{"id":"https://openalex.org/W4319164488","doi":"https://doi.org/10.1093/bib/bbad029","title":"netANOVA: novel graph clustering technique with significance assessment via hierarchical ANOVA","display_name":"netANOVA: novel graph clustering technique with significance assessment via hierarchical ANOVA","publication_year":2023,"publication_date":"2023-01-12","ids":{"openalex":"https://openalex.org/W4319164488","doi":"https://doi.org/10.1093/bib/bbad029","pmid":"https://pubmed.ncbi.nlm.nih.gov/36738256"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbad029","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad029","pdf_url":"https://academic.oup.com/bib/article-pdf/24/2/bbad029/49560497/bbad029.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/article-pdf/24/2/bbad029/49560497/bbad029.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014105416","display_name":"Diane Duroux","orcid":"https://orcid.org/0000-0002-8564-3157"},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Diane Duroux","raw_affiliation_strings":["BIO3 - Systems Genetics, GIGA-R Medical Genomics, University of Liege , Liege , Belgium"],"affiliations":[{"raw_affiliation_string":"BIO3 - Systems Genetics, GIGA-R Medical Genomics, University of Liege , Liege , Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051714890","display_name":"Kristel Van Steen","orcid":"https://orcid.org/0000-0001-9868-5033"},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Kristel Van Steen","raw_affiliation_strings":["BIO3 - Systems Genetics, GIGA-R Medical Genomics, University of Liege , Liege , Belgium","BIO3 - Systems Medicine, Department of Human Genetics , KU Leuven, Leuven , Belgium"],"affiliations":[{"raw_affiliation_string":"BIO3 - Systems Genetics, GIGA-R Medical Genomics, University of Liege , Liege , Belgium","institution_ids":["https://openalex.org/I157674565"]},{"raw_affiliation_string":"BIO3 - Systems Medicine, Department of Human Genetics , KU Leuven, Leuven , Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014105416"],"corresponding_institution_ids":["https://openalex.org/I157674565"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":3962,"currency":"EUR","value_usd":4273},"fwci":0.7962,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.72076302,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"24","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10064","display_name":"Complex Network Analysis Techniques","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7374564409255981},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.6309778690338135},{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.5548023581504822},{"id":"https://openalex.org/keywords/permutation","display_name":"Permutation (music)","score":0.5291457772254944},{"id":"https://openalex.org/keywords/hierarchical-clustering","display_name":"Hierarchical clustering","score":0.5140198469161987},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.4538019299507141},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.44012731313705444},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.43295568227767944},{"id":"https://openalex.org/keywords/statistical-hypothesis-testing","display_name":"Statistical hypothesis testing","score":0.4224187731742859},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3894297480583191},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1418038010597229},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.13436397910118103}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7374564409255981},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6309778690338135},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.5548023581504822},{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.5291457772254944},{"id":"https://openalex.org/C92835128","wikidata":"https://www.wikidata.org/wiki/Q1277447","display_name":"Hierarchical clustering","level":3,"score":0.5140198469161987},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.4538019299507141},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.44012731313705444},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.43295568227767944},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.4224187731742859},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3894297480583191},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1418038010597229},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.13436397910118103},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bib/bbad029","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad029","pdf_url":"https://academic.oup.com/bib/article-pdf/24/2/bbad029/49560497/bbad029.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36738256","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36738256","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:lirias2repo.kuleuven.be:20.500.12942/717200","is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/20.500.12942/717200","pdf_url":"https://lirias.kuleuven.be/retrieve/cb793a71-72a9-4139-9c59-970714b83a94","source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform, vol. 24 (2)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/304837","is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/304837","pdf_url":"https://orbi.uliege.be/bitstream/2268/304837/1/Duroux2023.pdf","source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Briefings in Bioinformatics, 24 (2) (2023-03-19)","raw_type":"peer reviewed"},{"id":"pmh:oai:pubmedcentral.nih.gov:10025436","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10025436","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10025436/pdf/bbad029.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbad029","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbad029","pdf_url":"https://academic.oup.com/bib/article-pdf/24/2/bbad029/49560497/bbad029.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5099999904632568,"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4319164488.pdf"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W317995076","https://openalex.org/W1816257748","https://openalex.org/W1974530346","https://openalex.org/W1980073965","https://openalex.org/W2008857988","https://openalex.org/W2012274058","https://openalex.org/W2056562706","https://openalex.org/W2089572795","https://openalex.org/W2097360283","https://openalex.org/W2115883395","https://openalex.org/W2133707124","https://openalex.org/W2137609262","https://openalex.org/W2138991775","https://openalex.org/W2159242554","https://openalex.org/W2161163382","https://openalex.org/W2185602187","https://openalex.org/W2282821441","https://openalex.org/W2559655401","https://openalex.org/W2567503720","https://openalex.org/W2568162413","https://openalex.org/W2597289420","https://openalex.org/W2610332124","https://openalex.org/W2620598837","https://openalex.org/W2734915232","https://openalex.org/W2747936636","https://openalex.org/W2766736793","https://openalex.org/W2794413653","https://openalex.org/W2805310212","https://openalex.org/W2904693133","https://openalex.org/W2943939637","https://openalex.org/W2948600471","https://openalex.org/W2963558938","https://openalex.org/W2966357564","https://openalex.org/W2991388718","https://openalex.org/W2997655715","https://openalex.org/W3003893414","https://openalex.org/W3006236094","https://openalex.org/W3007992747","https://openalex.org/W3098724363","https://openalex.org/W3101369110","https://openalex.org/W3152893301","https://openalex.org/W4210876095","https://openalex.org/W4221020277","https://openalex.org/W4294541781","https://openalex.org/W6683921922"],"related_works":["https://openalex.org/W1981780420","https://openalex.org/W2182707996","https://openalex.org/W45233828","https://openalex.org/W2964988449","https://openalex.org/W188202134","https://openalex.org/W2397952901","https://openalex.org/W2029380707","https://openalex.org/W4255934811","https://openalex.org/W2465382974","https://openalex.org/W2043222232"],"abstract_inverted_index":{"Many":[0],"problems":[1],"in":[2,80,115,177],"life":[3],"sciences":[4],"can":[5,142],"be":[6],"brought":[7],"back":[8],"to":[9,37,53,85,92,146,148,169],"a":[10,16],"comparison":[11,189],"of":[12,18,33,41,56,88,97,107,126,160],"graphs.":[13],"Even":[14],"though":[15],"multitude":[17],"such":[19],"techniques":[20],"exist,":[21],"often,":[22],"these":[23,46],"assume":[24],"prior":[25],"knowledge":[26],"about":[27],"the":[28,31,67,94,124,131,156,199],"partitioning":[29],"or":[30],"number":[32,96],"clusters":[34],"and":[35,77,151,158,166,223],"fail":[36],"provide":[38],"statistical":[39],"significance":[40,122],"observed":[42],"between-network":[43],"heterogeneity.":[44],"Addressing":[45],"issues,":[47],"we":[48,64,99,120,134],"developed":[49],"an":[50,81,167],"unsupervised":[51,82],"workflow":[52],"identify":[54,86],"groups":[55,106],"graphs":[57,76],"from":[58],"reliable":[59],"network-based":[60],"statistics.":[61],"In":[62],"particular,":[63],"first":[65],"compute":[66],"similarity":[68],"between":[69,75,104],"networks":[70,218],"via":[71,123,163,215],"appropriate":[72],"distance":[73,128],"measures":[74],"use":[78],"them":[79],"hierarchical":[83],"algorithm":[84],"classes":[87],"similar":[89],"networks.":[90,108],"Then,":[91],"determine":[93],"optimal":[95],"clusters,":[98],"recursively":[100],"test":[101,110],"for":[102,210],"distances":[103],"two":[105,170],"The":[109],"itself":[111],"finds":[112],"its":[113],"inspiration":[114],"distance-wise":[116],"ANOVA":[117],"algorithms.":[118],"Finally,":[119],"assess":[121],"permutation":[125],"between-object":[127],"matrices.":[129],"Notably,":[130],"approach,":[132],"which":[133,211],"will":[135],"call":[136],"netANOVA,":[137],"is":[138,196],"flexible":[139],"since":[140],"users":[141],"choose":[143],"multiple":[144],"options":[145],"adapt":[147],"specific":[149],"contexts":[150],"network":[152],"types.":[153],"We":[154],"demonstrate":[155],"benefits":[157],"pitfalls":[159],"our":[161],"approach":[162],"extensive":[164],"simulations":[165],"application":[168,205],"real-life":[171],"datasets.":[172],"NetANOVA":[173],"achieved":[174],"high":[175],"performance":[176],"many":[178,204],"simulation":[179],"scenarios":[180],"while":[181],"controlling":[182],"type":[183],"I":[184],"error.":[185],"On":[186],"non-synthetic":[187],"data,":[188],"against":[190],"state-of-the-art":[191],"methods":[192],"showed":[193],"that":[194],"netANOVA":[195],"often":[197],"among":[198],"top":[200],"performers.":[201],"There":[202],"are":[203],"fields,":[206],"including":[207],"precision":[208],"medicine,":[209],"identifying":[212],"disease":[213,224],"subtypes":[214],"individual-level":[216],"biological":[217],"improves":[219],"prevention":[220],"programs,":[221],"diagnosis":[222],"monitoring.":[225]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3}],"updated_date":"2025-12-24T23:09:58.560324","created_date":"2025-10-10T00:00:00"}