{"id":"https://openalex.org/W4396875574","doi":"https://doi.org/10.1093/bib/bbae230","title":"Single-cell RNA-seq data analysis reveals functionally relevant biomarkers of early brain development and their regulatory footprints in human embryonic stem cells (hESCs)","display_name":"Single-cell RNA-seq data analysis reveals functionally relevant biomarkers of early brain development and their regulatory footprints in human embryonic stem cells (hESCs)","publication_year":2024,"publication_date":"2024-03-27","ids":{"openalex":"https://openalex.org/W4396875574","doi":"https://doi.org/10.1093/bib/bbae230","pmid":"https://pubmed.ncbi.nlm.nih.gov/38739758"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae230","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae230","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bib/bbae230","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101594627","display_name":"Md. Alamin","orcid":"https://orcid.org/0000-0001-7993-3863"},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Md Alamin","raw_affiliation_strings":["School of Life Sciences , Department of Biology, , Southern University of Science and Technology, Shenzhen 518055, Guangdong , China","Shenzhen Key Laboratory of Gene Regulation and Systems Biology , Department of Biology, , Southern University of Science and Technology, Shenzhen 518055, Guangdong , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences , Department of Biology, , Southern University of Science and Technology, Shenzhen 518055, Guangdong , China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Shenzhen Key Laboratory of Gene Regulation and Systems Biology , Department of Biology, , Southern University of Science and Technology, Shenzhen 518055, Guangdong , China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060224062","display_name":"Most. Humaira Sultana","orcid":null},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Most Humaira Sultana","raw_affiliation_strings":["Institute of Bioinformatics, Zhejiang University , Hangzhou 310058 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics, Zhejiang University , Hangzhou 310058 , China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045068486","display_name":"Isaac A. Babarinde","orcid":"https://orcid.org/0000-0002-8503-2460"},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Isaac Adeyemi Babarinde","raw_affiliation_strings":["School of Life Sciences , Department of Biology, , Southern University of Science and Technology, Shenzhen 518055, Guangdong , China","Shenzhen Key Laboratory of Gene Regulation and Systems Biology , Department of Biology, , Southern University of Science and Technology, Shenzhen 518055, Guangdong , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences , Department of Biology, , Southern University of Science and Technology, Shenzhen 518055, Guangdong , China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Shenzhen Key Laboratory of Gene Regulation and Systems Biology , Department of Biology, , Southern University of Science and Technology, Shenzhen 518055, Guangdong , China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055852370","display_name":"AKM Azad","orcid":"https://orcid.org/0000-0002-5251-2214"},"institutions":[{"id":"https://openalex.org/I240666556","display_name":"Imam Mohammad ibn Saud Islamic University","ror":"https://ror.org/05gxjyb39","country_code":"SA","type":"education","lineage":["https://openalex.org/I240666556"]},{"id":"https://openalex.org/I4210096041","display_name":"Riyadh Elm University","ror":"https://ror.org/00rz3mr26","country_code":"SA","type":"education","lineage":["https://openalex.org/I4210096041"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"A K M Azad","raw_affiliation_strings":["Department of Mathematics and Statistics , College of Science, , Riyadh 11432 , Saudi Arabia","Imam Muhammad Ibn Saud Islamic University , College of Science, , Riyadh 11432 , Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics , College of Science, , Riyadh 11432 , Saudi Arabia","institution_ids":["https://openalex.org/I4210096041"]},{"raw_affiliation_string":"Imam Muhammad Ibn Saud Islamic University , College of Science, , Riyadh 11432 , Saudi Arabia","institution_ids":["https://openalex.org/I240666556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034828056","display_name":"Mohammad Ali Moni","orcid":"https://orcid.org/0000-0003-0756-1006"},"institutions":[{"id":"https://openalex.org/I153230381","display_name":"Charles Sturt University","ror":"https://ror.org/00wfvh315","country_code":"AU","type":"education","lineage":["https://openalex.org/I153230381"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mohammad Ali Moni","raw_affiliation_strings":["Artificial Intelligence and Cyber Futures Institute, Charles Sturt University , Bathurst, NSW 2795 , Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence and Cyber Futures Institute, Charles Sturt University , Bathurst, NSW 2795 , Australia","institution_ids":["https://openalex.org/I153230381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056079345","display_name":"Haiming Xu","orcid":"https://orcid.org/0000-0002-0675-4087"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiming Xu","raw_affiliation_strings":["Institute of Bioinformatics, Zhejiang University , Hangzhou 310058 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics, Zhejiang University , Hangzhou 310058 , China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":1.7658,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.84491205,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"25","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9883999824523926,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7509744167327881},{"id":"https://openalex.org/keywords/embryonic-stem-cell","display_name":"Embryonic stem cell","score":0.6568732261657715},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5547503232955933},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"Neurogenesis","score":0.5486869215965271},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.4846113622188568},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.46970078349113464},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.4628104269504547},{"id":"https://openalex.org/keywords/cellular-differentiation","display_name":"Cellular differentiation","score":0.4418529272079468},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4159368574619293},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3877338171005249},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3351684808731079}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7509744167327881},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6568732261657715},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5547503232955933},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.5486869215965271},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4846113622188568},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46970078349113464},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4628104269504547},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4418529272079468},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4159368574619293},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3877338171005249},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3351684808731079}],"mesh":[{"descriptor_ui":"D000066449","descriptor_name":"Human Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D000066449","descriptor_name":"Human Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D000066449","descriptor_name":"Human Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D000066449","descriptor_name":"Human Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D000066449","descriptor_name":"Human Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D000066449","descriptor_name":"Human Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000066449","descriptor_name":"Human Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000066449","descriptor_name":"Human Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000066449","descriptor_name":"Human Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000066449","descriptor_name":"Human Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbae230","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae230","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38739758","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38739758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11089419","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11089419","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11089419/pdf/bbae230.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/f06288e1-fcd1-475f-9e5f-546613b848c3","is_oa":true,"landing_page_url":"https://researchoutput.csu.edu.au/en/publications/f06288e1-fcd1-475f-9e5f-546613b848c3","pdf_url":null,"source":{"id":"https://openalex.org/S7407055442","display_name":"Charles Sturt University Research Output (CRO)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alamin, M, Humaira Sultana, M, Babarinde, I A, Azad, A K M, Moni, M A & Xu, H 2024, 'Single-cell RNA-seq data analysis reveals functionally relevant biomarkers of early brain development and their regulatory footprints in human embryonic stem cells (hESCs)', Briefings in Bioinformatics, vol. 25, no. 3, bbae230, pp. 1-16. https://doi.org/10.1093/bib/bbae230","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae230","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae230","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5797066792","display_name":null,"funder_award_id":"2021YFF1200900","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320327605","display_name":"Southern University of Science and Technology","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W95485003","https://openalex.org/W1534988355","https://openalex.org/W1535089634","https://openalex.org/W1555679702","https://openalex.org/W1978695468","https://openalex.org/W1988391018","https://openalex.org/W1988579734","https://openalex.org/W1992482740","https://openalex.org/W1993019240","https://openalex.org/W2011637823","https://openalex.org/W2012199594","https://openalex.org/W2016106370","https://openalex.org/W2017625776","https://openalex.org/W2063011506","https://openalex.org/W2063849763","https://openalex.org/W2078264780","https://openalex.org/W2078526277","https://openalex.org/W2094295469","https://openalex.org/W2098407201","https://openalex.org/W2098717020","https://openalex.org/W2106524861","https://openalex.org/W2116631863","https://openalex.org/W2117446594","https://openalex.org/W2130410032","https://openalex.org/W2146512944","https://openalex.org/W2148316867","https://openalex.org/W2159319913","https://openalex.org/W2172513520","https://openalex.org/W2175370850","https://openalex.org/W2179438025","https://openalex.org/W2190545194","https://openalex.org/W2247766769","https://openalex.org/W2290509322","https://openalex.org/W2302019043","https://openalex.org/W2322523258","https://openalex.org/W2343887501","https://openalex.org/W2395296394","https://openalex.org/W2397158768","https://openalex.org/W2403934794","https://openalex.org/W2511896561","https://openalex.org/W2514239685","https://openalex.org/W2537679995","https://openalex.org/W2541088566","https://openalex.org/W2559270081","https://openalex.org/W2596707196","https://openalex.org/W2605810679","https://openalex.org/W2765099814","https://openalex.org/W2768632638","https://openalex.org/W2792479428","https://openalex.org/W2794252237","https://openalex.org/W2794458614","https://openalex.org/W2799273685","https://openalex.org/W2799922543","https://openalex.org/W2802101579","https://openalex.org/W2809249042","https://openalex.org/W2884450284","https://openalex.org/W2928665623","https://openalex.org/W2935024989","https://openalex.org/W2945883683","https://openalex.org/W2971900792","https://openalex.org/W3007623777","https://openalex.org/W3021740815","https://openalex.org/W3026988635","https://openalex.org/W3028563371","https://openalex.org/W3042733940","https://openalex.org/W3098136870","https://openalex.org/W3110466396","https://openalex.org/W3127079499","https://openalex.org/W3167886428","https://openalex.org/W3175752499","https://openalex.org/W3177351332","https://openalex.org/W3179736428","https://openalex.org/W3192993874","https://openalex.org/W3209689422","https://openalex.org/W3212618717","https://openalex.org/W4200043367","https://openalex.org/W4220849087","https://openalex.org/W4225852092","https://openalex.org/W4281751254","https://openalex.org/W4297477889","https://openalex.org/W4308834893","https://openalex.org/W4321785452","https://openalex.org/W4322724048","https://openalex.org/W4323975035","https://openalex.org/W4385563551","https://openalex.org/W4386424323","https://openalex.org/W4390500889","https://openalex.org/W6603850666","https://openalex.org/W6725502576","https://openalex.org/W6749852281","https://openalex.org/W6761319427","https://openalex.org/W6776906990","https://openalex.org/W6785974299","https://openalex.org/W6797786779","https://openalex.org/W6855846505"],"related_works":["https://openalex.org/W2053561999","https://openalex.org/W2010571965","https://openalex.org/W2002709996","https://openalex.org/W2891054691","https://openalex.org/W3128451840","https://openalex.org/W4387092964","https://openalex.org/W2103471012","https://openalex.org/W2966064480","https://openalex.org/W2115810854","https://openalex.org/W2380236774"],"abstract_inverted_index":{"The":[0,155,209,260],"complicated":[1],"process":[2,17],"of":[3,80,166,171,188],"neuronal":[4,64,151],"development":[5,152,258,276],"is":[6,27],"initiated":[7],"early":[8,109,256],"in":[9,149,153,168,198,219,225],"life,":[10],"with":[11],"the":[12,77,102,167,194,201,220],"genetic":[13],"mechanisms":[14,104],"governing":[15,108],"this":[16,96,139],"yet":[18],"to":[19,55,75,91,100,129,145,173,206],"be":[20],"fully":[21],"elucidated.":[22],"Single-cell":[23],"RNA":[24],"sequencing":[25],"(scRNA-seq)":[26],"a":[28],"potent":[29],"instrument":[30],"for":[31,62,270],"pinpointing":[32],"biomarkers":[33,191],"that":[34,193,214],"exhibit":[35],"differential":[36],"expression":[37],"across":[38],"various":[39],"cell":[40],"types":[41],"and":[42,86,105,120,124,136,163,184,234,239,241,244,263,277],"developmental":[43],"stages.":[44],"By":[45,113],"employing":[46],"scRNA-seq":[47,144,156],"on":[48,132,159,255],"human":[49,110,133,274],"embryonic":[50],"stem":[51],"cells,":[52],"we":[53,127,141],"aim":[54],"identify":[56,146],"differentially":[57],"expressed":[58],"genes":[59,82],"(DEGs)":[60],"crucial":[61],"early-stage":[63,150],"development.":[65,112],"Our":[66,177,246],"focus":[67],"extends":[68],"beyond":[69],"simply":[70],"identifying":[71],"DEGs.":[72],"We":[73,228],"strive":[74],"investigate":[76],"functional":[78],"roles":[79],"these":[81,118],"through":[83],"enrichment":[84,187],"analysis":[85,178,212],"construct":[87],"gene":[88,264],"regulatory":[89,265],"networks":[90,266],"understand":[92],"their":[93],"interactions.":[94],"Ultimately,":[95],"comprehensive":[97],"approach":[98],"aspires":[99],"illuminate":[101],"molecular":[103],"transcriptional":[106,236],"dynamics":[107],"brain":[111,257,275],"uncovering":[114],"potential":[115],"links":[116],"between":[117,182,222,232,242],"DEGs":[119,147,181,196,203,216,233,262],"intelligence,":[121],"mental":[122],"disorders,":[123,126],"neurodevelopmental":[125,278],"hope":[128],"shed":[130],"light":[131,254],"neurological":[134],"health":[135],"disease.":[137],"In":[138],"study,":[140],"have":[142],"used":[143],"involved":[148,218],"hESCs.":[154],"data,":[157],"collected":[158],"days":[160],"26":[161],"(D26)":[162],"54":[164],"(D54),":[165],"vitro":[169],"differentiation":[170],"hESCs":[172],"neurons":[174],"were":[175,204,217],"analyzed.":[176],"identified":[179,248,261],"539":[180],"D26":[183],"D54.":[185],"Functional":[186],"those":[189],"DEG":[190],"indicated":[192],"up-regulated":[195],"participated":[197],"neurogenesis,":[199],"while":[200],"down-regulated":[202,215],"linked":[205],"synapse":[207,226],"regulation.":[208],"Reactome":[210],"pathway":[211],"revealed":[213],"interactions":[221,231],"proteins":[223],"located":[224],"pathways.":[227],"also":[229],"discovered":[230],"miRNA,":[235],"factors":[237],"(TFs)":[238],"DEGs,":[240],"TF":[243],"miRNA.":[245],"study":[247],"20":[249],"significant":[250],"transcription":[251],"factors,":[252],"shedding":[253],"genetics.":[259],"are":[267],"valuable":[268],"resources":[269],"future":[271],"research":[272],"into":[273],"disorders.":[279]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3}],"updated_date":"2026-08-04T08:18:43.703281","created_date":"2025-10-10T00:00:00"}