{"id":"https://openalex.org/W4387478341","doi":"https://doi.org/10.1093/bib/bbad346","title":"COIMMR: a computational framework to reveal the contribution of herbal ingredients against human cancer via immune microenvironment and metabolic reprogramming","display_name":"COIMMR: a computational framework to reveal the contribution of herbal ingredients against human cancer via immune microenvironment and metabolic reprogramming","publication_year":2023,"publication_date":"2023-09-22","ids":{"openalex":"https://openalex.org/W4387478341","doi":"https://doi.org/10.1093/bib/bbad346","pmid":"https://pubmed.ncbi.nlm.nih.gov/37816138"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbad346","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad346","pdf_url":"https://academic.oup.com/bib/article-pdf/24/6/bbad346/51921693/bbad346.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/article-pdf/24/6/bbad346/51921693/bbad346.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035316822","display_name":"Sai Tian","orcid":"https://orcid.org/0000-0003-2498-190X"},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Saisai Tian","raw_affiliation_strings":["College of Pharmacy, Ningxia Medical University , Yinchuan 750004 , China","School of Pharmacy, Second Military Medical University , Shanghai, 200433 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Ningxia Medical University , Yinchuan 750004 , China","institution_ids":["https://openalex.org/I4210127460"]},{"raw_affiliation_string":"School of Pharmacy, Second Military Medical University , Shanghai, 200433 , China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115602120","display_name":"Yanan Li","orcid":"https://orcid.org/0000-0001-5999-0430"},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanan Li","raw_affiliation_strings":["College of Pharmacy, Ningxia Medical University , Yinchuan 750004 , China","School of Pharmacy, Second Military Medical University , Shanghai, 200433 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Ningxia Medical University , Yinchuan 750004 , China","institution_ids":["https://openalex.org/I4210127460"]},{"raw_affiliation_string":"School of Pharmacy, Second Military Medical University , Shanghai, 200433 , China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101077296","display_name":"Jia Xu","orcid":"https://orcid.org/0009-0002-4036-4338"},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Xu","raw_affiliation_strings":["College of Pharmacy, Henan University , Kaifeng 475000 , China","School of Pharmacy, Second Military Medical University , Shanghai, 200433 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Henan University , Kaifeng 475000 , China","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"School of Pharmacy, Second Military Medical University , Shanghai, 200433 , China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100448159","display_name":"Lijun Zhang","orcid":"https://orcid.org/0000-0002-6438-5486"},"institutions":[{"id":"https://openalex.org/I4210146685","display_name":"National Institute for Communicable Disease Control and Prevention","ror":"https://ror.org/04f7g6845","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210146685","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijun Zhang","raw_affiliation_strings":["The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine","institution_ids":["https://openalex.org/I4210146685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100729174","display_name":"Jinbo Zhang","orcid":"https://orcid.org/0000-0001-8287-3259"},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinbo Zhang","raw_affiliation_strings":["Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China Department of Pharmacy, Tianjin Rehabilitation Center of Joint Logistics Support Force , Tianjin, 300110 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China Department of Pharmacy, Tianjin Rehabilitation Center of Joint Logistics Support Force , Tianjin, 300110 , China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088091163","display_name":"Jinyuan Lu","orcid":"https://orcid.org/0009-0006-9517-467X"},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinyuan Lu","raw_affiliation_strings":["College of Pharmacy, Anhui University of Chinese Medicine , Anhui 230012 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Anhui University of Chinese Medicine , Anhui 230012 , China","institution_ids":["https://openalex.org/I253932293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112598968","display_name":"Xi\u2010Ke Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xike Xu","raw_affiliation_strings":["School of Pharmacy, Second Military Medical University , Shanghai, 200433 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Second Military Medical University , Shanghai, 200433 , China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090176999","display_name":"Xin Luan","orcid":"https://orcid.org/0000-0003-3674-256X"},"institutions":[{"id":"https://openalex.org/I4210146685","display_name":"National Institute for Communicable Disease Control and Prevention","ror":"https://ror.org/04f7g6845","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210146685","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Luan","raw_affiliation_strings":["The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine","institution_ids":["https://openalex.org/I4210146685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101613714","display_name":"Jing Zhao","orcid":"https://orcid.org/0000-0001-5627-4156"},"institutions":[{"id":"https://openalex.org/I4210146685","display_name":"National Institute for Communicable Disease Control and Prevention","ror":"https://ror.org/04f7g6845","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210146685","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhao","raw_affiliation_strings":["The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine","institution_ids":["https://openalex.org/I4210146685"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100428737","display_name":"Weidong Zhang","orcid":"https://orcid.org/0000-0002-2433-6823"},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]},{"id":"https://openalex.org/I4210146685","display_name":"National Institute for Communicable Disease Control and Prevention","ror":"https://ror.org/04f7g6845","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210146685","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weidong Zhang","raw_affiliation_strings":["College of Pharmacy, Ningxia Medical University , Yinchuan 750004 , China","School of Pharmacy, Second Military Medical University , Shanghai, 200433 , China","The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Ningxia Medical University , Yinchuan 750004 , China","institution_ids":["https://openalex.org/I4210127460"]},{"raw_affiliation_string":"School of Pharmacy, Second Military Medical University , Shanghai, 200433 , China","institution_ids":["https://openalex.org/I177933477"]},{"raw_affiliation_string":"The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine","institution_ids":["https://openalex.org/I4210146685"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5035316822","https://openalex.org/A5100428737"],"corresponding_institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210127460","https://openalex.org/I4210146685"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":8.6534,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.98660062,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"24","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9898999929428101,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reprogramming","display_name":"Reprogramming","score":0.8288840055465698},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6957601308822632},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"Tumor microenvironment","score":0.6076952219009399},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4975486099720001},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4658755958080292},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.34582510590553284},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.33866602182388306},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.33438459038734436},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.2008243203163147},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.15596124529838562},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1346358358860016},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.0668681263923645}],"concepts":[{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.8288840055465698},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6957601308822632},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6076952219009399},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4975486099720001},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4658755958080292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34582510590553284},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33866602182388306},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33438459038734436},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2008243203163147},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.15596124529838562},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1346358358860016},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0668681263923645}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029001","descriptor_name":"Herbal Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029001","descriptor_name":"Herbal Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029001","descriptor_name":"Herbal Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbad346","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad346","pdf_url":"https://academic.oup.com/bib/article-pdf/24/6/bbad346/51921693/bbad346.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37816138","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37816138","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10564268","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10564268","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10564268/pdf/bbad346.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbad346","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad346","pdf_url":"https://academic.oup.com/bib/article-pdf/24/6/bbad346/51921693/bbad346.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1112760424","display_name":null,"funder_award_id":"82141203","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7169906910","display_name":null,"funder_award_id":"2022YFC3502000","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8766688743","display_name":null,"funder_award_id":"82004003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4387478341.pdf"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W1520790719","https://openalex.org/W1573226709","https://openalex.org/W1939183472","https://openalex.org/W1980807309","https://openalex.org/W1980989523","https://openalex.org/W1984084871","https://openalex.org/W2036976990","https://openalex.org/W2055553698","https://openalex.org/W2060372676","https://openalex.org/W2083045667","https://openalex.org/W2088940256","https://openalex.org/W2098371880","https://openalex.org/W2098967508","https://openalex.org/W2111542778","https://openalex.org/W2112411768","https://openalex.org/W2113680845","https://openalex.org/W2117145998","https://openalex.org/W2117227343","https://openalex.org/W2132799399","https://openalex.org/W2145824104","https://openalex.org/W2148652399","https://openalex.org/W2167181696","https://openalex.org/W2188829391","https://openalex.org/W2234115940","https://openalex.org/W2279928617","https://openalex.org/W2297606889","https://openalex.org/W2389729229","https://openalex.org/W2502470328","https://openalex.org/W2513414068","https://openalex.org/W2575227529","https://openalex.org/W2587478484","https://openalex.org/W2591862054","https://openalex.org/W2609261056","https://openalex.org/W2612467560","https://openalex.org/W2615058391","https://openalex.org/W2734505834","https://openalex.org/W2741560216","https://openalex.org/W2747229058","https://openalex.org/W2782128977","https://openalex.org/W2790788848","https://openalex.org/W2805276875","https://openalex.org/W2886708232","https://openalex.org/W2889646458","https://openalex.org/W2890240722","https://openalex.org/W2892913867","https://openalex.org/W2903111396","https://openalex.org/W2905375440","https://openalex.org/W2906007612","https://openalex.org/W2923914675","https://openalex.org/W2924517120","https://openalex.org/W2945863457","https://openalex.org/W2949144056","https://openalex.org/W2952752961","https://openalex.org/W2975441595","https://openalex.org/W2982686049","https://openalex.org/W2983326574","https://openalex.org/W2990827591","https://openalex.org/W2998462049","https://openalex.org/W3004642442","https://openalex.org/W3011469361","https://openalex.org/W3031704900","https://openalex.org/W3032051702","https://openalex.org/W3034809608","https://openalex.org/W3039484069","https://openalex.org/W3040339918","https://openalex.org/W3049036781","https://openalex.org/W3084221310","https://openalex.org/W3090837964","https://openalex.org/W3090990034","https://openalex.org/W3091822333","https://openalex.org/W3093716682","https://openalex.org/W3119828888","https://openalex.org/W3120650925","https://openalex.org/W3123469366","https://openalex.org/W3128335342","https://openalex.org/W3131439703","https://openalex.org/W3134553072","https://openalex.org/W3169495197","https://openalex.org/W3186387625","https://openalex.org/W3217266844","https://openalex.org/W4200182485","https://openalex.org/W4220734682","https://openalex.org/W4226172846","https://openalex.org/W4280571878","https://openalex.org/W4285733720","https://openalex.org/W4298152936","https://openalex.org/W4318671044","https://openalex.org/W6769692541","https://openalex.org/W6783598583","https://openalex.org/W6790875288"],"related_works":["https://openalex.org/W1631979401","https://openalex.org/W2395945797","https://openalex.org/W2129470469","https://openalex.org/W2368295610","https://openalex.org/W1543102035","https://openalex.org/W1497716427","https://openalex.org/W2946692299","https://openalex.org/W3014941007","https://openalex.org/W2183075003","https://openalex.org/W2990520546"],"abstract_inverted_index":{"Immune":[0],"evasion":[1],"and":[2,22,53,66,111,154,164,173,192,226,232],"metabolism":[3],"reprogramming":[4,156,199],"have":[5,72],"been":[6,40,73,85],"regarded":[7],"as":[8],"two":[9],"vital":[10],"hallmarks":[11],"of":[12,15,49,122,131,150],"the":[13,19,23,47,50,120,123,127,148,151,170,186],"mechanism":[14],"carcinogenesis.":[16],"Thus,":[17],"targeting":[18,95,169,224],"immune":[20,51,152,171,225],"microenvironment":[21,52,153,172],"reprogrammed":[24,54],"metabolic":[25,55,155,174,198,227],"processes":[26],"will":[27],"aid":[28],"in":[29,158,189,200,204,211,229,239],"developing":[30],"novel":[31],"anti-cancer":[32,104],"drugs.":[33],"In":[34],"recent":[35],"decades,":[36],"herbal":[37,59,100,132,159,167],"medicine":[38],"has":[39,84],"widely":[41],"utilized":[42],"to":[43,75,87,90,126,135,146,180],"treat":[44],"cancer":[45,163,231],"through":[46],"modulation":[48],"processes.":[56],"However,":[57],"labor-based":[58],"ingredient":[60],"screening":[61],"is":[62,243],"time":[63],"consuming,":[64],"laborious":[65],"costly.":[67],"Luckily,":[68],"some":[69],"computational":[70,144],"approaches":[71,117],"proposed":[74],"screen":[76,91,166],"candidates":[77,93],"for":[78,99,221,236],"drug":[79,92,237],"discovery":[80],"rapidly.":[81],"Yet,":[82],"it":[83],"challenging":[86],"develop":[88],"methods":[89],"exclusively":[94],"specific":[96,124],"pathways,":[97],"especially":[98],"ingredients":[101,160,168],"which":[102],"exert":[103],"effects":[105],"by":[106],"multiple":[107,109],"targets,":[108],"pathways":[110],"synergistic":[112],"ways.":[113],"Meanwhile,":[114],"currently":[115],"employed":[116],"cannot":[118],"quantify":[119],"contribution":[121,149],"pathway":[125],"overall":[128],"curative":[129],"effect":[130],"ingredients.":[133],"Hence,":[134],"address":[136],"this":[137,139],"problem,":[138],"study":[140],"proposes":[141],"a":[142],"new":[143,219,234],"framework":[145],"infer":[147],"(COIMMR)":[157],"against":[161],"human":[162,230],"specifically":[165,184,196],"reprogramming.":[175],"Finally,":[176],"COIMMR":[177,242],"was":[178],"applied":[179],"identify":[181],"isoliquiritigenin":[182],"that":[183,195],"regulates":[185],"T":[187],"cells":[188],"stomach":[190],"adenocarcinoma":[191],"cephaelin":[193],"hydrochloride":[194],"targets":[197],"low-grade":[201],"glioma.":[202],"The":[203],"silico":[205],"results":[206],"were":[207],"further":[208],"verified":[209],"using":[210],"vitro":[212],"experiments.":[213],"Taken":[214],"together,":[215],"our":[216],"approach":[217],"opens":[218],"possibilities":[220],"repositioning":[222],"drugs":[223],"dysfunction":[228],"provides":[233],"insights":[235],"development":[238],"other":[240],"diseases.":[241],"available":[244],"at":[245],"https://github.com/LYN2323/COIMMR.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":19}],"updated_date":"2026-07-16T13:24:37.021932","created_date":"2025-10-10T00:00:00"}