{"id":"https://openalex.org/W4398761926","doi":"https://doi.org/10.1093/bib/bbae249","title":"Mutational signatures of colorectal cancers according to distinct computational workflows","display_name":"Mutational signatures of colorectal cancers according to distinct computational workflows","publication_year":2024,"publication_date":"2024-05-23","ids":{"openalex":"https://openalex.org/W4398761926","doi":"https://doi.org/10.1093/bib/bbae249","pmid":"https://pubmed.ncbi.nlm.nih.gov/38783705"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae249","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae249","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae249/57845364/bbae249.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae249/57845364/bbae249.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007110695","display_name":"Paolo Battuello","orcid":null},"institutions":[{"id":"https://openalex.org/I4210114103","display_name":"IFOM","ror":"https://ror.org/02hcsa680","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210114103"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Battuello","raw_affiliation_strings":["Department of Oncology , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","Genomics of Cancer and Targeted Therapies Unit , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","The AIRC Institute of Molecular Oncology , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","University of Turin , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","Genomics of Cancer and Targeted Therapies Unit, IFOM ETS, The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy","Department of Oncology, Molecular Biotechnology Center, University of Turin, Piazza Nizza 44, 10126, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Genomics of Cancer and Targeted Therapies Unit , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","institution_ids":["https://openalex.org/I4210114103"]},{"raw_affiliation_string":"The AIRC Institute of Molecular Oncology , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","institution_ids":["https://openalex.org/I4210114103"]},{"raw_affiliation_string":"University of Turin , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Genomics of Cancer and Targeted Therapies Unit, IFOM ETS, The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy","institution_ids":["https://openalex.org/I4210114103"]},{"raw_affiliation_string":"Department of Oncology, Molecular Biotechnology Center, University of Turin, Piazza Nizza 44, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052141168","display_name":"Giorgio Corti","orcid":"https://orcid.org/0000-0001-6379-4117"},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Corti","raw_affiliation_strings":["Candiolo Cancer Institute , FPO - IRCCS, Strada Provinciale 142 - km 3.95, 10060, Candiolo, Turin , Italy","Department of Oncology , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","University of Turin , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","Candiolo Cancer Institute, FPO - IRCCS, Strada Provinciale 142 - km 3.95, 10060, Candiolo, Turin, Italy","Department of Oncology, Molecular Biotechnology Center, University of Turin, Piazza Nizza 44, 10126, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute , FPO - IRCCS, Strada Provinciale 142 - km 3.95, 10060, Candiolo, Turin , Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Oncology , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"University of Turin , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Candiolo Cancer Institute, FPO - IRCCS, Strada Provinciale 142 - km 3.95, 10060, Candiolo, Turin, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Oncology, Molecular Biotechnology Center, University of Turin, Piazza Nizza 44, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059864900","display_name":"Alice Bartolini","orcid":"https://orcid.org/0000-0003-3492-0772"},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alice Bartolini","raw_affiliation_strings":["Candiolo Cancer Institute , FPO - IRCCS, Strada Provinciale 142 - km 3.95, 10060, Candiolo, Turin , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute , FPO - IRCCS, Strada Provinciale 142 - km 3.95, 10060, Candiolo, Turin , Italy","institution_ids":["https://openalex.org/I4210151091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078307539","display_name":"Annalisa Lorenzato","orcid":"https://orcid.org/0000-0002-9324-2337"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annalisa Lorenzato","raw_affiliation_strings":["Department of Oncology , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","University of Turin , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","Department of Oncology, Molecular Biotechnology Center, University of Turin, Piazza Nizza 44, 10126, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"University of Turin , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Oncology, Molecular Biotechnology Center, University of Turin, Piazza Nizza 44, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044490291","display_name":"Alberto Sogari","orcid":"https://orcid.org/0000-0003-0612-6109"},"institutions":[{"id":"https://openalex.org/I4210114103","display_name":"IFOM","ror":"https://ror.org/02hcsa680","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210114103"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Sogari","raw_affiliation_strings":["Department of Oncology , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","Genomics of Cancer and Targeted Therapies Unit , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","The AIRC Institute of Molecular Oncology , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","University of Turin , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","Department of Oncology, Molecular Biotechnology Center, University of Turin, Piazza Nizza 44, 10126, Turin, Italy","Genomics of Cancer and Targeted Therapies Unit, IFOM ETS, The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Genomics of Cancer and Targeted Therapies Unit , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","institution_ids":["https://openalex.org/I4210114103"]},{"raw_affiliation_string":"The AIRC Institute of Molecular Oncology , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","institution_ids":["https://openalex.org/I4210114103"]},{"raw_affiliation_string":"University of Turin , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Oncology, Molecular Biotechnology Center, University of Turin, Piazza Nizza 44, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Genomics of Cancer and Targeted Therapies Unit, IFOM ETS, The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy","institution_ids":["https://openalex.org/I4210114103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074646422","display_name":"Mariangela Russo","orcid":"https://orcid.org/0000-0003-4625-1449"},"institutions":[{"id":"https://openalex.org/I4210114103","display_name":"IFOM","ror":"https://ror.org/02hcsa680","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210114103"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariangela Russo","raw_affiliation_strings":["Department of Oncology , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","Genomics of Cancer and Targeted Therapies Unit , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","The AIRC Institute of Molecular Oncology , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","University of Turin , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","Genomics of Cancer and Targeted Therapies Unit, IFOM ETS, The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy","Department of Oncology, Molecular Biotechnology Center, University of Turin, Piazza Nizza 44, 10126, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Genomics of Cancer and Targeted Therapies Unit , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","institution_ids":["https://openalex.org/I4210114103"]},{"raw_affiliation_string":"The AIRC Institute of Molecular Oncology , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","institution_ids":["https://openalex.org/I4210114103"]},{"raw_affiliation_string":"University of Turin , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Genomics of Cancer and Targeted Therapies Unit, IFOM ETS, The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy","institution_ids":["https://openalex.org/I4210114103"]},{"raw_affiliation_string":"Department of Oncology, Molecular Biotechnology Center, University of Turin, Piazza Nizza 44, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004556147","display_name":"Federica Di Nicolantonio","orcid":"https://orcid.org/0000-0001-9618-2010"},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Di Nicolantonio","raw_affiliation_strings":["Candiolo Cancer Institute , FPO - IRCCS, Strada Provinciale 142 - km 3.95, 10060, Candiolo, Turin , Italy","Department of Oncology , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","University of Turin , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","Department of Oncology, Molecular Biotechnology Center, University of Turin, Piazza Nizza 44, 10126, Turin, Italy","Candiolo Cancer Institute, FPO - IRCCS, Strada Provinciale 142 - km 3.95, 10060, Candiolo, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute , FPO - IRCCS, Strada Provinciale 142 - km 3.95, 10060, Candiolo, Turin , Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Oncology , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"University of Turin , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Oncology, Molecular Biotechnology Center, University of Turin, Piazza Nizza 44, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Candiolo Cancer Institute, FPO - IRCCS, Strada Provinciale 142 - km 3.95, 10060, Candiolo, Turin, Italy","institution_ids":["https://openalex.org/I4210151091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064011158","display_name":"Alberto Bardelli","orcid":"https://orcid.org/0000-0003-1647-5070"},"institutions":[{"id":"https://openalex.org/I4210114103","display_name":"IFOM","ror":"https://ror.org/02hcsa680","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210114103"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Alberto Bardelli","raw_affiliation_strings":["Department of Oncology , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","Genomics of Cancer and Targeted Therapies Unit , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","The AIRC Institute of Molecular Oncology , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","University of Turin , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","Department of Oncology, Molecular Biotechnology Center, University of Turin, Piazza Nizza 44, 10126, Turin, Italy","Genomics of Cancer and Targeted Therapies Unit, IFOM ETS, The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Genomics of Cancer and Targeted Therapies Unit , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","institution_ids":["https://openalex.org/I4210114103"]},{"raw_affiliation_string":"The AIRC Institute of Molecular Oncology , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","institution_ids":["https://openalex.org/I4210114103"]},{"raw_affiliation_string":"University of Turin , Molecular Biotechnology Center, , Piazza Nizza 44, 10126, Turin , Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Oncology, Molecular Biotechnology Center, University of Turin, Piazza Nizza 44, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Genomics of Cancer and Targeted Therapies Unit, IFOM ETS, The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy","institution_ids":["https://openalex.org/I4210114103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016649801","display_name":"Giovanni Crisafulli","orcid":"https://orcid.org/0000-0002-5511-1555"},"institutions":[{"id":"https://openalex.org/I4210114103","display_name":"IFOM","ror":"https://ror.org/02hcsa680","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210114103"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giovanni Crisafulli","raw_affiliation_strings":["Genomics of Cancer and Targeted Therapies Unit , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","The AIRC Institute of Molecular Oncology , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","Genomics of Cancer and Targeted Therapies Unit, IFOM ETS, The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5511-1555","affiliations":[{"raw_affiliation_string":"Genomics of Cancer and Targeted Therapies Unit , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","institution_ids":["https://openalex.org/I4210114103"]},{"raw_affiliation_string":"The AIRC Institute of Molecular Oncology , IFOM ETS, , Via Adamello 16, 20139, Milan , Italy","institution_ids":["https://openalex.org/I4210114103"]},{"raw_affiliation_string":"Genomics of Cancer and Targeted Therapies Unit, IFOM ETS, The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy","institution_ids":["https://openalex.org/I4210114103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5016649801","https://openalex.org/A5064011158"],"corresponding_institution_ids":["https://openalex.org/I4210114103","https://openalex.org/I55143463"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":2.8458,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.91418078,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"25","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9886999726295471,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.613103985786438},{"id":"https://openalex.org/keywords/exome","display_name":"Exome","score":0.4571085572242737},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44591665267944336},{"id":"https://openalex.org/keywords/exome-sequencing","display_name":"Exome sequencing","score":0.4220018684864044},{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.421130508184433},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.40317094326019287},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3375990390777588},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.2413088083267212},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.21718519926071167},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.08069860935211182}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.613103985786438},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.4571085572242737},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44591665267944336},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.4220018684864044},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.421130508184433},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40317094326019287},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3375990390777588},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2413088083267212},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21718519926071167},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.08069860935211182}],"mesh":[{"descriptor_ui":"D000073359","descriptor_name":"Exome Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000073359","descriptor_name":"Exome Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000073359","descriptor_name":"Exome Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000073359","descriptor_name":"Exome Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae249","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae249","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae249/57845364/bbae249.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38783705","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38783705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11116831","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11116831","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11116831/pdf/bbae249.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae249","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae249","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae249/57845364/bbae249.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"awards":[{"id":"https://openalex.org/G2000562663","display_name":null,"funder_award_id":"28922","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G2809905454","display_name":null,"funder_award_id":"GEACC18004TAB","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3970340483","display_name":null,"funder_award_id":"MFAG 2021","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G3994082246","display_name":null,"funder_award_id":"A28223","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G4228847076","display_name":"Building a reproducible single-cell experimental workflow to capture tumour cell persistence","funder_award_id":"101007937","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4474667827","display_name":null,"funder_award_id":"IG 2023","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G4975469392","display_name":"Targeting DNA repair pathways, sparking anti cancer immunity","funder_award_id":"101020342","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G5718954505","display_name":null,"funder_award_id":"A26825","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G5807909345","display_name":null,"funder_award_id":"MFAG 2021-ID 26439","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G7422434410","display_name":"Targeting DNA repair pathways, sparking anti cancer immunity","funder_award_id":"101020342","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7525003355","display_name":null,"funder_award_id":"22795","funder_id":"https://openalex.org/F4320317988","funder_display_name":"Artificial Intelligence Research Center"},{"id":"https://openalex.org/G7756906289","display_name":null,"funder_award_id":"21091","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G7938143140","display_name":null,"funder_award_id":"101007937","funder_id":"https://openalex.org/F4320317988","funder_display_name":"Artificial Intelligence Research Center"},{"id":"https://openalex.org/G8449251771","display_name":null,"funder_award_id":"22795","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"}],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320317988","display_name":"Artificial Intelligence Research Center","ror":null},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4398761926.pdf"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1973702005","https://openalex.org/W2013475854","https://openalex.org/W2037898576","https://openalex.org/W2066560754","https://openalex.org/W2103441770","https://openalex.org/W2108234281","https://openalex.org/W2129136620","https://openalex.org/W2145606954","https://openalex.org/W2152061559","https://openalex.org/W2158485828","https://openalex.org/W2276335691","https://openalex.org/W2569086487","https://openalex.org/W2596164112","https://openalex.org/W2800002600","https://openalex.org/W2892387054","https://openalex.org/W2898789672","https://openalex.org/W2919337517","https://openalex.org/W2920863623","https://openalex.org/W2922492752","https://openalex.org/W2938255062","https://openalex.org/W2954515247","https://openalex.org/W2954688009","https://openalex.org/W2965681416","https://openalex.org/W2965934400","https://openalex.org/W2973051835","https://openalex.org/W2987694236","https://openalex.org/W3004480399","https://openalex.org/W3006132030","https://openalex.org/W3008359597","https://openalex.org/W3008960140","https://openalex.org/W3110528877","https://openalex.org/W3119814152","https://openalex.org/W3138258440","https://openalex.org/W3153389700","https://openalex.org/W3162617742","https://openalex.org/W3186397855","https://openalex.org/W3187069226","https://openalex.org/W3206775306","https://openalex.org/W3209399659","https://openalex.org/W4223510971","https://openalex.org/W4225262807","https://openalex.org/W4225371212","https://openalex.org/W4226440498","https://openalex.org/W4229017525","https://openalex.org/W4229049043","https://openalex.org/W4282980285","https://openalex.org/W4288042084","https://openalex.org/W4296819410","https://openalex.org/W4298002134","https://openalex.org/W4389767336"],"related_works":["https://openalex.org/W2093932542","https://openalex.org/W2043256480","https://openalex.org/W2172231381","https://openalex.org/W1983406990","https://openalex.org/W2106924416","https://openalex.org/W2772505697","https://openalex.org/W3083501552","https://openalex.org/W2400191746","https://openalex.org/W2484239316","https://openalex.org/W3024198590"],"abstract_inverted_index":{"Tumor":[0],"mutational":[1,34,132,142,160,194,211,237],"signatures":[2,143],"have":[3],"gained":[4],"prominence":[5],"in":[6,49,105,130,214],"cancer":[7,21,55,65],"research,":[8],"yet":[9],"the":[10,28,106,111,131,151,165,168,199,230],"lack":[11],"of":[12,30,113,141,154,167,232],"standardized":[13],"methods":[14],"hinders":[15],"reproducibility":[16],"and":[17,42,70,85,96,116,146,149,180,204,208,216],"robustness.":[18],"Leveraging":[19],"colorectal":[20],"(CRC)":[22],"as":[23],"a":[24,97,138,184,225],"model,":[25],"we":[26,101,136,172],"explored":[27],"influence":[29],"computational":[31,234],"parameters":[32],"on":[33,178,236],"signature":[35,133,161,195,212],"analyses":[36],"across":[37],"230":[38],"CRC":[39,44],"cell":[40],"lines":[41],"152":[43],"patients.":[45],"Results":[46],"were":[47],"validated":[48],"three":[50],"independent":[51],"datasets:":[52],"483":[53],"endometrial":[54],"patients":[56,66],"stratified":[57],"by":[58,67,197],"mismatch":[59],"repair":[60],"(MMR)":[61],"status,":[62],"35":[63],"lung":[64],"smoking":[68],"status":[69],"12":[71],"patient-derived":[72],"organoids":[73],"(PDOs)":[74],"annotated":[75],"for":[76,158],"colibactin":[77],"exposure.":[78],"Assessing":[79],"various":[80],"bioinformatic":[81,185],"tools,":[82],"reference":[83,206],"datasets":[84,207],"input":[86],"data":[87],"sizes":[88],"including":[89],"whole":[90,93],"genome":[91],"sequencing,":[92],"exome":[94],"sequencing":[95],"pan-cancer":[98],"gene":[99],"panel,":[100],"demonstrated":[102],"significant":[103],"variability":[104,129],"results.":[107],"We":[108],"report":[109],"that":[110],"use":[112],"distinct":[114,233],"algorithms":[115],"references":[117],"led":[118],"to":[119,190,209,228],"statistically":[120],"different":[121],"results,":[122],"highlighting":[123],"how":[124],"arbitrary":[125],"choices":[126],"may":[127],"induce":[128],"contributions.":[134],"Furthermore,":[135],"found":[137],"differential":[139],"contribution":[140],"between":[144],"coding":[145,215],"intergenic":[147],"regions":[148],"defined":[150],"minimum":[152],"number":[153],"somatic":[155],"variants":[156],"required":[157],"reliable":[159],"assignment.":[162],"To":[163],"facilitate":[164],"identification":[166],"most":[169],"suitable":[170],"workflows,":[171],"developed":[173],"Comparative":[174],"Mutational":[175],"Signature":[176],"analysis":[177,196],"Coding":[179],"Extragenic":[181],"Regions":[182],"(CoMSCER),":[183],"tool":[186],"which":[187],"allows":[188],"researchers":[189],"easily":[191],"perform":[192],"comparative":[193,226],"coupling":[198],"results":[200],"from":[201],"several":[202],"tools":[203],"public":[205],"assess":[210],"contributions":[213],"non-coding":[217],"genomic":[218],"regions.":[219],"In":[220],"conclusion,":[221],"our":[222],"study":[223],"provides":[224],"framework":[227],"elucidate":[229],"impact":[231],"workflows":[235],"signatures.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3}],"updated_date":"2026-05-29T09:21:14.243279","created_date":"2025-10-10T00:00:00"}
