{"id":"https://openalex.org/W4385332147","doi":"https://doi.org/10.1093/bib/bbad271","title":"A dual-modal graph learning framework for identifying interaction events among chemical and biotech drugs","display_name":"A dual-modal graph learning framework for identifying interaction events among chemical and biotech drugs","publication_year":2023,"publication_date":"2023-07-28","ids":{"openalex":"https://openalex.org/W4385332147","doi":"https://doi.org/10.1093/bib/bbad271","pmid":"https://pubmed.ncbi.nlm.nih.gov/37507113"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbad271","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad271","pdf_url":"https://academic.oup.com/bib/advance-article-pdf/doi/10.1093/bib/bbad271/50996988/bbad271.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/advance-article-pdf/doi/10.1093/bib/bbad271/50996988/bbad271.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhongying Ru","orcid":"https://orcid.org/0000-0001-7889-1489"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongying Ru","raw_affiliation_strings":["Center for Data Science, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China","Polytechnic Institute, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China"],"raw_orcid":"https://orcid.org/0000-0001-7889-1489","affiliations":[{"raw_affiliation_string":"Center for Data Science, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Polytechnic Institute, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101976531","display_name":"Yangyang Wu","orcid":"https://orcid.org/0000-0001-9531-0906"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangyang Wu","raw_affiliation_strings":["Center for Data Science, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Data Science, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000899263","display_name":"Jinning Shao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210165815","display_name":"Hangzhou Cancer Hospital","ror":"https://ror.org/05psp9534","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210165815"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinning Shao","raw_affiliation_strings":["Institute of Drug Metabolism and Pharmaceutical Analysis , Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China","Zhejiang University , Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China","Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, Zhejiang University, 866 Yuhangtang Rd, 310058, Hangzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Drug Metabolism and Pharmaceutical Analysis , Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China","institution_ids":["https://openalex.org/I4210165815"]},{"raw_affiliation_string":"Zhejiang University , Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, Zhejiang University, 866 Yuhangtang Rd, 310058, Hangzhou, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069353502","display_name":"Jianwei Yin","orcid":"https://orcid.org/0000-0003-4703-7348"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianwei Yin","raw_affiliation_strings":["Center for Data Science, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China","College of Computer Science, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Data Science, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"College of Computer Science, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060115660","display_name":"Linghui Qian","orcid":"https://orcid.org/0000-0001-7889-1489"},"institutions":[{"id":"https://openalex.org/I4210165815","display_name":"Hangzhou Cancer Hospital","ror":"https://ror.org/05psp9534","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210165815"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Linghui Qian","raw_affiliation_strings":["Institute of Drug Metabolism and Pharmaceutical Analysis , Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China","Zhejiang University , Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China","Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, Zhejiang University, 866 Yuhangtang Rd, 310058, Hangzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Drug Metabolism and Pharmaceutical Analysis , Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China","institution_ids":["https://openalex.org/I4210165815"]},{"raw_affiliation_string":"Zhejiang University , Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, Zhejiang University, 866 Yuhangtang Rd, 310058, Hangzhou, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014150958","display_name":"Xiaoye Miao","orcid":"https://orcid.org/0000-0002-8632-1539"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoye Miao","raw_affiliation_strings":["Center for Data Science, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-8632-1539","affiliations":[{"raw_affiliation_string":"Center for Data Science, Zhejiang University , 866 Yuhangtang Rd, 310058, Hangzhou , P.R. China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5014150958","https://openalex.org/A5060115660"],"corresponding_institution_ids":["https://openalex.org/I4210165815","https://openalex.org/I76130692"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.359,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.83769005,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"24","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9646999835968018,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9438999891281128,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5520623922348022},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5346803665161133},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5229297876358032},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4831528067588806},{"id":"https://openalex.org/keywords/dual","display_name":"Dual (grammatical number)","score":0.4630442261695862},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4563567638397217},{"id":"https://openalex.org/keywords/modal","display_name":"Modal","score":0.4522736966609955},{"id":"https://openalex.org/keywords/small-molecule","display_name":"Small molecule","score":0.4457213282585144},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.43945908546447754},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.341325581073761},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2872774600982666},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2429991066455841},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.22569948434829712},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.21582812070846558},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.18880784511566162}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5520623922348022},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5346803665161133},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5229297876358032},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4831528067588806},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.4630442261695862},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4563567638397217},{"id":"https://openalex.org/C71139939","wikidata":"https://www.wikidata.org/wiki/Q910194","display_name":"Modal","level":2,"score":0.4522736966609955},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.4457213282585144},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.43945908546447754},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.341325581073761},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2872774600982666},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2429991066455841},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.22569948434829712},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.21582812070846558},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18880784511566162},{"id":"https://openalex.org/C124952713","wikidata":"https://www.wikidata.org/wiki/Q8242","display_name":"Literature","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbad271","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad271","pdf_url":"https://academic.oup.com/bib/advance-article-pdf/doi/10.1093/bib/bbad271/50996988/bbad271.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37507113","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37507113","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bib/bbad271","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad271","pdf_url":"https://academic.oup.com/bib/advance-article-pdf/doi/10.1093/bib/bbad271/50996988/bbad271.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1977736942","display_name":null,"funder_award_id":"61825205","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G317602081","display_name":null,"funder_award_id":"LR21F020005","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G5485918612","display_name":null,"funder_award_id":"81903574","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5851876968","display_name":null,"funder_award_id":"2021FZZX001-25","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G628069048","display_name":null,"funder_award_id":"61902343","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6565590116","display_name":null,"funder_award_id":"82273887","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6716220049","display_name":null,"funder_award_id":"2021FZZX001","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4385332147.pdf"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1573434238","https://openalex.org/W1968874541","https://openalex.org/W1980002210","https://openalex.org/W1985875476","https://openalex.org/W1988037271","https://openalex.org/W1994219663","https://openalex.org/W2024985940","https://openalex.org/W2029335938","https://openalex.org/W2068556004","https://openalex.org/W2069722675","https://openalex.org/W2075678951","https://openalex.org/W2091439417","https://openalex.org/W2109482131","https://openalex.org/W2111823238","https://openalex.org/W2114340287","https://openalex.org/W2141058448","https://openalex.org/W2186222003","https://openalex.org/W2297721181","https://openalex.org/W2310115806","https://openalex.org/W2419501139","https://openalex.org/W2484065175","https://openalex.org/W2558217333","https://openalex.org/W2562110925","https://openalex.org/W2597646117","https://openalex.org/W2604314403","https://openalex.org/W2767891136","https://openalex.org/W2786016794","https://openalex.org/W2802060229","https://openalex.org/W2802200505","https://openalex.org/W2804822363","https://openalex.org/W2885852526","https://openalex.org/W2905174775","https://openalex.org/W2968734407","https://openalex.org/W3016161809","https://openalex.org/W3032123378","https://openalex.org/W3034239155","https://openalex.org/W3037601681","https://openalex.org/W3044927477","https://openalex.org/W3089843526","https://openalex.org/W3140107645","https://openalex.org/W3198755792","https://openalex.org/W3208102118","https://openalex.org/W4210409925","https://openalex.org/W4214639484","https://openalex.org/W4220784339","https://openalex.org/W4224946912","https://openalex.org/W4236965008","https://openalex.org/W4256361765","https://openalex.org/W4313249679","https://openalex.org/W4313405519","https://openalex.org/W4367843506","https://openalex.org/W6687483927","https://openalex.org/W6717434760","https://openalex.org/W6754929296","https://openalex.org/W6754951831","https://openalex.org/W6757398345","https://openalex.org/W6760402595","https://openalex.org/W6770446764","https://openalex.org/W6774931820","https://openalex.org/W6779393347","https://openalex.org/W6784196213"],"related_works":["https://openalex.org/W3044962842","https://openalex.org/W3154750840","https://openalex.org/W2038252445","https://openalex.org/W3031857447","https://openalex.org/W1852608922","https://openalex.org/W4221071935","https://openalex.org/W3129624046","https://openalex.org/W584139414","https://openalex.org/W2890221005","https://openalex.org/W4308980533"],"abstract_inverted_index":{"Drug-drug":[0],"interaction":[1,98],"(DDI)":[2],"identification":[3],"is":[4],"essential":[5],"to":[6,42,84,164,176],"clinical":[7],"medicine":[8,40],"and":[9,20,45,77,91,100,132,171,200],"drug":[10,166,185],"discovery.":[11],"The":[12],"two":[13,101,136],"categories":[14],"of":[15,58,64,104,128,139,145,155,204],"drugs":[16,19,32,57,63,117,131],"(i.e.":[17,153],"chemical":[18,56,90],"biotech":[21,62,92],"drugs)":[22],"differ":[23],"remarkably":[24],"in":[25,38,142,188,197],"molecular":[26,105,129],"properties,":[27],"action":[28],"mechanisms,":[29],"etc.":[30],"Biotech":[31],"are":[33,135,148],"up-to-comers":[34],"but":[35],"highly":[36],"promising":[37,202],"modern":[39],"due":[41],"higher":[43],"specificity":[44],"fewer":[46],"side":[47],"effects.":[48],"However,":[49],"existing":[50],"DDI":[51,198],"prediction":[52,199],"methods":[53,163],"only":[54],"consider":[55],"small":[59],"molecules,":[60],"not":[61],"large":[65],"molecules.":[66],"Here,":[67],"we":[68],"build":[69],"a":[70,79,184],"large-scale":[71],"dual-modal":[72],"graph":[73,160],"database":[74],"named":[75,82],"CB-DB":[76,94],"customize":[78],"graph-based":[80],"framework":[81],"CB-TIP":[83,158],"reason":[85],"event-aware":[86],"DDIs":[87],"for":[88],"both":[89],"drugs.":[93],"comprehensively":[95],"integrates":[96],"various":[97],"events":[99,152],"heterogeneous":[102,137],"kinds":[103,138],"structures.":[106],"It":[107],"imports":[108],"endogenous":[109,123,133],"proteins":[110,134],"founded":[111],"on":[112],"the":[113,126,143,201],"fact":[114],"that":[115],"most":[116],"take":[118],"effects":[119],"by":[120,151],"interacting":[121],"with":[122],"proteins.":[124],"In":[125],"modality":[127,144,170],"structure,":[130],"graphs,":[140],"while":[141],"interaction,":[146],"they":[147],"nodes":[149],"connected":[150],"edges":[154],"different":[156],"relationships).":[157],"employs":[159],"representation":[161],"learning":[162],"generate":[165],"representations":[167],"from":[168],"either":[169],"then":[172],"contrastively":[173],"mixes":[174],"them":[175],"predict":[177],"how":[178],"likely":[179],"an":[180,189],"event":[181],"occurs":[182],"when":[183],"meets":[186],"another":[187],"end-to-end":[190],"manner.":[191],"Experiments":[192],"demonstrate":[193],"CB-TIP's":[194],"great":[195],"superiority":[196],"potential":[203],"uncovering":[205],"novel":[206],"DDIs.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-05-02T08:42:23.175194","created_date":"2025-10-10T00:00:00"}