{"id":"https://openalex.org/W4392393059","doi":"https://doi.org/10.1093/bib/bbae061","title":"Deeply integrating latent consistent representations in high-noise multi-omics data for cancer subtyping","display_name":"Deeply integrating latent consistent representations in high-noise multi-omics data for cancer subtyping","publication_year":2024,"publication_date":"2024-01-22","ids":{"openalex":"https://openalex.org/W4392393059","doi":"https://doi.org/10.1093/bib/bbae061","pmid":"https://pubmed.ncbi.nlm.nih.gov/38426322"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae061","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae061","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae061/56793230/bbae061.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae061/56793230/bbae061.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102976275","display_name":"Yueyi Cai","orcid":"https://orcid.org/0009-0004-3713-523X"},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yueyi Cai","raw_affiliation_strings":["Department of Computer Science and Engineering , School of Information Science and Engineering, , Kunming, 650504, Yunnan , China","Yunnan University , School of Information Science and Engineering, , Kunming, 650504, Yunnan , China","Department of Computer Science and Engineering, School of Information Science and Engineering, Yunnan University, Kunming, 650504, Yunnan, China"],"raw_orcid":"https://orcid.org/0009-0004-3713-523X","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering , School of Information Science and Engineering, , Kunming, 650504, Yunnan , China","institution_ids":["https://openalex.org/I189210763"]},{"raw_affiliation_string":"Yunnan University , School of Information Science and Engineering, , Kunming, 650504, Yunnan , China","institution_ids":["https://openalex.org/I189210763"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, School of Information Science and Engineering, Yunnan University, Kunming, 650504, Yunnan, China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040105964","display_name":"Shunfang Wang","orcid":"https://orcid.org/0000-0002-1927-8753"},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shunfang Wang","raw_affiliation_strings":["Department of Computer Science and Engineering , School of Information Science and Engineering, , Kunming, 650504, Yunnan , China","Yunnan University , School of Information Science and Engineering, , Kunming, 650504, Yunnan , China","Department of Computer Science and Engineering, School of Information Science and Engineering, Yunnan University, Kunming, 650504, Yunnan, China"],"raw_orcid":"https://orcid.org/0000-0002-1927-8753","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering , School of Information Science and Engineering, , Kunming, 650504, Yunnan , China","institution_ids":["https://openalex.org/I189210763"]},{"raw_affiliation_string":"Yunnan University , School of Information Science and Engineering, , Kunming, 650504, Yunnan , China","institution_ids":["https://openalex.org/I189210763"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, School of Information Science and Engineering, Yunnan University, Kunming, 650504, Yunnan, China","institution_ids":["https://openalex.org/I189210763"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040105964"],"corresponding_institution_ids":["https://openalex.org/I189210763"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":7.0068,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.97694052,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"25","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subtyping","display_name":"Subtyping","score":0.8106110095977783},{"id":"https://openalex.org/keywords/omics","display_name":"Omics","score":0.7197582721710205},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.653188943862915},{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.5586891174316406},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.5557990074157715},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.46724653244018555},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4368230998516083},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4331275522708893},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4247279167175293},{"id":"https://openalex.org/keywords/data-integration","display_name":"Data integration","score":0.4122858941555023},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.29175275564193726},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15345647931098938}],"concepts":[{"id":"https://openalex.org/C83852419","wikidata":"https://www.wikidata.org/wiki/Q2713292","display_name":"Subtyping","level":2,"score":0.8106110095977783},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.7197582721710205},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.653188943862915},{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.5586891174316406},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.5557990074157715},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.46724653244018555},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4368230998516083},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4331275522708893},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4247279167175293},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.4122858941555023},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29175275564193726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15345647931098938},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae061","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae061","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae061/56793230/bbae061.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38426322","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38426322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10939425","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10939425","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10939425/pdf/bbae061.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae061","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae061","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae061/56793230/bbae061.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8799999952316284}],"awards":[{"id":"https://openalex.org/G5170125095","display_name":null,"funder_award_id":"KC-23233880","funder_id":"https://openalex.org/F4320324731","funder_display_name":"Yunnan University"},{"id":"https://openalex.org/G648225990","display_name":null,"funder_award_id":"62062067","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324731","display_name":"Yunnan University","ror":"https://ror.org/0040axw97"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392393059.pdf"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1959608418","https://openalex.org/W1978034558","https://openalex.org/W1987219048","https://openalex.org/W1991154912","https://openalex.org/W2008929650","https://openalex.org/W2044702943","https://openalex.org/W2083763767","https://openalex.org/W2093871448","https://openalex.org/W2096283457","https://openalex.org/W2097453652","https://openalex.org/W2100495367","https://openalex.org/W2105528101","https://openalex.org/W2105717378","https://openalex.org/W2108786888","https://openalex.org/W2117572593","https://openalex.org/W2139967559","https://openalex.org/W2147430729","https://openalex.org/W2156483112","https://openalex.org/W2185729964","https://openalex.org/W2224319365","https://openalex.org/W2230320310","https://openalex.org/W2285093314","https://openalex.org/W2335012284","https://openalex.org/W2481151430","https://openalex.org/W2560367415","https://openalex.org/W2624701078","https://openalex.org/W2741943936","https://openalex.org/W2752829361","https://openalex.org/W2783685429","https://openalex.org/W2790649116","https://openalex.org/W2884724578","https://openalex.org/W2906107882","https://openalex.org/W2950878899","https://openalex.org/W2951209146","https://openalex.org/W2993280565","https://openalex.org/W3009624681","https://openalex.org/W3092994367","https://openalex.org/W3130672622","https://openalex.org/W3163443268","https://openalex.org/W3173513735","https://openalex.org/W3202182910","https://openalex.org/W3202225292","https://openalex.org/W4206174637","https://openalex.org/W4207063191","https://openalex.org/W4224291115","https://openalex.org/W4252676770","https://openalex.org/W4281636170","https://openalex.org/W4287643567","https://openalex.org/W4309976975","https://openalex.org/W4313485004","https://openalex.org/W4378782144","https://openalex.org/W4384207011","https://openalex.org/W4385245566","https://openalex.org/W4385564753","https://openalex.org/W6602002561","https://openalex.org/W6631235637","https://openalex.org/W6640963894","https://openalex.org/W6644927703","https://openalex.org/W6713708190","https://openalex.org/W6739901393","https://openalex.org/W6742649196","https://openalex.org/W6752793870","https://openalex.org/W6770717842","https://openalex.org/W6801925766","https://openalex.org/W6807785742"],"related_works":["https://openalex.org/W2396009657","https://openalex.org/W2799110842","https://openalex.org/W2924366642","https://openalex.org/W4392558563","https://openalex.org/W3173875945","https://openalex.org/W3159101980","https://openalex.org/W2966125521","https://openalex.org/W3003192283","https://openalex.org/W2996736193","https://openalex.org/W2909364225"],"abstract_inverted_index":{"Cancer":[0,145],"is":[1,14],"a":[2,64],"complex":[3],"and":[4,21,56,83,95,148,168,195],"high-mortality":[5],"disease":[6],"regulated":[7],"by":[8,37,189],"multiple":[9,79],"factors.":[10],"Accurate":[11],"cancer":[12,31,141,174,185],"subtyping":[13],"crucial":[15],"for":[16],"formulating":[17],"personalized":[18],"treatment":[19],"plans":[20],"improving":[22],"patient":[23],"survival":[24],"rates.":[25],"The":[26,132,144,155],"underlying":[27],"mechanisms":[28],"that":[29,158],"drive":[30],"progression":[32],"can":[33],"be":[34],"comprehensively":[35],"understood":[36],"analyzing":[38],"multi-omics":[39],"data.":[40],"However,":[41],"the":[42,120,162,177],"high":[43],"noise":[44,91],"levels":[45,115],"in":[46,52,165,173],"omics":[47,93,114,166],"data":[48,94,167],"often":[49],"pose":[50],"challenges":[51],"capturing":[53],"consistent":[54,98,110,163],"representations":[55,111,164],"adequately":[57],"integrating":[58],"their":[59],"information.":[60],"This":[61],"paper":[62],"proposed":[63,107],"novel":[65],"variational":[66,81],"autoencoder-based":[67],"deep":[68],"learning":[69],"model,":[70],"named":[71],"Deeply":[72],"Integrating":[73],"Latent":[74],"Consistent":[75],"Representations":[76],"(DILCR).":[77],"Firstly,":[78],"independent":[80],"autoencoders":[82],"contrastive":[84],"loss":[85],"functions":[86],"were":[87,187],"designed":[88],"to":[89,108,126],"separate":[90],"from":[92,143],"capture":[96],"latent":[97],"representations.":[99],"Subsequently,":[100],"an":[101],"Attention":[102],"Deep":[103,122],"Integration":[104],"Network":[105],"was":[106,136],"integrate":[109],"across":[112],"different":[113],"effectively.":[116],"Additionally,":[117],"we":[118],"introduced":[119],"Improved":[121],"Embedded":[123],"Clustering":[124],"algorithm":[125],"make":[127],"integrated":[128],"variable":[129],"clustering":[130],"friendly.":[131],"effectiveness":[133],"of":[134],"DILCR":[135,159,190],"evaluated":[137],"using":[138],"10":[139],"typical":[140],"datasets":[142],"Genome":[146],"Atlas":[147],"compared":[149],"with":[150,191],"14":[151],"state-of-the-art":[152],"integration":[153,171],"methods.":[154],"results":[156],"demonstrated":[157],"effectively":[160],"captures":[161],"outperforms":[169],"other":[170],"methods":[172],"subtyping.":[175],"In":[176],"Kidney":[178],"Renal":[179],"Clear":[180],"Cell":[181],"Carcinoma":[182],"case":[183],"study,":[184],"subtypes":[186],"identified":[188],"significant":[192],"biological":[193],"significance":[194],"interpretability.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":2}],"updated_date":"2026-06-18T10:00:31.954636","created_date":"2025-10-10T00:00:00"}