{"id":"https://openalex.org/W4391758618","doi":"https://doi.org/10.1093/bib/bbae023","title":"Genomic hallmarks and therapeutic targets of ribosome biogenesis in cancer","display_name":"Genomic hallmarks and therapeutic targets of ribosome biogenesis in cancer","publication_year":2024,"publication_date":"2024-01-22","ids":{"openalex":"https://openalex.org/W4391758618","doi":"https://doi.org/10.1093/bib/bbae023","pmid":"https://pubmed.ncbi.nlm.nih.gov/38343327"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae023","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae023","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae023/56659760/bbae023.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae023/56659760/bbae023.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102257282","display_name":"Yue Zang","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Zang","raw_affiliation_strings":["HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences and Institute of Genomic Medicine, Wenzhou Medical University , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences and Institute of Genomic Medicine, Wenzhou Medical University , China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051835110","display_name":"Ran Xia","orcid":"https://orcid.org/0000-0001-6963-8836"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Ran","raw_affiliation_strings":["Liangzhu Laboratory, Zhejiang University Medical Center , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liangzhu Laboratory, Zhejiang University Medical Center , China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025314542","display_name":"Jie Yuan","orcid":"https://orcid.org/0000-0002-9639-8273"},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Yuan","raw_affiliation_strings":["BGI Education Center, University of Chinese Academy of Sciences , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BGI Education Center, University of Chinese Academy of Sciences , China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102824116","display_name":"Hao Wu","orcid":"https://orcid.org/0000-0002-7767-9192"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Wu","raw_affiliation_strings":["Institute of Genomic Medicine, Wenzhou Medical University , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genomic Medicine, Wenzhou Medical University , China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045954563","display_name":"Youya Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youya Wang","raw_affiliation_strings":["Institute of Genomic Medicine, Wenzhou Medical University , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genomic Medicine, Wenzhou Medical University , China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100317895","display_name":"He Li","orcid":"https://orcid.org/0000-0002-9470-7167"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"He Li","raw_affiliation_strings":["Institute of Genomic Medicine, Wenzhou Medical University , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genomic Medicine, Wenzhou Medical University , China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068012395","display_name":"Huajing Teng","orcid":"https://orcid.org/0000-0001-9952-3618"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huajing Teng","raw_affiliation_strings":["Department of Radiation Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) at Peking University Cancer Hospital and Institute , Beijing 100142, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) at Peking University Cancer Hospital and Institute , Beijing 100142, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210093964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101624947","display_name":"Zhongsheng Sun","orcid":"https://orcid.org/0000-0003-1992-2681"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhongsheng Sun","raw_affiliation_strings":["HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Institute of Genomic Medicine, Wenzhou Medical University, and Beijing Institutes of Life Science, Chinese Academy of Sciences , Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0003-1992-2681","affiliations":[{"raw_affiliation_string":"HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Institute of Genomic Medicine, Wenzhou Medical University, and Beijing Institutes of Life Science, Chinese Academy of Sciences , Hangzhou, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5068012395","https://openalex.org/A5101624947"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I27781120","https://openalex.org/I4210093964"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":11.5785,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.99150586,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"25","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9902999997138977,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biogenesis","display_name":"Biogenesis","score":0.722131073474884},{"id":"https://openalex.org/keywords/ribosome-biogenesis","display_name":"Ribosome biogenesis","score":0.663588285446167},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6221370100975037},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5581513047218323},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.47414395213127136},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.43839892745018005},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3728798031806946},{"id":"https://openalex.org/keywords/ribosome","display_name":"Ribosome","score":0.3550871014595032},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.16914421319961548}],"concepts":[{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.722131073474884},{"id":"https://openalex.org/C2779419633","wikidata":"https://www.wikidata.org/wiki/Q7322423","display_name":"Ribosome biogenesis","level":5,"score":0.663588285446167},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6221370100975037},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5581513047218323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47414395213127136},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43839892745018005},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3728798031806946},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.3550871014595032},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.16914421319961548}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae023","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae023","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae023/56659760/bbae023.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38343327","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38343327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10859687","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10859687","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10859687/pdf/bbae023.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae023","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae023","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae023/56659760/bbae023.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1570643498","display_name":null,"funder_award_id":"32170650","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1919700578","display_name":null,"funder_award_id":"32370684","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4811764159","display_name":null,"funder_award_id":"Z230007","funder_id":"https://openalex.org/F4320322919","funder_display_name":"Natural Science Foundation of Beijing Municipality"},{"id":"https://openalex.org/G8851473969","display_name":null,"funder_award_id":"32071156","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322919","display_name":"Natural Science Foundation of Beijing Municipality","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4391758618.pdf"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W323797365","https://openalex.org/W1766270080","https://openalex.org/W1980373840","https://openalex.org/W1985387528","https://openalex.org/W1986304086","https://openalex.org/W2003540115","https://openalex.org/W2015619266","https://openalex.org/W2037235549","https://openalex.org/W2066272205","https://openalex.org/W2069501602","https://openalex.org/W2076826746","https://openalex.org/W2080213688","https://openalex.org/W2082573799","https://openalex.org/W2089643849","https://openalex.org/W2100893053","https://openalex.org/W2121413649","https://openalex.org/W2129104457","https://openalex.org/W2137909076","https://openalex.org/W2142929114","https://openalex.org/W2144996366","https://openalex.org/W2157852151","https://openalex.org/W2159707944","https://openalex.org/W2179438025","https://openalex.org/W2255955546","https://openalex.org/W2264399954","https://openalex.org/W2329901740","https://openalex.org/W2393905053","https://openalex.org/W2409883313","https://openalex.org/W2500686989","https://openalex.org/W2557435811","https://openalex.org/W2591905283","https://openalex.org/W2621126205","https://openalex.org/W2752006971","https://openalex.org/W2753467283","https://openalex.org/W2755416835","https://openalex.org/W2773619385","https://openalex.org/W2883789273","https://openalex.org/W2886956635","https://openalex.org/W2889293401","https://openalex.org/W2892533594","https://openalex.org/W2900032527","https://openalex.org/W2901745232","https://openalex.org/W2905197516","https://openalex.org/W2910848742","https://openalex.org/W2913823173","https://openalex.org/W2945629440","https://openalex.org/W2963279792","https://openalex.org/W2966984447","https://openalex.org/W2973367846","https://openalex.org/W2996335191","https://openalex.org/W3004859565","https://openalex.org/W3005445761","https://openalex.org/W3081250201","https://openalex.org/W3087133080","https://openalex.org/W3090990034","https://openalex.org/W3096523604","https://openalex.org/W3116283359","https://openalex.org/W3121525105","https://openalex.org/W3134236823","https://openalex.org/W3134916687","https://openalex.org/W3165762517","https://openalex.org/W3182293965","https://openalex.org/W3191922386","https://openalex.org/W3195944231","https://openalex.org/W3198338615","https://openalex.org/W3209465832","https://openalex.org/W3213470589","https://openalex.org/W4200116291","https://openalex.org/W4205140682","https://openalex.org/W4205930233","https://openalex.org/W4207073494","https://openalex.org/W4210438248","https://openalex.org/W4220730497","https://openalex.org/W4220746304","https://openalex.org/W4220794698","https://openalex.org/W4225422708","https://openalex.org/W4225932675","https://openalex.org/W4226354587","https://openalex.org/W4282965548","https://openalex.org/W4282980285","https://openalex.org/W4306174824","https://openalex.org/W4308532635","https://openalex.org/W4311472897","https://openalex.org/W4313800177","https://openalex.org/W4315754639","https://openalex.org/W4319438392","https://openalex.org/W4372334727","https://openalex.org/W4377940884","https://openalex.org/W4379619608","https://openalex.org/W4385619985","https://openalex.org/W4386482591","https://openalex.org/W6637933118","https://openalex.org/W6691790871","https://openalex.org/W6758286160"],"related_works":["https://openalex.org/W1515258209","https://openalex.org/W2030750127","https://openalex.org/W4393867437","https://openalex.org/W2791236597","https://openalex.org/W166816587","https://openalex.org/W2071785498","https://openalex.org/W2006328391","https://openalex.org/W2068309125","https://openalex.org/W3133656302","https://openalex.org/W2893572166"],"abstract_inverted_index":{"Hyperactive":[0],"ribosome":[1],"biogenesis":[2],"(RiboSis)":[3],"fuels":[4],"unrestricted":[5],"cell":[6],"proliferation,":[7],"whereas":[8],"genomic":[9],"hallmarks":[10],"and":[11,20,53,63,87,111,134,155,189],"therapeutic":[12,140],"targets":[13],"of":[14,56,78,83,90,101,109,126,148,173,196,206],"RiboSis":[15,25,41,79,97,118,128,149,157,197,210],"in":[16,35,80,93,117,163,209],"cancers":[17],"remain":[18],"elusive,":[19],"efficient":[21],"approaches":[22],"to":[23,38],"quantify":[24],"activity":[26,42,77,147],"are":[27],"still":[28],"limited.":[29],"Here,":[30],"we":[31,73,143,183],"have":[32],"established":[33],"an":[34],"silico":[36],"approach":[37,52],"conveniently":[39],"score":[40],"based":[43],"on":[44],"individual":[45],"transcriptome":[46],"data.":[47],"By":[48],"employing":[49],"this":[50],"novel":[51],"RNA-seq":[54],"data":[55,104],"14":[57],"645":[58],"samples":[59],"from":[60],"TCGA/GTEx":[61],"dataset":[62],"917":[64],"294":[65],"single-cell":[66],"expression":[67,194],"profiles":[68],"across":[69,212],"13":[70],"cancer":[71,165],"types,":[72],"observed":[74,144],"the":[75,113,146,171,193],"elevated":[76],"malignant":[81],"cells":[82],"various":[84],"human":[85],"cancers,":[86,213],"high":[88,96],"risk":[89],"severe":[91],"outcomes":[92,162],"patients":[94,166],"with":[95,152,160,192],"activity.":[98],"Our":[99],"mining":[100],"pan-cancer":[102],"multi-omics":[103],"characterized":[105],"numerous":[106],"molecular":[107,207],"alterations":[108,208],"RiboSis,":[110],"unveiled":[112],"predominant":[114],"somatic":[115],"alteration":[116],"genes":[119,211],"was":[120,150,158],"copy":[121],"number":[122],"variation.":[123],"A":[124],"total":[125],"128":[127],"genes,":[129],"including":[130,187],"EXOSC4,":[131],"BOP1,":[132],"RPLP0P6":[133],"UTP23,":[135],"were":[136],"identified":[137],"as":[138],"potential":[139],"targets.":[141],"Interestingly,":[142],"that":[145],"associated":[151,159,191],"TP53":[153,168,175],"mutations,":[154,169],"hyperactive":[156],"poor":[161],"lung":[164],"without":[167],"highlighting":[170],"importance":[172],"considering":[174],"mutations":[176],"during":[177],"therapy":[178],"by":[179],"impairing":[180],"RiboSis.":[181],"Moreover,":[182],"predicted":[184],"23":[185],"compounds,":[186],"methotrexate":[188],"CX-5461,":[190],"signature":[195],"genes.":[198],"The":[199],"current":[200],"study":[201],"generates":[202],"a":[203,216],"comprehensive":[204],"blueprint":[205],"which":[214],"provides":[215],"valuable":[217],"resource":[218],"for":[219],"RiboSis-based":[220],"anti-tumor":[221],"therapy.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":32},{"year":2024,"cited_by_count":7}],"updated_date":"2026-01-21T23:30:37.877113","created_date":"2025-10-10T00:00:00"}