{"id":"https://openalex.org/W4396627755","doi":"https://doi.org/10.1093/bib/bbae199","title":"Metabolic models predict fotemustine and the combination of eflornithine/rifamycin and adapalene/cannabidiol for the treatment of gliomas","display_name":"Metabolic models predict fotemustine and the combination of eflornithine/rifamycin and adapalene/cannabidiol for the treatment of gliomas","publication_year":2024,"publication_date":"2024-03-27","ids":{"openalex":"https://openalex.org/W4396627755","doi":"https://doi.org/10.1093/bib/bbae199","pmid":"https://pubmed.ncbi.nlm.nih.gov/38701414"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae199","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/bib/bbae199","pdf_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae199/57390406/bbae199.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae199/57390406/bbae199.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057750170","display_name":"Ali Kishk","orcid":"https://orcid.org/0000-0003-3710-5909"},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Ali Kishk","raw_affiliation_strings":["Department of Life Sciences and Medicine, University of Luxembourg , L-4367 Belvaux , Luxembourg"],"raw_orcid":"https://orcid.org/0000-0003-3710-5909","affiliations":[{"raw_affiliation_string":"Department of Life Sciences and Medicine, University of Luxembourg , L-4367 Belvaux , Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022936776","display_name":"Maria Pires Pacheco","orcid":"https://orcid.org/0000-0001-7956-8093"},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Maria Pires Pacheco","raw_affiliation_strings":["Department of Life Sciences and Medicine, University of Luxembourg , L-4367 Belvaux , Luxembourg"],"raw_orcid":"https://orcid.org/0000-0001-7956-8093","affiliations":[{"raw_affiliation_string":"Department of Life Sciences and Medicine, University of Luxembourg , L-4367 Belvaux , Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046350634","display_name":"Tony Heurtaux","orcid":"https://orcid.org/0000-0002-1709-5312"},"institutions":[{"id":"https://openalex.org/I162487826","display_name":"Centre Hospitalier de Luxembourg","ror":"https://ror.org/03xq7w797","country_code":"LU","type":"healthcare","lineage":["https://openalex.org/I162487826"]},{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Tony Heurtaux","raw_affiliation_strings":["Department of Life Sciences and Medicine, University of Luxembourg , L-4367 Belvaux , Luxembourg","Luxembourg Centre of Neuropathology , L-3555 Dudelange , Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences and Medicine, University of Luxembourg , L-4367 Belvaux , Luxembourg","institution_ids":["https://openalex.org/I186903577"]},{"raw_affiliation_string":"Luxembourg Centre of Neuropathology , L-3555 Dudelange , Luxembourg","institution_ids":["https://openalex.org/I162487826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050871083","display_name":"Thomas Sauter","orcid":"https://orcid.org/0000-0001-8225-2954"},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":true,"raw_author_name":"Thomas Sauter","raw_affiliation_strings":["Department of Life Sciences and Medicine, University of Luxembourg , L-4367 Belvaux , Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences and Medicine, University of Luxembourg , L-4367 Belvaux , Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050871083"],"corresponding_institution_ids":["https://openalex.org/I186903577"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":1.0775,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.76944666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"25","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9865999817848206,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioma","display_name":"Glioma","score":0.7764554619789124},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6095082759857178},{"id":"https://openalex.org/keywords/temozolomide","display_name":"Temozolomide","score":0.5959291458129883},{"id":"https://openalex.org/keywords/eflornithine","display_name":"Eflornithine","score":0.5957686305046082},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.4848262071609497},{"id":"https://openalex.org/keywords/lomustine","display_name":"Lomustine","score":0.47728362679481506},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4205242991447449},{"id":"https://openalex.org/keywords/irinotecan","display_name":"Irinotecan","score":0.4126274585723877},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3468683362007141},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.34619563817977905},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"Chemotherapy","score":0.3154216408729553},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.25961974263191223},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.18392619490623474},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1834888756275177},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.1340407133102417},{"id":"https://openalex.org/keywords/vincristine","display_name":"Vincristine","score":0.06646767258644104}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7764554619789124},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6095082759857178},{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.5959291458129883},{"id":"https://openalex.org/C2780722877","wikidata":"https://www.wikidata.org/wiki/Q424751","display_name":"Eflornithine","level":4,"score":0.5957686305046082},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4848262071609497},{"id":"https://openalex.org/C2779434656","wikidata":"https://www.wikidata.org/wiki/Q415378","display_name":"Lomustine","level":5,"score":0.47728362679481506},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4205242991447449},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.4126274585723877},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3468683362007141},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34619563817977905},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3154216408729553},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25961974263191223},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18392619490623474},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1834888756275177},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.1340407133102417},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.06646767258644104},{"id":"https://openalex.org/C2777497464","wikidata":"https://www.wikidata.org/wiki/Q418834","display_name":"Spermidine","level":3,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002185","descriptor_name":"Cannabidiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002185","descriptor_name":"Cannabidiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002185","descriptor_name":"Cannabidiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002185","descriptor_name":"Cannabidiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002185","descriptor_name":"Cannabidiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002185","descriptor_name":"Cannabidiol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002185","descriptor_name":"Cannabidiol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002185","descriptor_name":"Cannabidiol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002185","descriptor_name":"Cannabidiol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002185","descriptor_name":"Cannabidiol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbae199","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/bib/bbae199","pdf_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae199/57390406/bbae199.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38701414","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38701414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:orbilu.uni.lu:10993/61139","is_oa":true,"landing_page_url":"https://orbilu.uni.lu/handle/10993/61139","pdf_url":"https://orbilu.uni.lu/bitstream/10993/61139/1/bbae199.pdf","source":{"id":"https://openalex.org/S4306401815","display_name":"Open Repository and Bibliography (University of Luxembourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I186903577","host_organization_name":"University of Luxembourg","host_organization_lineage":["https://openalex.org/I186903577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Briefings in Bioinformatics, 25 (3) (2024-03-27)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:pubmedcentral.nih.gov:11066901","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11066901","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11066901/pdf/bbae199.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae199","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/bib/bbae199","pdf_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae199/57390406/bbae199.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310700","display_name":"Universit\u00e9 du Luxembourg","ror":"https://ror.org/036x5ad56"},{"id":"https://openalex.org/F4320321038","display_name":"Fonds National de la Recherche Luxembourg","ror":"https://ror.org/039z13y21"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4396627755.pdf"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W256016815","https://openalex.org/W1500300692","https://openalex.org/W1967196235","https://openalex.org/W2012958621","https://openalex.org/W2018838463","https://openalex.org/W2020330977","https://openalex.org/W2028037535","https://openalex.org/W2032043292","https://openalex.org/W2040262826","https://openalex.org/W2043251521","https://openalex.org/W2045921664","https://openalex.org/W2059481780","https://openalex.org/W2087594681","https://openalex.org/W2103322958","https://openalex.org/W2106614748","https://openalex.org/W2107288975","https://openalex.org/W2114473492","https://openalex.org/W2120289860","https://openalex.org/W2130879249","https://openalex.org/W2169767481","https://openalex.org/W2170160933","https://openalex.org/W2264489059","https://openalex.org/W2290606825","https://openalex.org/W2302516330","https://openalex.org/W2399494723","https://openalex.org/W2461966769","https://openalex.org/W2604527271","https://openalex.org/W2624779254","https://openalex.org/W2739601826","https://openalex.org/W2762019694","https://openalex.org/W2763145619","https://openalex.org/W2767083007","https://openalex.org/W2767891136","https://openalex.org/W2770932522","https://openalex.org/W2789128799","https://openalex.org/W2790327980","https://openalex.org/W2795802217","https://openalex.org/W2890911268","https://openalex.org/W2905302554","https://openalex.org/W2909817598","https://openalex.org/W2939500924","https://openalex.org/W2944993265","https://openalex.org/W2967843340","https://openalex.org/W2979143021","https://openalex.org/W3009746164","https://openalex.org/W3010629926","https://openalex.org/W3024389728","https://openalex.org/W3029912146","https://openalex.org/W3092757831","https://openalex.org/W3095049046","https://openalex.org/W3103314130","https://openalex.org/W3120217730","https://openalex.org/W3124148540","https://openalex.org/W3126345200","https://openalex.org/W3134916687","https://openalex.org/W3144575654","https://openalex.org/W3174246647","https://openalex.org/W3176391058","https://openalex.org/W3179833536","https://openalex.org/W3200397230","https://openalex.org/W3211921782","https://openalex.org/W4206744254","https://openalex.org/W4213443321","https://openalex.org/W4226096024","https://openalex.org/W4237142329","https://openalex.org/W4280589597","https://openalex.org/W4283324066","https://openalex.org/W4283385398","https://openalex.org/W4286294395","https://openalex.org/W4286580751","https://openalex.org/W4286587342","https://openalex.org/W4290999142","https://openalex.org/W4293661039","https://openalex.org/W4301595791","https://openalex.org/W4313729238","https://openalex.org/W4316464931","https://openalex.org/W4323036391","https://openalex.org/W4361304224","https://openalex.org/W4387965228","https://openalex.org/W6655614917","https://openalex.org/W6676110561","https://openalex.org/W6807182660"],"related_works":["https://openalex.org/W2078219238","https://openalex.org/W4313656783","https://openalex.org/W2304205254","https://openalex.org/W4309018543","https://openalex.org/W2374912696","https://openalex.org/W1986632087","https://openalex.org/W2916546025","https://openalex.org/W4249720218","https://openalex.org/W2809253815","https://openalex.org/W2914199948"],"abstract_inverted_index":{"Gliomas":[0],"are":[1],"the":[2,65,92,97,148,216,233,253],"most":[3],"common":[4],"type":[5],"of":[6,18,29,67,108,136,147,235],"malignant":[7],"brain":[8],"tumors,":[9],"with":[10,80,213],"glioblastoma":[11],"multiforme":[12],"(GBM)":[13],"having":[14],"a":[15],"median":[16],"survival":[17,217],"15":[19],"months":[20],"due":[21],"to":[22,57,90,165,200,219],"drug":[23,68,70,98,126,138,150,187,241],"resistance":[24],"and":[25,35,64,69,86,94,112,120,157,175,182,198,204,207,209,225,250],"relapse.":[26],"The":[27,76,100],"treatment":[28],"gliomas":[30],"relies":[31],"on":[32],"surgery,":[33],"radiotherapy":[34],"chemotherapy.":[36],"Only":[37],"12":[38],"anti-brain":[39],"tumor":[40],"chemotherapies":[41],"(AntiBCs),":[42],"mostly":[43],"alkylating":[44],"agents,":[45],"have":[46,140],"been":[47,141],"approved":[48],"so":[49],"far.":[50],"Glioma":[51],"subtype-specific":[52],"metabolic":[53,236,246],"models":[54,103],"were":[55,78,128,163,177],"reconstructed":[56],"simulate":[58],"metabolite":[59],"exchanges,":[60],"in":[61,144,154,159,192,211,221,238],"silico":[62],"knockouts":[63],"prediction":[66],"combinations":[71,127,162,251],"for":[72,133,168,180,252],"all":[73,169],"three":[74,101,170],"subtypes.":[75,255],"simulations":[77],"confronted":[79],"literature,":[81],"high-throughput":[82],"screenings":[83],"(HTSs),":[84],"xenograft":[85],"clinical":[87,228],"trial":[88],"data":[89],"validate":[91],"workflow":[93],"further":[95],"prioritize":[96],"candidates.":[99],"subtype":[102],"accurately":[104,244],"displayed":[105],"different":[106],"degrees":[107],"dependencies":[109],"toward":[110],"glutamine":[111],"glutamate.":[113],"Furthermore,":[114],"33":[115],"single":[116],"drugs,":[117],"mainly":[118],"antimetabolites":[119],"TXNRD1-inhibitors,":[121],"as":[122,124,130],"well":[123],"17":[125],"predicted":[129,164,178,245],"potential":[131,234],"candidates":[132,139,151,188],"gliomas.":[134],"Half":[135,146],"these":[137],"previously":[142],"tested":[143,149],"HTSs.":[145],"reduce":[152],"proliferation":[153],"cell":[155],"lines":[156],"two-thirds":[158],"xenografts.":[160],"Most":[161,186],"be":[166],"efficient":[167],"glioma":[171,227,240,254],"types.":[172],"However,":[173,202],"eflornithine/rifamycin":[174],"cannabidiol/adapalene":[176],"specifically":[179],"GBM":[181],"low-grade":[183],"glioma,":[184],"respectively.":[185],"had":[189],"comparable":[190],"efficiency":[191],"preclinical":[193],"tests,":[194],"cerebrospinal":[195],"fluid":[196],"bioavailability":[197],"mode-of-action":[199],"AntiBCs.":[201],"fotemustine":[203],"valganciclovir":[205],"alone":[206],"eflornithine":[208],"celecoxib":[210],"combination":[212],"AntiBCs":[214,220],"improved":[215],"compared":[218],"two-arms,":[222],"phase":[223],"I/II":[224],"higher":[226],"trials.":[229],"Our":[230],"work":[231],"highlights":[232],"modeling":[237],"advancing":[239],"discovery,":[242],"which":[243],"vulnerabilities,":[247],"repurposable":[248],"drugs":[249]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}