{"id":"https://openalex.org/W4318671044","doi":"https://doi.org/10.1093/bib/bbad027","title":"Exploring pharmacological active ingredients of traditional Chinese medicine by pharmacotranscriptomic map in ITCM","display_name":"Exploring pharmacological active ingredients of traditional Chinese medicine by pharmacotranscriptomic map in ITCM","publication_year":2023,"publication_date":"2023-01-31","ids":{"openalex":"https://openalex.org/W4318671044","doi":"https://doi.org/10.1093/bib/bbad027","pmid":"https://pubmed.ncbi.nlm.nih.gov/36719094"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbad027","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbad027","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035316822","display_name":"Sai Tian","orcid":"https://orcid.org/0000-0003-2498-190X"},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Saisai Tian","raw_affiliation_strings":["Second Military Medical University School of Pharmacy, , Shanghai, 200433, China"],"affiliations":[{"raw_affiliation_string":"Second Military Medical University School of Pharmacy, , Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100729174","display_name":"Jinbo Zhang","orcid":"https://orcid.org/0000-0001-8287-3259"},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinbo Zhang","raw_affiliation_strings":["Second Military Medical University School of Pharmacy, , Shanghai, 200433, China","Tianjin Rehabilitation Center of Joint Logistics Support Force Department of Pharmacy, , Tianjin, 300110, China"],"affiliations":[{"raw_affiliation_string":"Second Military Medical University School of Pharmacy, , Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477"]},{"raw_affiliation_string":"Tianjin Rehabilitation Center of Joint Logistics Support Force Department of Pharmacy, , Tianjin, 300110, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006518103","display_name":"Shunling Yuan","orcid":null},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shunling Yuan","raw_affiliation_strings":["Second Military Medical University School of Pharmacy, , Shanghai, 200433, China"],"affiliations":[{"raw_affiliation_string":"Second Military Medical University School of Pharmacy, , Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115694863","display_name":"Qun Wang","orcid":"https://orcid.org/0009-0000-4025-0037"},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qun Wang","raw_affiliation_strings":["Shanghai University of Traditional Chinese Medicine The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine Research, , Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai University of Traditional Chinese Medicine The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine Research, , Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083238725","display_name":"Chao Lv","orcid":"https://orcid.org/0000-0002-6907-9736"},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Lv","raw_affiliation_strings":["Shanghai University of Traditional Chinese Medicine The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine Research, , Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai University of Traditional Chinese Medicine The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine Research, , Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100369623","display_name":"Jin\u2010Xing Wang","orcid":"https://orcid.org/0000-0003-0283-3930"},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinxing Wang","raw_affiliation_strings":["Second Military Medical University School of Pharmacy, , Shanghai, 200433, China"],"affiliations":[{"raw_affiliation_string":"Second Military Medical University School of Pharmacy, , Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029470846","display_name":"Jiansong Fang","orcid":"https://orcid.org/0000-0002-6998-5384"},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiansong Fang","raw_affiliation_strings":["Guangzhou University of Chinese Medicine Science and Technology Innovation Center, , Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Guangzhou University of Chinese Medicine Science and Technology Innovation Center, , Guangzhou, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067947880","display_name":"Lu Fu","orcid":"https://orcid.org/0000-0002-4898-7831"},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Fu","raw_affiliation_strings":["Second Military Medical University School of Pharmacy, , Shanghai, 200433, China"],"affiliations":[{"raw_affiliation_string":"Second Military Medical University School of Pharmacy, , Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101606905","display_name":"Jian Yang","orcid":"https://orcid.org/0000-0002-2401-6571"},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Yang","raw_affiliation_strings":["Second Military Medical University School of Pharmacy, , Shanghai, 200433, China"],"affiliations":[{"raw_affiliation_string":"Second Military Medical University School of Pharmacy, , Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014930009","display_name":"Xianpeng Zu","orcid":"https://orcid.org/0000-0003-2682-0755"},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianpeng Zu","raw_affiliation_strings":["Second Military Medical University School of Pharmacy, , Shanghai, 200433, China"],"affiliations":[{"raw_affiliation_string":"Second Military Medical University School of Pharmacy, , Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009960665","display_name":"Jing Zhao","orcid":"https://orcid.org/0000-0002-2439-2876"},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhao","raw_affiliation_strings":["Shanghai University of Traditional Chinese Medicine The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine Research, , Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai University of Traditional Chinese Medicine The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine Research, , Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100428749","display_name":"Weidong Zhang","orcid":"https://orcid.org/0000-0002-7384-2490"},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weidong Zhang","raw_affiliation_strings":["Second Military Medical University School of Pharmacy, , Shanghai, 200433, China","Shanghai University of Traditional Chinese Medicine The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine Research, , Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Second Military Medical University School of Pharmacy, , Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477"]},{"raw_affiliation_string":"Shanghai University of Traditional Chinese Medicine The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosafety, Institute of Interdisciplinary Integrative Medicine Research, , Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5035316822"],"corresponding_institution_ids":["https://openalex.org/I177933477"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":24.0993,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.99701294,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"24","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/active-ingredient","display_name":"Active ingredient","score":0.7491178512573242},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.6475009322166443},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5895709991455078},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.4905838072299957},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"Traditional Chinese medicine","score":0.4788379967212677},{"id":"https://openalex.org/keywords/resource","display_name":"Resource (disambiguation)","score":0.4472957253456116},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4100755453109741},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3220404386520386},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2632502317428589},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.18475115299224854},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13716229796409607},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.1290665566921234},{"id":"https://openalex.org/keywords/alternative-medicine","display_name":"Alternative medicine","score":0.0867939293384552}],"concepts":[{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.7491178512573242},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6475009322166443},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5895709991455078},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.4905838072299957},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.4788379967212677},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.4472957253456116},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4100755453109741},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3220404386520386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2632502317428589},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.18475115299224854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13716229796409607},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1290665566921234},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0867939293384552},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbad027","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbad027","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36719094","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36719094","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1112760424","display_name":null,"funder_award_id":"82141203","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5017981367","display_name":null,"funder_award_id":"82004215","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7169906910","display_name":null,"funder_award_id":"2022YFC3502000","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8461056115","display_name":null,"funder_award_id":"2021YFE0200900","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8766688743","display_name":null,"funder_award_id":"82004003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":101,"referenced_works":["https://openalex.org/W1495214424","https://openalex.org/W1963745184","https://openalex.org/W1984034991","https://openalex.org/W1987209448","https://openalex.org/W1993352447","https://openalex.org/W2010154617","https://openalex.org/W2017852953","https://openalex.org/W2036274810","https://openalex.org/W2039936465","https://openalex.org/W2074160143","https://openalex.org/W2086400609","https://openalex.org/W2086744970","https://openalex.org/W2088226047","https://openalex.org/W2105391162","https://openalex.org/W2110480353","https://openalex.org/W2118770646","https://openalex.org/W2118968734","https://openalex.org/W2120572492","https://openalex.org/W2121604817","https://openalex.org/W2124679671","https://openalex.org/W2127938920","https://openalex.org/W2130410032","https://openalex.org/W2143446969","https://openalex.org/W2146511318","https://openalex.org/W2167778120","https://openalex.org/W2214074259","https://openalex.org/W2345398159","https://openalex.org/W2500727927","https://openalex.org/W2548357532","https://openalex.org/W2595454228","https://openalex.org/W2607129810","https://openalex.org/W2612467560","https://openalex.org/W2624747153","https://openalex.org/W2766193612","https://openalex.org/W2766490148","https://openalex.org/W2767891136","https://openalex.org/W2788432893","https://openalex.org/W2793518816","https://openalex.org/W2796168562","https://openalex.org/W2799995337","https://openalex.org/W2887511219","https://openalex.org/W2889850091","https://openalex.org/W2896810005","https://openalex.org/W2898264436","https://openalex.org/W2898468989","https://openalex.org/W2899291554","https://openalex.org/W2907579063","https://openalex.org/W2910773350","https://openalex.org/W2924961853","https://openalex.org/W2930078124","https://openalex.org/W2939264032","https://openalex.org/W2946657092","https://openalex.org/W2950753203","https://openalex.org/W2952752961","https://openalex.org/W2953190652","https://openalex.org/W2956031974","https://openalex.org/W2982664082","https://openalex.org/W2983166786","https://openalex.org/W2984599876","https://openalex.org/W2990827591","https://openalex.org/W2999988993","https://openalex.org/W3008830538","https://openalex.org/W3010497490","https://openalex.org/W3011030655","https://openalex.org/W3015608194","https://openalex.org/W3017312058","https://openalex.org/W3021939159","https://openalex.org/W3025962447","https://openalex.org/W3033359824","https://openalex.org/W3040907131","https://openalex.org/W3041222256","https://openalex.org/W3082514297","https://openalex.org/W3082562727","https://openalex.org/W3088672484","https://openalex.org/W3090297365","https://openalex.org/W3092122033","https://openalex.org/W3092540339","https://openalex.org/W3093061534","https://openalex.org/W3093194543","https://openalex.org/W3108860514","https://openalex.org/W3116917620","https://openalex.org/W3119787853","https://openalex.org/W3124919154","https://openalex.org/W3125923658","https://openalex.org/W3133590568","https://openalex.org/W3134548309","https://openalex.org/W3153687839","https://openalex.org/W3164416447","https://openalex.org/W3187236162","https://openalex.org/W3193526107","https://openalex.org/W3211281229","https://openalex.org/W4200241873","https://openalex.org/W4205974265","https://openalex.org/W4206737621","https://openalex.org/W4210297646","https://openalex.org/W4220734682","https://openalex.org/W4225262157","https://openalex.org/W4226172846","https://openalex.org/W4229373412","https://openalex.org/W6678463936","https://openalex.org/W6783545980"],"related_works":["https://openalex.org/W4244777403","https://openalex.org/W4231699368","https://openalex.org/W4249953473","https://openalex.org/W4243609823","https://openalex.org/W4281673370","https://openalex.org/W3010058077","https://openalex.org/W2920569584","https://openalex.org/W2951512731","https://openalex.org/W4400243266","https://openalex.org/W2046431380"],"abstract_inverted_index":{"With":[0],"the":[1,17,74,88,102,117,149,167,172,181,206,217],"emergence":[2],"of":[3,16,54,57,91,106,208,220,225],"high-throughput":[4,98],"technologies,":[5],"computational":[6],"screening":[7,53,90,162],"based":[8],"on":[9,36],"gene":[10],"expression":[11],"profiles":[12],"has":[13,43,62],"become":[14],"one":[15,119],"most":[18],"effective":[19,89],"methods":[20,142],"for":[21,87,153,171],"drug":[22,209,229],"discovery.":[23,210,230],"More":[24],"importantly,":[25],"profile-based":[26,51],"approaches":[27],"remarkably":[28],"enhance":[29],"novel":[30],"drug-disease":[31],"pair":[32],"discovery":[33],"without":[34],"relying":[35],"drug-":[37],"or":[38],"disease-specific":[39],"prior":[40],"knowledge,":[41],"which":[42,111],"been":[44,63],"widely":[45],"used":[46],"in":[47],"modern":[48],"medicine.":[49],"However,":[50],"systematic":[52],"active":[55,78,92,109,145,169,193,218],"ingredients":[56,146,170,219],"traditional":[58,83],"Chinese":[59,84],"medicine":[60,85],"(TCM)":[61],"scarcely":[64],"performed":[65,96,130],"due":[66],"to":[67,131,143,165,191,204,214],"inadequate":[68],"pharmacotranscriptomic":[69,80],"data.":[70],"Here,":[71],"we":[72,95,136,157,177,188],"develop":[73],"largest-to-date":[75],"online":[76],"TCM":[77,221],"ingredients-based":[79],"platform":[81],"integrated":[82,158],"(ITCM)":[86],"ingredients.":[93],"First,":[94],"unified":[97],"experiments":[99],"and":[100,147,196,202,222,228],"constructed":[101],"largest":[103],"data":[104],"repository":[105],"496":[107],"representative":[108],"ingredients,":[110],"was":[112,128,212],"five":[113],"times":[114],"larger":[115],"than":[116],"previous":[118],"built":[120],"by":[121,184],"our":[122],"team.":[123],"The":[124],"transcriptome-based":[125],"multi-scale":[126],"analysis":[127],"also":[129,178],"elucidate":[132],"their":[133],"mechanism.":[134],"Then,":[135],"developed":[137],"six":[138],"state-of-art":[139],"signature":[140,151],"search":[141],"screen":[144],"determine":[148],"optimal":[150],"size":[152],"all":[154],"methods.":[155],"Moreover,":[156],"them":[159],"into":[160],"a":[161],"strategy,":[163],"TCM-Query,":[164],"identify":[166],"potential":[168],"special":[173],"disease.":[174],"In":[175],"addition,":[176],"comprehensively":[179,215],"collected":[180],"TCM-related":[182],"resource":[183],"literature":[185],"mining.":[186],"Finally,":[187],"applied":[189],"ITCM":[190,211,231],"an":[192],"ingredient":[194],"bavachinin,":[195],"two":[197],"diseases,":[198],"including":[199],"prostate":[200],"cancer":[201],"COVID-19,":[203],"demonstrate":[205],"power":[207],"aimed":[213],"explore":[216],"boost":[223],"studies":[224],"pharmacological":[226],"action":[227],"is":[232],"available":[233],"at":[234],"http://itcm.biotcm.net.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":46},{"year":2024,"cited_by_count":39},{"year":2023,"cited_by_count":11}],"updated_date":"2026-04-14T08:04:32.555800","created_date":"2025-10-10T00:00:00"}