{"id":"https://openalex.org/W4388931898","doi":"https://doi.org/10.1093/bib/bbad417","title":"CellGO: a novel deep learning-based framework and webserver for cell-type-specific gene function interpretation","display_name":"CellGO: a novel deep learning-based framework and webserver for cell-type-specific gene function interpretation","publication_year":2023,"publication_date":"2023-11-08","ids":{"openalex":"https://openalex.org/W4388931898","doi":"https://doi.org/10.1093/bib/bbad417","pmid":"https://pubmed.ncbi.nlm.nih.gov/37995133"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbad417","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad417","pdf_url":"https://academic.oup.com/bib/article-pdf/25/1/bbad417/55464894/bbad417.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/article-pdf/25/1/bbad417/55464894/bbad417.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073353958","display_name":"Peilong Li","orcid":"https://orcid.org/0009-0002-7411-3676"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]},{"id":"https://openalex.org/I4391768195","display_name":"State Key Laboratory of Medical Neurobiology","ror":"https://ror.org/00nn53y54","country_code":null,"type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768195"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peilong Li","raw_affiliation_strings":["Huashan Hospital, Fudan University State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science and Department of Neurosurgery, , Shanghai 200032, China"],"affiliations":[{"raw_affiliation_string":"Huashan Hospital, Fudan University State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science and Department of Neurosurgery, , Shanghai 200032, China","institution_ids":["https://openalex.org/I4210159575","https://openalex.org/I24943067","https://openalex.org/I4391768195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101631946","display_name":"Junfeng Wei","orcid":null},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]},{"id":"https://openalex.org/I4391768195","display_name":"State Key Laboratory of Medical Neurobiology","ror":"https://ror.org/00nn53y54","country_code":null,"type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768195"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junfeng Wei","raw_affiliation_strings":["Huashan Hospital, Fudan University State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science and Department of Neurosurgery, , Shanghai 200032, China"],"affiliations":[{"raw_affiliation_string":"Huashan Hospital, Fudan University State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science and Department of Neurosurgery, , Shanghai 200032, China","institution_ids":["https://openalex.org/I4210159575","https://openalex.org/I24943067","https://openalex.org/I4391768195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052189702","display_name":"Ying Zhu","orcid":"https://orcid.org/0000-0001-5247-6324"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]},{"id":"https://openalex.org/I4391768195","display_name":"State Key Laboratory of Medical Neurobiology","ror":"https://ror.org/00nn53y54","country_code":null,"type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768195"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Zhu","raw_affiliation_strings":["Huashan Hospital, Fudan University State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science and Department of Neurosurgery, , Shanghai 200032, China"],"affiliations":[{"raw_affiliation_string":"Huashan Hospital, Fudan University State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science and Department of Neurosurgery, , Shanghai 200032, China","institution_ids":["https://openalex.org/I4210159575","https://openalex.org/I24943067","https://openalex.org/I4391768195"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052189702"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575","https://openalex.org/I4391768195"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.9115,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.75979772,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"25","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.6816139817237854},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5897380113601685},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5569489002227783},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5349598526954651},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4394111633300781},{"id":"https://openalex.org/keywords/gene-knockout","display_name":"Gene knockout","score":0.42956608533859253},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.34770968556404114},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34029462933540344},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.33036381006240845},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.20222815871238708}],"concepts":[{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.6816139817237854},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5897380113601685},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5569489002227783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5349598526954651},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4394111633300781},{"id":"https://openalex.org/C77957584","wikidata":"https://www.wikidata.org/wiki/Q1133550","display_name":"Gene knockout","level":3,"score":0.42956608533859253},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.34770968556404114},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34029462933540344},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33036381006240845},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20222815871238708}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbad417","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad417","pdf_url":"https://academic.oup.com/bib/article-pdf/25/1/bbad417/55464894/bbad417.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37995133","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37995133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10790717","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10790717","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10790717/pdf/bbad417.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbad417","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad417","pdf_url":"https://academic.oup.com/bib/article-pdf/25/1/bbad417/55464894/bbad417.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G188991704","display_name":null,"funder_award_id":"82071259","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3085993365","display_name":null,"funder_award_id":"(Grant No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3852078645","display_name":null,"funder_award_id":"STI2030","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5760752404","display_name":null,"funder_award_id":"Projects","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5777034644","display_name":null,"funder_award_id":"2018SHZDZX01","funder_id":"https://openalex.org/F4320319772","funder_display_name":"Shanghai Center for Brain Science and Brain-Inspired Technology"},{"id":"https://openalex.org/G5939423041","display_name":null,"funder_award_id":"Technology","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7726157001","display_name":null,"funder_award_id":"Grant No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8899475930","display_name":null,"funder_award_id":"2018SHZDZX01","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8955107213","display_name":null,"funder_award_id":"Major","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320319772","display_name":"Shanghai Center for Brain Science and Brain-Inspired Technology","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388931898.pdf","grobid_xml":"https://content.openalex.org/works/W4388931898.grobid-xml"},"referenced_works_count":110,"referenced_works":["https://openalex.org/W1961529886","https://openalex.org/W1972676659","https://openalex.org/W2009742334","https://openalex.org/W2035763500","https://openalex.org/W2052628586","https://openalex.org/W2054892633","https://openalex.org/W2064885915","https://openalex.org/W2065914817","https://openalex.org/W2100980426","https://openalex.org/W2103017472","https://openalex.org/W2113624587","https://openalex.org/W2124954099","https://openalex.org/W2125943945","https://openalex.org/W2130410032","https://openalex.org/W2135856405","https://openalex.org/W2158217645","https://openalex.org/W2159707944","https://openalex.org/W2273101790","https://openalex.org/W2290195878","https://openalex.org/W2301966253","https://openalex.org/W2346595516","https://openalex.org/W2591909999","https://openalex.org/W2737928686","https://openalex.org/W2770244901","https://openalex.org/W2774947569","https://openalex.org/W2790179710","https://openalex.org/W2796464660","https://openalex.org/W2806989085","https://openalex.org/W2807653293","https://openalex.org/W2884615724","https://openalex.org/W2885927965","https://openalex.org/W2900044275","https://openalex.org/W2908670724","https://openalex.org/W2911725378","https://openalex.org/W2914464170","https://openalex.org/W2918086501","https://openalex.org/W2923203084","https://openalex.org/W2944545583","https://openalex.org/W2946016273","https://openalex.org/W2951560273","https://openalex.org/W2962979703","https://openalex.org/W2969167159","https://openalex.org/W2969366465","https://openalex.org/W2969948459","https://openalex.org/W2972719726","https://openalex.org/W2975507539","https://openalex.org/W2976681669","https://openalex.org/W2979832776","https://openalex.org/W2986932567","https://openalex.org/W3003257820","https://openalex.org/W3004345103","https://openalex.org/W3017227862","https://openalex.org/W3019747475","https://openalex.org/W3020538763","https://openalex.org/W3027333525","https://openalex.org/W3047549677","https://openalex.org/W3048965828","https://openalex.org/W3080237557","https://openalex.org/W3080545875","https://openalex.org/W3093124672","https://openalex.org/W3094159395","https://openalex.org/W3103145119","https://openalex.org/W3110052021","https://openalex.org/W3112600195","https://openalex.org/W3118272853","https://openalex.org/W3126997388","https://openalex.org/W3129861733","https://openalex.org/W3136216847","https://openalex.org/W3157320940","https://openalex.org/W3162218953","https://openalex.org/W3165101514","https://openalex.org/W3175688392","https://openalex.org/W3175752499","https://openalex.org/W3175922295","https://openalex.org/W3179788429","https://openalex.org/W3180940268","https://openalex.org/W3184188306","https://openalex.org/W3184208286","https://openalex.org/W3184285717","https://openalex.org/W3194509722","https://openalex.org/W3197876317","https://openalex.org/W3199585733","https://openalex.org/W3202349862","https://openalex.org/W3204443805","https://openalex.org/W3207213424","https://openalex.org/W3208130902","https://openalex.org/W3212895337","https://openalex.org/W3213137406","https://openalex.org/W3214651914","https://openalex.org/W4220757453","https://openalex.org/W4223521725","https://openalex.org/W4223591189","https://openalex.org/W4225491855","https://openalex.org/W4226185169","https://openalex.org/W4226308686","https://openalex.org/W4229054631","https://openalex.org/W4244074209","https://openalex.org/W4252684946","https://openalex.org/W4255375128","https://openalex.org/W4283017210","https://openalex.org/W4283790499","https://openalex.org/W4289261711","https://openalex.org/W4293242863","https://openalex.org/W4294051824","https://openalex.org/W4297977428","https://openalex.org/W4304943317","https://openalex.org/W4311261902","https://openalex.org/W4312182173","https://openalex.org/W4319964300","https://openalex.org/W6797786779"],"related_works":["https://openalex.org/W4307993920","https://openalex.org/W1898241694","https://openalex.org/W2091570353","https://openalex.org/W4390695629","https://openalex.org/W2036616013","https://openalex.org/W3157307916","https://openalex.org/W2141091415","https://openalex.org/W2786822253","https://openalex.org/W2895456557","https://openalex.org/W4401169882"],"abstract_inverted_index":{"Interpreting":[0],"the":[1,24,47,62,78,103,131,242],"function":[2],"of":[3,105,133,144,198],"genes":[4,140,195,199],"and":[5,52,138,141,183,204,236],"gene":[6,54,120,155,190],"sets":[7,197],"identified":[8],"from":[9],"omics":[10],"experiments":[11],"remains":[12],"a":[13,67,72,118,154,222,228,234],"challenge,":[14],"as":[15,29,221],"current":[16],"pathway":[17],"analysis":[18,143],"tools":[19],"often":[20],"fail":[21],"to":[22,56,76,90,112,164,212],"consider":[23],"critical":[25],"biological":[26,124],"context,":[27],"such":[28],"tissue":[30],"or":[31,196],"cell-type":[32,159],"specificity.":[33],"To":[34,122,146],"address":[35],"this":[36,43],"limitation,":[37],"we":[38],"introduced":[39],"CellGO.":[40],"CellGO":[41,87,108,126,150,208,225],"tackles":[42],"challenge":[44],"by":[45,101,189],"leveraging":[46],"visible":[48],"neural":[49],"network":[50],"(VNN)":[51],"single-cell":[53],"expressions":[55],"mimic":[57],"cell-type-specific":[58,79,92,114,186,214],"signaling":[59],"propagation":[60],"along":[61],"Gene":[63],"Ontology":[64],"tree":[65],"within":[66],"cell.":[68],"This":[69],"design":[70],"enables":[71],"novel":[73],"scoring":[74],"system":[75],"calculate":[77],"gene-pathway":[80],"paired":[81],"active":[82,93,115,135,166],"scores,":[83],"based":[84],"on":[85],"which,":[86],"is":[88],"able":[89],"identify":[91,113],"pathways":[94,116,167,187],"associated":[95],"with":[96],"single":[97,106,194],"genes.":[98,219],"In":[99],"addition,":[100],"aggregating":[102],"activities":[104],"genes,":[107],"extends":[109],"its":[110,148,162,210],"capability":[111],"for":[117,216,239],"given":[119],"set.":[121],"enhance":[123],"interpretation,":[125],"offers":[127],"additional":[128],"features,":[129],"including":[130],"identification":[132],"significantly":[134],"cell":[136,170,181],"types":[137,182],"driver":[139],"community":[142],"pathways.":[145],"validate":[147],"performance,":[149],"was":[151],"assessed":[152],"using":[153,192],"set":[156],"comprising":[157],"mixed":[158],"markers,":[160],"confirming":[161],"ability":[163,211],"discern":[165],"across":[168],"distinct":[169],"types.":[171],"Subsequent":[172],"benchmarking":[173],"analyses":[174],"demonstrated":[175,209],"CellGO's":[176],"superiority":[177],"in":[178,241],"effectively":[179],"identifying":[180],"their":[184],"corresponding":[185],"affected":[188],"knockouts,":[191],"either":[193],"differentially":[200],"expressed":[201],"between":[202],"knockout":[203],"control":[205],"samples.":[206],"Moreover,":[207],"infer":[213],"pathogenesis":[215],"disease":[217],"risk":[218],"Accessible":[220],"Python":[223],"package,":[224],"also":[226],"provides":[227],"user-friendly":[229],"web":[230],"interface,":[231],"making":[232],"it":[233],"versatile":[235],"accessible":[237],"tool":[238],"researchers":[240],"field.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-04-13T07:58:08.660418","created_date":"2025-10-10T00:00:00"}
