{"id":"https://openalex.org/W4390888939","doi":"https://doi.org/10.1093/bib/bbad478","title":"Diagnostic Prediction of portal vein thrombosis in chronic cirrhosis patients using data-driven precision medicine model","display_name":"Diagnostic Prediction of portal vein thrombosis in chronic cirrhosis patients using data-driven precision medicine model","publication_year":2023,"publication_date":"2023-11-22","ids":{"openalex":"https://openalex.org/W4390888939","doi":"https://doi.org/10.1093/bib/bbad478","pmid":"https://pubmed.ncbi.nlm.nih.gov/38221905"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbad478","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad478","pdf_url":"https://academic.oup.com/bib/article-pdf/25/1/bbad478/55676539/bbad478.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/article-pdf/25/1/bbad478/55676539/bbad478.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100413989","display_name":"Ying Li","orcid":"https://orcid.org/0000-0001-5062-0230"},"institutions":[{"id":"https://openalex.org/I4210163492","display_name":"First Hospital of Lanzhou University","ror":"https://ror.org/05d2xpa49","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163492"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Li","raw_affiliation_strings":["The First Hospital of Lanzhou University , Lanzhou , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Hospital of Lanzhou University , Lanzhou , China","institution_ids":["https://openalex.org/I76214153","https://openalex.org/I4210163492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068668862","display_name":"Jing Gao","orcid":"https://orcid.org/0000-0002-7732-456X"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210152515","display_name":"Centre for Palaeogenetics","ror":"https://ror.org/04sx39q13","country_code":"SE","type":"facility","lineage":["https://openalex.org/I161593684","https://openalex.org/I2801711128","https://openalex.org/I4210152515"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN","FI","SE"],"is_corresponding":false,"raw_author_name":"Jing Gao","raw_affiliation_strings":["Heart and Lung Centre, Department of Pulmonary Medicine , University of Helsinki and Helsinki University Hospital, Helsinki, Finland","Karolinska Institutet , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden","Respiratory Medicine Unit , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden","The First School of Clinical Medicine , Lanzhou University, Lanzhou, China","Respiratory Medicine Unit, Department of Medicine & Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart and Lung Centre, Department of Pulmonary Medicine , University of Helsinki and Helsinki University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112","https://openalex.org/I133731052"]},{"raw_affiliation_string":"Karolinska Institutet , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Respiratory Medicine Unit , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden","institution_ids":["https://openalex.org/I4210152515"]},{"raw_affiliation_string":"The First School of Clinical Medicine , Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]},{"raw_affiliation_string":"Respiratory Medicine Unit, Department of Medicine & Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035816463","display_name":"Xubin Zheng","orcid":"https://orcid.org/0000-0003-2322-857X"},"institutions":[{"id":"https://openalex.org/I4396570619","display_name":"Great Bay University","ror":"https://ror.org/01hdgge16","country_code":null,"type":"education","lineage":["https://openalex.org/I4396570619"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xubin Zheng","raw_affiliation_strings":["School of Computing and Information Technology , Great Bay University, Guangdong , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing and Information Technology , Great Bay University, Guangdong , China","institution_ids":["https://openalex.org/I4396570619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042001447","display_name":"Guole Nie","orcid":"https://orcid.org/0000-0001-6313-5357"},"institutions":[{"id":"https://openalex.org/I4210163492","display_name":"First Hospital of Lanzhou University","ror":"https://ror.org/05d2xpa49","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163492"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guole Nie","raw_affiliation_strings":["The First Hospital of Lanzhou University , Lanzhou , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Hospital of Lanzhou University , Lanzhou , China","institution_ids":["https://openalex.org/I76214153","https://openalex.org/I4210163492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109674413","display_name":"Jican Qin","orcid":null},"institutions":[{"id":"https://openalex.org/I4396570619","display_name":"Great Bay University","ror":"https://ror.org/01hdgge16","country_code":null,"type":"education","lineage":["https://openalex.org/I4396570619"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jican Qin","raw_affiliation_strings":["School of Computing and Information Technology , Great Bay University, Guangdong , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing and Information Technology , Great Bay University, Guangdong , China","institution_ids":["https://openalex.org/I4396570619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100672248","display_name":"Haiping Wang","orcid":"https://orcid.org/0009-0004-4841-6467"},"institutions":[{"id":"https://openalex.org/I4210163492","display_name":"First Hospital of Lanzhou University","ror":"https://ror.org/05d2xpa49","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163492"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiping Wang","raw_affiliation_strings":["The First Hospital of Lanzhou University , Lanzhou , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Hospital of Lanzhou University , Lanzhou , China","institution_ids":["https://openalex.org/I76214153","https://openalex.org/I4210163492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100927735","display_name":"Tao He","orcid":"https://orcid.org/0009-0000-2731-9132"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao He","raw_affiliation_strings":["Jilin Hepato-Biliary Diseases Hospital , Changchun , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin Hepato-Biliary Diseases Hospital , Changchun , China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015015915","display_name":"\u00c5sa M. Wheelock","orcid":"https://orcid.org/0000-0002-8013-2745"},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210152515","display_name":"Centre for Palaeogenetics","ror":"https://ror.org/04sx39q13","country_code":"SE","type":"facility","lineage":["https://openalex.org/I161593684","https://openalex.org/I2801711128","https://openalex.org/I4210152515"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"\u00c5sa Wheelock","raw_affiliation_strings":["Department of Respiratory Medicine and Allergy, Karolinska University Hospital , Stockholm , Sweden","Karolinska Institutet , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden","Respiratory Medicine Unit , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden","Respiratory Medicine Unit, Department of Medicine & Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Allergy, Karolinska University Hospital , Stockholm , Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Karolinska Institutet , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Respiratory Medicine Unit , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden","institution_ids":["https://openalex.org/I4210152515"]},{"raw_affiliation_string":"Respiratory Medicine Unit, Department of Medicine & Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064777784","display_name":"Chuanxing Li","orcid":"https://orcid.org/0000-0003-2189-5010"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210152515","display_name":"Centre for Palaeogenetics","ror":"https://ror.org/04sx39q13","country_code":"SE","type":"facility","lineage":["https://openalex.org/I161593684","https://openalex.org/I2801711128","https://openalex.org/I4210152515"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Chuan-Xing Li","raw_affiliation_strings":["Karolinska Institutet , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden","Respiratory Medicine Unit , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden","Respiratory Medicine Unit, Department of Medicine & Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institutet , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Respiratory Medicine Unit , Department of Medicine & Centre for Molecular Medicine, , Stockholm , Sweden","institution_ids":["https://openalex.org/I4210152515"]},{"raw_affiliation_string":"Respiratory Medicine Unit, Department of Medicine & Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021845548","display_name":"Lixin Cheng","orcid":"https://orcid.org/0000-0002-9427-383X"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lixin Cheng","raw_affiliation_strings":["Shenzhen People's Hospital , The First Affiliated Hospital of Southern University of Science and Technology, , Shenzhen , China","The Second Clinical Medical College of Jinan University , The First Affiliated Hospital of Southern University of Science and Technology, , Shenzhen , China","Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen People's Hospital , The First Affiliated Hospital of Southern University of Science and Technology, , Shenzhen , China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"The Second Clinical Medical College of Jinan University , The First Affiliated Hospital of Southern University of Science and Technology, , Shenzhen , China","institution_ids":["https://openalex.org/I3045169105","https://openalex.org/I159948400"]},{"raw_affiliation_string":"Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen, China","institution_ids":["https://openalex.org/I3045169105","https://openalex.org/I159948400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100341839","display_name":"Xun\ufffd Li","orcid":"https://orcid.org/0000-0001-6862-7692"},"institutions":[{"id":"https://openalex.org/I4210163492","display_name":"First Hospital of Lanzhou University","ror":"https://ror.org/05d2xpa49","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163492"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xun Li","raw_affiliation_strings":["The First Hospital of Lanzhou University , Lanzhou , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Hospital of Lanzhou University , Lanzhou , China","institution_ids":["https://openalex.org/I76214153","https://openalex.org/I4210163492"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5021845548","https://openalex.org/A5064777784","https://openalex.org/A5100341839"],"corresponding_institution_ids":["https://openalex.org/I159948400","https://openalex.org/I28166907","https://openalex.org/I3045169105","https://openalex.org/I4210152515","https://openalex.org/I4210163492","https://openalex.org/I76214153"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":2.8247,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.91695101,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"25","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.8622999787330627,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.8622999787330627,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.06210000067949295,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.7083268165588379},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.6648977994918823},{"id":"https://openalex.org/keywords/cirrhosis","display_name":"Cirrhosis","score":0.663588285446167},{"id":"https://openalex.org/keywords/quadratic-classifier","display_name":"Quadratic classifier","score":0.5516628623008728},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.5167202353477478},{"id":"https://openalex.org/keywords/prothrombin-time","display_name":"Prothrombin time","score":0.4998142719268799},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4987907409667969},{"id":"https://openalex.org/keywords/portal-vein-thrombosis","display_name":"Portal vein thrombosis","score":0.4955657720565796},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.45551034808158875},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.446170449256897},{"id":"https://openalex.org/keywords/naive-bayes-classifier","display_name":"Naive Bayes classifier","score":0.43040943145751953},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.22171449661254883}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7083268165588379},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6648977994918823},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.663588285446167},{"id":"https://openalex.org/C52620605","wikidata":"https://www.wikidata.org/wiki/Q7268357","display_name":"Quadratic classifier","level":3,"score":0.5516628623008728},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.5167202353477478},{"id":"https://openalex.org/C2780434524","wikidata":"https://www.wikidata.org/wiki/Q1144385","display_name":"Prothrombin time","level":2,"score":0.4998142719268799},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4987907409667969},{"id":"https://openalex.org/C2778800853","wikidata":"https://www.wikidata.org/wiki/Q1704044","display_name":"Portal vein thrombosis","level":3,"score":0.4955657720565796},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45551034808158875},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.446170449256897},{"id":"https://openalex.org/C52001869","wikidata":"https://www.wikidata.org/wiki/Q812530","display_name":"Naive Bayes classifier","level":3,"score":0.43040943145751953},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.22171449661254883}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D011169","descriptor_name":"Portal Vein","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011169","descriptor_name":"Portal Vein","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011169","descriptor_name":"Portal Vein","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011169","descriptor_name":"Portal Vein","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011169","descriptor_name":"Portal Vein","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011169","descriptor_name":"Portal Vein","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011169","descriptor_name":"Portal Vein","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbad478","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad478","pdf_url":"https://academic.oup.com/bib/article-pdf/25/1/bbad478/55676539/bbad478.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38221905","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38221905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10788706","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10788706","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10788706/pdf/bbad478.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbad478","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad478","pdf_url":"https://academic.oup.com/bib/article-pdf/25/1/bbad478/55676539/bbad478.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.5400000214576721}],"awards":[{"id":"https://openalex.org/G688162940","display_name":null,"funder_award_id":"32300554","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6967701105","display_name":null,"funder_award_id":"32370711","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390888939.pdf"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W244366875","https://openalex.org/W1461055456","https://openalex.org/W1603928981","https://openalex.org/W1973804461","https://openalex.org/W1978989373","https://openalex.org/W1992235530","https://openalex.org/W2060380869","https://openalex.org/W2072425701","https://openalex.org/W2072747037","https://openalex.org/W2115748573","https://openalex.org/W2142011623","https://openalex.org/W2230508580","https://openalex.org/W2317341382","https://openalex.org/W2323877778","https://openalex.org/W2328270930","https://openalex.org/W2328637859","https://openalex.org/W2342473733","https://openalex.org/W2400908595","https://openalex.org/W2461921227","https://openalex.org/W2557299952","https://openalex.org/W2618877362","https://openalex.org/W2686635952","https://openalex.org/W2803287085","https://openalex.org/W2892228400","https://openalex.org/W2895409920","https://openalex.org/W2964382187","https://openalex.org/W2969855084","https://openalex.org/W3040428397","https://openalex.org/W3080486468","https://openalex.org/W3081407745","https://openalex.org/W3091302752","https://openalex.org/W3106549462","https://openalex.org/W3121263723","https://openalex.org/W3127678470","https://openalex.org/W3132262747","https://openalex.org/W3154984820","https://openalex.org/W3183672024","https://openalex.org/W3195169609","https://openalex.org/W3205951293","https://openalex.org/W4206010614","https://openalex.org/W4206541276","https://openalex.org/W4212774754","https://openalex.org/W4239091587","https://openalex.org/W4281626913","https://openalex.org/W4286252253","https://openalex.org/W4287550324","https://openalex.org/W4293217740","https://openalex.org/W4315928147","https://openalex.org/W4322730846","https://openalex.org/W4378171938","https://openalex.org/W4384663343","https://openalex.org/W4390563842","https://openalex.org/W6737947904","https://openalex.org/W6784146143","https://openalex.org/W6794462526","https://openalex.org/W6806939144","https://openalex.org/W6817173170","https://openalex.org/W6841017510","https://openalex.org/W6850942981","https://openalex.org/W6852690649","https://openalex.org/W6854561992"],"related_works":["https://openalex.org/W4287752245","https://openalex.org/W3158073924","https://openalex.org/W2303264775","https://openalex.org/W2375403766","https://openalex.org/W3176751324","https://openalex.org/W2390658467","https://openalex.org/W2078670925","https://openalex.org/W2368299322","https://openalex.org/W92531827","https://openalex.org/W2368396039"],"abstract_inverted_index":{"BACKGROUND:":[0],"Portal":[1,134,140],"vein":[2],"thrombosis":[3],"(PVT)":[4],"is":[5],"a":[6,20,38,69,91,212,230],"significant":[7,179],"issue":[8],"in":[9,27,219,236],"cirrhotic":[10,220],"patients,":[11,221],"necessitating":[12],"early":[13],"detection.":[14],"This":[15,66],"study":[16,210],"aims":[17],"to":[18,233],"develop":[19],"data-driven":[21,214],"predictive":[22,87],"model":[23,201,215,228],"for":[24,55,64,216],"PVT":[25,120,182,217,235],"diagnosis":[26,218],"chronic":[28,42],"hepatitis":[29],"liver":[30],"cirrhosis":[31,43,82],"patients.":[32],"METHODS:":[33],"We":[34],"employed":[35,90],"data":[36],"from":[37,122],"total":[39],"of":[40,72,129],"816":[41],"patients":[44],"with":[45],"PVT,":[46],"divided":[47],"into":[48],"the":[49,58,110,126,164,169,175],"Lanzhou":[50,111,170],"cohort":[51,60,171],"(n":[52,61],"=":[53,62,187,191],"468)":[54],"training":[56],"and":[57,81,103,114,154,172,183,189],"Jilin":[59,176],"348)":[63],"validation.":[65],"dataset":[67],"encompassed":[68],"wide":[70],"range":[71],"variables,":[73],"including":[74],"general":[75],"characteristics,":[76],"blood":[77],"parameters,":[78],"ultrasonography":[79],"findings":[80],"grading.":[83],"To":[84],"build":[85],"our":[86,199],"model,":[88,160],"we":[89],"sophisticated":[92],"stacking":[93],"approach,":[94],"which":[95,130],"included":[96],"Support":[97],"Vector":[98],"Machine":[99],"(SVM),":[100],"Na\u00efve":[101,115],"Bayes":[102,116],"Quadratic":[104],"Discriminant":[105],"Analysis":[106],"(QDA).":[107],"RESULTS:":[108],"In":[109],"cohort,":[112,177],"SVM":[113],"classifiers":[117],"effectively":[118],"classified":[119],"cases":[121,185],"non-PVT":[123,184],"cases,":[124],"among":[125],"top":[127],"features":[128,167],"seven":[131,165],"were":[132],"shared:":[133],"Velocity":[135],"(PV),":[136],"Prothrombin":[137,144],"Time":[138,145,151],"(PT),":[139],"Vein":[141],"Diameter":[142],"(PVD),":[143],"Activity":[146],"(PTA),":[147],"Activated":[148],"Partial":[149],"Thromboplastin":[150],"(APTT),":[152],"age":[153],"Child-Pugh":[155],"score":[156],"(CPS).":[157],"The":[158,225],"QDA":[159,200],"trained":[161],"based":[162],"on":[163,168,174],"shared":[166],"validated":[173],"demonstrated":[178],"differentiation":[180],"between":[181],"(AUROC":[186],"0.73":[188],"AUROC":[190],"0.86,":[192],"respectively).":[193],"Subsequently,":[194],"comparative":[195],"analysis":[196],"showed":[197],"that":[198],"outperformed":[202],"several":[203],"other":[204],"machine":[205],"learning":[206],"methods.":[207],"CONCLUSION:":[208],"Our":[209],"presents":[211],"comprehensive":[213],"enhancing":[222],"clinical":[223],"decision-making.":[224],"SVM-Na\u00efve":[226],"Bayes-QDA":[227],"offers":[229],"precise":[231],"approach":[232],"managing":[234],"this":[237],"population.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":5}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}