{"id":"https://openalex.org/W4328142023","doi":"https://doi.org/10.1093/bib/bbad078","title":"Prioritizing prognostic-associated subpopulations and individualized recurrence risk signatures from single-cell transcriptomes of colorectal cancer","display_name":"Prioritizing prognostic-associated subpopulations and individualized recurrence risk signatures from single-cell transcriptomes of colorectal cancer","publication_year":2023,"publication_date":"2023-03-22","ids":{"openalex":"https://openalex.org/W4328142023","doi":"https://doi.org/10.1093/bib/bbad078","pmid":"https://pubmed.ncbi.nlm.nih.gov/36946415"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbad078","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad078","pdf_url":"https://academic.oup.com/bib/article-pdf/24/3/bbad078/50410436/bbad078.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/24/3/bbad078/50410436/bbad078.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108823969","display_name":"Mengsha Tong","orcid":null},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mengsha Tong","raw_affiliation_strings":["National Institute for Data Science in Health and Medicine, Xiamen University , Xiamen, Fujian 361102 , China","State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","Xiamen University , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Data Science in Health and Medicine, Xiamen University , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"Xiamen University , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002483167","display_name":"Yuxiang Lin","orcid":"https://orcid.org/0000-0001-8854-2995"},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxiang Lin","raw_affiliation_strings":["National Institute for Data Science in Health and Medicine, Xiamen University , Xiamen, Fujian 361102 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Data Science in Health and Medicine, Xiamen University , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062411566","display_name":"Wenxian Yang","orcid":"https://orcid.org/0000-0002-5349-9680"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenxian Yang","raw_affiliation_strings":["Aginome Scientific , Xiamen, Fujian 316005 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aginome Scientific , Xiamen, Fujian 316005 , China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032276638","display_name":"Jinsheng Song","orcid":null},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinsheng Song","raw_affiliation_strings":["State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","Xiamen University , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"Xiamen University , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089862145","display_name":"Zheyang Zhang","orcid":"https://orcid.org/0009-0006-3923-6864"},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheyang Zhang","raw_affiliation_strings":["National Institute for Data Science in Health and Medicine, Xiamen University , Xiamen, Fujian 361102 , China","State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","Xiamen University , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Data Science in Health and Medicine, Xiamen University , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"Xiamen University , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030762640","display_name":"Jiajing Xie","orcid":"https://orcid.org/0009-0004-0853-5859"},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajing Xie","raw_affiliation_strings":["National Institute for Data Science in Health and Medicine, Xiamen University , Xiamen, Fujian 361102 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Data Science in Health and Medicine, Xiamen University , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075139838","display_name":"Jingyi Tian","orcid":null},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Tian","raw_affiliation_strings":["State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","Xiamen University , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"Xiamen University , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076414326","display_name":"Shijie Luo","orcid":"https://orcid.org/0000-0001-8693-2412"},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shijie Luo","raw_affiliation_strings":["State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","Xiamen University , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"Xiamen University , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006838316","display_name":"Chenyu Liang","orcid":null},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenyu Liang","raw_affiliation_strings":["National Institute for Data Science in Health and Medicine, Xiamen University , Xiamen, Fujian 361102 , China","State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","Xiamen University , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Data Science in Health and Medicine, Xiamen University , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"Xiamen University , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044939327","display_name":"Jialiang Huang","orcid":"https://orcid.org/0000-0002-5218-1144"},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jialiang Huang","raw_affiliation_strings":["National Institute for Data Science in Health and Medicine, Xiamen University , Xiamen, Fujian 361102 , China","State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","Xiamen University , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Data Science in Health and Medicine, Xiamen University , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"Xiamen University , School of Life Sciences, Faculty of Medicine and Life Sciences, , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068270780","display_name":"Rongshan Yu","orcid":"https://orcid.org/0000-0003-2179-173X"},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rongshan Yu","raw_affiliation_strings":["Aginome Scientific , Xiamen, Fujian 316005 , China","National Institute for Data Science in Health and Medicine, Xiamen University , Xiamen, Fujian 361102 , China","School of Informatics, Xiamen University , Xiamen 316000 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aginome Scientific , Xiamen, Fujian 316005 , China","institution_ids":[]},{"raw_affiliation_string":"National Institute for Data Science in Health and Medicine, Xiamen University , Xiamen, Fujian 361102 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"School of Informatics, Xiamen University , Xiamen 316000 , China","institution_ids":["https://openalex.org/I191208505"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044939327","https://openalex.org/A5068270780","https://openalex.org/A5108823969"],"corresponding_institution_ids":["https://openalex.org/I191208505"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.9418,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.74690716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"24","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.7653094530105591},{"id":"https://openalex.org/keywords/concordance","display_name":"Concordance","score":0.7307029366493225},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.6417085528373718},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.5074681639671326},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.489360511302948},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.429910808801651},{"id":"https://openalex.org/keywords/gene-signature","display_name":"Gene signature","score":0.41535013914108276},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.40797728300094604},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.40152233839035034},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3793480694293976},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3325042724609375},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3297358453273773},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3085610568523407},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.28816676139831543},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.20186224579811096},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12329208850860596}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7653094530105591},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.7307029366493225},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6417085528373718},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.5074681639671326},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.489360511302948},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.429910808801651},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.41535013914108276},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40797728300094604},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40152233839035034},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3793480694293976},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3325042724609375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3297358453273773},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3085610568523407},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28816676139831543},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20186224579811096},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12329208850860596}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbad078","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad078","pdf_url":"https://academic.oup.com/bib/article-pdf/24/3/bbad078/50410436/bbad078.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36946415","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36946415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bib/bbad078","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad078","pdf_url":"https://academic.oup.com/bib/article-pdf/24/3/bbad078/50410436/bbad078.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3699647886","display_name":null,"funder_award_id":"2020\u00a0J01028","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"},{"id":"https://openalex.org/G5489807358","display_name":null,"funder_award_id":"2020\u00a0J05012","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"},{"id":"https://openalex.org/G6084333872","display_name":null,"funder_award_id":"31871317","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6492551579","display_name":null,"funder_award_id":"32070635","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6590297191","display_name":null,"funder_award_id":"82002529","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7275941149","display_name":null,"funder_award_id":"20720210095","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321878","display_name":"Natural Science Foundation of Fujian Province","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4328142023.pdf","grobid_xml":"https://content.openalex.org/works/W4328142023.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W1893007615","https://openalex.org/W1934094702","https://openalex.org/W1985987855","https://openalex.org/W2007615926","https://openalex.org/W2033751993","https://openalex.org/W2075077128","https://openalex.org/W2085963386","https://openalex.org/W2096192437","https://openalex.org/W2100922775","https://openalex.org/W2116634113","https://openalex.org/W2130410032","https://openalex.org/W2142295792","https://openalex.org/W2149199519","https://openalex.org/W2149668671","https://openalex.org/W2310046094","https://openalex.org/W2467345490","https://openalex.org/W2486262821","https://openalex.org/W2512899508","https://openalex.org/W2533508881","https://openalex.org/W2541478996","https://openalex.org/W2546257383","https://openalex.org/W2586254558","https://openalex.org/W2600453489","https://openalex.org/W2609197200","https://openalex.org/W2746288782","https://openalex.org/W2770459634","https://openalex.org/W2771418085","https://openalex.org/W2773278295","https://openalex.org/W2793791988","https://openalex.org/W2801279436","https://openalex.org/W2802206159","https://openalex.org/W2803164733","https://openalex.org/W2905949588","https://openalex.org/W2922696774","https://openalex.org/W2937818441","https://openalex.org/W2942610007","https://openalex.org/W2952100718","https://openalex.org/W2957125530","https://openalex.org/W2960514003","https://openalex.org/W2963210853","https://openalex.org/W2966569571","https://openalex.org/W2970295470","https://openalex.org/W2972895479","https://openalex.org/W2980845005","https://openalex.org/W3003058300","https://openalex.org/W3009963727","https://openalex.org/W3015416694","https://openalex.org/W3016020856","https://openalex.org/W3016360824","https://openalex.org/W3027774968","https://openalex.org/W3047106569","https://openalex.org/W3087952073","https://openalex.org/W3102447658","https://openalex.org/W3119687579","https://openalex.org/W3120654115","https://openalex.org/W3128209586","https://openalex.org/W3134936846","https://openalex.org/W3135900081","https://openalex.org/W3138699913","https://openalex.org/W3169274538","https://openalex.org/W3172107206","https://openalex.org/W3211405363","https://openalex.org/W4200485099","https://openalex.org/W4206010614","https://openalex.org/W4206841660","https://openalex.org/W4210461181","https://openalex.org/W4212781348","https://openalex.org/W4213218531","https://openalex.org/W4283376791","https://openalex.org/W4292291670","https://openalex.org/W6806939144","https://openalex.org/W6808672278"],"related_works":["https://openalex.org/W1601684588","https://openalex.org/W2108427450","https://openalex.org/W2104328188","https://openalex.org/W648938440","https://openalex.org/W4220795960","https://openalex.org/W2789177613","https://openalex.org/W2915108716","https://openalex.org/W2396330467","https://openalex.org/W1897313079","https://openalex.org/W2506500726"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1],"(CRC)":[2],"is":[3,33,144],"one":[4],"of":[5,69,93,129],"the":[6,67,127,130,157],"most":[7,45],"common":[8],"gastrointestinal":[9],"malignancies.":[10],"There":[11],"are":[12],"few":[13],"recurrence":[14,119],"risk":[15,120],"signatures":[16,116],"for":[17,27,121,136,160],"CRC":[18],"patients.":[19],"Single-cell":[20],"RNA-sequencing":[21],"(scRNA-seq)":[22],"provides":[23],"a":[24,79,151],"high-resolution":[25],"platform":[26],"prognostic":[28,137],"signature":[29],"detection.":[30],"However,":[31],"scRNA-seq":[32,74,134],"not":[34],"practical":[35],"in":[36,73,133,156,163],"large":[37],"cohorts":[38],"due":[39],"to":[40,57,65,82,117],"its":[41],"high":[42],"cost":[43],"and":[44,103,140,165],"single-cell":[46,97,113],"experiments":[47],"lack":[48],"clinical":[49],"phenotype":[50],"information.":[51],"Few":[52],"studies":[53],"have":[54],"been":[55],"reported":[56],"use":[58],"external":[59],"bulk":[60],"transcriptome":[61],"with":[62,106],"survival":[63],"time":[64],"guide":[66],"detection":[68],"key":[70],"cell":[71,85],"subtypes":[72],"data.":[75],"We":[76],"proposed":[77],"scRankXMBD,":[78],"computational":[80],"framework":[81],"prioritize":[83],"prognostic-associated":[84],"subpopulations":[86],"based":[87],"on":[88],"within-cell":[89],"relative":[90],"expression":[91],"orderings":[92],"gene":[94,114],"pairs":[95],"from":[96],"transcriptomes.":[98],"scRankXMBD":[99,143],"achieves":[100],"higher":[101],"precision":[102,141],"concordance":[104],"compared":[105],"five":[107],"existing":[108],"methods.":[109],"Moreover,":[110],"we":[111],"developed":[112],"pair":[115],"predict":[118],"patients":[122],"individually.":[123],"Our":[124],"work":[125],"facilitates":[126],"application":[128],"rank-based":[131],"method":[132],"data":[135],"biomarker":[138],"discovery":[139],"oncology.":[142],"available":[145],"at":[146],"https://github.com/xmuyulab/scRank-XMBD.":[147],"(XMBD:Xiamen":[148],"Big":[149],"Data,":[150],"biomedical":[152],"open":[153],"software":[154],"initiative":[155],"National":[158],"Institute":[159],"Data":[161],"Science":[162],"Health":[164],"Medicine,":[166],"Xiamen":[167],"University,":[168],"China.).":[169]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}