{"id":"https://openalex.org/W4399042313","doi":"https://doi.org/10.1093/bib/bbae243","title":"irGSEA: the integration of single-cell rank-based gene set enrichment analysis","display_name":"irGSEA: the integration of single-cell rank-based gene set enrichment analysis","publication_year":2024,"publication_date":"2024-05-23","ids":{"openalex":"https://openalex.org/W4399042313","doi":"https://doi.org/10.1093/bib/bbae243","pmid":"https://pubmed.ncbi.nlm.nih.gov/38801700"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae243","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae243","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae243/57927551/bbae243.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae243/57927551/bbae243.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048891752","display_name":"Chuiqin Fan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210152664","display_name":"Shenzhen Children's Hospital","ror":"https://ror.org/0409k5a27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152664"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuiqin Fan","raw_affiliation_strings":["Department of Hematology and Oncology, Shenzhen Children's Hospital of China Medical University , Shenzhen 518038 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Shenzhen Children's Hospital of China Medical University , Shenzhen 518038 , China","institution_ids":["https://openalex.org/I4210152664","https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103069604","display_name":"Fuyi Chen","orcid":"https://orcid.org/0000-0001-8883-5739"},"institutions":[{"id":"https://openalex.org/I4210092091","display_name":"Third Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00fb35g87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092091"]},{"id":"https://openalex.org/I4210098034","display_name":"Key Laboratory of Guangdong Province","ror":"https://ror.org/00swtqp09","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210098034"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fuyi Chen","raw_affiliation_strings":["Department of Obstetrics and Gynecology; Department of Pediatrics; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affi1iated Hospital of Guangzhou Medical University , Guangzhou 510150 , China","Department of Pediatrics","Department of Obstetrics and Gynecology","Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology","Guangdong Provincial Key Laboratory of Major Obstetric Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology; Department of Pediatrics; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affi1iated Hospital of Guangzhou Medical University , Guangzhou 510150 , China","institution_ids":["https://openalex.org/I4210092091","https://openalex.org/I92039509"]},{"raw_affiliation_string":"Department of Pediatrics","institution_ids":[]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Major Obstetric Diseases","institution_ids":["https://openalex.org/I4210098034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104314117","display_name":"Yuanguo Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I4210152664","display_name":"Shenzhen Children's Hospital","ror":"https://ror.org/0409k5a27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152664"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanguo Chen","raw_affiliation_strings":["Department of Hematology and Oncology, Shenzhen Children's Hospital of China Medical University , Shenzhen 518038 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Shenzhen Children's Hospital of China Medical University , Shenzhen 518038 , China","institution_ids":["https://openalex.org/I4210152664","https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061342997","display_name":"Liangping Huang","orcid":"https://orcid.org/0000-0002-7694-1531"},"institutions":[{"id":"https://openalex.org/I4210152664","display_name":"Shenzhen Children's Hospital","ror":"https://ror.org/0409k5a27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152664"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liangping Huang","raw_affiliation_strings":["Department of Hematology and Oncology, Shenzhen Children's Hospital of China Medical University , Shenzhen 518038 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Shenzhen Children's Hospital of China Medical University , Shenzhen 518038 , China","institution_ids":["https://openalex.org/I4210152664","https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074773172","display_name":"Manna Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210092091","display_name":"Third Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00fb35g87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092091"]},{"id":"https://openalex.org/I4210098034","display_name":"Key Laboratory of Guangdong Province","ror":"https://ror.org/00swtqp09","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210098034"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Manna Wang","raw_affiliation_strings":["Department of Obstetrics and Gynecology; Department of Pediatrics; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affi1iated Hospital of Guangzhou Medical University , Guangzhou 510150 , China","Department of Obstetrics and Gynecology","Department of Pediatrics","Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology","Guangdong Provincial Key Laboratory of Major Obstetric Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology; Department of Pediatrics; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affi1iated Hospital of Guangzhou Medical University , Guangzhou 510150 , China","institution_ids":["https://openalex.org/I4210092091","https://openalex.org/I92039509"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Major Obstetric Diseases","institution_ids":["https://openalex.org/I4210098034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100343753","display_name":"Yulin Liu","orcid":"https://orcid.org/0000-0003-0273-0296"},"institutions":[{"id":"https://openalex.org/I32574673","display_name":"Shantou University","ror":"https://ror.org/01a099706","country_code":"CN","type":"education","lineage":["https://openalex.org/I32574673"]},{"id":"https://openalex.org/I4210121200","display_name":"Second Affiliated Hospital of Shantou University Medical College","ror":"https://ror.org/035rs9v13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121200"]},{"id":"https://openalex.org/I4210152664","display_name":"Shenzhen Children's Hospital","ror":"https://ror.org/0409k5a27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152664"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yulin Liu","raw_affiliation_strings":["Department of Hematology and Oncology, Shenzhen Children's Hospital of China Medical University , Shenzhen 518038 , China","Department of Pediatrics, The Second Affiliated Hospital of Shantou University Medical College , Shantou 515041 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Shenzhen Children's Hospital of China Medical University , Shenzhen 518038 , China","institution_ids":["https://openalex.org/I4210152664","https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Pediatrics, The Second Affiliated Hospital of Shantou University Medical College , Shantou 515041 , China","institution_ids":["https://openalex.org/I4210121200","https://openalex.org/I32574673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423468","display_name":"Yu Wang","orcid":"https://orcid.org/0000-0002-8098-2491"},"institutions":[{"id":"https://openalex.org/I4210152664","display_name":"Shenzhen Children's Hospital","ror":"https://ror.org/0409k5a27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152664"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Wang","raw_affiliation_strings":["Department of Hematology and Oncology, Shenzhen Children's Hospital of China Medical University , Shenzhen 518038 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Shenzhen Children's Hospital of China Medical University , Shenzhen 518038 , China","institution_ids":["https://openalex.org/I4210152664","https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114027148","display_name":"Huijie Guo","orcid":null},"institutions":[{"id":"https://openalex.org/I4210152664","display_name":"Shenzhen Children's Hospital","ror":"https://ror.org/0409k5a27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152664"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huijie Guo","raw_affiliation_strings":["Department of Hematology and Oncology, Shenzhen Children's Hospital of China Medical University , Shenzhen 518038 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Shenzhen Children's Hospital of China Medical University , Shenzhen 518038 , China","institution_ids":["https://openalex.org/I4210152664","https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112543273","display_name":"Nanpeng Zheng","orcid":null},"institutions":[{"id":"https://openalex.org/I32574673","display_name":"Shantou University","ror":"https://ror.org/01a099706","country_code":"CN","type":"education","lineage":["https://openalex.org/I32574673"]},{"id":"https://openalex.org/I4210121200","display_name":"Second Affiliated Hospital of Shantou University Medical College","ror":"https://ror.org/035rs9v13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121200"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nanpeng Zheng","raw_affiliation_strings":["Department of Pediatrics, The Second Affiliated Hospital of Shantou University Medical College , Shantou 515041 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The Second Affiliated Hospital of Shantou University Medical College , Shantou 515041 , China","institution_ids":["https://openalex.org/I4210121200","https://openalex.org/I32574673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101651402","display_name":"Yanbing Liu","orcid":"https://orcid.org/0000-0001-9849-7948"},"institutions":[{"id":"https://openalex.org/I32574673","display_name":"Shantou University","ror":"https://ror.org/01a099706","country_code":"CN","type":"education","lineage":["https://openalex.org/I32574673"]},{"id":"https://openalex.org/I4210121200","display_name":"Second Affiliated Hospital of Shantou University Medical College","ror":"https://ror.org/035rs9v13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121200"]},{"id":"https://openalex.org/I4210152664","display_name":"Shenzhen Children's Hospital","ror":"https://ror.org/0409k5a27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152664"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanbing Liu","raw_affiliation_strings":["Department of Hematology and Oncology, Shenzhen Children's Hospital of China Medical University , Shenzhen 518038 , China","Department of Pediatrics, The Second Affiliated Hospital of Shantou University Medical College , Shantou 515041 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Shenzhen Children's Hospital of China Medical University , Shenzhen 518038 , China","institution_ids":["https://openalex.org/I4210152664","https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Pediatrics, The Second Affiliated Hospital of Shantou University Medical College , Shantou 515041 , China","institution_ids":["https://openalex.org/I4210121200","https://openalex.org/I32574673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100782947","display_name":"Hongwu Wang","orcid":"https://orcid.org/0000-0001-6401-977X"},"institutions":[{"id":"https://openalex.org/I32574673","display_name":"Shantou University","ror":"https://ror.org/01a099706","country_code":"CN","type":"education","lineage":["https://openalex.org/I32574673"]},{"id":"https://openalex.org/I4210121200","display_name":"Second Affiliated Hospital of Shantou University Medical College","ror":"https://ror.org/035rs9v13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121200"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongwu Wang","raw_affiliation_strings":["Department of Pediatrics, The Second Affiliated Hospital of Shantou University Medical College , Shantou 515041 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The Second Affiliated Hospital of Shantou University Medical College , Shantou 515041 , China","institution_ids":["https://openalex.org/I4210121200","https://openalex.org/I32574673"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101883799","display_name":"Lian Ma","orcid":"https://orcid.org/0000-0002-0736-4582"},"institutions":[{"id":"https://openalex.org/I4210092091","display_name":"Third Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00fb35g87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092091"]},{"id":"https://openalex.org/I4210098034","display_name":"Key Laboratory of Guangdong Province","ror":"https://ror.org/00swtqp09","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210098034"]},{"id":"https://openalex.org/I4210152664","display_name":"Shenzhen Children's Hospital","ror":"https://ror.org/0409k5a27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152664"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lian Ma","raw_affiliation_strings":["Department of Hematology and Oncology, Shenzhen Children's Hospital of China Medical University , Shenzhen 518038 , China","Department of Obstetrics and Gynecology; Department of Pediatrics; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affi1iated Hospital of Guangzhou Medical University , Guangzhou 510150 , China","Department of Pediatrics","Department of Obstetrics and Gynecology","Guangdong Provincial Key Laboratory of Major Obstetric Diseases","Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology"],"raw_orcid":"https://orcid.org/0000-0002-0736-4582","affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Shenzhen Children's Hospital of China Medical University , Shenzhen 518038 , China","institution_ids":["https://openalex.org/I4210152664","https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology; Department of Pediatrics; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affi1iated Hospital of Guangzhou Medical University , Guangzhou 510150 , China","institution_ids":["https://openalex.org/I4210092091","https://openalex.org/I92039509"]},{"raw_affiliation_string":"Department of Pediatrics","institution_ids":[]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Major Obstetric Diseases","institution_ids":["https://openalex.org/I4210098034"]},{"raw_affiliation_string":"Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5100782947","https://openalex.org/A5101883799"],"corresponding_institution_ids":["https://openalex.org/I32574673","https://openalex.org/I4210092091","https://openalex.org/I4210098034","https://openalex.org/I4210121200","https://openalex.org/I4210152664","https://openalex.org/I91656880","https://openalex.org/I92039509"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":26.6081,"has_fulltext":true,"cited_by_count":132,"citation_normalized_percentile":{"value":0.9983303,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"25","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7662056684494019},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.7310032844543457},{"id":"https://openalex.org/keywords/r-package","display_name":"R package","score":0.6601775288581848},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.578481912612915},{"id":"https://openalex.org/keywords/rank","display_name":"Rank (graph theory)","score":0.5576622486114502},{"id":"https://openalex.org/keywords/documentation","display_name":"Documentation","score":0.5331600904464722},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.5171800851821899},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5020284652709961},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.461392879486084},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.4364899694919586},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.37019896507263184},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.3691760301589966},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35988423228263855},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3053225874900818},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13342732191085815},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11632734537124634},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.072151780128479}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7662056684494019},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.7310032844543457},{"id":"https://openalex.org/C2984074130","wikidata":"https://www.wikidata.org/wiki/Q73539779","display_name":"R package","level":2,"score":0.6601775288581848},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.578481912612915},{"id":"https://openalex.org/C164226766","wikidata":"https://www.wikidata.org/wiki/Q7293202","display_name":"Rank (graph theory)","level":2,"score":0.5576622486114502},{"id":"https://openalex.org/C56666940","wikidata":"https://www.wikidata.org/wiki/Q788790","display_name":"Documentation","level":2,"score":0.5331600904464722},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.5171800851821899},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5020284652709961},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.461392879486084},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.4364899694919586},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.37019896507263184},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3691760301589966},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35988423228263855},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3053225874900818},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13342732191085815},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11632734537124634},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.072151780128479},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C459310","wikidata":"https://www.wikidata.org/wiki/Q117801","display_name":"Computational science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae243","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae243","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae243/57927551/bbae243.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38801700","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38801700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11129768","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11129768","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11129768/pdf/bbae243.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae243","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae243","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae243/57927551/bbae243.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":0.7300000190734863}],"awards":[{"id":"https://openalex.org/G1000693210","display_name":null,"funder_award_id":"SZSM 202011005","funder_id":"https://openalex.org/F4320335767","funder_display_name":"Sanming Project of Medicine in Shenzhen"},{"id":"https://openalex.org/G2500505339","display_name":null,"funder_award_id":"2020-53-112","funder_id":"https://openalex.org/F4320335795","funder_display_name":"Science and Technology Planning Project of Guangdong Province"},{"id":"https://openalex.org/G6491425610","display_name":null,"funder_award_id":"81070478","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322841","display_name":"Universidade de Macau","ror":"https://ror.org/01r4q9n85"},{"id":"https://openalex.org/F4320335767","display_name":"Sanming Project of Medicine in Shenzhen","ror":null},{"id":"https://openalex.org/F4320335795","display_name":"Science and Technology Planning Project of Guangdong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399042313.pdf"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1992045522","https://openalex.org/W2100980426","https://openalex.org/W2130410032","https://openalex.org/W2146511318","https://openalex.org/W2158384363","https://openalex.org/W2159707944","https://openalex.org/W2344159403","https://openalex.org/W2406250479","https://openalex.org/W2472255748","https://openalex.org/W2616922646","https://openalex.org/W2900032527","https://openalex.org/W2949093503","https://openalex.org/W2952602120","https://openalex.org/W2961304458","https://openalex.org/W2976681669","https://openalex.org/W3009737049","https://openalex.org/W3041112668","https://openalex.org/W3125797470","https://openalex.org/W3164692211","https://openalex.org/W3174072032","https://openalex.org/W4214560271","https://openalex.org/W4220673122","https://openalex.org/W4226406993","https://openalex.org/W4254687493","https://openalex.org/W4323076296","https://openalex.org/W4366977935","https://openalex.org/W4386707745","https://openalex.org/W6681508280","https://openalex.org/W6705099798","https://openalex.org/W6713834121","https://openalex.org/W6850777018","https://openalex.org/W6869013481","https://openalex.org/W6869258730","https://openalex.org/W6869701545","https://openalex.org/W6869772533","https://openalex.org/W6869879933"],"related_works":["https://openalex.org/W2068608913","https://openalex.org/W3124914020","https://openalex.org/W2141033859","https://openalex.org/W2077542787","https://openalex.org/W2156434174","https://openalex.org/W2071701083","https://openalex.org/W2383687187","https://openalex.org/W2070401501","https://openalex.org/W2121496884","https://openalex.org/W2387910809"],"abstract_inverted_index":{"irGSEA":[0,92,137],"is":[1],"an":[2],"R":[3],"package":[4,24,113,138],"designed":[5],"to":[6,18,65,99],"assess":[7],"the":[8,33,60,78,87,101],"outcomes":[9],"of":[10,36,62,82,104,119,134],"various":[11],"gene":[12,80,106],"set":[13],"scoring":[14,28,110],"methods":[15,29,47,64,98],"when":[16],"applied":[17],"single-cell":[19],"RNA":[20],"sequencing":[21],"data.":[22],"This":[23],"incorporates":[25],"six":[26,97],"distinct":[27],"that":[30],"rely":[31],"on":[32,77,145],"expression":[34,40,81,120],"ranks":[35],"genes,":[37],"emphasizing":[38],"relative":[39,79],"levels":[41],"over":[42],"absolute":[43],"values.":[44],"The":[45,112,136],"implemented":[46],"include":[48],"AUCell,":[49],"UCell,":[50],"singscore,":[51],"ssGSEA,":[52],"JASMINE":[53],"and":[54,70,139],"Viper.":[55],"Previous":[56],"studies":[57],"have":[58],"demonstrated":[59],"robustness":[61],"these":[63],"variations":[66],"in":[67],"dataset":[68],"size":[69],"composition,":[71],"generating":[72],"enrichment":[73],"scores":[74],"based":[75],"solely":[76],"individual":[83],"cells.":[84],"By":[85],"employing":[86],"robust":[88],"rank":[89],"aggregation":[90],"algorithm,":[91],"amalgamates":[93],"results":[94],"from":[95],"all":[96],"ascertain":[100],"statistical":[102],"significance":[103],"target":[105],"sets":[107],"across":[108],"diverse":[109],"methods.":[111],"prioritizes":[114],"user-friendliness,":[115],"allowing":[116],"direct":[117],"input":[118],"matrices":[121],"or":[122],"seamless":[123],"interaction":[124],"with":[125],"Seurat":[126],"objects.":[127],"Furthermore,":[128],"it":[129],"facilitates":[130],"a":[131],"comprehensive":[132],"visualization":[133],"results.":[135],"its":[140],"accompanying":[141],"documentation":[142],"are":[143],"accessible":[144],"GitHub":[146],"(https://github.com/chuiqin/irGSEA).":[147]},"counts_by_year":[{"year":2026,"cited_by_count":36},{"year":2025,"cited_by_count":81},{"year":2024,"cited_by_count":15}],"updated_date":"2026-06-18T10:00:31.954636","created_date":"2025-10-10T00:00:00"}