{"id":"https://openalex.org/W4387327098","doi":"https://doi.org/10.1093/bib/bbad341","title":"Cracking the pattern of tumor evolution based on single-cell copy number alterations","display_name":"Cracking the pattern of tumor evolution based on single-cell copy number alterations","publication_year":2023,"publication_date":"2023-09-22","ids":{"openalex":"https://openalex.org/W4387327098","doi":"https://doi.org/10.1093/bib/bbad341","pmid":"https://pubmed.ncbi.nlm.nih.gov/37791583"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbad341","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad341","pdf_url":"https://academic.oup.com/bib/article-pdf/24/6/bbad341/51840365/bbad341.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/24/6/bbad341/51840365/bbad341.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100347268","display_name":"Ying Wang","orcid":"https://orcid.org/0000-0003-4868-6147"},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Guangdong Cardiovascular Institute\uff0cGuangdong Provincial People\u2019s Hospital\uff0cGuangdong Academy of Medical Sciences and Medical Research Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University","Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences and Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Cardiovascular Institute\uff0cGuangdong Provincial People\u2019s Hospital\uff0cGuangdong Academy of Medical Sciences and Medical Research Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences and Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100671582","display_name":"Min Zhang","orcid":"https://orcid.org/0000-0003-4506-8212"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Zhang","raw_affiliation_strings":["Institute of Precision Medicine, The First Affiliated Hospital, Sun Yan-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Precision Medicine, The First Affiliated Hospital, Sun Yan-Sen University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100754566","display_name":"Jian Shi","orcid":"https://orcid.org/0000-0003-3255-8263"},"institutions":[{"id":"https://openalex.org/I3018851911","display_name":"Institute of Precision Mechanics","ror":"https://ror.org/02bxtrk46","country_code":"PL","type":"facility","lineage":["https://openalex.org/I3018851911"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jian Shi","raw_affiliation_strings":["Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University","institution_ids":["https://openalex.org/I3018851911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100714516","display_name":"Yue Zhu","orcid":"https://orcid.org/0000-0001-7719-9263"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yue Zhu","raw_affiliation_strings":["Department of Breast Surgery at Harbin Medical University Cancer Hospital and the Medical Research Institute of Guangdong Provincial People's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery at Harbin Medical University Cancer Hospital and the Medical Research Institute of Guangdong Provincial People's Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100395729","display_name":"Xin Wang","orcid":"https://orcid.org/0000-0003-0273-5724"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Wang","raw_affiliation_strings":["Institute of Precision Medicine, The First Affiliated Hospital, Sun Yan-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Precision Medicine, The First Affiliated Hospital, Sun Yan-Sen University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100607388","display_name":"Shaojun Zhang","orcid":"https://orcid.org/0000-0001-5760-5797"},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shaojun Zhang","raw_affiliation_strings":["Medical Research Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University","Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100321405","display_name":"Fang Wang","orcid":"https://orcid.org/0000-0002-3510-4550"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fang Wang","raw_affiliation_strings":["Institute of Precision Medicine, The First Affiliated Hospital, Sun Yan-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Precision Medicine, The First Affiliated Hospital, Sun Yan-Sen University","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100321405","https://openalex.org/A5100607388"],"corresponding_institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.2121,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.46591236,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"24","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatic-evolution-in-cancer","display_name":"Somatic evolution in cancer","score":0.6808353066444397},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"Copy-number variation","score":0.6105972528457642},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6026246547698975},{"id":"https://openalex.org/keywords/single-cell-sequencing","display_name":"Single cell sequencing","score":0.5563647150993347},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5345695614814758},{"id":"https://openalex.org/keywords/single-cell-analysis","display_name":"Single-cell analysis","score":0.5199390649795532},{"id":"https://openalex.org/keywords/evolutionary-dynamics","display_name":"Evolutionary dynamics","score":0.4755943715572357},{"id":"https://openalex.org/keywords/comparative-genomic-hybridization","display_name":"Comparative genomic hybridization","score":0.44699418544769287},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.43462464213371277},{"id":"https://openalex.org/keywords/chromothripsis","display_name":"Chromothripsis","score":0.4313523769378662},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.42599695920944214},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.3382352888584137},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.33549201488494873},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.3272169828414917},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3146355450153351},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3067965507507324},{"id":"https://openalex.org/keywords/exome-sequencing","display_name":"Exome sequencing","score":0.26626449823379517},{"id":"https://openalex.org/keywords/genome-instability","display_name":"Genome instability","score":0.2490214705467224},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2171664535999298},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.18236878514289856},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.18196028470993042},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.07885748147964478},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.07468569278717041}],"concepts":[{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.6808353066444397},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.6105972528457642},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6026246547698975},{"id":"https://openalex.org/C174749747","wikidata":"https://www.wikidata.org/wiki/Q15917269","display_name":"Single cell sequencing","level":5,"score":0.5563647150993347},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5345695614814758},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.5199390649795532},{"id":"https://openalex.org/C171578705","wikidata":"https://www.wikidata.org/wiki/Q5418700","display_name":"Evolutionary dynamics","level":3,"score":0.4755943715572357},{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.44699418544769287},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.43462464213371277},{"id":"https://openalex.org/C99983632","wikidata":"https://www.wikidata.org/wiki/Q1087765","display_name":"Chromothripsis","level":5,"score":0.4313523769378662},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.42599695920944214},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.3382352888584137},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.33549201488494873},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3272169828414917},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3146355450153351},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3067965507507324},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.26626449823379517},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.2490214705467224},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2171664535999298},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.18236878514289856},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.18196028470993042},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07885748147964478},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.07468569278717041},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbad341","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad341","pdf_url":"https://academic.oup.com/bib/article-pdf/24/6/bbad341/51840365/bbad341.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37791583","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37791583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bib/bbad341","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad341","pdf_url":"https://academic.oup.com/bib/article-pdf/24/6/bbad341/51840365/bbad341.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2532130263","display_name":null,"funder_award_id":"32170666","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4453338134","display_name":null,"funder_award_id":"32270699","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387327098.pdf"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1997817740","https://openalex.org/W2016299037","https://openalex.org/W2032518018","https://openalex.org/W2034979835","https://openalex.org/W2041937775","https://openalex.org/W2068127752","https://openalex.org/W2068674866","https://openalex.org/W2088735033","https://openalex.org/W2133174470","https://openalex.org/W2135640980","https://openalex.org/W2145126338","https://openalex.org/W2153056550","https://openalex.org/W2157852151","https://openalex.org/W2177689130","https://openalex.org/W2260951263","https://openalex.org/W2515472395","https://openalex.org/W2579382924","https://openalex.org/W2586629973","https://openalex.org/W2796153225","https://openalex.org/W2800852522","https://openalex.org/W2898824002","https://openalex.org/W2936414047","https://openalex.org/W2984472267","https://openalex.org/W2996885413","https://openalex.org/W2999754525","https://openalex.org/W2999990233","https://openalex.org/W3004765765","https://openalex.org/W3015416694","https://openalex.org/W3022968840","https://openalex.org/W3078555423","https://openalex.org/W3129513070","https://openalex.org/W3133932842","https://openalex.org/W3137654632","https://openalex.org/W3155717007","https://openalex.org/W3157384750","https://openalex.org/W3168048358","https://openalex.org/W3173819558","https://openalex.org/W3175892313","https://openalex.org/W3193419934","https://openalex.org/W3198396939","https://openalex.org/W3198511950","https://openalex.org/W3198548668","https://openalex.org/W4226155266","https://openalex.org/W4229016240","https://openalex.org/W4246691268","https://openalex.org/W4283797388","https://openalex.org/W4290075472","https://openalex.org/W4296838339","https://openalex.org/W4309013615","https://openalex.org/W4318475995","https://openalex.org/W4378953806","https://openalex.org/W6849574743"],"related_works":["https://openalex.org/W2035020647","https://openalex.org/W3029029205","https://openalex.org/W3205054884","https://openalex.org/W2515472395","https://openalex.org/W2980374641","https://openalex.org/W2588451495","https://openalex.org/W2589061457","https://openalex.org/W2041380745","https://openalex.org/W2922477528","https://openalex.org/W3120290214"],"abstract_inverted_index":{"Copy":[0],"number":[1,64,118],"alterations":[2],"(CNAs)":[3],"are":[4,47],"a":[5,22,96,110,125],"key":[6],"characteristic":[7],"of":[8,15,43,66,83,90,127,210],"tumor":[9,19,27,44,67,111,144],"development":[10,20],"and":[11,85,105,129,133,140,161],"progression.":[12],"The":[13,207],"accumulation":[14],"various":[16,190],"CNAs":[17,34,84],"during":[18],"plays":[21],"critical":[23],"role":[24],"in":[25,56,142,171],"driving":[26],"evolution.":[28],"Heterogeneous":[29],"clones":[30],"driven":[31],"by":[32],"distinct":[33],"have":[35,60],"different":[36],"selective":[37],"advantages,":[38],"leading":[39],"to":[40,78,151,182],"differential":[41,197],"patterns":[42,82,108],"evolution":[45,165],"that":[46,100,163,196],"essential":[48],"for":[49,109],"developing":[50],"effective":[51],"cancer":[52,159,191],"therapies.":[53],"Recent":[54],"advances":[55],"single-cell":[57,71,116,131,152,183],"sequencing":[58,154,185],"technology":[59],"enabled":[61],"genome-wide":[62],"copy":[63,117],"profiling":[65],"cell":[68,112,199],"populations":[69],"at":[70,215],"resolution.":[72],"This":[73],"has":[74],"made":[75],"it":[76],"possible":[77],"explore":[79],"the":[80,88,167,180],"evolutionary":[81,107,145,169,205],"accurately":[86],"discover":[87],"mechanisms":[89],"intra-tumor":[91],"heterogeneity.":[92],"Here,":[93],"we":[94,194],"propose":[95],"two-step":[97],"statistical":[98],"approach":[99,123,150,181],"distinguishes":[101],"neutral,":[102],"linear,":[103],"branching":[104],"punctuated":[106,164],"population":[113],"based":[114],"on":[115],"profiles.":[119],"We":[120,147],"assessed":[121],"our":[122,149,211],"using":[124],"variety":[126],"simulated":[128],"real":[130],"genomic":[132],"transcriptomic":[134],"datasets,":[135],"demonstrating":[136],"its":[137],"high":[138],"accuracy":[139],"robustness":[141],"predicting":[143],"patterns.":[146,206],"applied":[148],"DNA":[153],"data":[155,186],"from":[156,188],"20":[157],"breast":[158,172],"patients":[160],"observed":[162],"is":[166,201,213],"dominant":[168],"pattern":[170],"cancer.":[173],"Similar":[174],"conclusions":[175],"were":[176],"drawn":[177],"when":[178],"applying":[179],"RNA":[184],"obtained":[187],"132":[189],"patients.":[192],"Moreover,":[193],"found":[195],"immune":[198],"infiltration":[200],"associated":[202],"with":[203],"specific":[204],"source":[208],"code":[209],"study":[212],"available":[214],"https://github.com/FangWang-SYSU/PTEM.":[216]},"counts_by_year":[{"year":2024,"cited_by_count":2}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
