotype","score":0.3087556064128876},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2567673921585083},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2032185196876526},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18810352683067322},{"id":"https://openalex.org/keywords/allele","display_name":"Allele","score":0.16983866691589355},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.1635766625404358},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1327839195728302},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.1230786144733429},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11733239889144897}],"concepts":[{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.6190921664237976},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5685777068138123},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5675438642501831},{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.5371487736701965},{"id":"https://openalex.org/C196083921","wikidata":"https://www.wikidata.org/wiki/Q7915758","display_name":"Variance (accounting)","level":2,"score":0.49443602561950684},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.47485899925231934},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.45788586139678955},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.43600282073020935},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3338255286216736},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.3087556064128876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2567673921585083},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2032185196876526},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18810352683067322},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.16983866691589355},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.1635766625404358},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1327839195728302},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1230786144733429},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11733239889144897},{"id":"https://openalex.org/C121955636","wikidata":"https://www.wikidata.org/wiki/Q4116214","display_name":"Accounting","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae290","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/bib/bbae290","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae290/58267785/bbae290.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38888457","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38888457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11184901","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11184901","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11184901/pdf/bbae290.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae290","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/bib/bbae290","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae290/58267785/bbae290.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2288589777","display_name":"WTCCC2 core activities","funder_award_id":"085475","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3081004578","display_name":null,"funder_award_id":"32270673","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8687842391","display_name":"WTCCC3 core activities.","funder_award_id":"090355","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G869766580","display_name":"\u9ad8\u901a\u91cf\u6807\u8bb0\u5173\u8054\u7fa4\u4f53\u9ad8\u6548\u5feb\u901f\u68c0\u6d4b\u73af\u5883\u4e92\u4f5cQTN\u65b9\u6cd5\u5b66\u7814\u7a76\u548c\u8f6f\u4ef6\u5305\u7814\u5236","funder_award_id":"32070557","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8987205718","display_name":"The genetics of weight, BMI, adiposity and obesity","funder_award_id":"076113","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399760089.pdf"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1510439895","https://openalex.org/W1894938765","https://openalex.org/W1966077257","https://openalex.org/W1966775465","https://openalex.org/W1966825973","https://openalex.org/W1978329681","https://openalex.org/W1993849755","https://openalex.org/W1997320920","https://openalex.org/W2013866489","https://openalex.org/W2019961888","https://openalex.org/W2033151532","https://openalex.org/W2044833878","https://openalex.org/W2047714674","https://openalex.org/W2053848388","https://openalex.org/W2063627275","https://openalex.org/W2078315665","https://openalex.org/W2079927753","https://openalex.org/W2088486634","https://openalex.org/W2095796640","https://openalex.org/W2099085143","https://openalex.org/W2107438842","https://openalex.org/W2117654632","https://openalex.org/W2127684760","https://openalex.org/W2131060185","https://openalex.org/W2134036574","https://openalex.org/W2134783591","https://openalex.org/W2141916112","https://openalex.org/W2155496693","https://openalex.org/W2202191676","https://openalex.org/W2252512272","https://openalex.org/W2267834167","https://openalex.org/W2307506820","https://openalex.org/W2346769521","https://openalex.org/W2557097554","https://openalex.org/W2783657549","https://openalex.org/W2895486342","https://openalex.org/W2950099124","https://openalex.org/W2952535009","https://openalex.org/W2953380456","https://openalex.org/W2955994579","https://openalex.org/W2962931338","https://openalex.org/W2981829655","https://openalex.org/W2991212521","https://openalex.org/W3095189661","https://openalex.org/W3113283547","https://openalex.org/W3147783644","https://openalex.org/W3207405073","https://openalex.org/W3210382439","https://openalex.org/W4213284259","https://openalex.org/W4230362492","https://openalex.org/W4293258550","https://openalex.org/W4306353172","https://openalex.org/W4308616119","https://openalex.org/W4315644439","https://openalex.org/W4321434469","https://openalex.org/W4392385142","https://openalex.org/W6705129976","https://openalex.org/W7057439426"],"related_works":["https://openalex.org/W1523912222","https://openalex.org/W2594299395","https://openalex.org/W1480804049","https://openalex.org/W2066467839","https://openalex.org/W2111842731","https://openalex.org/W2170506381","https://openalex.org/W2765794416","https://openalex.org/W2039666944","https://openalex.org/W1531630856","https://openalex.org/W2924960962"],"abstract_inverted_index":{"Large":[0],"sample":[1,92],"datasets":[2],"have":[3],"been":[4],"regarded":[5],"as":[6,154,156],"the":[7,14,38,122,143,169,187,192,203,211],"primary":[8],"basis":[9],"for":[10,59,83],"innovative":[11,79],"discoveries":[12],"and":[13,32,51,62,96,129,139,158,178,209],"solution":[15],"to":[16,76,91,201],"missing":[17],"heritability":[18],"in":[19,54,131,168],"genome-wide":[20],"association":[21],"studies.":[22],"However,":[23],"their":[24],"computational":[25,74,94],"complexity":[26],"cannot":[27],"consider":[28],"all":[29,33,49],"comprehensive":[30],"effects":[31,50],"polygenic":[34,52],"backgrounds,":[35],"which":[36,112],"reduces":[37],"effectiveness":[39],"of":[40,124,165,206],"large":[41,84],"datasets.":[42],"To":[43,100],"address":[44,210],"these":[45],"challenges,":[46],"we":[47,147],"included":[48],"backgrounds":[53],"a":[55,198],"mixed":[56],"logistic":[57],"model":[58,71],"binary":[60,207],"traits":[61,208],"compressed":[63,70],"four":[64],"variance":[65],"components":[66],"into":[67],"two.":[68],"The":[69],"combined":[72],"three":[73],"algorithms":[75,88],"develop":[77],"an":[78],"method,":[80],"called":[81],"FastBiCmrMLM,":[82,116],"data":[85],"analysis.":[86],"These":[87,195],"were":[89,107],"tailored":[90],"size,":[93],"speed,":[95],"reduced":[97],"memory":[98],"requirements.":[99],"mine":[101],"additional":[102],"genes,":[103,174],"linkage":[104],"disequilibrium":[105],"markers":[106],"replaced":[108],"by":[109,115,186],"bin-based":[110],"haplotypes,":[111],"are":[113],"analyzed":[114],"named":[117],"FastBiCmrMLM-Hap.":[118],"Simulation":[119],"studies":[120],"highlighted":[121],"superiority":[123],"FastBiCmrMLM":[125,150],"over":[126],"GMMAT,":[127],"SAIGE":[128],"fastGWA-GLMM":[130],"identifying":[132],"dominant,":[133],"small":[134,155],"\u03b1":[135,160],"(allele":[136],"substitution":[137],"effect),":[138],"rare":[140],"variants.":[141],"In":[142,163],"UK":[144],"Biobank-scale":[145],"dataset,":[146],"demonstrated":[148],"that":[149],"could":[151],"detect":[152],"variants":[153,183],"0.03%":[157],"with":[159,175],"\u2248":[161],"0.":[162],"re-analyses":[164],"seven":[166],"diseases":[167],"WTCCC":[170],"datasets,":[171],"29":[172],"candidate":[173],"both":[176],"functional":[177],"TWAS":[179],"evidence,":[180],"around":[181],"36":[182],"identified":[184],"only":[185],"new":[188,193,199],"methods,":[189],"strongly":[190],"validated":[191],"methods.":[194],"methods":[196],"offer":[197],"way":[200],"decipher":[202],"genetic":[204],"architecture":[205],"challenges":[212],"outlined":[213],"above.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}