{"id":"https://openalex.org/W4396954010","doi":"https://doi.org/10.1093/bib/bbae231","title":"SGCLDGA: unveiling drug\u2013gene associations through simple graph contrastive learning","display_name":"SGCLDGA: unveiling drug\u2013gene associations through simple graph contrastive learning","publication_year":2024,"publication_date":"2024-03-27","ids":{"openalex":"https://openalex.org/W4396954010","doi":"https://doi.org/10.1093/bib/bbae231","pmid":"https://pubmed.ncbi.nlm.nih.gov/38754409"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae231","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae231","pdf_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae231/57701968/bbae231.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae231/57701968/bbae231.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032822444","display_name":"Yanhao Fan","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanhao Fan","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , 410075, Changsha , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , 410075, Changsha , China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045260031","display_name":"Che Zhang","orcid":"https://orcid.org/0000-0001-6757-4306"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Che Zhang","raw_affiliation_strings":["School of software, Xinjiang University , 830046, Urumqi , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of software, Xinjiang University , 830046, Urumqi , China","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101610203","display_name":"Xiaowen Hu","orcid":"https://orcid.org/0000-0002-7339-3007"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaowen Hu","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , 410075, Changsha , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , 410075, Changsha , China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101972109","display_name":"Zhijian Huang","orcid":"https://orcid.org/0000-0001-7169-9689"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhijian Huang","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , 410075, Changsha , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , 410075, Changsha , China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007078838","display_name":"Jiameng Xue","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiameng Xue","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , 410075, Changsha , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , 410075, Changsha , China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113262237","display_name":"Lei Deng","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Deng","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , 410075, Changsha , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , 410075, Changsha , China","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5032822444"],"corresponding_institution_ids":["https://openalex.org/I139660479"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":3.3215,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.92763382,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"25","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11273","display_name":"Advanced Graph Neural Networks","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simple","display_name":"Simple (philosophy)","score":0.565722644329071},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5441381335258484},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5045615434646606},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.48568519949913025},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.45472753047943115},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.43761250376701355},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.37303411960601807},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.36055678129196167},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2791941463947296},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27848631143569946},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.1757323443889618},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.06944838166236877},{"id":"https://openalex.org/keywords/philosophy","display_name":"Philosophy","score":0.06187519431114197}],"concepts":[{"id":"https://openalex.org/C2780586882","wikidata":"https://www.wikidata.org/wiki/Q7520643","display_name":"Simple (philosophy)","level":2,"score":0.565722644329071},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5441381335258484},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5045615434646606},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.48568519949913025},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45472753047943115},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.43761250376701355},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.37303411960601807},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.36055678129196167},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2791941463947296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27848631143569946},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.1757323443889618},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.06944838166236877},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.06187519431114197},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae231","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae231","pdf_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae231/57701968/bbae231.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38754409","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38754409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11097980","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11097980","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11097980/pdf/bbae231.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae231","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae231","pdf_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae231/57701968/bbae231.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/4","score":0.4099999964237213,"display_name":"Quality Education"}],"awards":[{"id":"https://openalex.org/G2008773563","display_name":null,"funder_award_id":"62272490","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5299854802","display_name":null,"funder_award_id":"U23A20321","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7610172040","display_name":null,"funder_award_id":"No. 62272490","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321514","display_name":"Central South University","ror":"https://ror.org/00f1zfq44"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4396954010.pdf"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W34962992","https://openalex.org/W1985270532","https://openalex.org/W2002185065","https://openalex.org/W2091439417","https://openalex.org/W2106417713","https://openalex.org/W2117599112","https://openalex.org/W2117756735","https://openalex.org/W2127553917","https://openalex.org/W2135029798","https://openalex.org/W2154011501","https://openalex.org/W2775185492","https://openalex.org/W2789652838","https://openalex.org/W2802314916","https://openalex.org/W2842511635","https://openalex.org/W2891614933","https://openalex.org/W2909637325","https://openalex.org/W2919115771","https://openalex.org/W2919378721","https://openalex.org/W2963026948","https://openalex.org/W2970472075","https://openalex.org/W2995908837","https://openalex.org/W3000043291","https://openalex.org/W3000082418","https://openalex.org/W3009999522","https://openalex.org/W3045200674","https://openalex.org/W3048656122","https://openalex.org/W3048858802","https://openalex.org/W3093030756","https://openalex.org/W3107626709","https://openalex.org/W3120280121","https://openalex.org/W3158143432","https://openalex.org/W3189831819","https://openalex.org/W3203619936","https://openalex.org/W3211486457","https://openalex.org/W3213337333","https://openalex.org/W4220885170","https://openalex.org/W4220895045","https://openalex.org/W4224983022","https://openalex.org/W4225402571","https://openalex.org/W4281675752","https://openalex.org/W4294968705","https://openalex.org/W4297808394","https://openalex.org/W4313707003","https://openalex.org/W4318260464","https://openalex.org/W4381046896","https://openalex.org/W4385331028","https://openalex.org/W4387191019","https://openalex.org/W4389616450","https://openalex.org/W4391347933","https://openalex.org/W6680012447"],"related_works":["https://openalex.org/W1585007175","https://openalex.org/W2382521049","https://openalex.org/W2144385241","https://openalex.org/W4300101996","https://openalex.org/W2165950148","https://openalex.org/W4253593777","https://openalex.org/W2951497643","https://openalex.org/W4403053866","https://openalex.org/W2142393343","https://openalex.org/W2338854850"],"abstract_inverted_index":{"Drug":[0],"repurposing":[1],"offers":[2],"a":[3,51,67,126],"viable":[4],"strategy":[5],"for":[6,193],"discovering":[7,185],"new":[8,186],"drugs":[9,91,150],"and":[10,28,75,92,110,134,151,170,179,191],"therapeutic":[11],"targets":[12],"through":[13,125],"the":[14,95,108,156,174],"analysis":[15],"of":[16,90,176],"drug-gene":[17,81,187],"interactions.":[18],"However,":[19],"traditional":[20],"experimental":[21],"methods":[22],"are":[23,195],"plagued":[24],"by":[25],"their":[26,40],"costliness":[27],"inefficiency.":[29],"Despite":[30],"graph":[31,72,109],"convolutional":[32],"network":[33],"(GCN)-based":[34],"models'":[35],"state-of-the-art":[36,166],"performance":[37,162],"in":[38,54,184],"prediction,":[39],"reliance":[41],"on":[42,155],"supervised":[43],"learning":[44,77,118,178],"makes":[45],"them":[46],"vulnerable":[47],"to":[48,78,86,106,130,145],"data":[49],"sparsity,":[50],"common":[52],"challenge":[53],"drug":[55],"discovery,":[56],"further":[57],"complicating":[58],"model":[59,70,115],"development.":[60],"In":[61],"this":[62],"study,":[63],"we":[64],"propose":[65],"SGCLDGA,":[66],"novel":[68],"computational":[69],"leveraging":[71],"neural":[73],"networks":[74],"contrastive":[76,117,127,177],"predict":[79],"unknown":[80],"associations.":[82,188],"SGCLDGA":[83,194],"employs":[84],"GCNs":[85],"extract":[87],"vector":[88,123],"representations":[89,124],"genes":[93],"from":[94],"original":[96],"bipartite":[97],"graph.":[98],"Subsequently,":[99],"singular":[100],"value":[101],"decomposition":[102],"(SVD)":[103],"is":[104],"employed":[105],"enhance":[107],"generate":[111],"multiple":[112],"views.":[113],"The":[114,137,189],"performs":[116],"across":[119],"these":[120],"views,":[121],"optimizing":[122],"loss":[128],"function":[129],"better":[131],"distinguish":[132],"positive":[133],"negative":[135],"samples.":[136],"final":[138],"step":[139],"involves":[140],"utilizing":[141],"inner":[142],"product":[143],"calculations":[144],"determine":[146],"association":[147],"scores":[148],"between":[149],"genes.":[152],"Experimental":[153],"results":[154],"DGIdb4.0":[157],"dataset":[158,192],"demonstrate":[159],"SGCLDGA's":[160,182],"superior":[161],"compared":[163],"with":[164],"six":[165],"methods.":[167],"Ablation":[168],"studies":[169],"case":[171],"analyses":[172],"validate":[173],"significance":[175],"SVD,":[180],"highlighting":[181],"potential":[183],"code":[190],"freely":[196],"available":[197],"at":[198],"https://github.com/one-melon/SGCLDGA.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4}],"updated_date":"2026-06-02T09:04:35.204637","created_date":"2025-10-10T00:00:00"}