{"id":"https://openalex.org/W4392899358","doi":"https://doi.org/10.1093/bib/bbae097","title":"FusionNW, a potential clinical impact assessment of kinases in pan-cancer fusion gene network","display_name":"FusionNW, a potential clinical impact assessment of kinases in pan-cancer fusion gene network","publication_year":2024,"publication_date":"2024-01-22","ids":{"openalex":"https://openalex.org/W4392899358","doi":"https://doi.org/10.1093/bib/bbae097","pmid":"https://pubmed.ncbi.nlm.nih.gov/38493341"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae097","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/bib/bbae097","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae097/56995135/bbae097.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae097/56995135/bbae097.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079468958","display_name":"Chengyuan Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chengyuan Yang","raw_affiliation_strings":["School of Public Health, The University of Texas Health Science Center at Houston , Houston, TX 77030 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, The University of Texas Health Science Center at Houston , Houston, TX 77030 , USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058345145","display_name":"Himansu Kumar","orcid":"https://orcid.org/0000-0002-4335-4517"},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Himansu Kumar","raw_affiliation_strings":["McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston , Houston, TX 77030 , USA"],"raw_orcid":"https://orcid.org/0000-0002-4335-4517","affiliations":[{"raw_affiliation_string":"McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston , Houston, TX 77030 , USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014102611","display_name":"Pora Kim","orcid":"https://orcid.org/0000-0002-8321-6864"},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pora Kim","raw_affiliation_strings":["McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston , Houston, TX 77030 , USA"],"raw_orcid":"https://orcid.org/0000-0002-8321-6864","affiliations":[{"raw_affiliation_string":"McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston , Houston, TX 77030 , USA","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014102611"],"corresponding_institution_ids":["https://openalex.org/I919571938"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.16,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.45909536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"25","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9905999898910522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fusion-gene","display_name":"Fusion gene","score":0.7248826026916504},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.6899245381355286},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6332111358642578},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.49124544858932495},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.45499736070632935},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.38788729906082153},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3257603645324707}],"concepts":[{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.7248826026916504},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6899245381355286},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6332111358642578},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49124544858932495},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45499736070632935},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38788729906082153},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3257603645324707}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050939","descriptor_name":"Gene Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050939","descriptor_name":"Gene Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050939","descriptor_name":"Gene Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050939","descriptor_name":"Gene Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050939","descriptor_name":"Gene Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbae097","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/bib/bbae097","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae097/56995135/bbae097.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38493341","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38493341","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10944571","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10944571","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10944571/pdf/bbae097.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:uthshis_docs-1229","is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/uthshis_docs/228","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty, Staff and Student Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae097","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/bib/bbae097","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae097/56995135/bbae097.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46000000834465027}],"awards":[{"id":"https://openalex.org/G1616208907","display_name":null,"funder_award_id":"R35GM138184","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5807566396","display_name":null,"funder_award_id":"R35GM138184","funder_id":"https://openalex.org/F4320313675","funder_display_name":"University of Texas Health Science Center at Houston"},{"id":"https://openalex.org/G797813585","display_name":"Functional annotation of new genes aided by deep learning","funder_award_id":"5r35gm138184-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320313675","display_name":"University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4392899358.pdf"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1644197353","https://openalex.org/W1964020745","https://openalex.org/W2000223052","https://openalex.org/W2108501770","https://openalex.org/W2160709761","https://openalex.org/W2342330592","https://openalex.org/W2556467266","https://openalex.org/W2564216510","https://openalex.org/W2768813519","https://openalex.org/W2887065076","https://openalex.org/W2952350893","https://openalex.org/W3044562385","https://openalex.org/W3093660856","https://openalex.org/W3096333766","https://openalex.org/W3137898789","https://openalex.org/W3139532774","https://openalex.org/W3209896479","https://openalex.org/W3214538404","https://openalex.org/W3217485783","https://openalex.org/W4212774754","https://openalex.org/W4282938106","https://openalex.org/W4302283406","https://openalex.org/W6675944832","https://openalex.org/W6730333270","https://openalex.org/W6730485747","https://openalex.org/W6754105616"],"related_works":["https://openalex.org/W2391738941","https://openalex.org/W3005554875","https://openalex.org/W2409398161","https://openalex.org/W2131250617","https://openalex.org/W4385969805","https://openalex.org/W2147060678","https://openalex.org/W2381945189","https://openalex.org/W4243321829","https://openalex.org/W4233034052","https://openalex.org/W2371030422"],"abstract_inverted_index":{"Kinase":[0],"fusion":[1,7,13,29,47,57,84,96,144,151,185],"genes":[2,30,48,85,129,165,182],"are":[3],"the":[4,18,24,41,53,68,82,101,106,110,142,163],"most":[5],"active":[6],"gene":[8,97,145,152],"group":[9],"in":[10,45,86,113,119,183,199],"human":[11,65,197],"cancer":[12,25],"genes.":[14,58,186],"To":[15,115,154],"help":[16],"choose":[17],"clinically":[19],"significant":[20],"kinase":[21,83,93,95,111,143,150],"so":[22],"that":[23,27,108],"patients":[26],"have":[28],"can":[31,99],"be":[32],"better":[33,157],"diagnosed,":[34],"we":[35,122,161],"need":[36],"a":[37,124,131,156,170,191],"metric":[38],"to":[39,135,194],"infer":[40,136],"assessment":[42,90],"of":[43,60,74,92,103,105,127,148,159,177,180,196],"kinases":[44,66,140,198],"pan-cancer":[46,184],"rather":[49],"than":[50],"relying":[51],"on":[52],"sample":[54],"frequency":[55],"expressed":[56],"Most":[59],"all,":[61],"multiple":[62,72],"studies":[63,91],"assessed":[64],"as":[67],"drug":[69],"targets":[70],"using":[71,130],"types":[73],"genomic":[75],"and":[76],"clinical":[77],"information,":[78],"but":[79],"none":[80],"used":[81],"their":[87],"study.":[88],"The":[89],"without":[94],"events":[98],"miss":[100],"effect":[102],"one":[104],"mechanisms":[107],"enhance":[109],"function":[112],"cancer.":[114,200],"fill":[116],"this":[117,120],"gap,":[118],"study,":[121],"suggest":[123],"novel":[125,192],"way":[126,193],"assessing":[128],"network":[132,146],"propagation":[133],"approach":[134,188],"how":[137],"likely":[138],"individual":[139,181],"influence":[141],"composed":[147],"~5K":[149],"pairs.":[153],"select":[155],"seed":[158],"propagation,":[160],"chose":[162],"top":[164],"via":[166],"dimensionality":[167],"reduction":[168],"like":[169],"principal":[171],"component":[172],"or":[173],"latent":[174],"layer":[175],"information":[176],"six":[178],"features":[179],"Our":[187],"may":[189],"provide":[190],"assess":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-08-06T08:24:18.245995","created_date":"2025-10-10T00:00:00"}