{"id":"https://openalex.org/W4392021342","doi":"https://doi.org/10.1093/bib/bbae051","title":"STW-MD: a novel spatio-temporal weighting and multi-step decision tree method for considering spatial heterogeneity in brain gene expression data","display_name":"STW-MD: a novel spatio-temporal weighting and multi-step decision tree method for considering spatial heterogeneity in brain gene expression data","publication_year":2024,"publication_date":"2024-01-22","ids":{"openalex":"https://openalex.org/W4392021342","doi":"https://doi.org/10.1093/bib/bbae051","pmid":"https://pubmed.ncbi.nlm.nih.gov/38385881"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae051","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae051","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae051/56728712/bbae051.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae051/56728712/bbae051.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017864467","display_name":"Shanjun Mao","orcid":"https://orcid.org/0000-0003-2047-3465"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanjun Mao","raw_affiliation_strings":["Department of Statistics, Hunan University , Shijiachong Road, Changsha 410000 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Hunan University , Shijiachong Road, Changsha 410000 , China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102647427","display_name":"Xiao Huang","orcid":"https://orcid.org/0009-0002-2162-9935"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Huang","raw_affiliation_strings":["Department of Statistics, Hunan University , Shijiachong Road, Changsha 410000 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Hunan University , Shijiachong Road, Changsha 410000 , China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057211147","display_name":"Runjiu Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Runjiu Chen","raw_affiliation_strings":["Department of Statistics, Hunan University , Shijiachong Road, Changsha 410000 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Hunan University , Shijiachong Road, Changsha 410000 , China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100337323","display_name":"Chenyang Zhang","orcid":"https://orcid.org/0000-0002-9128-5376"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenyang Zhang","raw_affiliation_strings":["Department of Statistics, Hunan University , Shijiachong Road, Changsha 410000 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Hunan University , Shijiachong Road, Changsha 410000 , China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yizhu Diao","orcid":null},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yizhu Diao","raw_affiliation_strings":["Department of Statistics, Hunan University , Shijiachong Road, Changsha 410000 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Hunan University , Shijiachong Road, Changsha 410000 , China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101475457","display_name":"Zongjin Li","orcid":"https://orcid.org/0000-0003-2134-2651"},"institutions":[{"id":"https://openalex.org/I137867983","display_name":"Central University of Finance and Economics","ror":"https://ror.org/008e3hf02","country_code":"CN","type":"education","lineage":["https://openalex.org/I137867983"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zongjin Li","raw_affiliation_strings":["Central University of Finance and Economics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central University of Finance and Economics","institution_ids":["https://openalex.org/I137867983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110146534","display_name":"Qingzhe Wang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qingzhe Wang","raw_affiliation_strings":["Shanghai Institute for Advanced Studies, University of Science and Technology of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute for Advanced Studies, University of Science and Technology of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101829347","display_name":"Shan Tang","orcid":"https://orcid.org/0009-0003-2196-3201"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shan Tang","raw_affiliation_strings":["Department of Statistics, Hunan University , Shijiachong Road, Changsha 410000 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Hunan University , Shijiachong Road, Changsha 410000 , China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053141671","display_name":"Shuixia Guo","orcid":"https://orcid.org/0000-0003-2714-3477"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuixia Guo","raw_affiliation_strings":["MOE-LCSM, School of Mathematics and Statistics, Hunan Normal University , Lushan Road, Changsha 410000 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOE-LCSM, School of Mathematics and Statistics, Hunan Normal University , Lushan Road, Changsha 410000 , China","institution_ids":["https://openalex.org/I173759888"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5053141671","https://openalex.org/A5101829347"],"corresponding_institution_ids":["https://openalex.org/I16609230","https://openalex.org/I173759888"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.1866,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50084356,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"25","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.9700000286102295,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/weighting","display_name":"Weighting","score":0.728434681892395},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5195279717445374},{"id":"https://openalex.org/keywords/brain-development","display_name":"Brain development","score":0.4652107357978821},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.41565772891044617},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4045230746269226},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3665815591812134},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.33547478914260864},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3319524824619293},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3213483393192291},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1171790361404419}],"concepts":[{"id":"https://openalex.org/C183115368","wikidata":"https://www.wikidata.org/wiki/Q856577","display_name":"Weighting","level":2,"score":0.728434681892395},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5195279717445374},{"id":"https://openalex.org/C2984223407","wikidata":"https://www.wikidata.org/wiki/Q1345738","display_name":"Brain development","level":2,"score":0.4652107357978821},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.41565772891044617},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4045230746269226},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3665815591812134},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.33547478914260864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3319524824619293},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3213483393192291},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1171790361404419},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae051","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae051","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae051/56728712/bbae051.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38385881","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38385881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10883420","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10883420","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10883420/pdf/bbae051.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae051","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae051","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae051/56728712/bbae051.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7900000214576721,"id":"https://metadata.un.org/sdg/16","display_name":"Peace, Justice and strong institutions"}],"awards":[{"id":"https://openalex.org/G3701458047","display_name":null,"funder_award_id":"531118010643","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8493218639","display_name":"\u57fa\u4e8e\u795e\u7ecf\u5f71\u50cf\u8111\u8fde\u63a5\u7ec4\u5927\u6570\u636e\u7684\u8111\u75be\u75c5\u7814\u7a76","funder_award_id":"12071124","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392021342.pdf"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W2005743500","https://openalex.org/W2022689242","https://openalex.org/W2028372123","https://openalex.org/W2031205682","https://openalex.org/W2039880574","https://openalex.org/W2056840798","https://openalex.org/W2109163351","https://openalex.org/W2114104545","https://openalex.org/W2119608950","https://openalex.org/W2179438025","https://openalex.org/W2182154268","https://openalex.org/W2309442902","https://openalex.org/W2463725636","https://openalex.org/W2525348374","https://openalex.org/W2593921779","https://openalex.org/W2782160930","https://openalex.org/W2790599046","https://openalex.org/W2790955799","https://openalex.org/W2798054687","https://openalex.org/W2836368391","https://openalex.org/W2892812660","https://openalex.org/W2902941624","https://openalex.org/W2903418495","https://openalex.org/W2904577036","https://openalex.org/W2904647285","https://openalex.org/W2909599334","https://openalex.org/W2911860080","https://openalex.org/W2951159567","https://openalex.org/W2973208504","https://openalex.org/W2985645328","https://openalex.org/W2991331424","https://openalex.org/W3003245439","https://openalex.org/W3005219145","https://openalex.org/W3009710697","https://openalex.org/W3022386977","https://openalex.org/W3036780800","https://openalex.org/W3089213722","https://openalex.org/W3103221179","https://openalex.org/W3108416644","https://openalex.org/W3108941787","https://openalex.org/W3117882517","https://openalex.org/W3132133099","https://openalex.org/W3163562879","https://openalex.org/W3164271582","https://openalex.org/W3164692211","https://openalex.org/W3165827221","https://openalex.org/W3171637117","https://openalex.org/W3196813858","https://openalex.org/W3210445590","https://openalex.org/W4205777871","https://openalex.org/W4206046172","https://openalex.org/W4206774749","https://openalex.org/W4220948119","https://openalex.org/W4225107780","https://openalex.org/W4225459682","https://openalex.org/W4225460844","https://openalex.org/W4286447802","https://openalex.org/W4294733796","https://openalex.org/W4297106203","https://openalex.org/W4304185364","https://openalex.org/W4311115821","https://openalex.org/W4315871740","https://openalex.org/W4376225182","https://openalex.org/W4376629805","https://openalex.org/W4377088397","https://openalex.org/W4377094940","https://openalex.org/W4380894009","https://openalex.org/W4381435341","https://openalex.org/W4384283586","https://openalex.org/W4385760568","https://openalex.org/W4387692359","https://openalex.org/W6796940182","https://openalex.org/W6807258594","https://openalex.org/W6810427761"],"related_works":["https://openalex.org/W2180954594","https://openalex.org/W2052835778","https://openalex.org/W2049003611","https://openalex.org/W2108418243","https://openalex.org/W2127804977","https://openalex.org/W164103134","https://openalex.org/W2787352659","https://openalex.org/W1970611213","https://openalex.org/W4206560911","https://openalex.org/W4372260270"],"abstract_inverted_index":{"Gene":[0],"expression":[1,128],"during":[2],"brain":[3,27,52,56,104,112,138,164,171,191],"development":[4,7,53,139,143,165],"or":[5,29,54],"abnormal":[6,55,190],"is":[8,13,36],"a":[9,30,47,75],"biological":[10],"process":[11],"that":[12],"highly":[14],"dynamic":[15],"in":[16,111,155],"spatio":[17],"and":[18,63,84,96,102,106,133,136,159,166,173,181,189],"temporal.":[19],"Previous":[20],"studies":[21,180],"have":[22],"mainly":[23],"focused":[24],"on":[25,80,119,163],"individual":[26],"regions":[28,113,172],"certain":[31],"developmental":[32],"stage.":[33],"Our":[34,146],"motivation":[35],"to":[37,45,64,144],"address":[38],"this":[39,71],"gap":[40],"by":[41],"incorporating":[42],"spatio-temporal":[43],"information":[44,82],"gain":[46],"more":[48],"complete":[49],"understanding":[50],"of":[51,68,151,187],"development,":[57],"such":[58],"as":[59],"Alzheimer's":[60],"disease":[61],"(AD),":[62],"identify":[65],"potential":[66],"determinants":[67],"response.":[69],"In":[70],"study,":[72],"we":[73],"propose":[74],"novel":[76],"two-step":[77],"framework":[78,89,154],"based":[79],"spatial-temporal":[81],"weighting":[83],"multi-step":[85],"decision":[86],"trees.":[87],"This":[88],"can":[90],"effectively":[91],"exploit":[92],"the":[93,122,137,149,152,185],"spatial":[94],"similarity":[95],"temporal":[97],"dependence":[98],"between":[99],"different":[100,103],"stages":[101],"regions,":[105],"facilitate":[107],"differential":[108],"gene":[109,127,157],"analysis":[110],"with":[114,178],"high":[115],"heterogeneity.":[116],"We":[117],"focus":[118],"two":[120],"datasets:":[121],"AD":[123,167],"dataset,":[124,140],"which":[125],"includes":[126],"data":[129],"from":[130],"early,":[131],"middle":[132],"late":[134],"stages,":[135],"spanning":[141],"fetal":[142],"adulthood.":[145],"findings":[147,176],"highlight":[148],"advantages":[150],"proposed":[153],"discovering":[156],"classes":[158],"elucidating":[160],"their":[161],"impact":[162],"progression":[168],"across":[169],"diverse":[170],"stages.":[174],"These":[175],"align":[177],"existing":[179],"provide":[182],"insights":[183],"into":[184],"processes":[186],"normal":[188],"development.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}