{"id":"https://openalex.org/W4394870153","doi":"https://doi.org/10.1093/bib/bbae171","title":"stDiff: a diffusion model for imputing spatial transcriptomics through single-cell transcriptomics","display_name":"stDiff: a diffusion model for imputing spatial transcriptomics through single-cell transcriptomics","publication_year":2024,"publication_date":"2024-03-27","ids":{"openalex":"https://openalex.org/W4394870153","doi":"https://doi.org/10.1093/bib/bbae171","pmid":"https://pubmed.ncbi.nlm.nih.gov/38628114"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae171","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae171","pdf_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae171/57241929/bbae171.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae171/57241929/bbae171.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033129655","display_name":"Kongming Li","orcid":null},"institutions":[{"id":"https://openalex.org/I113389987","display_name":"Handan College","ror":"https://ror.org/03fkpw052","country_code":"CN","type":"education","lineage":["https://openalex.org/I113389987"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kongming Li","raw_affiliation_strings":["Fudan University , Handan Street, 200433 Shanghai , China","School of Computer Science and Technology , Handan Street, 200433 Shanghai , China","Shanghai Key Lab of Intelligent Information Processing , Handan Street, 200433 Shanghai , China","School of Computer Science and Technology, Fudan UniversityHandan Street, 200433 Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fudan University , Handan Street, 200433 Shanghai , China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"School of Computer Science and Technology , Handan Street, 200433 Shanghai , China","institution_ids":["https://openalex.org/I113389987","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Key Lab of Intelligent Information Processing , Handan Street, 200433 Shanghai , China","institution_ids":[]},{"raw_affiliation_string":"School of Computer Science and Technology, Fudan UniversityHandan Street, 200433 Shanghai, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100328383","display_name":"Jia-Hao Li","orcid":"https://orcid.org/0009-0003-2889-0965"},"institutions":[{"id":"https://openalex.org/I113389987","display_name":"Handan College","ror":"https://ror.org/03fkpw052","country_code":"CN","type":"education","lineage":["https://openalex.org/I113389987"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahao Li","raw_affiliation_strings":["Fudan University , Handan Street, 200433 Shanghai , China","School of Computer Science and Technology , Handan Street, 200433 Shanghai , China","Shanghai Key Lab of Intelligent Information Processing , Handan Street, 200433 Shanghai , China","School of Computer Science and Technology, Fudan UniversityHandan Street, 200433 Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fudan University , Handan Street, 200433 Shanghai , China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"School of Computer Science and Technology , Handan Street, 200433 Shanghai , China","institution_ids":["https://openalex.org/I113389987","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Key Lab of Intelligent Information Processing , Handan Street, 200433 Shanghai , China","institution_ids":[]},{"raw_affiliation_string":"School of Computer Science and Technology, Fudan UniversityHandan Street, 200433 Shanghai, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066090370","display_name":"Yuhao Tao","orcid":null},"institutions":[{"id":"https://openalex.org/I113389987","display_name":"Handan College","ror":"https://ror.org/03fkpw052","country_code":"CN","type":"education","lineage":["https://openalex.org/I113389987"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhao Tao","raw_affiliation_strings":["Fudan University , Handan Street, 200433 Shanghai , China","School of Computer Science and Technology , Handan Street, 200433 Shanghai , China","Shanghai Key Lab of Intelligent Information Processing , Handan Street, 200433 Shanghai , China","School of Computer Science and Technology, Fudan UniversityHandan Street, 200433 Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fudan University , Handan Street, 200433 Shanghai , China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"School of Computer Science and Technology , Handan Street, 200433 Shanghai , China","institution_ids":["https://openalex.org/I113389987","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Key Lab of Intelligent Information Processing , Handan Street, 200433 Shanghai , China","institution_ids":[]},{"raw_affiliation_string":"School of Computer Science and Technology, Fudan UniversityHandan Street, 200433 Shanghai, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100455714","display_name":"Fei Wang","orcid":"https://orcid.org/0000-0001-5890-0448"},"institutions":[{"id":"https://openalex.org/I113389987","display_name":"Handan College","ror":"https://ror.org/03fkpw052","country_code":"CN","type":"education","lineage":["https://openalex.org/I113389987"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fei Wang","raw_affiliation_strings":["Fudan University , Handan Street, 200433 Shanghai , China","School of Computer Science and Technology , Handan Street, 200433 Shanghai , China","Shanghai Key Lab of Intelligent Information Processing , Handan Street, 200433 Shanghai , China","School of Computer Science and Technology, Fudan UniversityHandan Street, 200433 Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0001-5890-0448","affiliations":[{"raw_affiliation_string":"Fudan University , Handan Street, 200433 Shanghai , China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"School of Computer Science and Technology , Handan Street, 200433 Shanghai , China","institution_ids":["https://openalex.org/I113389987","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Key Lab of Intelligent Information Processing , Handan Street, 200433 Shanghai , China","institution_ids":[]},{"raw_affiliation_string":"School of Computer Science and Technology, Fudan UniversityHandan Street, 200433 Shanghai, China","institution_ids":["https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100455714"],"corresponding_institution_ids":["https://openalex.org/I113389987","https://openalex.org/I24943067"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":6.3449,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.97513223,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"25","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6426793336868286},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.5557102560997009},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5401081442832947},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.5039648413658142},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4792356789112091},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.45274290442466736},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4271159768104553},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.4205642640590668},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.10967326164245605}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6426793336868286},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.5557102560997009},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5401081442832947},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.5039648413658142},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4792356789112091},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45274290442466736},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4271159768104553},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4205642640590668},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.10967326164245605},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae171","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae171","pdf_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae171/57241929/bbae171.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38628114","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38628114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11021815","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11021815","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11021815/pdf/bbae171.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae171","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae171","pdf_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae171/57241929/bbae171.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5397845877","display_name":"\u57fa\u4e8e\u4ee3\u8c22\u7f51\u7edc\u7684\u591a\u7ec4\u5b66\u6570\u636e\u6574\u5408\u7814\u7a76","funder_award_id":"61472086","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6377096218","display_name":null,"funder_award_id":"NSFC 61472086","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394870153.pdf"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1981276685","https://openalex.org/W2254387803","https://openalex.org/W2471536144","https://openalex.org/W2605624585","https://openalex.org/W2788348358","https://openalex.org/W2809368942","https://openalex.org/W2897249806","https://openalex.org/W2899224111","https://openalex.org/W2915848182","https://openalex.org/W2923300855","https://openalex.org/W2949535577","https://openalex.org/W2950976066","https://openalex.org/W2952383043","https://openalex.org/W2969948459","https://openalex.org/W2972445800","https://openalex.org/W3036167779","https://openalex.org/W3044382958","https://openalex.org/W3087138957","https://openalex.org/W3106188259","https://openalex.org/W3110998212","https://openalex.org/W3122762933","https://openalex.org/W3125011419","https://openalex.org/W3125488134","https://openalex.org/W3182503854","https://openalex.org/W3196495189","https://openalex.org/W3203364159","https://openalex.org/W3208940117","https://openalex.org/W4280533477","https://openalex.org/W4281702815","https://openalex.org/W4288359172","https://openalex.org/W4310530587","https://openalex.org/W4389135772","https://openalex.org/W6691749348","https://openalex.org/W6762361579","https://openalex.org/W6779823529","https://openalex.org/W6795288823","https://openalex.org/W6838738615","https://openalex.org/W6847302828"],"related_works":["https://openalex.org/W4298130764","https://openalex.org/W2804364458","https://openalex.org/W2132641928","https://openalex.org/W4310225030","https://openalex.org/W2090259340","https://openalex.org/W2393816671","https://openalex.org/W2158836806","https://openalex.org/W2083665254","https://openalex.org/W1926736923","https://openalex.org/W2942177010"],"abstract_inverted_index":{"Spatial":[0],"transcriptomics":[1,103],"(ST)":[2],"has":[3],"become":[4],"a":[5,83,159],"powerful":[6],"tool":[7],"for":[8,46,146,162,208],"exploring":[9],"the":[10,26,33,39,51,106,121,126,172,177,200],"spatial":[11,23,182,192],"organization":[12],"of":[13,35,41,115,205],"gene":[14,42,72,88],"expression":[15,73,89,183],"in":[16,31,75,92],"tissues.":[17],"Imaging-based":[18],"methods,":[19],"though":[20],"offering":[21],"superior":[22],"resolutions":[24],"at":[25],"single-cell":[27,58],"level,":[28],"are":[29],"limited":[30],"either":[32],"number":[34],"imaged":[36],"genes":[37],"or":[38],"sensitivity":[40],"detection.":[43],"Existing":[44],"approaches":[45],"enhancing":[47],"ST":[48,54,116,123,174,206,223],"rely":[49],"on":[50],"similarity":[52,141],"between":[53,71],"cells":[55],"and":[56,105,140,202],"reference":[57],"RNA":[59],"sequencing":[60],"(scRNA-seq)":[61],"cells.":[62],"In":[63,129],"contrast,":[64],"we":[65],"introduce":[66],"stDiff,":[67,214],"which":[68],"leverages":[69],"relationships":[70,91],"abundance":[74,90],"scRNA-seq":[76,93],"data":[77,94,104,124,175,207],"to":[78,102,109,150,198,221],"enhance":[79],"ST.":[80],"stDiff":[81,143],"employs":[82],"conditional":[84],"diffusion":[85],"model,":[86],"capturing":[87],"through":[95],"two":[96],"Markov":[97],"processes:":[98],"one":[99],"introducing":[100],"noise":[101],"other":[107],"denoising":[108,127],"recover":[110],"them.":[111],"The":[112],"missing":[113],"portion":[114],"is":[117],"predicted":[118,203],"by":[119],"incorporating":[120],"original":[122],"into":[125],"process.":[128],"our":[130,185],"comprehensive":[131],"performance":[132],"evaluation":[133],"across":[134],"16":[135],"datasets,":[136],"utilizing":[137],"multiple":[138],"clustering":[139],"metrics,":[142],"stands":[144],"out":[145],"its":[147,216],"exceptional":[148],"ability":[149],"preserve":[151],"topological":[152],"structures":[153],"among":[154],"cells,":[155],"positioning":[156],"itself":[157],"as":[158],"robust":[160],"solution":[161],"cell":[163],"population":[164],"identification.":[165],"Moreover,":[166],"stDiff's":[167,196],"enhancement":[168],"outcomes":[169],"closely":[170],"mirror":[171],"actual":[173],"within":[176],"batch":[178],"space.":[179],"Across":[180],"diverse":[181],"patterns,":[184],"model":[186],"accurately":[187],"reconstructs":[188],"them,":[189],"delineating":[190],"distinct":[191],"boundaries.":[193],"This":[194],"highlights":[195],"capability":[197],"unify":[199],"observed":[201],"segments":[204],"subsequent":[209],"analysis.":[210],"We":[211],"anticipate":[212],"that":[213],"with":[215],"innovative":[217],"approach,":[218],"will":[219],"contribute":[220],"advancing":[222],"imputation":[224],"methodologies.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":6}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}