{"id":"https://openalex.org/W4387840816","doi":"https://doi.org/10.1093/bib/bbad356","title":"Screening single-cell trajectories via continuity assessments for cell transition potential","display_name":"Screening single-cell trajectories via continuity assessments for cell transition potential","publication_year":2023,"publication_date":"2023-09-22","ids":{"openalex":"https://openalex.org/W4387840816","doi":"https://doi.org/10.1093/bib/bbad356","pmid":"https://pubmed.ncbi.nlm.nih.gov/37864296"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbad356","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad356","pdf_url":"https://academic.oup.com/bib/article-pdf/24/6/bbad356/52312618/bbad356.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/article-pdf/24/6/bbad356/52312618/bbad356.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084171262","display_name":"Zihan Zheng","orcid":"https://orcid.org/0000-0003-1486-9586"},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zihan Zheng","raw_affiliation_strings":["Army Medical University Biomedical Analysis Center, , Chongqing , China","Army Medical University Institute of Immunology PLA, , Chongqing , China","Chongqing International Institute for Immunology, Chongqing Department of Autoimmune Disease, , Chongqing , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Army Medical University Biomedical Analysis Center, , Chongqing , China","institution_ids":["https://openalex.org/I151075929"]},{"raw_affiliation_string":"Army Medical University Institute of Immunology PLA, , Chongqing , China","institution_ids":["https://openalex.org/I151075929"]},{"raw_affiliation_string":"Chongqing International Institute for Immunology, Chongqing Department of Autoimmune Disease, , Chongqing , China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026898844","display_name":"Ling Chang","orcid":"https://orcid.org/0000-0002-5855-356X"},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Chang","raw_affiliation_strings":["Army Medical University Institute of Immunology PLA, , Chongqing , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Army Medical University Institute of Immunology PLA, , Chongqing , China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058330480","display_name":"Yinong Li","orcid":"https://orcid.org/0000-0002-4491-0140"},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinong Li","raw_affiliation_strings":["Army Medical University Biomedical Analysis Center, , Chongqing , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Army Medical University Biomedical Analysis Center, , Chongqing , China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100398741","display_name":"K. Liu","orcid":"https://orcid.org/0000-0001-5807-0501"},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Liu","raw_affiliation_strings":["Army Medical University Biomedical Analysis Center, , Chongqing , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Army Medical University Biomedical Analysis Center, , Chongqing , China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067658278","display_name":"Jie Mu","orcid":"https://orcid.org/0000-0002-9773-3838"},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Mu","raw_affiliation_strings":["Army Medical University Biomedical Analysis Center, , Chongqing , China","Chongqing University School of Big Data and Software Engineering, , Chongqing , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Army Medical University Biomedical Analysis Center, , Chongqing , China","institution_ids":["https://openalex.org/I151075929"]},{"raw_affiliation_string":"Chongqing University School of Big Data and Software Engineering, , Chongqing , China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016594841","display_name":"Song Zhang","orcid":"https://orcid.org/0000-0003-2051-6605"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Song Zhang","raw_affiliation_strings":["Nankai University College of Life Sciences, Institute for Immunology, , Tianjin , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nankai University College of Life Sciences, Institute for Immunology, , Tianjin , China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100399433","display_name":"Jingyi Li","orcid":"https://orcid.org/0000-0002-3126-7889"},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Li","raw_affiliation_strings":["Chongqing International Institute for Immunology Department of Autoimmune Disease, , Chongqing, Chongqing , China","First Affiliated Hospital of Army Medical University Department of Rheumatology and Immunology, , Chongqing , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing International Institute for Immunology Department of Autoimmune Disease, , Chongqing, Chongqing , China","institution_ids":[]},{"raw_affiliation_string":"First Affiliated Hospital of Army Medical University Department of Rheumatology and Immunology, , Chongqing , China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210129459","https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101166751","display_name":"Yuzhang Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuzhang Wu","raw_affiliation_strings":["Army Medical University Institute of Immunology PLA, , Chongqing , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Army Medical University Institute of Immunology PLA, , Chongqing , China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101438496","display_name":"Liyun Zou","orcid":"https://orcid.org/0000-0001-5449-8869"},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyun Zou","raw_affiliation_strings":["Army Medical University Institute of Immunology PLA, , Chongqing , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Army Medical University Institute of Immunology PLA, , Chongqing , China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084288123","display_name":"Qingshan Ni","orcid":"https://orcid.org/0000-0002-7267-8932"},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingshan Ni","raw_affiliation_strings":["Army Medical University Biomedical Analysis Center, , Chongqing , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Army Medical University Biomedical Analysis Center, , Chongqing , China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029079458","display_name":"Ying Wan","orcid":"https://orcid.org/0000-0001-7922-4434"},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Wan","raw_affiliation_strings":["Army Medical University Biomedical Analysis Center, , Chongqing , China","Chongqing University School of Big Data and Software Engineering, , Chongqing , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Army Medical University Biomedical Analysis Center, , Chongqing , China","institution_ids":["https://openalex.org/I151075929"]},{"raw_affiliation_string":"Chongqing University School of Big Data and Software Engineering, , Chongqing , China","institution_ids":["https://openalex.org/I158842170"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5029079458"],"corresponding_institution_ids":["https://openalex.org/I151075929","https://openalex.org/I158842170"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.8722,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.75152956,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"24","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trajectory","display_name":"Trajectory","score":0.7850208282470703},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.73094642162323},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.6809179782867432},{"id":"https://openalex.org/keywords/divergence","display_name":"Divergence (linguistics)","score":0.5649148225784302},{"id":"https://openalex.org/keywords/a-priori-and-a-posteriori","display_name":"A priori and a posteriori","score":0.46136775612831116},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.460345059633255},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3519487977027893},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3450669050216675},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3207855820655823}],"concepts":[{"id":"https://openalex.org/C13662910","wikidata":"https://www.wikidata.org/wiki/Q193139","display_name":"Trajectory","level":2,"score":0.7850208282470703},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.73094642162323},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6809179782867432},{"id":"https://openalex.org/C207390915","wikidata":"https://www.wikidata.org/wiki/Q1230525","display_name":"Divergence (linguistics)","level":2,"score":0.5649148225784302},{"id":"https://openalex.org/C75553542","wikidata":"https://www.wikidata.org/wiki/Q178161","display_name":"A priori and a posteriori","level":2,"score":0.46136775612831116},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.460345059633255},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3519487977027893},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3450669050216675},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3207855820655823},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbad356","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad356","pdf_url":"https://academic.oup.com/bib/article-pdf/24/6/bbad356/52312618/bbad356.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37864296","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37864296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10589400","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10589400","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10589400/pdf/bbad356.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbad356","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad356","pdf_url":"https://academic.oup.com/bib/article-pdf/24/6/bbad356/52312618/bbad356.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1622195669","display_name":null,"funder_award_id":"31972896","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1649730735","display_name":null,"funder_award_id":"81921004","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G249610605","display_name":null,"funder_award_id":"2017YFA0700404","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G3035859079","display_name":null,"funder_award_id":"81971546","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3063980690","display_name":null,"funder_award_id":"82171787","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4066208478","display_name":null,"funder_award_id":"82241218","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4545507588","display_name":null,"funder_award_id":"2021YFA1201103","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G457631713","display_name":null,"funder_award_id":"81971537","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4387840816.pdf"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1813068103","https://openalex.org/W1944355477","https://openalex.org/W1984883254","https://openalex.org/W2024121049","https://openalex.org/W2051244361","https://openalex.org/W2065220128","https://openalex.org/W2096142215","https://openalex.org/W2111435630","https://openalex.org/W2113741025","https://openalex.org/W2144890743","https://openalex.org/W2146081758","https://openalex.org/W2168901267","https://openalex.org/W2373831850","https://openalex.org/W2610228741","https://openalex.org/W2767423581","https://openalex.org/W2794480084","https://openalex.org/W2795331645","https://openalex.org/W2800028441","https://openalex.org/W2801820889","https://openalex.org/W2806678383","https://openalex.org/W2808957884","https://openalex.org/W2894687190","https://openalex.org/W2898120081","https://openalex.org/W2912272542","https://openalex.org/W2927507212","https://openalex.org/W2949067670","https://openalex.org/W2950372712","https://openalex.org/W2951799803","https://openalex.org/W2957836762","https://openalex.org/W2979874482","https://openalex.org/W2984472267","https://openalex.org/W2988369018","https://openalex.org/W3002417351","https://openalex.org/W3013151148","https://openalex.org/W3014807564","https://openalex.org/W3026988635","https://openalex.org/W3087166092","https://openalex.org/W3114485724","https://openalex.org/W3119870035","https://openalex.org/W3176085856","https://openalex.org/W3179857518","https://openalex.org/W3188707113","https://openalex.org/W3200101063","https://openalex.org/W3211402536","https://openalex.org/W4205428045","https://openalex.org/W4206957767","https://openalex.org/W4225981439","https://openalex.org/W4254687493","https://openalex.org/W4295135058","https://openalex.org/W4317476908","https://openalex.org/W4399524451","https://openalex.org/W4399585236","https://openalex.org/W4399636900"],"related_works":["https://openalex.org/W4388311650","https://openalex.org/W5922282","https://openalex.org/W1974056099","https://openalex.org/W4403822433","https://openalex.org/W4245343541","https://openalex.org/W2386077341","https://openalex.org/W563589758","https://openalex.org/W62490179","https://openalex.org/W2954004777","https://openalex.org/W2951102138"],"abstract_inverted_index":{"Advances":[0],"in":[1,97,110,132,160,202],"single-cell":[2,101],"sequencing":[3],"and":[4,37,49,78,99,127,140,181,205],"data":[5],"analysis":[6,41],"have":[7,85],"made":[8],"it":[9,67],"possible":[10],"to":[11,69,168,178],"infer":[12],"biological":[13],"trajectories":[14,24,148,190],"spanning":[15],"heterogeneous":[16],"cell":[17,138],"populations":[18],"based":[19],"on":[20,43,86],"transcriptome":[21],"variation.":[22],"These":[23],"yield":[25],"a":[26,72,82,119,163,170,184],"wealth":[27],"of":[28,46,63,113,135,172],"novel":[29],"insights":[30],"into":[31,96],"dynamic":[32],"processes":[33],"such":[34,81],"as":[35,183,196],"development":[36,139],"differentiation.":[38],"However,":[39],"trajectory":[40,47,74,114,125],"relies":[42],"an":[44],"assumption":[45],"continuity,":[48,77,126,180],"experimental":[50],"limitations":[51],"preclude":[52],"some":[53],"real-world":[54,133],"scenarios":[55],"from":[56,76],"meeting":[57],"this":[58],"condition.":[59],"The":[60],"current":[61],"lack":[62],"assessment":[64,154],"metrics":[65],"makes":[66],"difficult":[68],"ascertain":[70],"if/when":[71],"given":[73],"deviates":[75],"what":[79],"impact":[80],"divergence":[83],"would":[84],"inference":[87],"accuracy":[88,112],"is":[89,166,211],"unclear.":[90],"By":[91],"analyzing":[92],"simulated":[93],"breaks":[94],"introduced":[95],"silico":[98],"real":[100],"data,":[102],"we":[103],"found":[104,128],"that":[105,129],"discontinuity":[106],"caused":[107],"precipitous":[108],"drops":[109],"the":[111],"inference.":[115],"We":[116],"then":[117],"generate":[118],"simple":[120],"scoring":[121],"algorithm":[122],"for":[123,175,186,191],"assessing":[124],"continuity":[130],"assessments":[131],"cases":[134,161],"intestinal":[136],"stem":[137],"CD8":[141],"+":[142],"T":[143],"cells":[144],"differentiation":[145],"efficiently":[146],"identifies":[147],"consistent":[149],"with":[150],"empirical":[151,194],"knowledge.":[152],"This":[153,209],"approach":[155],"can":[156],"also":[157],"be":[158],"used":[159],"where":[162],"priori":[164],"knowledge":[165],"lacking":[167],"screen":[169],"pool":[171],"inferred":[173],"lineages":[174],"their":[176],"adherence":[177],"presumed":[179],"serve":[182],"means":[185],"weighing":[187],"higher":[188],"likelihood":[189],"validation":[192],"via":[193],"studies,":[195],"exemplified":[197],"by":[198],"our":[199],"case":[200],"studies":[201],"psoriatic":[203],"arthritis":[204],"acute":[206],"kidney":[207],"injury.":[208],"tool":[210],"freely":[212],"available":[213],"through":[214],"github":[215],"at":[216],"qingshanni/scEGRET.":[217]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}