{"id":"https://openalex.org/W4392393093","doi":"https://doi.org/10.1093/bib/bbae066","title":"CRISPRlnc: a machine learning method for lncRNA-specific single-guide RNA design of CRISPR/Cas9 system","display_name":"CRISPRlnc: a machine learning method for lncRNA-specific single-guide RNA design of CRISPR/Cas9 system","publication_year":2024,"publication_date":"2024-01-22","ids":{"openalex":"https://openalex.org/W4392393093","doi":"https://doi.org/10.1093/bib/bbae066","pmid":"https://pubmed.ncbi.nlm.nih.gov/38426328"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae066","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae066","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae066/56807770/bbae066.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae066/56807770/bbae066.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079924163","display_name":"Zitian Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I2801454379","display_name":"Xishuangbanna Tropical Botanical Garden","ror":"https://ror.org/02rz58g17","country_code":"CN","type":"archive","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801454379"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zitian Yang","raw_affiliation_strings":["CAS Key Laboratory of Tropical Plant Resources and Sustainable Use , Yunnan Key Laboratory of Crop Wild Relatives Omics, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223 , China","College of Life Sciences, University of Chinese Academy of Sciences , Beijing 100049 , China"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Tropical Plant Resources and Sustainable Use , Yunnan Key Laboratory of Crop Wild Relatives Omics, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223 , China","institution_ids":["https://openalex.org/I2801454379","https://openalex.org/I19820366"]},{"raw_affiliation_string":"College of Life Sciences, University of Chinese Academy of Sciences , Beijing 100049 , China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071518382","display_name":"Zexin Zhang","orcid":"https://orcid.org/0000-0002-4963-5002"},"institutions":[{"id":"https://openalex.org/I2801454379","display_name":"Xishuangbanna Tropical Botanical Garden","ror":"https://ror.org/02rz58g17","country_code":"CN","type":"archive","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801454379"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zexin Zhang","raw_affiliation_strings":["CAS Key Laboratory of Tropical Plant Resources and Sustainable Use , Yunnan Key Laboratory of Crop Wild Relatives Omics, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223 , China"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Tropical Plant Resources and Sustainable Use , Yunnan Key Laboratory of Crop Wild Relatives Omics, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223 , China","institution_ids":["https://openalex.org/I2801454379","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336753","display_name":"Jing Li","orcid":"https://orcid.org/0000-0001-5454-5135"},"institutions":[{"id":"https://openalex.org/I2801454379","display_name":"Xishuangbanna Tropical Botanical Garden","ror":"https://ror.org/02rz58g17","country_code":"CN","type":"archive","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801454379"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["CAS Key Laboratory of Tropical Plant Resources and Sustainable Use , Yunnan Key Laboratory of Crop Wild Relatives Omics, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223 , China"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Tropical Plant Resources and Sustainable Use , Yunnan Key Laboratory of Crop Wild Relatives Omics, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223 , China","institution_ids":["https://openalex.org/I2801454379","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015619158","display_name":"Wen Chen","orcid":"https://orcid.org/0000-0002-9522-4036"},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Chen","raw_affiliation_strings":["Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine , School of Medicine, Hunan University of Chinese Medicine, Changsha 410208 , China"],"affiliations":[{"raw_affiliation_string":"Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine , School of Medicine, Hunan University of Chinese Medicine, Changsha 410208 , China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101994407","display_name":"Changning Liu","orcid":"https://orcid.org/0000-0002-8914-198X"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801454379","display_name":"Xishuangbanna Tropical Botanical Garden","ror":"https://ror.org/02rz58g17","country_code":"CN","type":"archive","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801454379"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changning Liu","raw_affiliation_strings":["CAS Key Laboratory of Tropical Plant Resources and Sustainable Use , Yunnan Key Laboratory of Crop Wild Relatives Omics, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223 , China"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Tropical Plant Resources and Sustainable Use , Yunnan Key Laboratory of Crop Wild Relatives Omics, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223 , China","institution_ids":["https://openalex.org/I2801454379","https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101994407"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801454379"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":2.1696,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.86994293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"25","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crispr","display_name":"CRISPR","score":0.8474285006523132},{"id":"https://openalex.org/keywords/guide-rna","display_name":"Guide RNA","score":0.7608868479728699},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7112904787063599},{"id":"https://openalex.org/keywords/cas9","display_name":"Cas9","score":0.66802978515625},{"id":"https://openalex.org/keywords/subgenomic-mrna","display_name":"Subgenomic mRNA","score":0.6070458889007568},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5341547727584839},{"id":"https://openalex.org/keywords/genome-editing","display_name":"Genome editing","score":0.5207593441009521},{"id":"https://openalex.org/keywords/coding","display_name":"Coding (social sciences)","score":0.42066097259521484},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3625487983226776},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.26163870096206665},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19785571098327637}],"concepts":[{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.8474285006523132},{"id":"https://openalex.org/C97702854","wikidata":"https://www.wikidata.org/wiki/Q4039747","display_name":"Guide RNA","level":5,"score":0.7608868479728699},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7112904787063599},{"id":"https://openalex.org/C132455925","wikidata":"https://www.wikidata.org/wiki/Q16965677","display_name":"Cas9","level":4,"score":0.66802978515625},{"id":"https://openalex.org/C189819185","wikidata":"https://www.wikidata.org/wiki/Q384283","display_name":"Subgenomic mRNA","level":4,"score":0.6070458889007568},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5341547727584839},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.5207593441009521},{"id":"https://openalex.org/C179518139","wikidata":"https://www.wikidata.org/wiki/Q5140297","display_name":"Coding (social sciences)","level":2,"score":0.42066097259521484},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3625487983226776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26163870096206665},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19785571098327637},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094704","descriptor_name":"RNA, Guide, CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000094704","descriptor_name":"RNA, Guide, CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000094704","descriptor_name":"RNA, Guide, CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000094704","descriptor_name":"RNA, Guide, CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae066","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae066","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae066/56807770/bbae066.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38426328","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38426328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10905519","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10905519","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10905519/pdf/bbae066.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae066","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae066","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae066/56807770/bbae066.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1121271761","display_name":null,"funder_award_id":"Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1231421488","display_name":null,"funder_award_id":"under","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2633452614","display_name":null,"funder_award_id":"XDA26030301","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G3085993365","display_name":null,"funder_award_id":"(Grant No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4009049029","display_name":null,"funder_award_id":"Startup","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5939423041","display_name":null,"funder_award_id":"Technology","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6258415954","display_name":null,"funder_award_id":"Chinese","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6444234146","display_name":null,"funder_award_id":"31970609","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7608752429","display_name":null,"funder_award_id":"Talent","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7726157001","display_name":null,"funder_award_id":"Grant No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392393093.pdf"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W1869792624","https://openalex.org/W1879165674","https://openalex.org/W1892406518","https://openalex.org/W1906155566","https://openalex.org/W1915704240","https://openalex.org/W1968342623","https://openalex.org/W1972476556","https://openalex.org/W1973260880","https://openalex.org/W1977709885","https://openalex.org/W1981160614","https://openalex.org/W1982598879","https://openalex.org/W1982846895","https://openalex.org/W1999903619","https://openalex.org/W2003797386","https://openalex.org/W2005636452","https://openalex.org/W2006373538","https://openalex.org/W2036176224","https://openalex.org/W2050099686","https://openalex.org/W2059282068","https://openalex.org/W2064815984","https://openalex.org/W2077237334","https://openalex.org/W2077381938","https://openalex.org/W2077659966","https://openalex.org/W2084471200","https://openalex.org/W2087064593","https://openalex.org/W2087377443","https://openalex.org/W2091161969","https://openalex.org/W2092806325","https://openalex.org/W2096261947","https://openalex.org/W2101749257","https://openalex.org/W2104820165","https://openalex.org/W2114245320","https://openalex.org/W2115603949","https://openalex.org/W2117924928","https://openalex.org/W2118967129","https://openalex.org/W2133836136","https://openalex.org/W2134298288","https://openalex.org/W2145782793","https://openalex.org/W2148143831","https://openalex.org/W2152705149","https://openalex.org/W2153344788","https://openalex.org/W2157205823","https://openalex.org/W2160051211","https://openalex.org/W2167380395","https://openalex.org/W2170039745","https://openalex.org/W2170818583","https://openalex.org/W2172149993","https://openalex.org/W2176555004","https://openalex.org/W2188338489","https://openalex.org/W2231411829","https://openalex.org/W2252568502","https://openalex.org/W2295598076","https://openalex.org/W2304268185","https://openalex.org/W2461013690","https://openalex.org/W2524784061","https://openalex.org/W2544093984","https://openalex.org/W2561535772","https://openalex.org/W2561677973","https://openalex.org/W2591777705","https://openalex.org/W2616246685","https://openalex.org/W2623793810","https://openalex.org/W2625522207","https://openalex.org/W2765477541","https://openalex.org/W2770948545","https://openalex.org/W2778131996","https://openalex.org/W2803479625","https://openalex.org/W2894793173","https://openalex.org/W2902305894","https://openalex.org/W2939661038","https://openalex.org/W2952643052","https://openalex.org/W2958015815","https://openalex.org/W2970173547","https://openalex.org/W2971775201","https://openalex.org/W2973312556","https://openalex.org/W2982711111","https://openalex.org/W2991600264","https://openalex.org/W2994595730","https://openalex.org/W3007395363","https://openalex.org/W3011320708","https://openalex.org/W3115880421","https://openalex.org/W3173483657","https://openalex.org/W3202756067","https://openalex.org/W4221016141","https://openalex.org/W4234233003","https://openalex.org/W6687110099","https://openalex.org/W6756629155","https://openalex.org/W6790279009"],"related_works":["https://openalex.org/W2603161682","https://openalex.org/W2960163646","https://openalex.org/W2807464733","https://openalex.org/W2516842346","https://openalex.org/W2134268326","https://openalex.org/W2903635918","https://openalex.org/W2437118042","https://openalex.org/W2337751047","https://openalex.org/W3052741125","https://openalex.org/W2667943050"],"abstract_inverted_index":{"CRISPR/Cas9":[0,144],"is":[1],"a":[2,11,15,21,59,102,182],"promising":[3],"RNA-guided":[4],"genome":[5,93],"editing":[6,96],"technology,":[7],"which":[8,111],"consists":[9],"of":[10,23,58,61,68,79,129,143,178],"Cas9":[12],"nuclease":[13],"and":[14,71,95,119,136,166,186],"single-guide":[16],"RNA":[17,43],"(sgRNA).":[18],"So":[19],"far,":[20],"number":[22],"sgRNA":[24,172],"prediction":[25],"softwares":[26],"have":[27,47],"been":[28],"developed.":[29],"However,":[30],"they":[31],"were":[32],"usually":[33],"designed":[34],"for":[35,87,146,163,190],"protein-coding":[36],"genes":[37,45],"without":[38],"considering":[39],"that":[40,155],"long":[41],"non-coding":[42,72,147],"(lncRNA)":[44],"may":[46],"different":[48],"characteristics.":[49],"In":[50],"this":[51],"study,":[52],"we":[53,75,100,180],"first":[54],"evaluated":[55],"the":[56,66,77,84,126,133,170,176],"performances":[57,82],"series":[60],"known":[62],"sgRNA-designing":[63],"tools":[64],"in":[65],"context":[67],"both":[69,115,164],"coding":[70],"datasets.":[73],"Meanwhile,":[74],"analyzed":[76],"underpinnings":[78],"their":[80],"varied":[81],"on":[83,151,192],"sgRNA's":[85],"specificity":[86],"lncRNA":[88],"including":[89],"nucleic":[90],"acid":[91],"sequence,":[92],"location":[94],"mechanism":[97],"preference.":[98],"Furthermore,":[99],"introduce":[101],"support":[103],"vector":[104],"machine-based":[105],"machine":[106],"learning":[107],"algorithm":[108],"named":[109],"CRISPRlnc,":[110,179],"aims":[112],"to":[113,124,139,160],"model":[114],"CRISPR":[116,120],"knock-out":[117],"(CRISPRko)":[118],"inhibition":[121],"(CRISPRi)":[122],"mechanisms":[123,168],"predict":[125],"on-target":[127],"activity":[128],"targets.":[130],"CRISPRlnc":[131,156],"combined":[132],"paired-sgRNA":[134],"design":[135,142],"off-target":[137],"analysis":[138],"achieve":[140],"one-stop":[141],"sgRNAs":[145],"genes.":[148],"Performance":[149],"comparison":[150],"multiple":[152],"datasets":[153],"showed":[154],"was":[157],"far":[158],"superior":[159],"existing":[161],"methods":[162],"CRISPRko":[165],"CRISPRi":[167],"during":[169],"lncRNA-specific":[171],"design.":[173],"To":[174],"maximize":[175],"availability":[177],"developed":[181],"web":[183],"server":[184],"(http://predict.crisprlnc.cc)":[185],"made":[187],"it":[188],"available":[189],"download":[191],"GitHub.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4}],"updated_date":"2026-03-18T14:38:29.013473","created_date":"2025-10-10T00:00:00"}