{"id":"https://openalex.org/W4399052950","doi":"https://doi.org/10.1093/bib/bbae242","title":"A comprehensive benchmarking of machine learning algorithms and dimensionality reduction methods for drug sensitivity prediction","display_name":"A comprehensive benchmarking of machine learning algorithms and dimensionality reduction methods for drug sensitivity prediction","publication_year":2024,"publication_date":"2024-05-23","ids":{"openalex":"https://openalex.org/W4399052950","doi":"https://doi.org/10.1093/bib/bbae242","pmid":"https://pubmed.ncbi.nlm.nih.gov/38797968"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae242","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae242","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae242/57910132/bbae242.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae242/57910132/bbae242.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032823537","display_name":"Lea Eckhart","orcid":"https://orcid.org/0000-0002-1486-3267"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Lea Eckhart","raw_affiliation_strings":["Center for Bioinformatics, Saarland Informatics Campus , Saarland University, 66123, Saarland , Germany"],"raw_orcid":"https://orcid.org/0000-0002-1486-3267","affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Saarland Informatics Campus , Saarland University, 66123, Saarland , Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087001698","display_name":"Kerstin Lenhof","orcid":"https://orcid.org/0000-0003-1311-0367"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kerstin Lenhof","raw_affiliation_strings":["Center for Bioinformatics, Saarland Informatics Campus, Saarland University , 66123, Saarland , Germany"],"raw_orcid":"https://orcid.org/0000-0003-1311-0367","affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Saarland Informatics Campus, Saarland University , 66123, Saarland , Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093272963","display_name":"Lisa-Marie Rolli","orcid":"https://orcid.org/0009-0007-7860-8656"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lisa-Marie Rolli","raw_affiliation_strings":["Center for Bioinformatics, Saarland Informatics Campus, Saarland University , 66123, Saarland , Germany"],"raw_orcid":"https://orcid.org/0009-0007-7860-8656","affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Saarland Informatics Campus, Saarland University , 66123, Saarland , Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085594740","display_name":"Hans\u2010Peter Lenhof","orcid":"https://orcid.org/0000-0002-5820-9961"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Peter Lenhof","raw_affiliation_strings":["Center for Bioinformatics, Saarland Informatics Campus, Saarland University , 66123, Saarland , Germany"],"raw_orcid":"https://orcid.org/0000-0002-5820-9961","affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Saarland Informatics Campus, Saarland University , 66123, Saarland , Germany","institution_ids":["https://openalex.org/I91712215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5032823537"],"corresponding_institution_ids":["https://openalex.org/I91712215"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":6.6488,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.97290964,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"25","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11948","display_name":"Machine Learning in Materials Science","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.8262418508529663},{"id":"https://openalex.org/keywords/benchmarking","display_name":"Benchmarking","score":0.7869319319725037},{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.7196519374847412},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.7064344882965088},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.694663405418396},{"id":"https://openalex.org/keywords/gradient-boosting","display_name":"Gradient boosting","score":0.6165690422058105},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6156320571899414},{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.5475266575813293},{"id":"https://openalex.org/keywords/boosting","display_name":"Boosting (machine learning)","score":0.46703052520751953},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.46685224771499634},{"id":"https://openalex.org/keywords/curse-of-dimensionality","display_name":"Curse of dimensionality","score":0.4396930932998657},{"id":"https://openalex.org/keywords/prioritization","display_name":"Prioritization","score":0.43916332721710205},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4374021887779236},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.37789642810821533}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.8262418508529663},{"id":"https://openalex.org/C86251818","wikidata":"https://www.wikidata.org/wiki/Q816754","display_name":"Benchmarking","level":2,"score":0.7869319319725037},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.7196519374847412},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.7064344882965088},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.694663405418396},{"id":"https://openalex.org/C70153297","wikidata":"https://www.wikidata.org/wiki/Q5591907","display_name":"Gradient boosting","level":3,"score":0.6165690422058105},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6156320571899414},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.5475266575813293},{"id":"https://openalex.org/C46686674","wikidata":"https://www.wikidata.org/wiki/Q466303","display_name":"Boosting (machine learning)","level":2,"score":0.46703052520751953},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.46685224771499634},{"id":"https://openalex.org/C111030470","wikidata":"https://www.wikidata.org/wiki/Q1430460","display_name":"Curse of dimensionality","level":2,"score":0.4396930932998657},{"id":"https://openalex.org/C2777615720","wikidata":"https://www.wikidata.org/wiki/Q11888847","display_name":"Prioritization","level":2,"score":0.43916332721710205},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4374021887779236},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.37789642810821533},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae242","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae242","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae242/57910132/bbae242.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38797968","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38797968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11128483","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11128483","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11128483/pdf/bbae242.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae242","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae242","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae242/57910132/bbae242.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6600000262260437,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323322","display_name":"Universit\u00e4t des Saarlandes","ror":"https://ror.org/01jdpyv68"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399052950.pdf"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W19078547","https://openalex.org/W161930446","https://openalex.org/W1977619659","https://openalex.org/W2024046085","https://openalex.org/W2101234009","https://openalex.org/W2104718696","https://openalex.org/W2108933868","https://openalex.org/W2110065044","https://openalex.org/W2113890143","https://openalex.org/W2122825543","https://openalex.org/W2129860849","https://openalex.org/W2130410032","https://openalex.org/W2157076315","https://openalex.org/W2157395790","https://openalex.org/W2159482845","https://openalex.org/W2194596668","https://openalex.org/W2197241765","https://openalex.org/W2225963020","https://openalex.org/W2461427403","https://openalex.org/W2554401505","https://openalex.org/W2569335714","https://openalex.org/W2742007096","https://openalex.org/W2751088916","https://openalex.org/W2792791113","https://openalex.org/W2795257806","https://openalex.org/W2800484633","https://openalex.org/W2805406480","https://openalex.org/W2807463161","https://openalex.org/W2887685819","https://openalex.org/W2893531376","https://openalex.org/W2895134839","https://openalex.org/W2911535432","https://openalex.org/W2911964244","https://openalex.org/W2921591500","https://openalex.org/W2944727022","https://openalex.org/W2952285211","https://openalex.org/W2955502047","https://openalex.org/W2963046727","https://openalex.org/W2965014004","https://openalex.org/W2969085937","https://openalex.org/W2982894044","https://openalex.org/W2987883775","https://openalex.org/W3020992812","https://openalex.org/W3033741522","https://openalex.org/W3047825284","https://openalex.org/W3074545577","https://openalex.org/W3081972356","https://openalex.org/W3095177285","https://openalex.org/W3102027041","https://openalex.org/W3126851937","https://openalex.org/W3130891725","https://openalex.org/W3138819813","https://openalex.org/W3159412124","https://openalex.org/W3183522126","https://openalex.org/W3189476300","https://openalex.org/W3200428569","https://openalex.org/W3203480730","https://openalex.org/W3205307863","https://openalex.org/W3209882608","https://openalex.org/W3211402536","https://openalex.org/W4206095984","https://openalex.org/W4212799760","https://openalex.org/W4249440481","https://openalex.org/W4283075327","https://openalex.org/W4289884158","https://openalex.org/W4294216483","https://openalex.org/W4306361925","https://openalex.org/W4310642160","https://openalex.org/W4310642871","https://openalex.org/W4360745470","https://openalex.org/W4380871602","https://openalex.org/W4385737472","https://openalex.org/W4388722173","https://openalex.org/W4399130723","https://openalex.org/W4399650065","https://openalex.org/W6675354045","https://openalex.org/W6704772195","https://openalex.org/W6742903898","https://openalex.org/W6790008554","https://openalex.org/W6798736220","https://openalex.org/W6857863506"],"related_works":["https://openalex.org/W2967733078","https://openalex.org/W3204430031","https://openalex.org/W3137904399","https://openalex.org/W4310492845","https://openalex.org/W2885778889","https://openalex.org/W4310224730","https://openalex.org/W2766514146","https://openalex.org/W4289703016","https://openalex.org/W2885516856","https://openalex.org/W3094138326"],"abstract_inverted_index":{"A":[0],"major":[1],"challenge":[2],"of":[3,11,19,25,52,71,82,98,159],"precision":[4],"oncology":[5],"is":[6,58],"the":[7,20,39,49,96,131,155],"identification":[8],"and":[9,44,69,85,114,137,153,176],"prioritization":[10],"suitable":[12,67],"treatment":[13,45],"options":[14],"based":[15],"on":[16],"molecular":[17],"biomarkers":[18],"considered":[21],"tumor.":[22],"In":[23],"pursuit":[24],"this":[26],"goal,":[27],"large":[28],"cancer":[29],"cell":[30,103],"line":[31,104],"panels":[32],"have":[33],"successfully":[34],"been":[35],"studied":[36],"to":[37,48],"elucidate":[38],"relationship":[40],"between":[41,157],"cellular":[42],"features":[43,73],"response.":[46],"Due":[47],"high":[50],"dimensionality":[51],"these":[53],"datasets,":[54],"machine":[55],"learning":[56],"(ML)":[57],"commonly":[59],"used":[60],"for":[61,90,117,143],"their":[62],"analysis.":[63],"However,":[64],"choosing":[65],"a":[66,79,149],"algorithm":[68],"set":[70],"input":[72],"can":[74],"be":[75,186],"challenging.":[76],"We":[77,129],"performed":[78],"comprehensive":[80],"benchmarking":[81],"ML":[83,167],"methods":[84],"dimension":[86],"reduction":[87],"(DR)":[88],"techniques":[89],"predicting":[91],"drug":[92],"response":[93],"metrics.":[94],"Using":[95],"Genomics":[97],"Drug":[99],"Sensitivity":[100],"in":[101,188],"Cancer":[102],"panel,":[105],"we":[106,140,163],"trained":[107],"random":[108],"forests,":[109],"neural":[110],"networks,":[111],"boosting":[112],"trees":[113],"elastic":[115],"nets":[116],"179":[118],"anti-cancer":[119],"compounds":[120],"with":[121,148],"feature":[122],"sets":[123],"derived":[124],"from":[125,170],"nine":[126],"DR":[127,174],"approaches.":[128],"compare":[130],"results":[132],"regarding":[133],"statistical":[134],"performance,":[135],"runtime":[136],"interpretability.":[138],"Additionally,":[139],"provide":[141],"strategies":[142],"assessing":[144],"model":[145,152],"performance":[146],"compared":[147],"simple":[150],"baseline":[151],"measuring":[154],"trade-off":[156],"models":[158,168],"different":[160],"complexity.":[161],"Lastly,":[162],"show":[164],"that":[165,177],"complex":[166],"benefit":[169],"using":[171,181],"an":[172],"optimized":[173],"strategy,":[175],"standard":[178],"models-even":[179],"when":[180],"considerably":[182],"fewer":[183],"features-can":[184],"still":[185],"superior":[187],"performance.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}