{"id":"https://openalex.org/W4366464224","doi":"https://doi.org/10.1093/bib/bbad129","title":"NSRGRN: a network structure refinement method for gene regulatory network inference","display_name":"NSRGRN: a network structure refinement method for gene regulatory network inference","publication_year":2023,"publication_date":"2023-04-19","ids":{"openalex":"https://openalex.org/W4366464224","doi":"https://doi.org/10.1093/bib/bbad129","pmid":"https://pubmed.ncbi.nlm.nih.gov/37078865"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbad129","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad129","pdf_url":"https://academic.oup.com/bib/article-pdf/24/3/bbad129/50410476/bbad129.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/24/3/bbad129/50410476/bbad129.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100432002","display_name":"Wei Liu","orcid":"https://orcid.org/0000-0003-4507-7004"},"institutions":[{"id":"https://openalex.org/I4610292","display_name":"Xiangtan University","ror":"https://ror.org/00xsfaz62","country_code":"CN","type":"education","lineage":["https://openalex.org/I4610292"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Liu","raw_affiliation_strings":["Key Laboratory of Intelligent Computing and Information Processing of Ministry of Education, Xiangtan University , Xiangtan 411105 , China","School of Computer Science, Xiangtan University , Xiangtan 411105 , China"],"affiliations":[{"raw_affiliation_string":"Key Laboratory of Intelligent Computing and Information Processing of Ministry of Education, Xiangtan University , Xiangtan 411105 , China","institution_ids":["https://openalex.org/I4610292"]},{"raw_affiliation_string":"School of Computer Science, Xiangtan University , Xiangtan 411105 , China","institution_ids":["https://openalex.org/I4610292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100669269","display_name":"Yu Yang","orcid":"https://orcid.org/0009-0008-6581-9515"},"institutions":[{"id":"https://openalex.org/I4610292","display_name":"Xiangtan University","ror":"https://ror.org/00xsfaz62","country_code":"CN","type":"education","lineage":["https://openalex.org/I4610292"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Yang","raw_affiliation_strings":["Key Laboratory of Intelligent Computing and Information Processing of Ministry of Education, Xiangtan University , Xiangtan 411105 , China","School of Computer Science, Xiangtan University , Xiangtan 411105 , China"],"affiliations":[{"raw_affiliation_string":"Key Laboratory of Intelligent Computing and Information Processing of Ministry of Education, Xiangtan University , Xiangtan 411105 , China","institution_ids":["https://openalex.org/I4610292"]},{"raw_affiliation_string":"School of Computer Science, Xiangtan University , Xiangtan 411105 , China","institution_ids":["https://openalex.org/I4610292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100548518","display_name":"Xu Lu","orcid":"https://orcid.org/0000-0001-7987-7603"},"institutions":[{"id":"https://openalex.org/I2800970254","display_name":"State Intellectual Property Office","ror":"https://ror.org/00zrjgm10","country_code":"CN","type":"government","lineage":["https://openalex.org/I2800970254"]},{"id":"https://openalex.org/I4210122543","display_name":"Guangdong Polytechnic Normal University","ror":"https://ror.org/02pcb5m77","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210122543"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xu Lu","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Intellectual Property Big Data , Guangzhou 510665 , China","School of Computer Science, Guangdong Polytechnic Normal University , Guangzhou 510665 , China"],"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Intellectual Property Big Data , Guangzhou 510665 , China","institution_ids":["https://openalex.org/I2800970254"]},{"raw_affiliation_string":"School of Computer Science, Guangdong Polytechnic Normal University , Guangzhou 510665 , China","institution_ids":["https://openalex.org/I4210122543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044283271","display_name":"Xiangzheng Fu","orcid":"https://orcid.org/0000-0001-6840-2573"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangzheng Fu","raw_affiliation_strings":["College of Computer Science and Electronic Engineering, Hunan University , Changsha 410000 , China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Electronic Engineering, Hunan University , Changsha 410000 , China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033222509","display_name":"Ruiqing Sun","orcid":"https://orcid.org/0000-0003-4863-6529"},"institutions":[{"id":"https://openalex.org/I4610292","display_name":"Xiangtan University","ror":"https://ror.org/00xsfaz62","country_code":"CN","type":"education","lineage":["https://openalex.org/I4610292"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruiqing Sun","raw_affiliation_strings":["Key Laboratory of Intelligent Computing and Information Processing of Ministry of Education, Xiangtan University , Xiangtan 411105 , China","School of Computer Science, Xiangtan University , Xiangtan 411105 , China"],"affiliations":[{"raw_affiliation_string":"Key Laboratory of Intelligent Computing and Information Processing of Ministry of Education, Xiangtan University , Xiangtan 411105 , China","institution_ids":["https://openalex.org/I4610292"]},{"raw_affiliation_string":"School of Computer Science, Xiangtan University , Xiangtan 411105 , China","institution_ids":["https://openalex.org/I4610292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060731658","display_name":"Li Yang","orcid":"https://orcid.org/0000-0001-8614-4555"},"institutions":[{"id":"https://openalex.org/I4610292","display_name":"Xiangtan University","ror":"https://ror.org/00xsfaz62","country_code":"CN","type":"education","lineage":["https://openalex.org/I4610292"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Yang","raw_affiliation_strings":["Key Laboratory of Intelligent Computing and Information Processing of Ministry of Education, Xiangtan University , Xiangtan 411105 , China"],"affiliations":[{"raw_affiliation_string":"Key Laboratory of Intelligent Computing and Information Processing of Ministry of Education, Xiangtan University , Xiangtan 411105 , China","institution_ids":["https://openalex.org/I4610292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100432712","display_name":"Peng Li","orcid":"https://orcid.org/0000-0002-5078-5091"},"institutions":[{"id":"https://openalex.org/I121296143","display_name":"Hunan University of Science and Technology","ror":"https://ror.org/02m9vrb24","country_code":"CN","type":"education","lineage":["https://openalex.org/I121296143"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Li Peng","raw_affiliation_strings":["School of Computer Science and Engineering, Hunan University of Science and Technology , Xiangtan 411201 , China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Hunan University of Science and Technology , Xiangtan 411201 , China","institution_ids":["https://openalex.org/I121296143"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100432712","https://openalex.org/A5100548518"],"corresponding_institution_ids":["https://openalex.org/I121296143","https://openalex.org/I2800970254","https://openalex.org/I4210122543"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":4.2652,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.94653949,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"24","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.7429068684577942},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6963704228401184},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.6151865124702454},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.6138586401939392},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.4843643605709076},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.46873530745506287},{"id":"https://openalex.org/keywords/ranking","display_name":"Ranking (information retrieval)","score":0.4652228057384491},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.42012137174606323},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3220365047454834},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.29977619647979736},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17195570468902588},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16131648421287537},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13562315702438354}],"concepts":[{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.7429068684577942},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6963704228401184},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.6151865124702454},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.6138586401939392},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.4843643605709076},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.46873530745506287},{"id":"https://openalex.org/C189430467","wikidata":"https://www.wikidata.org/wiki/Q7293293","display_name":"Ranking (information retrieval)","level":2,"score":0.4652228057384491},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.42012137174606323},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3220365047454834},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.29977619647979736},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17195570468902588},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16131648421287537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13562315702438354},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbad129","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad129","pdf_url":"https://academic.oup.com/bib/article-pdf/24/3/bbad129/50410476/bbad129.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37078865","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37078865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bib/bbad129","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad129","pdf_url":"https://academic.oup.com/bib/article-pdf/24/3/bbad129/50410476/bbad129.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","score":0.5099999904632568,"id":"https://metadata.un.org/sdg/17"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366464224.pdf","grobid_xml":"https://content.openalex.org/works/W4366464224.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1175879704","https://openalex.org/W1965032353","https://openalex.org/W1996264210","https://openalex.org/W2015208937","https://openalex.org/W2023348596","https://openalex.org/W2027607571","https://openalex.org/W2034662766","https://openalex.org/W2037544231","https://openalex.org/W2044525257","https://openalex.org/W2046538693","https://openalex.org/W2064676287","https://openalex.org/W2076513103","https://openalex.org/W2078149659","https://openalex.org/W2084332810","https://openalex.org/W2099380913","https://openalex.org/W2106555403","https://openalex.org/W2108579152","https://openalex.org/W2110699703","https://openalex.org/W2111384508","https://openalex.org/W2122708083","https://openalex.org/W2129794000","https://openalex.org/W2139997707","https://openalex.org/W2151098983","https://openalex.org/W2151554678","https://openalex.org/W2153624566","https://openalex.org/W2161868542","https://openalex.org/W2161922735","https://openalex.org/W2163296115","https://openalex.org/W2175406438","https://openalex.org/W2258384806","https://openalex.org/W2295598076","https://openalex.org/W2337819340","https://openalex.org/W2467831893","https://openalex.org/W2561175740","https://openalex.org/W2803928488","https://openalex.org/W2976262099","https://openalex.org/W2982380908","https://openalex.org/W2997403971","https://openalex.org/W3000115658","https://openalex.org/W3024161231","https://openalex.org/W3084155903","https://openalex.org/W3088462269","https://openalex.org/W3102924767","https://openalex.org/W3127245931","https://openalex.org/W3127330229","https://openalex.org/W3136592363","https://openalex.org/W3159076767","https://openalex.org/W3170959707","https://openalex.org/W3191591838","https://openalex.org/W3198147676","https://openalex.org/W3200563416","https://openalex.org/W3205148446","https://openalex.org/W3217643826","https://openalex.org/W4200144569","https://openalex.org/W4205705151","https://openalex.org/W4206804332","https://openalex.org/W4220859562","https://openalex.org/W4221083556","https://openalex.org/W4225537122","https://openalex.org/W4226172551","https://openalex.org/W4247458062","https://openalex.org/W4283592141","https://openalex.org/W4313424256","https://openalex.org/W4360770766","https://openalex.org/W6670026339","https://openalex.org/W6783256472","https://openalex.org/W6804994502"],"related_works":["https://openalex.org/W2086397253","https://openalex.org/W2133122801","https://openalex.org/W2188500270","https://openalex.org/W2303858293","https://openalex.org/W2560421304","https://openalex.org/W2950199998","https://openalex.org/W2951387065","https://openalex.org/W2134575910","https://openalex.org/W4385727351","https://openalex.org/W4306798985"],"abstract_inverted_index":{"The":[0,103,125],"elucidation":[1],"of":[2,9,13,111,222],"gene":[3,112],"regulatory":[4],"networks":[5,169,198],"(GRNs)":[6],"is":[7,17,67,188],"one":[8],"the":[10,88,117,138,148,161,165,174,178,183,204,215,220],"central":[11],"challenges":[12],"systems":[14],"biology,":[15],"which":[16],"crucial":[18],"for":[19,31,82],"understanding":[20],"pathogenesis":[21],"and":[22,46,53,91,143,154,164,167,182,201],"curing":[23],"diseases.":[24],"Various":[25],"computational":[26],"methods":[27,193,224],"have":[28],"been":[29],"developed":[30],"GRN":[32,83,96,118],"inference,":[33],"but":[34],"identifying":[35],"redundant":[36,55],"regulation":[37],"remains":[38],"a":[39,68,77,107,121,129,212],"fundamental":[40],"problem.":[41],"Although":[42],"considering":[43],"topological":[44,89],"properties":[45,90],"edge":[47,92],"importance":[48,93],"measures":[49,94],"simultaneously":[50],"can":[51,218],"identify":[52],"reduce":[54],"regulations,":[56],"how":[57],"to":[58,114,136,159,172],"address":[59],"their":[60,65],"respective":[61],"weaknesses":[62],"whilst":[63],"leveraging":[64],"strengths":[66],"critical":[69],"problem":[70],"faced":[71],"by":[72],"researchers.":[73],"Here,":[74],"we":[75],"propose":[76],"network":[78,131,139,155],"structure":[79,132,140],"refinement":[80,133],"method":[81],"(NSRGRN)":[84],"that":[85],"effectively":[86],"combines":[87],"during":[95],"inference.":[97],"NSRGRN":[98,187],"has":[99],"two":[100],"major":[101],"parts.":[102],"first":[104],"part":[105,127],"constructs":[106],"preliminary":[108],"ranking":[109],"list":[110],"regulations":[113],"avoid":[115],"starting":[116],"inference":[119],"from":[120,141],"directed":[122],"complete":[123],"graph.":[124],"second":[126],"develops":[128],"novel":[130],"(NSR)":[134],"algorithm":[135,217],"refine":[137],"local":[142,162,179],"global":[144,184],"topology":[145],"perspectives.":[146],"Specifically,":[147],"Conditional":[149],"Mutual":[150],"Information":[151],"with":[152,190],"Directionality":[153],"motifs":[156],"are":[157,170],"applied":[158],"optimise":[160],"topology,":[163],"lower":[166],"upper":[168],"used":[171],"balance":[173],"bilateral":[175],"relationship":[176],"between":[177],"topology's":[180,185],"optimisation":[181],"maintenance.":[186],"compared":[189],"six":[191],"state-of-the-art":[192],"on":[194],"three":[195],"datasets":[196],"(26":[197],"in":[199,225],"total),":[200],"it":[202],"shows":[203],"best":[205],"all-round":[206],"performance.":[207],"Furthermore,":[208],"when":[209],"acting":[210],"as":[211],"post-processing":[213],"step,":[214],"NSR":[216],"improve":[219],"results":[221],"other":[223],"most":[226],"datasets.":[227]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10}],"updated_date":"2026-03-08T06:56:09.383167","created_date":"2025-10-10T00:00:00"}