{"id":"https://openalex.org/W4385968638","doi":"https://doi.org/10.1093/bib/bbad301","title":"OTTM: an automated classification tool for translational drug discovery from omics data","display_name":"OTTM: an automated classification tool for translational drug discovery from omics data","publication_year":2023,"publication_date":"2023-08-18","ids":{"openalex":"https://openalex.org/W4385968638","doi":"https://doi.org/10.1093/bib/bbad301","pmid":"https://pubmed.ncbi.nlm.nih.gov/37594310"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbad301","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad301","pdf_url":"https://academic.oup.com/bib/advance-article-pdf/doi/10.1093/bib/bbad301/51146495/bbad301.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/advance-article-pdf/doi/10.1093/bib/bbad301/51146495/bbad301.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114664712","display_name":"Xiaobo Yang","orcid":"https://orcid.org/0000-0003-2704-5551"},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaobo Yang","raw_affiliation_strings":["School of Life Science and Technology, ShanghaiTech University , 393 Huaxiazhong Road, Shanghai 200031 , China","ShanghaiTech University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, ShanghaiTech University , 393 Huaxiazhong Road, Shanghai 200031 , China","institution_ids":["https://openalex.org/I30809798"]},{"raw_affiliation_string":"ShanghaiTech University","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100446545","display_name":"Bei Zhang","orcid":"https://orcid.org/0000-0003-0948-8586"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bei Zhang","raw_affiliation_strings":["Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049 , China","Shanghai Institute of Materia Medica","Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049 , China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Shanghai Institute of Materia Medica","institution_ids":["https://openalex.org/I4210112820"]},{"raw_affiliation_string":"Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420068","display_name":"Siqi Wang","orcid":"https://orcid.org/0000-0002-1491-2962"},"institutions":[{"id":"https://openalex.org/I4210149540","display_name":"Beijing Proteome Research Center","ror":"https://ror.org/05pp5b412","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210149540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siqi Wang","raw_affiliation_strings":["Beijing Proteome Research Center","State Key Laboratory of Proteomics, Beijing Proteome Research Center, and National Center for Protein Sciences (Beijing)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Proteome Research Center","institution_ids":["https://openalex.org/I4210149540"]},{"raw_affiliation_string":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, and National Center for Protein Sciences (Beijing)","institution_ids":["https://openalex.org/I4210149540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046637756","display_name":"Ye L\u00fc","orcid":"https://orcid.org/0000-0002-2319-7681"},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ye Lu","raw_affiliation_strings":["Nanjing University of Chinese Medicine","School of Chinese Materia Medica, Nanjing University of Chinese Medicine , Nanjing 210023, China; Chemical Biology Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203 , China","School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanjing University of Chinese Medicine","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"School of Chinese Materia Medica, Nanjing University of Chinese Medicine , Nanjing 210023, China; Chemical Biology Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203 , China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I131434179","https://openalex.org/I19820366"]},{"raw_affiliation_string":"School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105978526","display_name":"Kaixian Chen","orcid":"https://orcid.org/0000-0001-9497-0689"},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaixian Chen","raw_affiliation_strings":["Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China; School of Life Science and Technology, ShanghaiTech University, 393 Huaxiazhong Road, Shanghai 200031, China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023 , China","academician medicinal scientist of the Chinese Academy of Sciences","School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China","University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China","School of Life Science and Technology, ShanghaiTech University, 393 Huaxiazhong Road, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China; School of Life Science and Technology, ShanghaiTech University, 393 Huaxiazhong Road, Shanghai 200031, China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023 , China","institution_ids":["https://openalex.org/I4210165038","https://openalex.org/I4210112820","https://openalex.org/I131434179","https://openalex.org/I30809798"]},{"raw_affiliation_string":"academician medicinal scientist of the Chinese Academy of Sciences","institution_ids":["https://openalex.org/I19820366"]},{"raw_affiliation_string":"School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"School of Life Science and Technology, ShanghaiTech University, 393 Huaxiazhong Road, Shanghai 200031, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024637740","display_name":"Cheng Luo","orcid":"https://orcid.org/0000-0003-3864-8382"},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cheng Luo","raw_affiliation_strings":["Chemical Biology Research Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023 , China","Shanghai Institute of Materia Medica","School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China","Chemical Biology Research Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology Research Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023 , China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I4210165038","https://openalex.org/I131434179"]},{"raw_affiliation_string":"Shanghai Institute of Materia Medica","institution_ids":["https://openalex.org/I4210112820"]},{"raw_affiliation_string":"School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"Chemical Biology Research Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101662218","display_name":"Aihua Sun","orcid":"https://orcid.org/0000-0001-7931-6662"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210149540","display_name":"Beijing Proteome Research Center","ror":"https://ror.org/05pp5b412","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210149540"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Aihua Sun","raw_affiliation_strings":["Beijing Proteome Research Center","State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics; Research Unit of Proteomics-driven Cancer Precision Medicine, Chinese Academy of Medical Sciences","State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Proteome Research Center","institution_ids":["https://openalex.org/I4210149540"]},{"raw_affiliation_string":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics; Research Unit of Proteomics-driven Cancer Precision Medicine, Chinese Academy of Medical Sciences","institution_ids":["https://openalex.org/I4210149540","https://openalex.org/I200296433"]},{"raw_affiliation_string":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics","institution_ids":["https://openalex.org/I4210149540"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100396936","display_name":"Hao Zhang","orcid":"https://orcid.org/0000-0002-6166-2089"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hao Zhang","raw_affiliation_strings":["Chemical Biology Research Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203 , China","Shanghai Institute of Materia Medica","Chemical Biology Research Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China"],"raw_orcid":"https://orcid.org/0000-0002-6166-2089","affiliations":[{"raw_affiliation_string":"Chemical Biology Research Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203 , China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Shanghai Institute of Materia Medica","institution_ids":["https://openalex.org/I4210112820"]},{"raw_affiliation_string":"Chemical Biology Research Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5024637740","https://openalex.org/A5100396936","https://openalex.org/A5101662218"],"corresponding_institution_ids":["https://openalex.org/I131434179","https://openalex.org/I19820366","https://openalex.org/I200296433","https://openalex.org/I4210112820","https://openalex.org/I4210149540","https://openalex.org/I4210165038"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.6727,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.70957332,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"24","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9684000015258789,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9684000015258789,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11281","display_name":"Asymmetric Hydrogenation and Catalysis","score":0.9591000080108643,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.7879704236984253},{"id":"https://openalex.org/keywords/omics","display_name":"Omics","score":0.6487258672714233},{"id":"https://openalex.org/keywords/approved-drug","display_name":"Approved drug","score":0.5710131525993347},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.5324921011924744},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5196603536605835},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.46929675340652466},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.44340458512306213},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.34568488597869873},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.231775164604187},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1549399197101593}],"concepts":[{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.7879704236984253},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.6487258672714233},{"id":"https://openalex.org/C2777494893","wikidata":"https://www.wikidata.org/wiki/Q4781752","display_name":"Approved drug","level":3,"score":0.5710131525993347},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5324921011924744},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5196603536605835},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.46929675340652466},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.44340458512306213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34568488597869873},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.231775164604187},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1549399197101593},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000090963","descriptor_name":"Translational Science, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090963","descriptor_name":"Translational Science, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090963","descriptor_name":"Translational Science, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbad301","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad301","pdf_url":"https://academic.oup.com/bib/advance-article-pdf/doi/10.1093/bib/bbad301/51146495/bbad301.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37594310","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37594310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10516341","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10516341","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10516341/pdf/bbad301.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbad301","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad301","pdf_url":"https://academic.oup.com/bib/advance-article-pdf/doi/10.1093/bib/bbad301/51146495/bbad301.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6700000166893005}],"awards":[{"id":"https://openalex.org/G1042291103","display_name":null,"funder_award_id":"2022YFC3400500","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G1325768545","display_name":null,"funder_award_id":"81903538","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2507855583","display_name":null,"funder_award_id":"202004","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2910979731","display_name":null,"funder_award_id":"2019B090904008","funder_id":"https://openalex.org/F4320324202","funder_display_name":"Guangdong Science and Technology Department"},{"id":"https://openalex.org/G3595733581","display_name":null,"funder_award_id":"2020YFE0202200","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G4322195117","display_name":null,"funder_award_id":"92253303","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4778903190","display_name":null,"funder_award_id":"81821005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6006989240","display_name":null,"funder_award_id":"2020YFE0202200","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6311684539","display_name":null,"funder_award_id":"202204","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8567954048","display_name":null,"funder_award_id":"2021ZD0203900","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8581042564","display_name":null,"funder_award_id":"2021B0909050003","funder_id":"https://openalex.org/F4320324202","funder_display_name":"Guangdong Science and Technology Department"},{"id":"https://openalex.org/G987564722","display_name":null,"funder_award_id":"2019-I2M-5-063","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323137","display_name":"Chinese Academy of Medical Sciences","ror":"https://ror.org/03cve4549"},{"id":"https://openalex.org/F4320324202","display_name":"Guangdong Science and Technology Department","ror":"https://ror.org/00tjzgn92"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4385968638.pdf"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1500036797","https://openalex.org/W1965872090","https://openalex.org/W1989949458","https://openalex.org/W1992412494","https://openalex.org/W2002520167","https://openalex.org/W2006452977","https://openalex.org/W2006667691","https://openalex.org/W2009313526","https://openalex.org/W2034537627","https://openalex.org/W2047360869","https://openalex.org/W2089986767","https://openalex.org/W2096814387","https://openalex.org/W2123500593","https://openalex.org/W2125887220","https://openalex.org/W2146211839","https://openalex.org/W2156779720","https://openalex.org/W2201571920","https://openalex.org/W2295182096","https://openalex.org/W2329592726","https://openalex.org/W2536723267","https://openalex.org/W2558217333","https://openalex.org/W2606218841","https://openalex.org/W2613447735","https://openalex.org/W2896002881","https://openalex.org/W2910820964","https://openalex.org/W2918023653","https://openalex.org/W2937307539","https://openalex.org/W2977528366","https://openalex.org/W2998462049","https://openalex.org/W3017710116","https://openalex.org/W3107527779","https://openalex.org/W3199000899","https://openalex.org/W3199050424","https://openalex.org/W3210331473","https://openalex.org/W4210774372","https://openalex.org/W4308558768"],"related_works":["https://openalex.org/W1488408180","https://openalex.org/W177137871","https://openalex.org/W4292302930","https://openalex.org/W2360290178","https://openalex.org/W3195112886","https://openalex.org/W4389089607","https://openalex.org/W3195480349","https://openalex.org/W2892201447","https://openalex.org/W2590543013","https://openalex.org/W2951512731"],"abstract_inverted_index":{"Omics":[0,95],"data":[1],"from":[2,28,84,227],"clinical":[3,140,171],"samples":[4],"are":[5,146,237],"the":[6,75,107,125,176,214],"predominant":[7],"source":[8],"of":[9,19,33,48,64,77,109,178,216,223,235],"target":[10,38,198],"discovery":[11,39,83,215],"and":[12,40,51,96,121,149,166,192,219,232],"drug":[13,82,118,163,172],"development.":[14],"Typically,":[15],"hundreds":[16],"or":[17,23,44,57,111,139],"thousands":[18,222],"differentially":[20],"expressed":[21],"genes":[22,52,112],"proteins":[24,50,110,128,199,225],"can":[25,104,212],"be":[26,195],"identified":[27,129,226],"omics":[29,85,228],"data.":[30,229],"This":[31,102],"scale":[32],"possibilities":[34],"is":[35,206],"overwhelming":[36],"for":[37,175,200],"validation":[41,116],"using":[42,221],"biochemical":[43],"cellular":[45],"experiments.":[46],"Most":[47],"these":[49],"have":[53,67,88],"no":[54],"corresponding":[55],"drugs":[56,218],"even":[58],"active":[59],"compounds.":[60],"Moreover,":[61],"a":[62,90],"proportion":[63],"them":[65],"may":[66,194],"been":[68],"previously":[69],"reported":[70],"as":[71],"being":[72],"relevant":[73],"to":[74],"disease":[76],"interest.":[78],"To":[79],"facilitate":[80],"translational":[81],"data,":[86],"we":[87],"developed":[89],"new":[91],"classification":[92,209],"tool":[93,103,210],"named":[94],"Text":[97],"driven":[98],"Translational":[99],"Medicine":[100],"(OTTM).":[101],"markedly":[105],"narrow":[106],"range":[108],"that":[113,190,211],"merit":[114],"further":[115],"via":[117],"availability":[119],"assessment":[120],"literature":[122],"mining.":[123],"For":[124],"4489":[126],"candidate":[127,224],"in":[130],"our":[131],"previous":[132],"proteomics":[133],"study,":[134],"OTTM":[135,205,236],"recommended":[136],"40":[137],"FDA-approved":[138,161],"trial":[141],"drugs.":[142],"Of":[143],"these,":[144],"15":[145],"available":[147,238],"commercially":[148],"were":[150],"tested":[151],"on":[152],"hepatocellular":[153,201],"carcinoma":[154],"Hep-G2":[155,186],"cells.":[156],"Two":[157],"drugs-tafenoquine":[158],"succinate":[159],"(an":[160],"antimalarial":[162],"targeting":[164,173],"CYC1)":[165],"branaplam":[167],"(a":[168],"Phase":[169],"3":[170],"SMN1":[174,193],"treatment":[177],"spinal":[179],"muscular":[180],"atrophy)-showed":[181],"potent":[182],"inhibitory":[183],"activity":[184],"against":[185],"cell":[187],"viability,":[188],"suggesting":[189],"CYC1":[191],"potential":[196],"therapeutic":[197],"carcinoma.":[202],"In":[203],"summary,":[204],"an":[207],"efficient":[208],"accelerate":[213],"effective":[217],"targets":[220],"The":[230],"online":[231],"local":[233],"versions":[234],"at":[239],"http://otter-simm.com/ottm.html.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-06-17T06:14:20.161405","created_date":"2025-10-10T00:00:00"}