{"id":"https://openalex.org/W4381157939","doi":"https://doi.org/10.1093/bib/bbad212","title":"DAmiRLocGNet: miRNA subcellular localization prediction by combining miRNA\u2013disease associations and graph convolutional networks","display_name":"DAmiRLocGNet: miRNA subcellular localization prediction by combining miRNA\u2013disease associations and graph convolutional networks","publication_year":2023,"publication_date":"2023-06-17","ids":{"openalex":"https://openalex.org/W4381157939","doi":"https://doi.org/10.1093/bib/bbad212","pmid":"https://pubmed.ncbi.nlm.nih.gov/37332057"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbad212","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbad212","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016991967","display_name":"Tao Bai","orcid":"https://orcid.org/0000-0003-1183-8207"},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]},{"id":"https://openalex.org/I4210102412","display_name":"Yan'an University","ror":"https://ror.org/01dyr7034","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210102412"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Bai","raw_affiliation_strings":["School of Computer Science and Technology, Beijing Institute of Technology , Beijing 100081 , China","School of Mathematics & Computer Science, Yan\u2019an University , Shaanxi 716000 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Beijing Institute of Technology , Beijing 100081 , China","institution_ids":["https://openalex.org/I125839683"]},{"raw_affiliation_string":"School of Mathematics & Computer Science, Yan\u2019an University , Shaanxi 716000 , China","institution_ids":["https://openalex.org/I4210102412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101667939","display_name":"Ke Yan","orcid":"https://orcid.org/0000-0002-5326-4267"},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ke Yan","raw_affiliation_strings":["School of Computer Science and Technology, Beijing Institute of Technology , Beijing 100081 , China"],"raw_orcid":"https://orcid.org/0000-0002-5326-4267","affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Beijing Institute of Technology , Beijing 100081 , China","institution_ids":["https://openalex.org/I125839683"]}]},{"author_position":"last","author":{"id":null,"display_name":"Bin Liu","orcid":"https://orcid.org/0000-0001-6314-0762"},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bin Liu","raw_affiliation_strings":["Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology , Beijing 100081 , China","School of Computer Science and Technology, Beijing Institute of Technology , Beijing 100081 , China"],"raw_orcid":"https://orcid.org/0000-0001-6314-0762","affiliations":[{"raw_affiliation_string":"Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology , Beijing 100081 , China","institution_ids":["https://openalex.org/I125839683"]},{"raw_affiliation_string":"School of Computer Science and Technology, Beijing Institute of Technology , Beijing 100081 , China","institution_ids":["https://openalex.org/I125839683"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101667939"],"corresponding_institution_ids":["https://openalex.org/I125839683"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.9997,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.87952254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"24","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6321872472763062},{"id":"https://openalex.org/keywords/autoencoder","display_name":"Autoencoder","score":0.6136960983276367},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5840156078338623},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5181187987327576},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"Subcellular localization","score":0.48243364691734314},{"id":"https://openalex.org/keywords/semantic-similarity","display_name":"Semantic similarity","score":0.48233744502067566},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.424452543258667},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"Non-coding RNA","score":0.4168210029602051},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3396780788898468},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3229841887950897},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.23820462822914124},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.21388712525367737},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15561619400978088}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6321872472763062},{"id":"https://openalex.org/C101738243","wikidata":"https://www.wikidata.org/wiki/Q786435","display_name":"Autoencoder","level":3,"score":0.6136960983276367},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5840156078338623},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5181187987327576},{"id":"https://openalex.org/C2776879804","wikidata":"https://www.wikidata.org/wiki/Q7630919","display_name":"Subcellular localization","level":3,"score":0.48243364691734314},{"id":"https://openalex.org/C130318100","wikidata":"https://www.wikidata.org/wiki/Q2268914","display_name":"Semantic similarity","level":2,"score":0.48233744502067566},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.424452543258667},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.4168210029602051},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3396780788898468},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3229841887950897},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23820462822914124},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.21388712525367737},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15561619400978088},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbad212","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbad212","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37332057","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37332057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6351260564","display_name":null,"funder_award_id":"62271049","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6446245973","display_name":null,"funder_award_id":"62250028","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7894669521","display_name":null,"funder_award_id":"U22A2039","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W1968008181","https://openalex.org/W1969156759","https://openalex.org/W2006247279","https://openalex.org/W2047967134","https://openalex.org/W2087064593","https://openalex.org/W2106029302","https://openalex.org/W2133299088","https://openalex.org/W2141222510","https://openalex.org/W2146642335","https://openalex.org/W2157825442","https://openalex.org/W2765950793","https://openalex.org/W2766935102","https://openalex.org/W2799307902","https://openalex.org/W2799341160","https://openalex.org/W2808950870","https://openalex.org/W2899322113","https://openalex.org/W2903227298","https://openalex.org/W2907789789","https://openalex.org/W2914584698","https://openalex.org/W2964015378","https://openalex.org/W2964951118","https://openalex.org/W2972223935","https://openalex.org/W2972551688","https://openalex.org/W2972771793","https://openalex.org/W3000082418","https://openalex.org/W3039465695","https://openalex.org/W3081856356","https://openalex.org/W3093996932","https://openalex.org/W3108133122","https://openalex.org/W3111567820","https://openalex.org/W3116906693","https://openalex.org/W3121961049","https://openalex.org/W3124828689","https://openalex.org/W3134163647","https://openalex.org/W3139418566","https://openalex.org/W3143789190","https://openalex.org/W3145736512","https://openalex.org/W3159197832","https://openalex.org/W3159261411","https://openalex.org/W3170677477","https://openalex.org/W3194531251","https://openalex.org/W3195764419","https://openalex.org/W3199924206","https://openalex.org/W3203741962","https://openalex.org/W3212684988","https://openalex.org/W4200031065","https://openalex.org/W4200043717","https://openalex.org/W4200472293","https://openalex.org/W4210567506","https://openalex.org/W4213072029","https://openalex.org/W4220859562","https://openalex.org/W4225665657","https://openalex.org/W4225752318","https://openalex.org/W4246271082","https://openalex.org/W4255562757","https://openalex.org/W4282921003","https://openalex.org/W4288364260","https://openalex.org/W4291618428","https://openalex.org/W4294992958","https://openalex.org/W4301401095","https://openalex.org/W4306811769","https://openalex.org/W4307440230","https://openalex.org/W4307947078","https://openalex.org/W4308259603","https://openalex.org/W4308370073","https://openalex.org/W4308370554","https://openalex.org/W4310665480","https://openalex.org/W4312094035","https://openalex.org/W6726873649","https://openalex.org/W6768381419","https://openalex.org/W6780031824","https://openalex.org/W6789134440","https://openalex.org/W6845703615"],"related_works":["https://openalex.org/W2159052453","https://openalex.org/W3013693939","https://openalex.org/W2566616303","https://openalex.org/W3131327266","https://openalex.org/W2752972570","https://openalex.org/W4297051394","https://openalex.org/W2734887215","https://openalex.org/W2803255133","https://openalex.org/W2909431601","https://openalex.org/W4294770367"],"abstract_inverted_index":{"MicroRNAs":[0],"(miRNAs)":[1],"are":[2,9,243],"human":[3],"post-transcriptional":[4],"regulators":[5],"in":[6,11,30],"humans,":[7],"which":[8],"involved":[10],"regulating":[12,17],"various":[13],"physiological":[14],"processes":[15],"by":[16,204],"the":[18,31,52,97,125,133,152,159,188,210,216,232],"gene":[19],"expression.":[20],"The":[21,130,184,207,238],"subcellular":[22,53,126,219],"localization":[23,54,220],"of":[24,33,55,87,99,128,154,162,190,218,221],"miRNAs":[25],"plays":[26],"a":[27,84,107],"crucial":[28],"role":[29],"discovery":[32],"their":[34],"biological":[35],"functions.":[36],"Although":[37],"several":[38],"computational":[39,197],"methods":[40],"based":[41,114,135],"on":[42,89,115,136],"miRNA":[43,67,101,137,236],"functional":[44,68,102,233],"similarity":[45,182],"networks":[46],"have":[47],"been":[48,83],"presented":[49],"to":[50,63,71,95,150,176,194,212,215],"identify":[51],"miRNAs,":[56],"it":[57,93,226],"remains":[58],"difficult":[59],"for":[60,123],"these":[61],"approaches":[62],"effectively":[64],"extract":[65],"well-referenced":[66],"representations":[69],"due":[70],"insufficient":[72,100],"miRNA-disease":[73,90,140,166],"association":[74,141,167],"representation":[75],"and":[76,120,143,157,169,241],"disease":[77,144,170],"semantic":[78,145,171],"representation.":[79,103],"Currently,":[80],"there":[81],"has":[82,209],"significant":[85],"amount":[86],"research":[88],"associations,":[91],"making":[92],"possible":[94],"address":[96],"issue":[98],"In":[104],"this":[105],"work,":[106],"novel":[108],"model":[109],"is":[110,148,174,192],"established,":[111],"named":[112],"DAmiRLocGNet,":[113],"graph":[116],"convolutional":[117],"network":[118,163],"(GCN)":[119],"autoencoder":[121],"(AE)":[122],"identifying":[124],"localizations":[127],"miRNA.":[129],"DAmiRLocGNet":[131,191,208],"constructs":[132],"features":[134,202],"sequence":[138,178,181],"information,":[139],"information":[142,153,161,168],"information.":[146,172],"GCN":[147],"utilized":[149],"gather":[151],"neighboring":[155],"nodes":[156],"capture":[158,177],"implicit":[160,201],"structures":[164],"from":[165,180,200],"AE":[173],"employed":[175],"semantics":[179],"networks.":[183],"evaluation":[185],"demonstrates":[186],"that":[187],"performance":[189],"superior":[193],"other":[195,222],"competing":[196],"approaches,":[198],"benefiting":[199],"captured":[203],"using":[205],"GCNs.":[206],"potential":[211],"be":[213],"applied":[214],"identification":[217],"non-coding":[223],"RNAs.":[224],"Moreover,":[225],"can":[227],"facilitate":[228],"further":[229],"investigation":[230],"into":[231],"mechanisms":[234],"underlying":[235],"localization.":[237],"source":[239],"code":[240],"datasets":[242],"accessed":[244],"at":[245],"http://bliulab.net/DAmiRLocGNet.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":7}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}