{"id":"https://openalex.org/W4393299296","doi":"https://doi.org/10.1093/bib/bbae104","title":"Meta-DHGNN: method for CRS-related cytokines analysis in CAR-T therapy based on meta-learning directed heterogeneous graph neural network","display_name":"Meta-DHGNN: method for CRS-related cytokines analysis in CAR-T therapy based on meta-learning directed heterogeneous graph neural network","publication_year":2024,"publication_date":"2024-03-27","ids":{"openalex":"https://openalex.org/W4393299296","doi":"https://doi.org/10.1093/bib/bbae104","pmid":"https://pubmed.ncbi.nlm.nih.gov/38546326"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae104","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae104","pdf_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae104/57101641/bbae104.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae104/57101641/bbae104.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011967355","display_name":"Zhenyu Wei","orcid":"https://orcid.org/0009-0001-2950-2560"},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenyu Wei","raw_affiliation_strings":["Intelligent Systems Science and Engineering College, Harbin Engineering University , Harbin 150001 , China"],"raw_orcid":"https://orcid.org/0009-0001-2950-2560","affiliations":[{"raw_affiliation_string":"Intelligent Systems Science and Engineering College, Harbin Engineering University , Harbin 150001 , China","institution_ids":["https://openalex.org/I151727225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007847919","display_name":"Chengkui Zhao","orcid":"https://orcid.org/0000-0002-4328-466X"},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengkui Zhao","raw_affiliation_strings":["Intelligent Systems Science and Engineering College, Harbin Engineering University , Harbin 150001 , China","Shanghai Unicar-Therapy BioMedicine Technology Co., Ltd , Shanghai , China"],"raw_orcid":"https://orcid.org/0000-0002-4328-466X","affiliations":[{"raw_affiliation_string":"Intelligent Systems Science and Engineering College, Harbin Engineering University , Harbin 150001 , China","institution_ids":["https://openalex.org/I151727225"]},{"raw_affiliation_string":"Shanghai Unicar-Therapy BioMedicine Technology Co., Ltd , Shanghai , China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028367783","display_name":"Min Zhang","orcid":"https://orcid.org/0000-0001-9928-5189"},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Zhang","raw_affiliation_strings":["Intelligent Systems Science and Engineering College, Harbin Engineering University , Harbin 150001 , China"],"raw_orcid":"https://orcid.org/0000-0001-9928-5189","affiliations":[{"raw_affiliation_string":"Intelligent Systems Science and Engineering College, Harbin Engineering University , Harbin 150001 , China","institution_ids":["https://openalex.org/I151727225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061167804","display_name":"Jiayu Xu","orcid":"https://orcid.org/0000-0001-7750-3210"},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayu Xu","raw_affiliation_strings":["Intelligent Systems Science and Engineering College, Harbin Engineering University , Harbin 150001 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intelligent Systems Science and Engineering College, Harbin Engineering University , Harbin 150001 , China","institution_ids":["https://openalex.org/I151727225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064813104","display_name":"Nan Xu","orcid":"https://orcid.org/0000-0003-1212-7773"},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Xu","raw_affiliation_strings":["School of Chemical and Molecular Engineering, East China Normal University , Shanghai 200000 , China","Shanghai Unicar-Therapy BioMedicine Technology Co., Ltd , Shanghai , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Molecular Engineering, East China Normal University , Shanghai 200000 , China","institution_ids":["https://openalex.org/I66867065"]},{"raw_affiliation_string":"Shanghai Unicar-Therapy BioMedicine Technology Co., Ltd , Shanghai , China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101934104","display_name":"Shiwei Wu","orcid":"https://orcid.org/0000-0002-3206-6827"},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiwei Wu","raw_affiliation_strings":["Intelligent Systems Science and Engineering College, Harbin Engineering University , Harbin 150001 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intelligent Systems Science and Engineering College, Harbin Engineering University , Harbin 150001 , China","institution_ids":["https://openalex.org/I151727225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086787860","display_name":"Xiaohui Xin","orcid":"https://orcid.org/0000-0002-4171-753X"},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohui Xin","raw_affiliation_strings":["Intelligent Systems Science and Engineering College, Harbin Engineering University , Harbin 150001 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intelligent Systems Science and Engineering College, Harbin Engineering University , Harbin 150001 , China","institution_ids":["https://openalex.org/I151727225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100662885","display_name":"Lei Yu","orcid":"https://orcid.org/0000-0002-8837-2022"},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Yu","raw_affiliation_strings":["School of Chemical and Molecular Engineering, East China Normal University , Shanghai 200000 , China","Shanghai Unicar-Therapy BioMedicine Technology Co., Ltd , Shanghai , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Molecular Engineering, East China Normal University , Shanghai 200000 , China","institution_ids":["https://openalex.org/I66867065"]},{"raw_affiliation_string":"Shanghai Unicar-Therapy BioMedicine Technology Co., Ltd , Shanghai , China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102953680","display_name":"Weixing Feng","orcid":null},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weixing Feng","raw_affiliation_strings":["Intelligent Systems Science and Engineering College, Harbin Engineering University , Harbin 150001 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intelligent Systems Science and Engineering College, Harbin Engineering University , Harbin 150001 , China","institution_ids":["https://openalex.org/I151727225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5011967355","https://openalex.org/A5100662885","https://openalex.org/A5102953680"],"corresponding_institution_ids":["https://openalex.org/I151727225","https://openalex.org/I66867065"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":1.0757,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.79184432,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"25","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9682000279426575,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6925727128982544},{"id":"https://openalex.org/keywords/adjacency-matrix","display_name":"Adjacency matrix","score":0.5567184686660767},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4894374907016754},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.46897515654563904},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"Chimeric antigen receptor","score":0.46862202882766724},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.45644691586494446},{"id":"https://openalex.org/keywords/cytokine","display_name":"Cytokine","score":0.45439887046813965},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.364007830619812},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.25977998971939087},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19933754205703735},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.17916715145111084},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.1495210826396942}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6925727128982544},{"id":"https://openalex.org/C180356752","wikidata":"https://www.wikidata.org/wiki/Q727035","display_name":"Adjacency matrix","level":3,"score":0.5567184686660767},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4894374907016754},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.46897515654563904},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.46862202882766724},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.45644691586494446},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.45439887046813965},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.364007830619812},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.25977998971939087},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19933754205703735},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17916715145111084},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.1495210826396942}],"mesh":[{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000080424","descriptor_name":"Cytokine Release Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000080424","descriptor_name":"Cytokine Release Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000080424","descriptor_name":"Cytokine Release Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000080424","descriptor_name":"Cytokine Release Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae104","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae104","pdf_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae104/57101641/bbae104.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38546326","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38546326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10976917","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10976917","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10976917/pdf/bbae104.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae104","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae104","pdf_url":"https://academic.oup.com/bib/article-pdf/25/3/bbae104/57101641/bbae104.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6899999976158142,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G6713303153","display_name":null,"funder_award_id":"62172121","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8482454962","display_name":null,"funder_award_id":"LH2022F012","funder_id":"https://openalex.org/F4320323085","funder_display_name":"Natural Science Foundation of Heilongjiang Province"},{"id":"https://openalex.org/G8657659977","display_name":null,"funder_award_id":"82073800","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323085","display_name":"Natural Science Foundation of Heilongjiang Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4393299296.pdf"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W2014743999","https://openalex.org/W2069992656","https://openalex.org/W2097308346","https://openalex.org/W2107830237","https://openalex.org/W2129239355","https://openalex.org/W2559137209","https://openalex.org/W2907492528","https://openalex.org/W2921532413","https://openalex.org/W2962756421","https://openalex.org/W3000899691","https://openalex.org/W3102272367","https://openalex.org/W3105908160","https://openalex.org/W3122111926","https://openalex.org/W3160295311","https://openalex.org/W3182774911","https://openalex.org/W4205497185","https://openalex.org/W4210257598","https://openalex.org/W4211207469","https://openalex.org/W4281685099","https://openalex.org/W4281784277","https://openalex.org/W4295756007","https://openalex.org/W4297571622","https://openalex.org/W4299878861","https://openalex.org/W4309699937","https://openalex.org/W6707620307"],"related_works":["https://openalex.org/W3011268210","https://openalex.org/W3024178724","https://openalex.org/W4311588896","https://openalex.org/W2238242969","https://openalex.org/W4381594543","https://openalex.org/W4387955394","https://openalex.org/W3032483461","https://openalex.org/W3029001555","https://openalex.org/W4292999382","https://openalex.org/W4292999066"],"abstract_inverted_index":{"Chimeric":[0],"antigen":[1],"receptor":[2],"T-cell":[3],"(CAR-T)":[4],"immunotherapy,":[5],"a":[6,52,70,127,150],"novel":[7],"approach":[8,104],"for":[9,28],"treating":[10],"blood":[11],"cancer,":[12],"is":[13,32,48,130],"associated":[14,61,174],"with":[15,62,175],"the":[16,39,92,97,109,121,133,137,155,166,182,193,199],"production":[17],"of":[18,99,108,115,170,203,243],"cytokine":[19,110,172],"release":[20],"syndrome":[21],"(CRS),":[22],"which":[23],"poses":[24],"significant":[25],"safety":[26],"concerns":[27],"patients.":[29],"Currently,":[30],"there":[31],"limited":[33,100],"knowledge":[34],"regarding":[35],"CRS-related":[36,116],"cytokines":[37,43,60],"and":[38,44,54,72,88,112,160,168,211,226,252],"intricate":[40],"relationship":[41],"between":[42],"cells.":[45],"Therefore,":[46],"it":[47],"imperative":[49],"to":[50,58,119,164,249],"explore":[51],"reliable":[53],"efficient":[55],"computational":[56],"method":[57,78,84],"identify":[59],"CRS.":[63],"In":[64],"this":[65],"study,":[66],"we":[67,196],"propose":[68],"Meta-DHGNN,":[69],"directed":[71,87,138,251],"heterogeneous":[73,89,156,253],"graph":[74],"neural":[75],"network":[76,111],"analysis":[77,107],"based":[79,191],"on":[80,181,192],"meta-learning.":[81],"The":[82,241],"proposed":[83],"integrates":[85],"both":[86],"algorithms,":[90],"while":[91,258],"meta-learning":[93,134],"module":[94],"effectively":[95,257],"addresses":[96],"issue":[98],"data":[101],"availability.":[102],"This":[103],"enables":[105],"comprehensive":[106],"accurate":[113],"prediction":[114,263],"cytokines.":[117],"Firstly,":[118],"tackle":[120],"challenge":[122],"posed":[123],"by":[124],"small":[125],"datasets,":[126],"pre-training":[128],"phase":[129],"conducted":[131],"using":[132],"module.":[135],"Consequently,":[136],"algorithm":[139,157],"constructs":[140],"an":[141],"adjacency":[142],"matrix":[143],"that":[144,185,228],"accurately":[145],"captures":[146],"potential":[147],"relationships":[148],"in":[149,205,233,246,255,264],"more":[151],"realistic":[152],"manner.":[153],"Ultimately,":[154],"employs":[158],"meta-photographs":[159],"multi-head":[161],"attention":[162],"mechanisms":[163],"enhance":[165],"realism":[167],"accuracy":[169],"predicting":[171],"information":[173],"positive":[176],"labels.":[177],"Our":[178],"experimental":[179],"verification":[180],"dataset":[183],"demonstrates":[184],"Meta-DHGNN":[186,244],"achieves":[187],"favorable":[188],"outcomes.":[189],"Furthermore,":[190],"predicted":[194],"results,":[195],"have":[197,229],"explored":[198],"multifaceted":[200],"formation":[201],"mechanism":[202],"CRS":[204,261],"CAR-T":[206,265],"therapy":[207],"from":[208],"various":[209],"perspectives":[210],"identified":[212],"several":[213],"cytokines,":[214],"such":[215],"as":[216],"IFNG":[217],"(IFN-\u03b3),":[218],"IFNA1,":[219],"IFNB1,":[220],"IFNA13,":[221],"IFNA2,":[222],"IFNAR1,":[223],"IFNAR2,":[224],"IFNGR1":[225],"IFNGR2":[227],"been":[230],"relatively":[231],"overlooked":[232],"previous":[234],"studies":[235],"but":[236],"potentially":[237],"play":[238],"pivotal":[239],"roles.":[240],"significance":[242],"lies":[245],"its":[247],"ability":[248],"analyze":[250],"networks":[254],"biology":[256],"also":[259],"facilitating":[260],"risk":[262],"therapy.":[266]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}